Negan Smith

We investigate AC Stark-shifted resonances in argon with ultrashort near-infrared pulses. Using 30 fs pulses, we observe periodic enhancements of the excitation yield in the intensity regions corresponding to the absorption of 13 and 14 photons. By reducing the pulse duration to 6 fs with only a few optical cycles, we also demonstrate that the enha...

Synopsis We report results for strong-field ionization and excitation of argon obtained by solving the time-dependent; Schrödinger equation in a single-active-electron model. We analyze the process of “frustrated tunnel ionization” and its dependence on the potential and a variety of laser parameters, such as the intensity, carrier-envelope phase,...

Case Report e-poster 107-year-old general anaesthesia for hemiarthroplasty 2 days post NSTEMI

The results of a pre-oxidation heat treatment at 930 °C in Ar/H2/H2O environments on a Si-bearing Nb-stabilised 20Cr25Ni austenitic steel are presented. The heat treatment was conducted under low pO2, achieved by the introduction of controlled amounts of moisture into the gas. The atmosphere promoted the formation of a continuous, dense, adherent,...

Austenitic stainless steel is used as fuel cladding in advanced gas-cooled nuclear reactors (AGR). At elevated temperatures, when the steel is exposed to CO2 based environments filamentary carbon deposits form on the surface of the steel. This filamentary carbon deposition is known to be catalysed by metallic nickel-rich particles. Adding trace amo...

Carbon deposition on 20Cr25Ni steel at 700 °C has been investigated in CO2-based gases containing 0.7 vol%, 1.0 vol% and 1.4 vol% CO, each with ∼1000vpm C2H4, at 700 °C. Filamentary carbon deposits were formed at the two lowest CO contents but not at 1.4 vol% CO. TEM analyses have shown that the different CO levels change the propensity for deposit...

Background: Belief in God is very common and tied to mental health/illness in the general population, yet its relevance to psychiatric patients has not been adequately studied. We examined relationships between belief in God and treatment outcomes, and identified mediating mechanisms. Methods: We conducted a prospective study with n¼159 patients in...

To cite this article: Rabe KF, Calhoun WJ, Smith N, Jimenez P. Can anti-IgE therapy prevent airway remodeling in allergic asthma? Allergy 2011; 66: 1142–1151. Airway remodeling is a central feature of asthma. It is exemplified by thickening of the lamina reticularis and structural changes to the epithelium, submucosa, smooth muscle, and vasculature...

The physician's global evaluation of treatment effectiveness (GETE) at 16 weeks has been shown to be the most effective assessment of response to omalizumab (XOLAIR®). This randomized, open-label, parallel-group study evaluated the persistency of treatment responder classification in patients receiving omalizumab added to optimized asthma therapy (...

Introduction In June 2010, the National Confidential Enquiry into Patient Outcome and Death published ‘A Mixed Bag: an enquiry into the care of in-patients receiving parenteral nutrition’ (PN). This study found only 19% of inpatients received care with respect to their PN that was considered good. It also revealed widespread variability in the type...

Introduction In June 2010, the National Confidential Enquiry into Patient Outcome and Death published ‘A Mixed Bag: an enquiry into the care of inpatients receiving parenteral nutrition' (PN). This study found that only 19% of inpatients received care with respect to their PN that was considered good by the advisors peer reviewing the study. Additi...

Introduction Recent emphasis has been placed on the importance of nutrition support teams (NSTs) in good nutritional care and management of patients on parenteral nutrition (PN). Evidence regarding their benefit, however, is surprisingly sparse, with the absence of large trials to evaluate their effectiveness. In 2010, the National Confidential Enq...

Asthma is a chronic inflammatory disease of the airways in which immunoglobulin E (IgE) plays a key role by activating a variety of inflammatory cells through interactions with FcepsilonRI and FcepsilonRII receptors. The role of IgE in allergic inflammation provided the rationale for developing omalizumab, a humanized monoclonal anti-IgE antibody,...

The NICE re-appraisal of anti-TNF requires demonstration of ongoing response, making the baseline 28-joint Disease Activity Score (DAS28) crucially important. A retrospective analysis of all RA patients on their first anti-TNF determined predictive factors for those classified as non-responders at 6 months according to current NICE guidelines. The...

Developments in 'print on demand' mean that book publishers need no longer speculate on print runs, can reduce their environmental footprint and perhaps bring a few Iong-lost classics back to the masses.

National Institute for Health and Clinical Excellence (NICE) guidelines for anti-tumour necrosis factor (TNF) in rheumatoid arthritis (RA) state that two pre-assessments of Disease Activity Score (DAS28) should be performed a month apart. We performed a retrospective audit of data from six centres to determine the stability of DAS28 between assessm...

Numerous concepts aimed at increasing airspace capacity have been proposed to meet the anticipated increase in future air traffic demand. NASA Ames and NASA Langley Research Centers have recently conducted a joint simulation to test the En Route Free Maneuvering concept element of Distributed Air-Ground Traffic Management (DAG-TM), which integrated...

The efficacy of different facemasks that can be used in the delivery of aerosol medication to children with recurrent wheeze or asthma was investigated. The results showed a statistically significant difference between some of the masks used, which has important implications for current clinical practice

In order to create the agile and adaptive force needed to enable NCW and EBO concepts, the force needs to be conceived as components that can be rapidly assembled to provide mission capability packages to meet the commander’s need. Previous work in this area has focussed on information exchanges. This paper proposes broadening our approach to consi...

In September 2002, NASA's Advanced Air Transportation Technologies project office sponsored a human-in-the-loop simulation of Distributed Air/Ground Traffic Management (DAG-TM) concepts. The simulation examined three DAG-TM Concept Elements (CEs) which included: (1) CE 5 which is En Route Free Maneuvering for: (a) User-Preferred Separation Assuranc...

The impact of routine hepatitis A vaccination of children living in large communities with elevated disease rates has not been evaluated. To determine the effect of routine vaccination of children on disease incidence in a community with recurrent hepatitis A epidemics. Community-based demonstration project conducted from January 12, 1995, through...

Combined chemo-radiotherapy produces significant responses in locally advanced NSCLC. Since accelerated repopulation can occur in tumours after 28 days of radiotherapy, treatment delivered within a four week period with concurrent cisplatinum should result in high levels of local tumour control, if normal tissue reactions are acceptable. We have tr...

BACKGROUND: Inhalational therapy is the mainstay of treatment in childhood asthma. For children less than 3 years of age a spacer device with a facemask attachment is the delivery method of choice. Face masks are also used for older children unable to inhale effectively from a spacer mouthpiece. It is known that the type of spacer chosen may signif...

Field-ready nondestructive examination technologies are examined in terms of their limitations, advantages, and overall reliability in determining the remaining life of reformer furnace tubes. The advantages and disadvantages of each technique compared with each other reduce the occurrence of false calls.

New procedures for human operators in complex systems must be both operationally effective and inexpensive to introduce. Procedures may require refinement to meet these objectives. The paper illustrates how process measures about operator performance using a new procedure can be derived via activity tracking, and how this information can supplement...

The taking of inadequate cervical cytological smears leads to patient anxiety, an increased burden on medical and laboratory staff and potentially misses cervical abnormalities. It has been suggested that screening programmes should collect information about the proportion of smears considered unfit for diagnostic purposes. We present an audit of t...

Heavy equipment is often used in hazardous situations where the operators are subjected to high-risk conditions. Under these circumstances, teleoperated machines can be used to avoid potential dangers to workers. We initiated a project in 1992 to develop a remote control package for a 86.5 kW (116 hp) wheel loader. The control system of the loader...

Zebra Finches are increasingly used as experimental animals, in particular in neuro-science research. There are presently no guidelines for the housing of these very active birds who are capable of exhibiting quite complex behaviour. The birds are often housed in monogamous pairs in small barren cages. In the present study it was investigated wheth...

This is the first case reported of recurrent Candida albicans septic arthritis in an HIV-positive man who was not an injecting drug user.

Zebra finches are often housed in monogamous pairs in small barren cages. In the present study it was investigated whether modest enrichment resulted in behavioural changes. Four plywood box cages of two different lengths were compared. A small and a large cage were used for the barren environment. Another small and large cage were used for the enr...

In chronic autoimmune thrombocytopenic purpura (AITP), an indirect monoclonal antibody immobilised platelet antigen (MAIPA) assay detected serum glycoprotein (GP) IIb/IIIa antibodies in 16/39 (41%) cases. In patients with clinically active AITP, a direct MAIPA assay detected platelet-associated GP IIb/IIIa kantibodies in 8/13 (62%) cases. Platelet...

Several species of marine fish caught in the wild and of freshwater ornamental fish were used in this study. Infected organs (liver, spleen, and kidney) were sampled for mycobacteria. Decontaminated tissue samples were plated onto selective media for mycobacterial recovery. After initial isolation, fluorescent and acid-fast staining techniques iden...

15 patients underwent plasma exchange using a standard 170-microns in-line filter with or without an additional 40-microns microaggregate filter in the return circuit. The mean platelet count fall immediately after plasma exchange in 15 patients was (54 +/- 6) x 10(9)/l and 48 h later was (23 +/- 8) x 10(9)/l representing a mean total platelet loss...

Twenty-one patients with autoimmune thrombocytopaenic purpura (AITP) were treated with anti-D immunoglobulin. There was no significant difference with low and high dose anti-D treatment in the platelet count response between homozygous and heterozygous Rh(D) positive patients. The heterogeneous responses seen in Rh(D) positive AITP patients treated...

Five patients with ITP were treated with 2 gram intravenous infusions of intramuscular human non specific immunoglobulin (IMIg). Increased platelet counts similar to those achieved with intravenous Rhesus anti D immunoglobulin were observed in four patients. 5000 iu anti D immunoglobulin contain up to 2 g of IMIg, and the clinical responses seen in...

Five patients with ITP were treated with 2 gram intravenous infusions of intramuscular human non specific immunoglobulin (IMIg). Increased platelet counts similar to those achieved with intravenous Rhesus anti D immunoglobulin were observed in four patients. 5000 iu anti D immunoglobulin contain up to 2 g of IMIg, and the clinical responses seen in...

A patient with chronic ITP relapsed after conventional therapy but following an infusion with low dose anti D (Rho) immunoglobulin, she entered a remission which has now lasted 10 months. This is difficult to explain on the basis of long term macrophage Fc receptor blockade and suggests an alternative mechanism of action.

The effects of acute global ischemia on cytosolic calcium transients were studied in perfused rabbit hearts loaded with the fluorescent calcium indicator indo 1. Indo 1-loaded hearts were illuminated at 360 nm, and fluorescence was recorded simultaneously at 400 and 550 nm from the epicardial surface of the left ventricle. The F400/F550 ratio was c...

To elucidate the role of cytosolic calcium, [Ca2+]i, in the physiology of the normal and ischemic heart, we have developed a method for recording [Ca2+]i transients from the epicardial surface of the rabbit ventricle after arterial perfusion with the cell-permeant cytosolic calcium indicator indo-1 AM. Hearts were illuminated at 360 nm, and fluores...

Much literature is available on the use of aquatic plants in the treatment of wastewater. However, since conditions for plant growth differ from place to place, it is necessary to establish the effectiveness of t h i s type of treatment for each locali y. A programme to test the effectiveness of aquatic plants in improving the quality of secondary...

We systematically paired auditory, olfactory, and social stimuli with each injection of morphine in rats. We found that, when morphine was kept constant at a low dose, the external stimuli acquired the property of a conditional stimulus (CS) to cause hyperthermia which was antagonized by naloxone. In rats in which morphine doses were regularly incr...

[35S]Bromosulfophthalein ([35C]BSP), [14C]sodium taurocholate ([14C]NaTC), AND 10 MG OF UNLABELED BSP.and of phenol-3,6-dibromophthalein disulfonate (DBSP) per kilogram body weight were injected in the caudal artery of free-swimming dogfish sharks (Squalus acanthias) and small skates (Raja erinacea). Twenty-four hours later, 85.8 +/- 15.7% of [35S]...

Bile composition and secretion were studied in tow elasmobranch species, Squalus acanthias (spiny dogfish shark) and Raja erinacea (small skate), after ligation of the common duct and insertion of cannulas into the gallbladder lumen. Fish were then allowed to swim freely in large pools and bile was collected in balloons attached to the externalized...

The hepatic metabolism of 35S-sulfobromophthalein was studied in the free-swimming Elasmobranchs, Squalus acanthias (spiny dogfish shark) and Raja erinacea (small skate), to evaluate the physiological significance of biliary excretion of organic anions in marine vertebrates. Twenty-four hours after intra-arterial injection, 85.8 +/- 15.7% of the ad...

Narcotic dependence in rats was established, in five days, by administering intravenous injections of morphine sulfate in increasing doses. From day six onward, dependence was maintained by administering a morphine injection (15 mg/kg) every 6 h throughout the day, and each of these injections was paired with a tone. After 16 morphine-tone pairings...

The radicals BH–3, CH3 and NH+3 are compared using ab initio UHF calculations after annihilation of the contaminating quartet spin state. Although there is a consistency in the trends predicted for the properties, these are not in accord with those determined experimentally. Although the out-of-plane zero-point energy vibration has a dominating inf...

The Roothaan, McWeeny and Fletcher methods of minimizing the electronic energy in the SCF method are compared. The CN radical is used as an example using the abinitio UHF method. It is concluded that a combination of the Fletcher and Roothaan methods should be generally applicable and also highly efficient.

6s-type and 4p-type gaussian basis sets are obtained for the second row atoms by fitting, using a least squares criterion, to 12s-type and 9p-type gaussian basis sets which are close to the self-consistent field atomic orbital wave functions. The small gaussian expansions are considered to be more suited for molecular calculations using double basi...

Formulae to calculate the anisotropic components of the hyperfine coupling tensor are given for gaussian type orbitals. These are used to evaluate the principal values, with their directions referred to molecular axes, of the hyperfine coupling tensor for every atom in the radicals NaH+, N–2, NO, CN, HCO, HCN–, HBO–, H2CN, C2H3.

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Summary This paper describes the use of rapid prototyping by researchers in the Human Factors Research and Technology Division at NASA Ames Research Center to explore advanced air traffic concepts. The paper addresses the main software components and their use throughout different prototyping and evaluation stages. Ongoing and future research on no...

The ''Teacher's Guide to Home Winterization'' was prepared as a guide to teachers in developing lesson plans for a Home Winterization Course which promotes the utilization of known Retrofit Technology to improve thermal characterizatics and conserve energy in residential housing. The Kit contains: Teacher's Guide to Home Winterization; Home Winteri...

Ab initio UHF calculations using a minimal basis set of orbitals for the radicals H2S−, H2S+, NH3+, CH3, CH3− and NH2 predict the hyperfine coupling constants to all nuclei with a consistent accuracy if SCF atomic orbitals are used.

The Home Weatherization Instructor's Guide is part of a set to be used as a teacher's guide. The set was prepared as a guide to teachers in developing lesson plans for a Home Winterization Course which promotes the utilization of known RETROfit TECHnology to improve thermal characteristics and conserve energy in residential housing. The course is i...

The hyperfine coupling constants for NH+3 are calculated to be aN= 10.57, aH=–22.65 G using the ab initio UHF method after spin annihilation of the quartet spin state and optimization of the NH bond length and hydrogen atom orbital exponent. It is calculated that the effect of the out-of-plane zero-point energy vibration modifies the hyperfine coup...

This report was prepared as a guide to teachers in developing lesson plans for a Home Winterization Course which promotes the utilization of known RETROfit TECHnology to improve thermal characteristics and conserve energy in residential housing. The job book is required material for the student. The course is intended for either of two audiences: (...

A report is given which promotes the use of known retrofit technology to improve thermal characteristics and conserve energy in residential housing. The course is intended for either of two audiences: (1) for work-crew supervisors to train community services groups in utilizing retro-fit technology in residential housing under government-aided wint...

The Home Weatherization Charts are part of a set to be used as a teacher's guide. The set was prepared as a guide to teachers in developing lesson plans for a Home Winterization Course which promotes the utilization of known RETROfit TECHnology to improve thermal characteristics and conserve energy in residential housing. The charts are designed fo...

Improved aerospace surveillance and battlespace management (ASBM) is fundamental to the defence of Australia and its interests. DSTO has been asked to assist in the development a capability roadmap for ASBM, which can chart the course from the current systems to the capability required in 20 years time i.e. 2023. In order to do this we need to unde...

Heat-transfer coefficients are calculated for forced convection from a heated flat plate, of finite breadth and infinite span, at zero incidence to a steady stream of viscous, incompressible fluid. The complete range of the Reynolds number R is considered and the results for large R are compared with the Pohlhausen boundary-layer solution for a pla...