Neeraj K. Sethiya

DIT University | DIT · Faculty of Pharmacy

Phyllanthin, a sparingly water-soluble hepatoprotective lignin obtained from Phyllanthus amarus Schum. et Thonn. (Euphorbiaceae) possesses low bioavailability. Phyllanthin along with piperine (a nutraceutical bioenhancer) was formulated as a mixed micellar lipid formulation (MMLF) in the present study and investigated to resolve the low bioavailabi...

Mangiferin (polyphenolic xanthone) and scopoletin (phenolic coumarin) are well-studied biological markers present in Canscora decussata (Roxb.) Roem. & Schult., Gentianaceae. The objective set for the present studies is to establish and develop a new, simple, selective, sensitive, and precise high performance thin layer chromatography method for th...

In this study, we investigated a new, simple, sensitive, selective and precise high-performance thin-layer chromatography (HPTLC) fingerprint and quantitative estimation method for the analysis of ursolic acid, betulinic acid, stigmasterol and lupeol in Shankhpushpi botanicals. Linear ascending development was carried out in a twin trough glass cha...

Context: The roots of Aerva lanata Linn. (Amaranthaceae) (AL) are employed traditionally as an antihyperglycaemic in the Ayurvedic system of medicine. Objective: The present investigation is focus for identification and isolation of the bioactive compound from methanol roots extract of AL against streptozocin-nicotinamide induced elevated serum...

Aim of the study: In southern India, ayurvedic practitioners traditionally employ the whole herb of Canscora decussata Schult. (CD) (Gentianaceae) as a traditional ayruvedic medicine, Shankhpushpi for its memory potentiating, anxiolytic and tranquilizing properties. The present study investigated the effect of CD, which is regarded as Shankhpushpi,...

This study explores the feasibility of leveraging consumer reviews for passive surveillance of foodborne illnesses, drawing parallels with pharmacovigilance systems. Utilizing a mixed-methods approach, including a literature review, qualitative interviews with key stakeholders, and quantitative analysis of 56,000 restaurant reviews using a bidirect...

Social media reviews are a valuable data source, reflecting consumer experiences and interactions with businesses. This study leverages such data to develop a passive surveillance framework for food safety in urban India. By employing a Bidirectional Encoder Representations from Transformers (BERT)-powered Aspect-Based Sentiment Analysis tool, bran...

The ultimate goal of nanoparticle‐based phototherapy is to suppress tumor growth. Photothermal therapy (PTT) and photothermal photodynamic therapy (PDT) are two types of physicochemical therapy that use light radiation with multiple wavelength ranges in the near‐infrared to treat cancer. When a laser is pointed at tissue, photons are taken in the i...

This study presents the development and validation of the "Eat at Right Place Initiative," a sentiment analysis tool for restaurant reviews. Combining a user-centric approach with the Scrum framework, the mHealth agile development and evaluation framework was implemented, deviating from the initially considered Scrum framework. A multidisciplinary...

COVID-19, also known as coronavirus disease 2019, is an extremely contagious viral sickness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After the first cases of this primarily respiratory viral illness were recorded in Wuhan, Hubei Province, China, in late December 2019, SARS-CoV-2 rapidly disseminated across the globe....

Kaempferol (KMP) belong to flavonoid class have developed in ethosomal formulation and were evaluated for their potential to treat diabetic foot ulcers. Even though ethosomes are highly deformable, they can pass through human skin intact. KMP ethosomes were formulated using the cold method and optimized by Box–Behnken design (BBD) (three‐factor, th...

Lifestyle disorders are types of noncommunicable diseases. A poor and unhealthy lifestyle may initiate a series of interactive disorders that could become fatal (if they go unrecognised and untreated). Several traditional treatment approaches have long been available to treat such diseases. These traditional medical treatments completely rely on he...

Background: In the current scenario, most of the population affected by neurogenera-tive disorders like Alzheimer's, Parkinson's, Huntington's, etc., exist among the 10% population 65 years of age group. Neurodegenerative diseases are characterised as chronic and progressive disorders that occur due to the degeneration of neurons. Baicalein is a fl...

Page 82-84 Abstract no 23 ser experiences on m-health ‘Swayam Diabetes care android application’ and testing of the application on utility and usability for self-care management of type 2 diabetes in urban home settings. Abhijeet P Sinha, Manmohan Singhal, Ashish Joshi, Neeraj Kumar Sethiya, PhD4, Bhawna Kumar, PhD5 1. * DIT University Ph.D. fel...

The Swayam Diabetes care application was designed for self-care management of type 2 diabetes and keeping the patient at the core, of the Android-based mobile application. Swayam Diabetes Care was designed with a user-centered focus, and a qualitative sequential study was done n=18 with in-depth interviews and the first version of the Swayam Diabet...

Swayam Diabetes Care mobile application was developed to facilitateself-care management for those with type 2 diabetesin an urbanhome setting.This Android-basedmobile application was designed to keepthe userat the centerof its design functionalityand features. The development of Swayam Diabetes Care prioritizeda user-centric approach, and qualitati...

Neurological ailments, including stroke, Alzheimer's disease (AD), epilepsy, Parkinson's disease (PD), and other related diseases, have affected around 1 billion people globally to date. PD stands second among the common neurodegenerative diseases caused as a result of dopaminergic neuron loss in the midbrain's substantia nigra regions. It affects...

Diabetes mellitus type 2 (T2DM) is one of the most common and widespread diseases in the world. It affects people in both rich and developing countries. With a growing population, it's getting harder and harder for healthcare services to provide good care. Given the nature of the disease and the setting of the healthcare system, it has become much...

Abstract The m-health application was designed for self-care management of type 2 diabetes and keeping the patient at the core, the application was designed, human-centered focusing on comprehensive self-care management, which included, daily dairy, nutrition, food update, exercise, medicine intake, and nutrition informatics to support for improvin...

Aspect-Based Sentiment Analysis (ASBA) concept has been worked extensively as a popular technique in consumer research. The commercial applications though limited are being tested. The research mainly focuses on using the existing ASBA model to be adopted, tested and validated for use in the context of consumer reviews for restaurants in Indian geo...

In this study, we investigated a new, simple, sensitive, selective and precise high-performance thin-layer chromatography (HPTLC) fingerprint and quantitative estimation method for the routine analysis of curcumin in Curcuma species viz. Curcuma amada, Curcuma caesia, Curcuma longa and Curcuma zedoaria. Linear ascending development was carried out...

Myricetin (MC), 3,5,7,3',4',5'-hexahydroxyflavone, chemically belongs to a flavonoid category known to confer antioxidant, antimicrobial, antidiabetic, and neuroprotective effects. MC is known to suppress the generation of Reactive Oxygen Species (ROS), lipid peroxidation (MDA), and inflammatory markers. It has been reported to improve insulin func...

Background: One of the most challenging effects of diabetes is diabetic foot ulceration (DFU). DFU may occur in up to one-third of individuals with diabetes mellitus (D.M.) at some point in their lives. The major cause of morbidity in D.M. patients is DFU. The length of treatment is difficult, and DFU recurrence is common. Objective: The most cr...

Lectin, a non-immunogenic origin protein, has properties of binding carbohydrates for the effective wound healing process. The process of wound healing is intricate and encompasses a diverse range of cells, extracellular matrix and soluble mediators involving the hemostasis, coagulation, inflammatory, proliferative, and remodeling or re-epitheliali...

Berberine (BRB) is a natural alkaloid of the isoquinoline class, mostly isolated from the Berberis genus, which exhibits antibiotic, immunostimulant, antitumor, cardiovascular protection, endocrine regulator, antidepressant, neuroprotective, antioxidant, anti-inflammatory, and other pharmacological properties. The poor aqueous solubility of BRB is...

Objectives Berberine has attracted prominent interest recently due to its wide pharmacological actions in management and treatments of several disease including liver. However, restricted bioavailability and permeability makes this drug as better choice to develop several value added products for improvement of both safety and efficacy. Many of res...

The primary objective of this paper is to develop a framework for continuous monitoring of the safety of food business operators without overburdening established regulatory systems through social media for food safety. A phase-wise methodology was adopted, wherein Phase 1 was dedicated to identifying available literature on Adverse Drugs Reactions...

Background The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring...

Antiviral medications are currently an emergent area of study, due to evaluation of several new mutated developing strains. These mutant strains are resistant to currently available regimens. It is well known that development of the new drug requires considerable period of times, and has to be authorized through stringent regulatory bodies for huma...

Allium wallichii (A. wallichii) Kunth, is an underutilized rare medicinal plant species with several beneficial ethnomedicinal health promotion activity Moreover, being so popular in both ethanobotanicals and traditional herbal system, still the plant is very less studied for phytochemical and nutritional composition analysis. Therefore, phytochemi...

Quantification of bioactive markers through modern analytical methods is very essential for establishing the authenticity and creditability of prescription and usage of herbal drugs formulations. In the present study, simultaneous quantification of rosmarinic acid (RA), quercetin (Q), glycyrrhizin (G) and betulinic acid (BA), in polyherbal formulat...

Diabetes is a long-term (chronic), challenging lifestyle (metabolic) disorder in which the body cannot regulate the amount of sugar in the blood and majorly affecting endocrine system and metabolic functions. Its complications majorly affect the neurons (as developing neuropathy), kidney (as nephropathy), and eye (as retinopathy). Diabetes also res...

Background: Allium wallichii Kunth (Family: Amaryllidaceae), commonly known as “Himalayan onion” is well recorded as popular ethnomedicine for medicinal and nutritional uses by different people and communities native to Bhutan, India, Myanmar, Nepal and Southwestern China. Methods: Despite the wide ethnomedicinal and pharmacological studies on A. w...

Nano-therapeutics often aims to design site-specific delivery of the therapeutics at the molecular level to treat diseased tissues or organs. On the contrary, both reachability and interaction of these therapeutic active molecules at the delivery site are challenging tasks, and most of the therapeutics are unable to achieve therapeutic efficacy, be...

The use of microscopic techniques for the identification of medicinal plants is one of the best practices and an important quality control tool for standardization. Stomata are important organs for the study of phylogenetic relationships including plant origin, evolution, and classification. Allium wallichii (A. wallichii) Kunth, is one of the thre...

Background Carbamazepine (Cbz) is a first line drug for epileptic seizures, but exhibit fluctuation at plasma level and side effects after oral administration. To overcome these problems Cbz should be targeted directly into the brain. Therefore, the current experimental design was aimed to formulate and optimize the Cbz containing solid lipid nanop...

Background Glycyrrhiza glabra L. (G. glabra) commonly known as liquorice is one of the highly exploited and utilized medicinal plant of the world. Since ancient times liquorice is considered as an auspicious and valuable traditional medicine across the world for treatment of various ailments. Method Several electronic online scientific databases s...

Allium wallichii (A. wallichii) Kunth, is an underutilized rare medicinal plant species with several beneficial ethnomedicinal health promotion activity Moreover, being so popular in both ethanobotanicals and traditional herbal system, still the plant is very less studied for phytochemical and nutritional composition analysis. Therefore, phytochemi...

Neurodegenerative disorders occur when nerve cells in the brain or peripheral nervous system partial or complete fail in their functions and sometimes even die due to some injuries or aging. Neurodegenerative disorders such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD), have been majorly resulted due to degeneration of neurons and neuroi...

Development of ocular drug delivery system is one of the most technically challenging tasks, when compared with other routes of drug delivery. Eye (an intricate organ) is highly sophisticated and sensitive organ due to presence of various structurally differed anatomical layers, which many times limits the drug delivery approaches. Despite several...

Xanthones are important chemical class of bioactive products that confers therapeutic benefits. Of several xanthones, mangiferin is known to be distributed widely across several fruits, vegetables and medicinal plants. Mangiferin has been shown to exert neuroprotective effects in both in-vitro and in-vivo models. Mangiferin attenuates cerebral infa...

The thin-layer chromatographic (TLC) analysis of extracts/compounds has several applications in the field of food, cosmetics, phytochemistry, and pharmaceutical industry. Mangiferin is a bioactive and natural antioxidant polyphenolic xanthone obtained from different dietary plants and recently gaining remarkable attention due to its high pharmacolo...

Objective: The present study was undertaken to evaluate the neuropharmacological effect of four herbs commonly identified as source of Shankhpushpi. Background: Shankhpushpi is an Ayurvedic drug, widely used for its actions on the central nervous system, especially to improve intellect and boost memory. Four botanicals viz. Canscora decussata Sc...

Abstract Ethnopharmacological relevance Ensete superbum (Roxb.) Cheesman. (Family: Musaceae), commonly known as “Wild Banana” is well recorded as popular ethnomedicine for medicinal and nutritional uses by different people and communities native to India, Ethiopia, Thailand, Myanmar and Vietnam. Aim of the review Despite the wide ethnomedicinal an...

Introduction: Shankhpushpi has been widely used in traditional Indian system of medicine as a brain and memory boosting tonic. There are a variety of botanicals reported to be used as a sources of Shankhpushpi in various parts of India. For instance, Canscora decussata Schult, Clitorea ternatea Linn., Convolvulus pluricaulis Choisy. and Evolvulus a...

This article explores the most recent evidence-based information on ethnomedicinal, phytochemical and pharmacological understanding of Hygrophila auriculata for the treatment of various diseases and health conditions. Various ethnomedicinal writings suggest the use of the plant or its parts for the treatment of jaundice, oedema, gastrointestinal ai...

In this study, chloroform extract derived from pseudostem of Ensete superbum (Roxb.) Cheesman (Family: Musaceae) powder was investigated for treatment of calcium oxalate urolithiasis. An in vitro antiurolithiatic study was carried out by conductometric titrations of CaCl2 with Na2C2O4 in the absence and presence of chloroform extract of Ensete supe...

The National Innovation Foundation (NIF) – India was set up by the Department of Science and Technology (DST), to promote and maintain the records of green grassroots innovations and innovators and is built on the philosophy akin to the behaviour of honey bee. To extract out Innovation from knowledge-rich but economically unprofessional poor people...

The present study investigates preliminary pharmacognostic, phytochemical and antioxidant property of Ensete Superbum (Roxb.) Cheesman pseudostem. Macroscopical and microscopical features of the pseudostem have been documented. Presence of phytochemicals such as steroids, terpenoids, alkaloids, flavanoids, tannins and sugar were tested by chemical...

'Gut health' is a term currently gaining much more attentions in veterinary literature especially in poultry. It covers multiple positive aspects of the gastrointestinal (GI) tract, such as the effective digestion by absorption of food, absence of GI illness, normal and stable intestinal microbiota, effective immune status and a state of well-being...

As a sequel to 4-volume series on HPLC titled Quantitative Analysis of Pharmaceutical Formulations containing detailed analytical procedures for 1082 fixed dose formulations published since 2001, the present four volumes (Volumes 5,6, 7, 8) have been compiled to update the literature in respect of HPLC methods of analysis for newly introduced formu...

As a sequel to 4-volume series on HPLC titled Quantitative Analysis of Pharmaceutical Formulations containing detailed analytical procedures for 1082 fixed dose formulations published since 2001, the present four volumes (Volumes 5,6, 7, 8) have been compiled to update the literature in respect of HPLC methods of analysis for newly introduced formu...

As a sequel to 4-volume series on HPLC titled Quantitative Analysis of Pharmaceutical Formulations containing detailed analytical procedures for 1082 fixed dose formulations published since 2001, the present four volumes (Volumes 5,6, 7, 8) have been compiled to update the literature in respect of HPLC methods of analysis for newly introduced formu...

As a sequel to 4-volume series on HPLC titled Quantitative Analysis of Pharmaceutical Formulations containing detailed analytical procedures for 1082 fixed dose formulations published since 2001, the present four volumes (Volumes 5,6, 7, 8) have been compiled to update the literature in respect of HPLC methods of analysis for newly introduced formu...

It gives us great happiness to introduce this book on GPAT containing fundamental concepts and fully solved multiple choice questions asked in previous examinations.. Though every candidate has ability to succeed but competitive environment, quality guidance and good source & references for study certainly give competitive edge. Competitive Examina...

Objective To investigate the effect of standardized methanol extract of Evolvulus alsinoids Linn. (E. alsinoids) on Plasmodium falciparum specific lactate dehydrogenase (PfLDH) enzyme inhibition. Methods To carry out enzyme inhibition studies, lactate dehydrogenase was cloned from Plasmodium falciparum 3D7 strain using expression vector pET28a and...

Most downloaded articles Page 1 [2] [3] [4] [5] [6] [7] [8] [9] [10] [Next Ten Pages] No. Title Year Issue Downloads Hits 1 An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine 2009 11 23259 32313 2 A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis: a pilot trial 2013 1 22827 24917...

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In search to potent natural antioxidant from plant-based metabolites, a comparative study was designed in present investigation. The antioxidant activity of various phytochemicals listed in text was determined by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing power assays (FRAP) and phosphomolybdenum complex method. The level of the an...