Neelesh K Nema

Synthite Industries Pvt. Ltd. · Nutraceuticals

This article is primarily reviewed and delivered a concise fact of the coronaviridae family, pathophysiology, mechanism of action, ethnopharmacological validated Indian herbs for inhibiting the virus with possible targets. Science mapping tool Bibliometrix R-package was used to understand bibliometric analysis on keywords associated with SARS-CoV-2...

The present study objective was to design and develop novel health-supplement formula from plant extracts and was to evaluate the formula for high episodic alcohol toxicities, and associated disorders against alcohol intoxicated and oxidative damaged Human Hepatoma HepG2 cell line. The CC50 of the supplement was determined based on MTT assay. To ge...

This comprehensive reference explores medicinal plants, phytomedicines, and traditional herbal remedies as potential sources for the prevention and treatment of COVID-19. It features 9 chapters authored and edited by renowned experts. The book specifically highlights the promising drug discovery opportunities grounded in bioactive compounds from me...

Elettaria cardamomum (L.) Maton (cardamom), popularly known as the “Queen of spices,” belongs to the Zingiberaceae family and is one of the world’s most expensive and unusual spices. It is high in phenolic compounds, volatile oils, and fixed oils. Cardamom oleoresin is a non-toxic, non-irritant, and non-sensitizing semi-solid liquid with a sweet an...

The sensory attributes that include factors such as appearance, taste, odor, flavor taste, and texture are often used in practice by consumers to evaluate food quality. During purchase, these indicators are compared with the already standardized reference food product and match the quality. Foodstuffs’ characteristics can be changed by utilizing th...

Skin aging is the result of programmed senescence and prolonged environmental injury to skin. Human skin is continuously exposed to environmental influences and is therefore subjected to both intrinsic as well as extrinsic aging processes. Aged skin is characterized by loss of skin tone and resilience, increased roughness and dryness, irregular pig...

Alcohol Dehydrogenase (ADH), Cytochrome P450 2E1 (CYP2E1), and catalase are bio-transformed alcohol to acetaldehyde, which further transformed to acetate by the mitochondrial Aldehyde Dehydrogenase (ALDH) enzyme and coming out from the liver to circulates into peripheral tissues. Non-oxidative pathway responsible for the esterification of alcohol,...

Pandemic coronavirus disease-2019 (COVID-19) is an infectious disease caused by the newly discovered virus “Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2)”. Considering the present scenario of COVID-19 outbreak and its impact on humankind, holistic remedies with respect to herbal medicine validated from ethnopharmacological rationale...

Pandemic coronavirus disease-2019 (COVID-19) is an infectious disease caused by the newly discovered virus “Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2)”. Considering the present scenario of COVID-19 outbreak and its impact on humankind, holistic remedies with respect to herbal medicine validated from ethnopharmacological rationale...

Antioxidant helps to reduce various disorders and control pathological conditions such as cancer, aging, cardiovascular disease, cataracts, immune system decline, and brain dysfunction etc. In this study, the top 200 highly cited articles (citations 327,657) with total 647 authors were retrieved from Elsevier’s Scopus database (105,440 hits) by the...

Introduction Chillies or red peppers are consumed globally as a spice, condiment, culinary and as folk medicine because of their pungent taste, spicy flavour and therapeutic values. Colour, pungency and capsaicinoids are the potential characteristic attributes for assessing the quality of the dried chilli and are accountable for market price, trade...

Skin aging is the result of programed senescence and prolonged environmental injury to skin. Human skin is continuously exposed to environmental influences and is therefore subjected to both intrinsic as well as extrinsic aging processes. Aged skin is characterized by the loss of skin tone and resilience, increased roughness and dryness, irregular...

Ethnopharmacological relevance: Marula (Sclerocarya birrea; family - Anacardiaceae) is an African plant, which enjoys wide socio-economic importance particularly in southern part of Africa. The fruits are consumed as food and also as alcoholic beverage (cream liquor). In different parts of Africa, the decoction of the bark is traditionally used fo...

Immunomodulation is the alteration of immune response which may increase or decrease the immune responsiveness. Medicinal plants, since times immemorial, have been used virtually in all cultures as a source of medicine for altering the immune systems. Several medicinal plants have been investigated for immunomodulatory potentials and they are prove...

The main objective of this study was to determine the in vitro Angiotensin Converting Enzyme (ACE) inhibition and antioxidant activity of standardized extract of the Ocimum sanctum L. leaves and its fractions. The ACE inhibition activity and antioxidant activity were investigated by UV method. In ACE inhibition method, the synthetic substrate hippu...

Aloe vera (L.) Burm. f. (Family Liliaceae) is an evergreen perennial succulent plant widely used from antiquity. Aloe vera contains various carbohydrate polymers, notably glucomannans, along with a range of other organic and inorganic components. Phenolic compounds have been identified so far as chromone, anthraquinone or anthrone derivatives. Thre...

India has a well-recorded and well-practiced knowledge of traditional herbal medicine for the treatment of chronic disease like diabetes. There is a growing demand for the leads with potential antidiabetic activity. Ethnomedical approach for diabetes is a practical, cost-effective, and a logical approach for its treatment and management. This chapt...

Matrix metalloproteinase (MMPs) are a family of zinc and calcium dependent endopeptidases. All MMPs have two molecular appearances, one is pre-peptide sequence that directs their secretion in the extracellular environment and another is pro-peptide domain that maintains them in their zymogenic form. MMPs play crucial roles in numerous pathophysiolo...

Context: Centella asiatica (L.) Urban (Apiaceae), a valuable herb described in Ayurveda, is used in the indigenous system of medicine as a tonic to treat skin diseases. Objective: Centella asiatica methanol extract and its ethyl acetate, n-butanol and aqueous fraction, were subjected for the evaluation of skin care potential through the in vitro...

Foeniculum vulgare Mill and Coriandrum sativum L. are very popular spices in Indian kitchens. The present study was an attempt to evaluate the angiotensin converting enzyme (ACE) inhibition and antioxidant activity of the standardized oils of F. vulgare and C. sativum by an UV method using hippuryl-L-histidyl- L-leucine (HHL) as substrate. Standard...

Cardiovascular disease is a threat to global health and one of the leading causes of death and disability worldwide. Cardiovascular disease includes myocardial infarction (MI), angina, stroke, hypertension, congestive heart failure (CHF), hardening of the arteries, and other circulatory system disease. According to the World Health Organization, mo...

In vitro Angiotensin Converting Enzyme (ACE) inhibition activity was determined with standardized extract of the Ocimumsanctum L. leaves and its fractions. The ACE inhibition activity and antioxidant activity were investigated by a UV method [1]. In the ACE inhibition method, the synthetic substrate hippuryl-L-histidyl-L-leucine was allowed to reac...

Traditionally, the herbal drugs are well established for their therapeutic benefits. Depending upon their geographical sources sometimes the trace and heavy metals' content may differ, which may lead to severe toxicity. So, the toxicological and safety assessment of these herbal drugs are one of the major issues in recent days. Eight different plan...

The fruit of Terminalia bellerica L. (Combretaceae) is an important ingredient of ‘Triphala’, which is a popular Ayurvedic formulation traditionally used to treat hypertension, to reduce cardiac depression and to decreases the risk factors associated with the heart. This study aimed to investigate the angiotensin converting enzyme (ACE) inhibitory...

Cucumber (Cucumis sativus L.) is a member of the Cucurbitaceae family like melon, squash and pumpkins. It is a popular vegetable crop used in Indian traditional medicine since ancient times. This vegetable is very high in water content and very low in calories. It has potential antidiabetic, lipid lowering and antioxidant activity. Cucumber has a c...

Aim: Plant Clitoria ternatea L. is claimed to possess a wide range of activities including antiinflammatory, local anesthetic and antidiabetic effect, etc. The aim of the present study was to evaluate the wound healing potential of standardized C. ternatea leaf extract in terms of different enzymatic models, which are mostly associated with skin wo...

Ayurveda, derives from the Sanskrit words Ayus (life) and Veda (knowledge) is the most ancient system of traditional medicine of the world. It has been practiced in Indian peninsula since 5000 BC to offer natural ways to treat diseases and to promote healthcare. We reviewed the literature on the history, principles and current status of Ayurveda. T...

Marigold (Tagetes erecta L.; Family: Asteraceae) has been reported for several pharmacological activities. This experiment was designed to develop a reverse phase HPLC method according to ICH and FDA guidelines to assure the quality standard of marigold flower for medicinal uses and to find out the content of its biomarkers. β-amyrin (yield 0.3% w/...

Skin aging involves degradation of extracellular matrix (ECM) in both the epidermal and dermal layers, it leaves visible signs on the surface of skin and the physical properties of the skin are modified. Chronological aging is due to passage of time, whereas premature aging occurred due to some environmental factors on skin produces visible signs s...

A RP-HPLC method was developed (λ (max) = 280) to quantify hydroxychavicol and chlorogenic acid in Piper betel Linn. The method was validated for linearity, limit of detection (LOD = 3:1σ/S), limit of quantification (LOQ = 10:1σ/S), precision, accuracy and ruggedness. The response was linear with good correlation between concentration and mean peak...

Traditionally Tagetes erecta Linn flower is claimed to treat skin diseases like sores, burns, wounds, ulcers, eczema and several other skin ailments. The aim of the present experiment was to evaluate the anti-wrinkle potential of standardized flower extract of Tagetes erecta. The Tagetes erecta extract and fractions were screened for hyaluronidase,...

Traditionally Calendula officinalis L. (Compositae) flower has been claimed for use in inflammation, wound healing, antiseptic, various skin diseases like ulceration, eczema etc. The present study was designed to validate its skin protective activity through inhibition of hyaluronidase, elastase and matrix metalloproteinase-1 (MMP-1). C. officinali...

The aim of this study was to screen the antioxidant, anti-hyaluronidase, and anti-elastase activity of the lyophilized juice of Cucumis sativus fruit (CSLJ). The CSLJ was subjected to DPPH and superoxide radical scavenging assay in reference to butylated hydroxytoluene. The hyaluronidase and elastase inhibitory assay was performed in reference to o...

Clerodendron serratum (Linn.) Moon (family: Verbenaceae) is used in Indian System of Medicine for asthma and cough. In the present study the extract of the bark of the plant was standardized using oleanolic acid as a marker. Methanolic extracts of the bark were prepared after defatting. HPTLC was used to quantify oleanolic acid in the extract. Perc...

To investigate the mast cell stabilization and antihistaminic activities of the rhizomes of Curculigo orchioides (COR). Extract of Curculigo orchioides Gaertn. (Fam. Amaryllidaceae) has been reported to possess immunostimulant, and anti-inflammatory potentials. In Indian traditional system of medicine it is also used as anti-asthmatic and anti-infl...

Glycyrrhiza glabra Linn (Family-Fabaceae) is active as an anti-allergic, anti-inflammatory, spasmolytic, mild laxative, antistress, antidepressive, antiulcer, liver protective, estrogenic, emmenagogue, and antidiabetic substance, and is widely used in the Indian system of medicine. The major bioactive constituent is glycyrrhizin. A simple HPTLC met...

Two preparations of herbal shampoo powder were formulated using some common traditional drugs used by folk and traditional people of Bundelkhand region (M.P) India, for hair care. The preparations were formulated using bahera, amla, neem tulsi, shikakai henna & brahmi evaluated for organoleptic, powder charecterestics, foam test and physical evalua...