Neelabh ..

Banaras Hindu University | BHU · Department of Zoology

Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Combinatorial and retroviral therapies have been found effective in the treatment of cryptococcosis, but safer and more potent antifungal therapeutics are the need of the hour. In this regard, the natural antifungal peptides (AFPs), the essential components of the innate immune sy...

Introduction: Since Covid-19 has emerged as a pandemic, it has taken innumerable lives and caused havoc in the developing as well as developed countries. The health facilities throughout the world have taken a toll and to counter this some immediate alternative measures have to be taken. Utilization of the plant-based products from the Indian tradi...

CITED2 is a transcription co-activator that interacts with TFAP2 and CBP/ P300 transcription factors to regulate the proliferation and differentiation of the cardiac progenitor cells. It acts upstream to NODAL-PITX2 pathways and regulates the left-right asymmetry. Both human genetic and model organism studies have shown that altered expression of C...

Polymorphism in biology refers to the discontinuous genetic variations leading to the existence of two or more forms, stages, or phenotypes existing in the same species within the same population

In the contemporary research, biological computational tools have emerged to play a pivotal role in facilitating both cost and time efficient research in several domains of biology. One such domain is addressing the prevailing food allergy issues, where these computational tools have been proven of vital importance. Different tools use different ma...

Actinobacteria are a group of microorganisms reflecting standard behavior of both bacteria and fungi and are known to play a multifunctional role in agricultural production systems. The primary functions include the production of a wide array of growth-promoting compounds and metabolites, including antibiotics that provide the host plants resistanc...

Cryptococcosis is a potentially fatal fungal disease which has aggrandized with the emergence of AIDS and antifungal resistance. The currently used antifungals lack the broad-spectrum activity and result in several toxicities during long treatment regimens. Thus, the present study aims to evaluate the antifungal activity of cinnamaldehyde against C...

Mustard is widely used in a variety of foods/food products to enhance the flavor and nutritional value that subsequently raise the risk of hypersensitivity reactions. Mustard allergy has been reported for many years and is increasing gradually especially in the areas where its consumption is comparatively higher, and it may be considered among the...

A series of 7‐benzamidocoumarin derivatives 10–25 starting from 7‐amino coumarins 7 and 8 has been synthesized, characterized and evaluated in vitro for antifilarial activity against the human lymphatic filarial parasite, Brugia malayi. Compounds 13 and 20–23 showed permanent paralysis of the worm with 90–95% inhibition of motility of adult worms a...

Purpose We investigated if substitutions in the ERCC1, ERCC2, and XRCC1 genes of the DNA repair pathway correlate with non-obstructive azoospermia and male infertility. Methods A total of 548 azoospermic infertile males and 410 fertile controls were genotyped for XRCC1 399A > G, 280G > A, and ERCC1 C > A 3′ UTR and 541 azoospermic infertile males...

Research has shown that drugs or therapeutic agents which are directed at a particular target often undergo a reduction in efficacy, undesired safety profiles, compensatory and neutralizing effects, anti-target and counter target activities and also resistance against the drug. Proper utilization of multiple targets can lead to a perfect blend betw...

Although, there has been a significant progress in the field of pharmaceuticals and drug designing in the recent past, yet there is a vacuum in the development of broad spectrum antifungal drugs. Those drugs that are at our disposal are not free from side effects having several risks and associated toxicities on prolonged usage. Therefore, there ha...

Drug development is a dynamic field which undergoes changes continuously. The past decade or so has witnessed huge strides in the field of screening of the drugs as well as target and ligand identifications but unfortunately this has not led to useful drugs. Many diseases still remain untreatable because we do not have proper drugs against them. In...

In the contemporary research, biological computational tools have emerged to play a pivotal role in facilitating both cost and time efficient research in several domains of biology. One such domain is addressing the prevailing food allergy issues, where these computational tools have been proven of vital importance. In the present study, we discuss...

Even in the contemporary age of technological advancement, allergy continues to pose a great problem for medical science. The immune system of our body is built to protect us from foreign, potentially disease-causing substances however, often our immune system identifies various proteins, found in environment, common food components etc., as diseas...

Leishmaniases are endemic in various countries and parasite is developing resistance against available drugs. Thus, development of new drugs against Leishmania is an open area of investigation for synthetic organic chemist. In order to meet this challenge, a series of 2-mercaptoquinoline derivatives have been synthesized and docked into the active...

An RNA sequence not coding for a protein is termed as a noncoding (nc) RNA.

Homeobox genes are a group of similar geneshaving a common DNA sequence (a homeobox)responsible for coding a homeodomain. They playa vital role in governing the formation of bodilysegmentation and cell differentiation duringembryonic development (PDF) Homeobox Gene. Available from: https://www.researchgate.net/publication/331988325_Homeobox_Gene...

Fungal diseases are amongst the emerging diseases to which humans are most susceptible pertaining to the present day life style. New drugs are being made but at a slow pace, not matching the resistance developing capacity of the fungal pathogens. Therefore, it is important to choose new drug targets peculiar to fungi but absent in humans.A common p...

Griseofulvin is a well known drug against dermatophytes. It is particularly prescribed for an infection called scrap ringworm or tinea capitis. In general, griseofulvin inhibits the tubulin protein that is responsible for the cell division. Not much is known about the effect of griseofulvin on Cryptococcus neoformans. Therefore, the authors made an...

Vast growth of multimedia information like images, audio and video on web has induced the scientific community for storage and retrieval of multimedia information more intuitively. Since one image can be interpreted in numerous ways, keyword based searching systems can retrieve the information to a limited extent. Moreover in few domains for exampl...

We describe Mus musculus castaneus as a new mammalian host for Cryptococcus neoformans var. grubii (VNI). Eighteen apparently healthy adults and pups of the rodent were collected from human dwellings in Varanasi, a city of India. Both clinical and behavioral examinations of the rodents did not reveal any sign of the disease. Among visceral organs,...

Emerging drug resistance varieties and hyper-virulent strains of microorganisms have compelled the scientific fraternity to develop more potent and less harmful therapeutics. Antimicrobial peptides could be one of such therapeutics. This review is an attempt to explore antifungal peptides naturally produced by prokaryotes as well as eukaryotes. The...

A bstract The morphologic conversion of the dimorphic fungi from mold to yeast is required for virulence. Conversion from mold to yeast form may offer protection against killing by neutrophils, monocytes and macrophages. Aspergillus versicolor is a cosmopolitan fungus which rarely causes deep infections in humans. It is an occasional agent of onych...

Identification of the epitopes aids in developing the molecules of clinical relevance and is also helpful in understanding the immunological importance of the antigens with respect to the structure/function relationship. Several bioinformatics tools have been deployed in this study to use orthologous genes as scaffolds leading to suitable drug targ...

Aciclovir is the best dr thymidine kinase made by the HSV. In the current study we have successfully designed a drug candidate " NKK " , which is far more efficient than aciclovir in terms of binding energy and physiochemical properties again used softwares viz. Autodock 4.0, FireDock and Hex dock in order to demonstrate that " NKK " is a better li...

Consumption of green gram (Vigna radiata L. Millsp), a legume (family: fabaceae) induces allergic symptoms in the susceptible individuals. In the present study, an attempt has been made to induce oral tolerance in BALB/c mice as a therapeutic tool for the prevention of green gram allergy. At first set of experiments, BALB/c mice were gavaged with g...