Neda Khaledi

Kharazmi University | KHU · Department of Exercise Physiology

Background: Childhood exercise enhances brain structure, while diabetes detrimentally affects it. This study examines early-life exercise's influence on adult diabetic rats' memory and neuroplasticity. Methods: Male Wistar pups were divided into Control, Diabetes, Exercise Training, and Diabetes exercise groups. Diabetes was induced on day 23 wi...

Transcranial magnetic stimulation (TMS) measures the excitability and inhibition of corticomotor networks. Despite its task-specificity, few studies have used TMS during dynamic movements and the reliability of TMS paired pulses has not been assessed during cycling. This study aimed to evaluate the reliability of motor evoked potentials (MEP) and s...

Background and Purpose: Beta-alanine supplement, which is a precursor of carnosine, may improve performance by providing a buffering effect. The purpose of this study was to investigate the effect of beta-alanine supplementation and regular Taekwondo training on anaerobic, aerobic, and endurance activity substrate metabolism in female Taekwondo ath...

Transcranial magnetic stimulation (TMS) measures the excitability and inhibition of corticomotor networks. Despite its task-specificity, few studies have used TMS during dynamic movements and the reliability of TMS-derived measures has not been assessed during cycling. This study aimed to evaluate the reliability of motor evoked potentials (MEP) an...

Exercise-induced hypoalgesia (EIH) is a transient decrease in pain perception that can be observed following various tasks, including non-painful low-intensity and painful high-intensity exercise. The application of blood flow occlusion (BFO) can help enhance exercise adaptations while being able to exercise at a low intensity, which has important...

Purpose Constant blood flow occlusion (BFO) superimposed on aerobic exercise can impair muscle function and exercise tolerance; however, no study has investigated the effect of intermittent BFO on the associated responses. Fourteen participants (n = 7 females) were recruited to compare neuromuscular, perceptual, and cardiorespiratory responses to s...

Objective: Diabetes is characterized by a comprehensive increase in apoptosis, mitochondrial dysfunction, and inflammation in skeletal muscle. Impaired mitochondrial function in skeletal muscle leads to an increase in Cytochrome C and Caspase-9, and muscle performance is reduced consequently. Exercise training through decreasing inflammatory factor...

Background and Purpose: There is now mounting evidence that pro-inflammatory pathways, which are mediated by T cells (that secrete IL-17 and IL-22), play a critical role in metabolic control. The aim of this study was to examine the effect of aerobic training along with aqueous extract of Garlic (Allium sativum L.) on relative expression of IL-17,...

Original Article Abstract Purpose: According to the controversy about the role of ATF3 as a non-inflammatory index of myocardia in metabolic abnormalities as diabetes, the purpose of this study was to compare the effect of high intensity interval versus progressive resistance training on ATF3 myocardial gene expression of male diabetic rats. Method...

Increasing the expression of FOXO1 gen in hippocampus as well as inflammatory factor of TNF-α in diabetic individual's causes the expression of genes involved in apoptosis and disrupts its performance. The aim of the present study was investigation of the effect of 6-weeks HIIT on FOXO1 gene expression in the hippocampus and level of serum TNF-α in...

Original Article Abstract Purpose: Exercise is a powerful driver for reducing the complications of diabetes. The aim of the present study was to investigate the effect of progressive resistance training on the expression of brain-derived neurotrophic factor gene in the hippocampus and serum changes of TNF α in Wistar diabetic rats. Methods: For thi...

Background and Objectives The fetal period is an important stage in a person’s life. Exercise during pregnancy has been considered as a positive factor in preventing chronic diseases in adulthood. The aim of this study was to investigate the role of maternal high intensity exercise before and during pregnancy on serum levels of lipid profile of adu...

Background and Objectives Chronic Kidney Disease (CKD) is characterized by progressive and irreversible loss of renal function. One of the complications of this disease is muscle wasting and atrophy. The aim of this study was to determine the effect of exercise training on CKD-induced muscle apoptosis in rats. Subjects and Methods In the present de...

Background: The most common causes of mortality in diabetic patients are cardiovascular disorders, one of the reasons being inflammatory factors. Given that physical activity can reduce inflammation, the present study was to investigate the effects of two types of Progressive Resistance Training (RT) and High Intensity Interval (HIIT) on the expres...

Both regular exercise training and vitamin D consumption are beneficial for patients with cancer. The study investigated the effects of interval exercise training (IET) or/and vitamin D supplementation on the gene expression involved in mitochondrial function of heart tissue, tumor size, and total antioxidant capacity (TAC) in breast cancer (BC) mo...

Aims Apoptosis is a type of cell death that is vital for tissue homeostasis. Exercise can lead to initial stimulation of apoptotic regulator genes. We investigated their response to an acute exercise and their adaptations to chronic exercise training with an emphasis on eccentric and sprint interval exercises. Main methods Male Sprague Dawley rats...

Background: Diabetics have many disabilities, including neuronal damege hippocampus, and BDNF is an effective factor in this field. This factor has the most impact on the hippocampus, also TNF-α is an inflammatory factor that increases in diabetes, the purpose of this study was to investigate the effect of 6 weeks of High Intensity interval trainin...

Background: Aerobic exercises induce adaptations that improve physiological function. However, aerobic exercises, oxidative reproduction may lead to injury and other health issues such as adverse cardiac effects. The aim of this study is to evaluate the effect of aerobic exercises on protein expression change in the heart left ventricle to determi...

The susceptibility to cardiovascular disease in offspring could be reduced prior to birth through maternal intervention, before and during pregnancy. We evaluated whether the initiation periods of maternal exercise in preconception and pregnancy periods induce beneficial effects in the adult male offspring. Thirty-two female rats were divided into...

Introduction: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in the transfer of ascorbic acid to slow-twitch fiber. The purpose of this study was investigating the effect of diabetes induction and exercise training on the level of ascorbic acid and muscle SVCT2 in rats. Methods: In this experimental study, 20 male Wistar r...

مقدمه: هدف از اجرای این پژوهش، بررسی تأثیر مکمل‌دهی زعفران بر متالوپروتئین‌های ماتریکس 9 (Matrix metallopeptidase 9 یا MMP9) و کسر جهشی به دنبال تمرین شدت بالا در بیماران پیوند عروق کرونری بود. روش‌ها: پژوهش حاضر از نظر روش‌شناسی به روش نيمه‌تجربي و از نوع کاربردي بود. تعداد 30 نفر از بیمارانی که حدود یک ماه از عمل جراحی آن‌ها گذشته بود، انتخاب و ب...

Background: This research aimed to examine the effect of aerobic exercise and melatonin consumption on the expression of Bax and Bcl-2 markers in rat myocard after ischemia-reperfusion by isoprenaline. Methods: 30 two- to three-months-old male Wistar rats were used weighing approximately 200-250 g. They were divided into five groups of pilot (n =...

Increasing evidences suggest that certain variations in the control region of mitochondrial DNA (mtDNA) are associated with physical performance levels of individuals. The aim of the present study was to assess whether mitochondrial haplogroups are associated with elite athlete status in Iranian population. The mtDNA haplogroups of 100 Iranian athl...

Skeletal muscle is a highly elastic tissue which can respond to various functional demands by altering fiber type composition. Exercise effects on muscle fiber phenotype. One of the transcription factors that induce fiber type transition is forkhead box O1 (FOXO1). Since eccentric contraction considered an essential part of exercise, so we are inte...

Purpose: Mammalian skeletal muscle has the two isoforms of actin binding protein, α-Actinin-2 and α-Actinin-3, which are located in the skeletal muscle Z-line where they cross-link the actin thin filaments. There is a common stop codon polymorphism R577X in the ACTN3 gene. Several association studies have demonstrated that the ACTN3 R577X genotype...

Background & purpose: The common inheritance of approximately 20000 genes defines each of us as human. A vast array of human phenotypes and several genetic variants (polymorphism) have been associated with elite performance.The purpose of this study was to investigate the polymorphism of candidate genes (ACTN3, PGC-1α, ACE, CKMM, and PPARγ) polymor...

Introduction: Myofibrillar Z-disc streaming and loss of cytoskeleton's proteins are considered the morphological hallmarks of eccentric contraction-induced injuries(Yu et al., 2003) Alpha (α)-actinins are one of the major structural proteins in the skeletal muscle Z-line and forms the bridges crosslinking the thin actin filaments from neighboring...

Purpose: Today, Cold Water Immersion has developed among athletes for recovery speed. With respect to the significance of heat stress and HSP70 in physiological adaptations as well unspecified HSP70 Plasma response under these circumstances, this study was conducted to survey the effect of Water Immersion of varying temperature during resistance ex...

It is generally believed that unaccustomed exercise causes myofibrillar damage. In recent years، cold water immersion (CWI) following heavy training sessions and matches has been common aiming at reducing soreness. However، there is no strong scientific rationality if this method really accelerates recovery after exercise. In addition، there is a q...

Background: Alpha-actinins are located in the skeletal muscle Z-line and form actin– actin cross-links. It belongs to a highly conserved family of actin-binding proteins- the spectrin superfamily, which also contains the spectrins and dystrophin. Mammalian skeletal muscle has two isoforms: alpha-actinins-2 and alpha-actinins-3. However, the respons...

Background: Alpha-actinins are located in the skeletal muscle Z-line and form actin- actin cross-links. It belongs to a highly conserved family of actin-binding proteins- the spectrin superfamily, which also contains the spectrins and dystrophin. Mammalian skeletal muscle has two isoforms: alpha-actinins-2 and alpha-actinins-3. However, the respons...

Background and Objectives: In recent years, the use of cold water immersion (CWI) following heavy training sessions has become a common habit among athletes aiming to reduce soreness, but there aren't strong scientific rational behind this belief. Hspb1 gene, which expressing heat shock protein 25 has an important role in recovery and adaptation to...

Introduction Alpha (α)-actinins are located in the skeletal muscle Z-line and form actin–actin cross-links(Frank et al 2006). The human ACTN3 gene encodes the protein α -actinin-3, a component of the contractile apparatus in fast skeletal muscle fibers. Kathryn et al (1999) identified a common polymorphism in ACTN3 (R577X) that results in absence...

Introduction In recent years, the use of cold water immersion (CWI) following heavy training sessions has become common among athletes aiming to reduce soreness, although there isn't any strong scientific rational behind this method. Objectives HSP25 as one of the stress proteins that have been shown to play an important role after damage and follo...

The minimal running velocity at which maximal oxygen uptake (VO2max) is elicited during an incremental test to exhaustion has been used to prescribe training for competitive middle- and long-distance runners. The purpose of this study was to determine the relationship between velocity at lactate turnpoint (vLTP) and vVO2max in long-distance runners...