Neda Khaledi

Neda Khaledi
Kharazmi University | KHU · Department of Exercise Physiology

PhD, Exercise physiology

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36
Publications
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46
Citations

Publications

Publications (36)
Article
Full-text available
Increasing the expression of FOXO1 gen in hippocampus as well as inflammatory factor of TNF-α in diabetic individual's causes the expression of genes involved in apoptosis and disrupts its performance. The aim of the present study was investigation of the effect of 6-weeks HIIT on FOXO1 gene expression in the hippocampus and level of serum TNF-α in...
Article
Full-text available
Original Article Abstract Purpose: Exercise is a powerful driver for reducing the complications of diabetes. The aim of the present study was to investigate the effect of progressive resistance training on the expression of brain-derived neurotrophic factor gene in the hippocampus and serum changes of TNF α in Wistar diabetic rats. Methods: For thi...
Article
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Background and Objectives The fetal period is an important stage in a person’s life. Exercise during pregnancy has been considered as a positive factor in preventing chronic diseases in adulthood. The aim of this study was to investigate the role of maternal high intensity exercise before and during pregnancy on serum levels of lipid profile of adu...
Article
Background and Objectives Chronic Kidney Disease (CKD) is characterized by progressive and irreversible loss of renal function. One of the complications of this disease is muscle wasting and atrophy. The aim of this study was to determine the effect of exercise training on CKD-induced muscle apoptosis in rats. Subjects and Methods In the present de...
Article
Background: The most common causes of mortality in diabetic patients are cardiovascular disorders, one of the reasons being inflammatory factors. Given that physical activity can reduce inflammation, the present study was to investigate the effects of two types of Progressive Resistance Training (RT) and High Intensity Interval (HIIT) on the expres...
Article
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Both regular exercise training and vitamin D consumption are beneficial for patients with cancer. The study investigated the effects of interval exercise training (IET) or/and vitamin D supplementation on the gene expression involved in mitochondrial function of heart tissue, tumor size, and total antioxidant capacity (TAC) in breast cancer (BC) mo...
Article
Aims Apoptosis is a type of cell death that is vital for tissue homeostasis. Exercise can lead to initial stimulation of apoptotic regulator genes. We investigated their response to an acute exercise and their adaptations to chronic exercise training with an emphasis on eccentric and sprint interval exercises. Main methods Male Sprague Dawley rats...
Article
Background: Diabetics have many disabilities, including neuronal damege hippocampus, and BDNF is an effective factor in this field. This factor has the most impact on the hippocampus, also TNF-α is an inflammatory factor that increases in diabetes, the purpose of this study was to investigate the effect of 6 weeks of High Intensity interval trainin...
Article
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Background: Aerobic exercises induce adaptations that improve physiological function. However, aerobic exercises, oxidative reproduction may lead to injury and other health issues such as adverse cardiac effects. The aim of this study is to evaluate the effect of aerobic exercises on protein expression change in the heart left ventricle to determi...
Article
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The susceptibility to cardiovascular disease in offspring could be reduced prior to birth through maternal intervention, before and during pregnancy. We evaluated whether the initiation periods of maternal exercise in preconception and pregnancy periods induce beneficial effects in the adult male offspring. Thirty-two female rats were divided into...
Article
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Introduction: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in the transfer of ascorbic acid to slow-twitch fiber. The purpose of this study was investigating the effect of diabetes induction and exercise training on the level of ascorbic acid and muscle SVCT2 in rats. Methods: In this experimental study, 20 male Wistar r...
Article
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مقدمه: هدف از اجرای این پژوهش، بررسی تأثیر مکمل‌دهی زعفران بر متالوپروتئین‌های ماتریکس 9 (Matrix metallopeptidase 9 یا MMP9) و کسر جهشی به دنبال تمرین شدت بالا در بیماران پیوند عروق کرونری بود. روش‌ها: پژوهش حاضر از نظر روش‌شناسی به روش نيمه‌تجربي و از نوع کاربردي بود. تعداد 30 نفر از بیمارانی که حدود یک ماه از عمل جراحی آن‌ها گذشته بود، انتخاب و ب...
Article
Full-text available
Background: This research aimed to examine the effect of aerobic exercise and melatonin consumption on the expression of Bax and Bcl-2 markers in rat myocard after ischemia-reperfusion by isoprenaline. Methods: 30 two- to three-months-old male Wistar rats were used weighing approximately 200-250 g. They were divided into five groups of pilot (n =...
Article
Increasing evidences suggest that certain variations in the control region of mitochondrial DNA (mtDNA) are associated with physical performance levels of individuals. The aim of the present study was to assess whether mitochondrial haplogroups are associated with elite athlete status in Iranian population. The mtDNA haplogroups of 100 Iranian athl...
Article
Skeletal muscle is a highly elastic tissue which can respond to various functional demands by altering fiber type composition. Exercise effects on muscle fiber phenotype. One of the transcription factors that induce fiber type transition is forkhead box O1 (FOXO1). Since eccentric contraction considered an essential part of exercise, so we are inte...
Article
Full-text available
Purpose: Mammalian skeletal muscle has the two isoforms of actin binding protein, α-Actinin-2 and α-Actinin-3, which are located in the skeletal muscle Z-line where they cross-link the actin thin filaments. There is a common stop codon polymorphism R577X in the ACTN3 gene. Several association studies have demonstrated that the ACTN3 R577X genotype...
Article
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Background & purpose: The common inheritance of approximately 20000 genes defines each of us as human. A vast array of human phenotypes and several genetic variants (polymorphism) have been associated with elite performance.The purpose of this study was to investigate the polymorphism of candidate genes (ACTN3, PGC-1α, ACE, CKMM, and PPARγ) polymor...
Conference Paper
Introduction: Myofibrillar Z-disc streaming and loss of cytoskeleton's proteins are considered the morphological hallmarks of eccentric contraction-induced injuries(Yu et al., 2003) Alpha (α)-actinins are one of the major structural proteins in the skeletal muscle Z-line and forms the bridges crosslinking the thin actin filaments from neighboring...
Article
Purpose: Today, Cold Water Immersion has developed among athletes for recovery speed. With respect to the significance of heat stress and HSP70 in physiological adaptations as well unspecified HSP70 Plasma response under these circumstances, this study was conducted to survey the effect of Water Immersion of varying temperature during resistance ex...
Article
Full-text available
It is generally believed that unaccustomed exercise causes myofibrillar damage. In recent years، cold water immersion (CWI) following heavy training sessions and matches has been common aiming at reducing soreness. However، there is no strong scientific rationality if this method really accelerates recovery after exercise. In addition، there is a q...
Article
Background: Alpha-actinins are located in the skeletal muscle Z-line and form actin– actin cross-links. It belongs to a highly conserved family of actin-binding proteins- the spectrin superfamily, which also contains the spectrins and dystrophin. Mammalian skeletal muscle has two isoforms: alpha-actinins-2 and alpha-actinins-3. However, the respons...
Article
Full-text available
Background: Alpha-actinins are located in the skeletal muscle Z-line and form actin- actin cross-links. It belongs to a highly conserved family of actin-binding proteins- the spectrin superfamily, which also contains the spectrins and dystrophin. Mammalian skeletal muscle has two isoforms: alpha-actinins-2 and alpha-actinins-3. However, the respons...
Article
Background and Objectives: In recent years, the use of cold water immersion (CWI) following heavy training sessions has become a common habit among athletes aiming to reduce soreness, but there aren't strong scientific rational behind this belief. Hspb1 gene, which expressing heat shock protein 25 has an important role in recovery and adaptation to...
Conference Paper
Full-text available
Introduction Alpha (α)-actinins are located in the skeletal muscle Z-line and form actin–actin cross-links(Frank et al 2006). The human ACTN3 gene encodes the protein α -actinin-3, a component of the contractile apparatus in fast skeletal muscle fibers. Kathryn et al (1999) identified a common polymorphism in ACTN3 (R577X) that results in absence...
Conference Paper
Introduction In recent years, the use of cold water immersion (CWI) following heavy training sessions has become common among athletes aiming to reduce soreness, although there isn't any strong scientific rational behind this method. Objectives HSP25 as one of the stress proteins that have been shown to play an important role after damage and follo...
Article
Full-text available
The minimal running velocity at which maximal oxygen uptake (VO2max) is elicited during an incremental test to exhaustion has been used to prescribe training for competitive middle- and long-distance runners. The purpose of this study was to determine the relationship between velocity at lactate turnpoint (vLTP) and vVO2max in long-distance runners...

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