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Nebojša V Kladar

Nebojša V Kladar
Faculty of Medicine, University of Novi Sad · Department of Pharmacy

PhD in Clinical Medcine

About

58
Publications
22,295
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584
Citations
Additional affiliations
September 2014 - present
Faculty of Medicine, University of Novi Sad
Position
  • Research Assistant
March 2012 - September 2014
Faculty of Medicine, University of Novi Sad
Position
  • Research Assistant

Publications

Publications (58)
Article
Full-text available
Since the appearance of the novel coronavirus disease of 2019—COVID-19, various therapeutic approaches were attempted, with complementary and alternative medicine (CAM) taking an important place. The aim of this study was to investigate the use of CAM with the purpose of prevention or treatment of COVID-19 during the pandemics. A prospective, cross...
Article
Full-text available
Mastitis is considered to be one of the most important diseases of dairy cows in terms of health, production, and economy. Being the most common cause of antibiotic consumption in dairy cows, treatment of this disease is one of the biggest challenges in the veterinary profession as an increasing number of pathogens develop resistance to antibiotics...
Article
Full-text available
Consumption of unrecorded fruit spirits produced in private homes or small-scale distilleries is a population-scale phenomenon in Serbia. With an aim to provide a profile of elements in spirits and to assess associated health risk, a total of 153 fruit spirits, 26 recorded and 127 unrecorded, was investigated using ICP-MS, or, in case of Hg, a dire...
Article
Full-text available
Although oral ulcers represent one of the most frequent oral mucosal diseases, the available treatment is not sufficient to provide complete ulcer recovery without side-effects. Therefore, the aim of our study was to prepare a mucoadhesive oral gel based on Galium verum ethanol extract (GVL gel) and reveal its healing effects in the model of aphtho...
Conference Paper
Full-text available
Heat-not-burn tobacco products (HNB) are electronic devices that heat processed tobacco instead of combusting and have been marketed by the tobacco industry as a less harmful alternative to conventional cigarettes. Here we conducted a literature review of the differences in chemical composition among aerosols of conventional cigarettes, electro...
Article
The phytochemical analysis of the investigated Immortelle essential oil revealed the presence of monoterpenes and sesquiterpenes as major components that might be efficient as a wound healing potential agent. The present study aimed to develop an ointment based on the Immortelle essential oil and investigate its wound healing effects on excision wo...
Article
Full-text available
The study was conducted on a commercial pig farm located in Serbia. Thirty Duroc or Landrace breed boars were randomly selected for this study. The experimental group was fed a compound feed with added organic selenium and Oxynat 3D. The antioxidant status parameters of boar seminal plasma were evaluated using a biochemical analyzer and commercial...
Article
Full-text available
Plant-derived products are frequently found as ingredients in cosmetics. However, the current data show non-neglectable skin sensitizing potential of these preparations suggesting an urgent need for data regarding their health safety profile. The aim of this study was to assess the skin sensitization potential of commercial essential oils by select...
Article
The alcohol-attributable mortality is an important issue in South-Eastern Europe, whereby consumption of homemade spirits is stated to be one of the leading causes. Presence of harmful volatiles in spirits in Serbia was investigated in 26 recorded and 127 unrecorded fruit spirits, collected in 2020 and analysed using GC-FID methods. Statistical ana...
Article
Full-text available
To examine antioxidant capacity and the hepatoprotective effect of carob pulp flour, microwave-assisted extraction was performed. The influence of ethanol concentration (0–40% w/w), extraction time (5–25 min) and irradiation power (400–800 W) on DPPH, FRAP and ABTS antioxidant activity of carob pulp flour extract was evaluated. The strongest influe...
Article
Full-text available
Mastitis is one of the most common and costly diseases affecting dairy cows worldwide. Since antibiotic resistance has become a global threat to both animal and human health, it is becoming more urgent to continuously search for new therapeutical alternatives for the control and treatment of bovine mastitis. Hence, our research aimed to test the th...
Article
Carnosine is known as a natural dipeptide, which inhibits the proliferation of tumor cells throughout its action on mitochondrial respiration and cell glycolysis. However, not much is known about its effects on the metabolism of healthy cells. We explored the effects of Karnozin EXTRA® capsule with different concentrations of L-carnosine, on the ce...
Article
Full-text available
Antimicrobial resistance (AMR) is considered one of the most prevalent global health issues in both veterinarian and human medicine. This complex problem requires a “One Health” approach with the cooperation of all healthcare sectors, as well as agriculture, finance, and consumers. We conducted a survey with the objective to assess the knowledge an...
Article
Full-text available
Mastitis represents a heavy burden for the dairy sector worldwide with high economic and animal welfare impact. Antibiotic treatment is an important component of mastitis control programs. However, emergence and transfer of antimicrobial-resistant (AMR) bacteria is becoming a growing concern. Therefore, the development of novel agents is required f...
Article
Full-text available
Since drug companies are driven by the need to produce profit they are unwilling to make large investments in the development of new drugs if there is no market large enough to justify such investment. For this reason, veterinarians face a major obstacle - the veterinary drug market is not very profitable, which sometimes leads to not having a lice...
Article
Full-text available
As proper wound management is crucial to reducing morbidity and improving quality of life, this study evaluated for the first time the wound healing potential of H. italicum essential oil (HIEO) prepared in the form of ointment and gel in streptozotocin-induced diabetic wound models in rats. After creating full-thickness cutaneous wounds, forty-eig...
Article
Full-text available
Hospital workers at the Oncology Department are occupationally exposed to antineoplastic drugs (ANTNP) or low doses of ionizing radiation (Irrad). Therefore, the aim of this study was to evaluate the level of DNA damage, the oxidative stress parameters and complete blood count (CBC) of hospital workers in order to analyze the negative health effect...
Article
Full-text available
Multiple positive effects that forests have on human health and overall well-being have been reported widely in the literature. Still, multiple elements of this relationship remain unidentified and unexplained. In this study, the composition of leaf volatile organic compounds (BVOCs) content in three common coniferous species: the Austrian pine (Pi...
Article
Full-text available
Traditional medicinal plants are used as an additional form of type 2 diabetes therapy in which oxidative stress is one of the progression factors. The aim of the study was the evaluation of antihyperglycemic and antioxidant potential of tea mixture registered as food and marketed for treatment of type 2 diabetes mellitus. Chemical profiling of the...
Article
The latest report on tetrahydrocannabinol (THC) exposure assessment performed by European Food Safety Authority showed that THC levels in certain food categories are high. However, the performed study included uncertainties regarding occurrence data and hemp-food consumption patterns. The aim of the present study was to quantify the levels of “tota...
Article
Background/aim Location of the gene encoding superoxide-dismutase on chromosome 21 suggests a possible impact on the maternal oxidative stress parameters. The aim of the study was to investigate the possible impact of the fetal trisomy 21 on the level of oxidative stress in mothers. Methods The study involved two groups of pregnant women: a study...
Conference Paper
Full-text available
This work combined experimental and computational analysis to investigate the stability and reactivity of diuretic pharmaceutical hydrochlorothiazide (HCTZ) detected in drinking and environmental waters. The HCTZ hydrolysis and photolysis were investigated in ultrapure and three different environmental waters, at (5±1) °C and (25±1) °C in the dark...
Article
Full-text available
Bovine mastitis is the most widespread and economically important disease worldwide. The present study aimed to determine bioactive compounds in two essential oils (EOs) from wild (Thymus serpyllum) and common thyme (Thymus vulgaris) and to assess the antioxidant potential as well as antibacterial efficacy of the EOs against mastitis-associated bac...
Article
Medicinal plants have many beneficial effects on human health. Garlic (Allium sativum, Alliaceae) is one of the most famous herbal species, used for various diseases and conditions. Unfortunately, garlic is also associated with adverse effects, including cutaneous manifestations. In this review, burn injuries caused by application of raw garlic are...
Article
Rosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae) plant species. It is considered responsible for a wide spectrum of biological and pharmacological activities of plants containing this compound. The aim of the current review is to present the fate of rosmarinic acid inside the human body, explained through pharmacok...
Article
Full-text available
St. John’s wort has been used for centuries in traditional medicine of many cultures, and nowadays it is well-known as a clinically important antidepressant drug. Considering the rising market demand for Hyperici herba, quality control of crude drug is of paramount importance. In this paper we performed HPLC-DAD chemical profiling of St. John’s wor...
Article
The aim of the present study was chemical characterization of the savory (Satureja kitaibelii, Lamiaceae) extract, evaluation of its antioxidant potential and time-dependent monitoring of oxidative degradation parameters in sunflower and olive oil with added savory during storage and during the heating process. The savory extract was preliminary an...
Article
Introduction Human in vivo models of skin damage were often used in research of cutaneous disorders. The most commonly used models were tape‐stripping as mechanical, sodium lauryl sulphate‐induced irritation as chemical and ultraviolet radiation as physical damage model. In regard to differences between models, they were expected to have different...
Article
Mints are the most popular economic and traditional herbs. The aim of this paper was chemical characterization of volatile compounds from wild populations of Mentha aquatica , M . arvensis , M . longifolia , M . microphylla, M . pulegium , M . spicata , M . × dumetorum , M . × gentillis and M . × verticillata , as well as cultivated samples of M ....
Article
Full-text available
Background/Aim. The gold standard in treating the advanced ovarian cancer (AOC) is primary debulking surgery (PDS) followed by platinum-based adjuvant chemotherapy. In the AOC, the extent of tumor resection (residual tumor volume) is the most important prognostic factor for overall survival (OS) and progression-free survival (PFS). Neoadjuvant chem...
Article
Full-text available
In vitro and in vivo research suggests that cinnamon, which is widely used as a spice, could have significant medicinal potential. However, the problem of using this spice for medicinal purposes is that there are hundreds of species and subspecies of cinnamon plant, and although the official source for spice production is Cinnamomum verum (zeylanic...
Conference Paper
Full-text available
In vitro and in vivo researches of cinnamon indicate the high medical potential of this widely used spice. Significant effects are antimicrobial, antiinflammatory, the effect on lowering cholesterol levels and lowering blood glucose levels. It is also an ingredient in various dietary supplements intended for coronary disease and diabetes prevention...
Conference Paper
Full-text available
Family Lamiaceae, one of the largest and the most important plant families, is promising potential sources of the medical active ingredients due to their high polyphenol content. The well-known and widely used members of this family are a variety of aromatic species such as thyme, mint, sage and winter savory. These plants are native to the Mediter...
Article
In this study, 48 herbal based products (41 for the pediatric population) were analyzed for the presence of ethanol and residual solvents. Ethanol was not detected in only 12% of the products designed for infants or toddlers aged under 2, and not quantified in only 5 of 14 'alcohol free' products. Actual content was higher than labeled in six out o...
Article
Objective Gastrointestinal (GI) disorders are estimated to be frequent among general population. Various types of traditional and complementary therapies, primarily phytotherapy, can be used for prevention and treatment of many diseases and conditions, including GI complaints. Thus, the aim of this study was to investigate the patterns of use of me...
Article
Full-text available
This paper summarizes published literature concerning different factors that could affect the content and composition of isoflavones in red clover (Trifolium pratense L., Fabaceae). Influence of genotype, plant part, geographic origin, ontogeny and storage conditions of raw material are discussed. Statistical analysis of available data on the profi...
Article
Objective: Besides conventional drugs, various vaginal disorders are often treated with complementary and alternative medicines. Different natural products are often used in treatment of genital infections. The aim is to present a case of treatment of vaginal infection with a garlic clove. Methods: A detailed interview was conducted with the sub...
Article
Full-text available
Oxidative stress has been associated with cervical cancer. Our aim was to examine lipid peroxidation and the extent of oxidative stress in women diagnosed with different stages of cervical cancer in order to evaluate its potential role in the evolution of cancer. We measured the concentration of thiobarbituric acid reactive substances, activities o...
Article
Full-text available
Introduction. Horehound (Marrubium vulgare, Lamiaceae) is a widely used plant in traditional medicine used for prevention and treatment of various diseases. High content of phenolic compounds makes it a significant source of natural antioxidants. The aim of this research was to examine in vitro antioxidant properties and anticholinesterase activity...
Article
Constant search for new drugs with antiviral properties often extends to products of natural origin. Lamiaceae is one of the most important herbal families, well known for various biological and medicinal effects of a variety of aromatic spices, including thyme, mint, oregano, basil, sage, savory, rosemary, self-heal, hyssop, lemon balm and many ot...
Article
Full-text available
St. John’s wort is a widely used medicinal plant. The quality of herbal drug, which is in most of the cases collected from nature, varies. Therefore, the aim of the present study was detailed chemical characterization of Hypericum perforatum subsp. perforatum samples collected in close time intervals during flowering and fruitification with the pur...
Article
Full-text available
Reynoutria japonica is on the IUCN list of the Worlds' 100 worst invasive species, but it is also, especially its rhißome, an integral part of traditional Chinese medicine. The objective of this study was to determine the amount of selected phenolic compounds in rhißome, stems, leaves and inflorescence methanol extracts of this plant, their antioxi...
Article
Full-text available
The roles of the pharmacist were transformed throughout the history and modern pharmacist as we know now beside providing products and playing in optimization of medicines has a crucial role in ensuring the efficacy and safety of applied drugs. A better life quality, global health and safety is the major goal of the 21st century and to achieve that...
Article
Full-text available
Ornithogalum umbellatum L. is a widely distributed species in Europe, that exhibit considerable variability at ecological, morpho-anatomical, and karyological level. Previous reports of the chemical investigations among Ornithogalum species indicate significant diversity of the secondary metabolites, as well. Knowing that environment affects the ph...
Article
Full-text available
The genus Hypericum includes over 500 widely distributed species. The main representative is St. John’s wort (Hypericum perforatum L. (1753), Hypericaceae), the only approved biological source of Hyperici herba by WHO and EMEA monographs. It is frequently used in the form of oil macerate for treatment of burns, scars, eczema and gastrointestinal di...
Chapter
Full-text available
Medicinal plants have a long tradition of use in folk and conventional medicine. In recent years numerous studies confirm various bioactivities of natural products, among them antibacterial activity. Natural antibacterial agents such are essential oils and isolated compounds now represent a notable source for pharmaceutical and food industry and ar...
Article
Thyme (Thymus vulgaris L., Lamiaceae) is, among numerous representatives of genus Thymus, the commonly used and cultivated species worldwide. This is mainly due to the presence of essential oil which has a number of notable and scientifically confirmed biological activities. However, the amount of thyme essential oil in the leaves is very low (0.8-...
Article
The genus Ganoderma includes about 80 species growing on cut or rotten trees. The most commonly used species is Ganoderma ludicum. Biomolecules responsible for the health benefits of Ganoderma are polysaccharides with an immunostimulative effect and triterpenes with a cytotoxic action. For more than 2000 years, it has been used traditionally in the...
Chapter
Full-text available
The genus Hypericum L. (Hypericaceae) comprises around 500 species divided in 36 sections. From ancient times, the common St. John’s wort (Hypericum perforatum L.) was often used in traditional pharmacy and medicine, and as important source of traditional drugs was, subjected to wide spectra of researches. Summarised data assured several clinical i...
Article
Full-text available
In this study, chemical composition, antioxidant and antibacterial activities of thyme and oregano essential oils, thymol and carvacrol, as well as their possible synergism were investigated. For chemical profiling of essential oils, GC-MS analysis was performed. Antioxidant capacity was assessed throughout neutralisation of DPPH and OH radicals. F...
Article
Full-text available
Numerous traditional and clinically approved indications have created constant raise of demand for Hyperici herba in the world. However, the quality of the plant material depends on the plant source and abiotic factors of the habitats. The scope of the research was to find out whether other Hypericum species have similar chemical characteristics fo...
Article
The chemical composition and antioxidant properties of the essential oil and EtOH extract of immortelle (Helichrysum italicum (Roth) G.Don subsp. italicum, Asteraceae) collected in Montenegro were evaluated. The essential oil was characterized by GC/MS analysis, and the content of total phenolics and flavonoids in the EtOH extract was determined us...
Article
Full-text available
Background/Aim. Tea and coffee are one of the most widely consumed beverages in the world due to their beneficial health effects which are largely associated with their phenolic compounds composition, including chlorogenic acid. The main aim of this study was to determine 5-caffeoylquinic acid (5-CQA), as one of the major classes of chlorogenic aci...
Article
Full-text available
The effect of ELF-EMF on DNA through changes in antioxidative enzyme activities has not been sufficiently explored yet. The aim of this study was to determine ELF-EMF effect on antioxidative enzymes in cancer cell line and genotoxic potential on normal human lymphocytes. K562 cells were exposed to 50 Hz ELF-EMF (40 μT, 100 μT; 3 h, 24 h) and spectr...
Article
Full-text available
Fullerenol (C60(OH)24) nanoparticles (FNP) have a significant role in biomedical research due to their numerous biological activities, some of which are cytoprotective and antioxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10% fetal bovine serum (F...
Article
Full-text available
The study shows the influence of the origin of plant material and biological source on the in vitro antioxidant (neutralization of DPPH and OH radical, nitric oxide, and inhibition of lipid peroxidation) and anticholinesterase activity of chemically characterized and quantified ethanol extracts of ten St. John's wort samples. The investigated sampl...

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