Nebiyu Dereje

• Doctor of Public Health
• Addis Ababa University

The World Health Organization (WHO) Global Benchmarking Tool (GBT) classifies regulatory systems into four maturity levels, with Maturity Level 3 (ML3) signifying a stable and effective regulatory environment. As of January 2025, eight African nations—Egypt, Ghana, Nigeria, Rwanda, Senegal, South Africa, Tanzania, and Zimbabwe—have attained ML3 sta...

The Abuja Declaration, which was endorsed in 2001, was a hallmark of African leadership’s decision to prevent and control human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) in Africa. Since this declaration, there have been several achievements recorded in the fight against HIV and AIDS. This includes increased domesti...

Background Vaccine hesitancy among healthcare workers (HCWs) hinders coronavirus disease 2019 (COVID-19) control efforts. Aim The aim of the study was to assess enhancers and barriers to the uptake of COVID-19 vaccine among HCWs in Ibadan, Nigeria. Setting Health facility-based cross-sectional study in Ibadan, a metropolitan city in Oyo state, Ni...

Background: Vaccine hesitancy hinders COVID-19 control, especially among healthcare workers (HCWs). Aim: This study examined factors influencing COVID-19 vaccine uptake and hesitancy among HCWs in Abidjan, Côte d’Ivoire. Setting: The study was conducted among healthcare workers in Abidjan, the capital city of Côte d’Ivoire. Methods: A cross-section...

Introduction The symbiotic relationship between academia and policymakers has long been recognised as crucial for evidence-based decision-making in public health. 1 However, a persistent gap between these two spheres has impeded the effective translation of research into practical policies, resulting in missed opportunities to enhance public health...

Background: COVID-19 vaccines were administered globally, and Malawi commenced vaccination on 11 March 2021.Aim: This study assessed the real-world effectiveness of COVID-19 vaccines and factors associated with disease severity and mortality in Malawi.Setting: A facility-based case-control study within the largest referral hospitals.Methods: Cases...

Background: Coronavirus disease 2019 (COVID-19) vaccination is crucial for healthcare workers (HCWs) to protect themselves and promote public health.Aim: This study assessed COVID-19 vaccination uptake, barriers and enhancers among HCWs in high-burden cities in Ethiopia.Setting: A cross-sectional survey among 600 randomly selected HCWs from 30 heal...

Background: Healthcare workers (HCWs) are crucial for coronavirus disease 2019 (COVID-19) vaccination programmes, but their perceptions of the vaccine, particularly in low-income countries, are underexplored. This study investigated HCWs perceptions of the COVID-19 vaccination in Rwanda.Aim: This study aimed to understand HCWs’ perceptions of the C...

Background: Coronavirus disease 2019 (COVID-19) vaccination is crucial for healthcare workers (HCWs) and understanding their perspectives is vital for promoting vaccine uptake in communities.Aim: This study assessed factors influencing COVID-19 vaccine uptake among HCWs in Kampala, Uganda.Setting: A cross-sectional study was done in seven high-volu...

Background: COVID-19 vaccination is critical in sub-Saharan Africa to reduce the disease burden. This study assessed real-world vaccine effectiveness (VE) in Zimbabwe.Aim: To determine COVID-19 VE and factors associated with disease severity and mortality in Zimbabwe.Setting: The study setting comprised a test-negative case-control study across hea...

Background: Coronavirus disease 2019 (COVID-19) vaccination is crucial for healthcare workers (HCWs). Understanding their vaccine uptake and perceptions is vital to promote acceptance.Aim: This study assessed COVID-19 vaccine uptake, associated factors and HCW willingness to recommend vaccination in Zimbabwe.Setting: The study was conducted through...

The DHIS2 system enabled real-time tracking of vaccine distribution and administration to facilitate data-driven decisions. Experts from the Africa Centres for Disease Control and Prevention (Africa CDC) Monitoring and Evaluation (M&E) and Management Information System (MIS) teams, with support from the Health Information Systems Program South Afri...

PURPOSE To analyze survival and its predictors among patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) in Ethiopia. MATERIALS AND METHODS We conducted a retrospective cohort study among patients who received TACE for HCC at MCM Hospital from December 1, 2016, to December 31, 2022. Data were extracted fro...

Background COVID-19 disrupted critical public health services globally. It is important to understand how the pandemic affected healthcare service delivery and utilisation in Nigeria to guide planning for future public health crises in the country. Aim This study aimed to explore how the COVID-19 pandemic affected health service delivery and utili...

Objective Cervical cancer remains the most diagnosed and deadly cancer among women in low and middle income countries, including Ethiopia, although it can be controlled if detected and treated early. However, research on contextual barriers to early diagnosis and treatment of cervical cancer is limited in Ethiopia. This study aimed to describe the...

PURPOSE The extent of symptoms of depression among patients with breast cancer compared with those without the disease is not well documented in Ethiopia and other sub-Saharan African countries. MATERIALS AND METHODS This study examines the prevalence of symptoms of depression in women with breast cancer (n = 436) compared with those without breas...

Enhancing the clinical trial capabilities within Africa is essential to augment the continent’s pandemic prevention, preparedness and response efforts. Here, we describe the critical challenges of clinical trials in Africa and draw upon the lessons learnt from the Consortium for COVID-19 Vaccine Clinical Trials (CONCVACT) experience, such as the im...

⇒ Despite the critical role of pharmacovigilance in providing timely and accurate data on vaccine safety and influencing data-driven decision-making, it frequently continues to be overlooked in the context of global health. ⇒ Given the current heterogeneous situation of pharmacovigilance in different African countries, improving capacity in countr...

Background The attainment of global health security goals and universal health coverage will remain a mirage unless African health systems are adequately funded to improve resilience to public health emergencies. The COVID-19 pandemic exposed the global inequity in accessing medical countermeasures, leaving African countries far behind. As we antic...

Introduction: Post-marketing safety surveillance is indispensable for ensuring safety and public trust in vaccines, particularly in African settings where evidence of COVID–19 vaccine safety is less documented. We aimed to identify the types of adverse events following immunization (AEFIs), the overall incidence, and factors associated with AEFIs d...

Influenza is an acute viral respiratory tract disease in humans, often characterized by fever, headache, myalgia, prostration, coryza, sore throat and cough. Influenza infection is clinically indistinguishable from other respiratory viral diseases without laboratory confirmation. This study aims to estimate the proportion of confirmed influenza cas...

Background Data on COVID-19 vaccine effectiveness to support regional vaccine policy and practice are limited in Africa. Thus, this review aimed to evaluate the efficacy and effectiveness of COVID-19 vaccines administered in Africa. Methods We systematically searched peer-reviewed randomized controlled trials (RCTs), prospective and retrospective...

Delivering COVID-19 vaccines with 4–6 weeks shelf life remains one of Africa’s most pressing challenges. The Africa Centres for Disease Control and Prevention (Africa CDC) leadership recognised that COVID-19 vaccines donated to many African countries were at risk of expiry considering the short shelf life on delivery in the Member States and slow v...

Background The COVID-19 pandemic is one of the most devastating public health emergencies of international concern to have occurred in the past century. To ensure a safe, scalable, and sustainable response, it is imperative to understand the burden of disease, epidemiological trends, and responses to activities that have already been implemented. W...

SARS-CoV-2 co-infection with the influenza virus or human respiratory syncytial virus (RSV) may complicate its progress and clinical outcomes. However, data on the co-detection of SARS-CoV-2 with other respiratory viruses are limited in Ethiopia and other parts of Africa to inform evidence-based response and decision-making. We analyzed 4,989 patie...

Background Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important follow...

PURPOSE Breast cancer (BC) is the leading cause of cancer morbidity and mortality in Ethiopia, yet financial hardship is often overlooked. Herein, we examined the financial hardship of BC among women newly diagnosed with the disease in Addis Ababa, Ethiopia. MATERIALS AND METHODS We conducted a comparative cross-sectional study of financial hardsh...

https://pubmed.ncbi.nlm.nih.gov/38092509/#full-view-affiliation-41

The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) is a multinational collaborative research study with >10,000 collaborators around the world. GBD generates a time series of summary measures of health, including prevalence, cause-specific mortality (CSMR), years of life lost (YLLs), years lived with disability (YLDs), and disabi...

PURPOSE There are limited data on the association between delay in breast cancer diagnosis after breast symptom recognition and survival, particularly in sub-Saharan Africa. The recently launched Global Breast Cancer Initiative by WHO includes measuring delay as the core indicator for quality of breast cancer care. Herein, we examined the associati...

Objective Data on COVID-19 vaccine hesitancy is limited in Ethiopia and other parts of Africa. Therefore, the aim of this study was to determine the level of COVID-19 vaccine hesitancy and its associated factors in Addis Ababa, Ethiopia. Design A community-based concurrent mixed-method study. Setting In a community setting. Participants Adult re...

Background Previous Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) studies have reported national health estimates for Ethiopia. Substantial regional variations in socioeconomic status, population, demography, and access to health care within Ethiopia require comparable estimates at the subnational level. The GBD 2019 Ethiopia su...

Background Cervical cancer is one of the most diagnosed and deadly cancers in women globally. Though vaccination is an effective way to reduce cervical cancer, people’s knowledge and acceptance of the vaccination remains a challenge in low and middle-income countries. Therefore, the aim of this study was to assess the level of knowledge and accepta...

Background End-Stage Kidney Disease, the most severe form of chronic kidney disease, is fatal if not treated by renal replacement therapy. Thus, patients with End-Stage Kidney Disease depend on hemodialysis as a lifesaving treatment for the remainder of their lives. However, the health-related quality of life (HRQOL) of patients on hemodialysis is...

There is shortage of radiotherapy machines in low‐income countries, including Ethiopia. Data on adverse effects of this on cancer outcomes are limited, however. Herein, we examined the extent of waiting time for radiotherapy and its association with disease progression based on a prospective cohort study of women diagnosed with stage IA‐IVA cervica...

Purpose Chemotherapy within 90 days following surgery for non-metastatic breast cancer is the standard of care. There are no data, however, on the extent of time to initiation of chemotherapy (TTC) in Africa settings, including Ethiopia. Methods A total of 223 women with stage I-III breast cancer treated with surgery and adjuvant chemotherapy duri...

Background Childhood undernutrition is a global problem contributing to more than a third of under-five mortality. Orphans and vulnerable children (OVC) fare worse than children living with their parents. However, the nutritional and healthcare needs of OVC are under-recognized in Ethiopia. Methods A community-based cross-sectional study was condu...

Background COVID-19 infection is a global pandemic threatening the public health. Due to the development and initiation of vaccination, currently significant difference upon vaccine acceptance is seen between developed and developing countries. However, there are no data on the level of COVID-19 vaccine hesitancy and its associated factors in Addis...

Background: Patients with End-Stage Kidney Disease (ESKD) depend on hemodialysis as a lifesaving treatment for the remainder of their lives. However, the health related quality of life (HRQOL) of patients on hemodialysis is much more underappreciated in resource limited countries, since the hemodialysis is mostly unaffordable or unavailable. Method...

Background: Childhood malnutrition is a global problem contributing to more than a third of under-five mortality. Orphans and vulnerable children (OVC) fare worse than children living with their parents. However, the nutritional and healthcare needs of OVC are under-recognized in Ethiopia. Methods: A community-based cross sectional study was conduc...

Introduction Diabetes is a global public health threat with a considerably high burden in low- and middle-income countries. The application of self-care practice by people living with diabetes helps to manage diabetes and its complications, and to lengthen their life. However, the level of diabetes self-care practice in Ethiopia is very low. Metho...

Summary Background In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published...

The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countr...

Objective Hypertension is a global public health problem, with its burden increasing particularly in developing countries. However, it has not yet received due attention in Ethiopia. The aim of this study was to determine the prevalence and associated factors of hypertension among adult population in Hosanna town, southern Ethiopia.Design Community...

Objective To describe the patterns and factors associated with advanced stage at diagnosis of cervical cancer among Addis Ababa residents, Ethiopia. Design A population-based cross-sectional study. Setting Seven major hospitals or diagnostic facilities in Addis Ababa, Ethiopia. Participants All histopathology-confirmed patients with incident cer...

Purpose Stage at diagnosis is a key determinant of breast cancer prognosis. In this study, we characterize stage at diagnosis and determine factors associated with advanced stage at diagnosis among women diagnosed with invasive breast cancer in Addis Ababa, capital city of Ethiopia. Methods Stage information was collected from medical records of 4...

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant...

Background/objectives: Diabetes is a global public health problem, and its burden is rising, particularly in developing countries. However, limited data is available from sub-Sahara African communities to assess and monitor the disease burden. The study aimed to determine the prevalence and associated factors of diabetes in Hosanna, Ethiopia. Met...

Background Intrauterine Contraceptive Device (IUCD) is a highly effective and reversible modern contraceptive, which is still significantly underutilized in Ethiopia. The aim of this study was to identify factors affecting the use of IUCDs among women of reproductive age group in Addis Ababa. Methods Facility-based, unmatched case-control study wa...

PURPOSE A substantial proportion of cervical cancers are diagnosed at advanced stage in Ethiopia. Therefore, the aim of this study was to determine the extent and predictors of delays in cervical cancer diagnosis in Addis Ababa. PATIENTS AND METHODS We prospectively recruited 231 patients with cervical cancer diagnosed from January 1, 2017, to Jun...

Globally, premarital sexual activities among adolescents have been reported to be increasing. Many studies in Sub-Saharan Africa, including Ethiopia, had reported that there were increasing premarital sexual activities among adolescents and youths. Besides, they are risk-takers who are more likely to make decisions about the future without adequate...

Background: Determining the glycemic index and load of foods has significant impact on meal planning for diabetes. However, there is no data on the glycemic index (GI) and glycemic load (GL) of Ethiopian foods. Therefore, the aim of this study was to analyze the glycemic index and glycemic load of Teff Injera, Corn Injera, and White Wheat Bread....

Purpose Data comparing the burden of the opportunistic infections among the Pre-ART and On-ART HIV-infected patients in Ethiopia are scarce. Therefore, this study aimed to compare the prevalence and predictors of opportunistic infections in Pre-ART and On-ART HIV-infected patients. Methods A comparative cross-sectional study was conducted among ad...

EVIDENCE REVIEW We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fer...

EVIDENCE REVIEW We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fer...

This appendix formed part of the original submission and has been peer reviewed. Supplement to: GBD 2017 SDG Collaborators. Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. L...

Background: Hypertension is a leading cause of cardio-vascular diseases and its attributed mortality. No previous study, however, assessed the prevalence and associated factors of hypertension in the study area. Methods: We recruited a representative sample of 627 adult individuals from selected kebeles of Hosanna town. A multi-stage sampling techn...

Background Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-leve...

Background Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-leve...

Background Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-leve...

Background Tobacco use is one of the leading public health threats in the world and the spread of is growing at fast among adolescents. However, little information is known about the magnitude and predictors of tobacco use in Ethiopia. Hence study was conducted to assess the prevalence and predictors of tobacco use among school adolescents of Ethio...

Background Tobacco is one of the leading public health burdens globally. The health system and healthcare providers can play a major role in promoting smoking cessation to their patients. However, the Ethiopian health system's responsiveness towards smoking cessation therapy is not well understood. Therefore study was conducted to assess the health...

Anemia is a chronic disease that seriously affects young children and pregnant women. Knowledge of disease clustering is important because it may provide insights into the etiology of disease and risk factors operating within different levels of the clusters. In this study, we tried to identify determinants of anemia among pre-school children aged...

Tobacco use is responsible for 6 million deaths globally per year, of which 600,000 deaths are due to secondhand smoke (SHS) mainly among women and children. This study aims to determine the prevalence of SHS exposure among school-going adolescents and highlights the essential determinants in developing successful strategies to prevent adverse heal...

Background: Severe acute malnutrition is one of the major killers of under five children in developing countries including Ethiopia. However, little information is known about the determinant factors of severe acute malnutrition. Hence this study identified the determinants of severe acute malnutrition in Shashogo woreda, Southern Ethiopia. Methods...