Nazlı Gamze Bülbül

Sultan Abdulhamid Han Research and Training Hospital · Neurology

Objectives: Alzheimer’s disease (AH) is the most prevalent cause of dementia, followed closely by vascular dementia. Mixed vascular-Alzheimer’s dementia (MVAD) is more evident in individuals aged 80 and above. Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after AH. Vascular risk factors play important role in...

Combined central and peripheral demyelination (CCPD) is is a rare disease characterized by demyelinating lesions in both the central nervous system (CNS) and peripheral nervous system (PNS). CCPD can present with acute, subacute or chronic onset. The initial symptom may be of CNS origin, PNS origin or both. The clinical manifestations of CCPD are q...

Background Detecting cognitive impairment such as Alzheimer’s disease early and tracking it over time is essential for individuals at risk of cognitive decline. Objective This research aimed to validate the Beynex app’s gamified assessment tests and the Beynex Performance Index (BPI) score, which monitor cognitive performance across seven categori...

Background One of the important factors that make it difficult to carry out activities of daily living independently is the decrease in functional mobility. Mobility‐related disability is a major public health issue that reduces the quality of life and increases the need for care, the burden, and the cost of care. However, in the early stages of de...

Background The care of individuals with Alzheimer’s disease is mostly provided by their spouses and children. It is stated that an average of 18 billion hours is spent annually on informal care provided by family members. It is known that caregiving affects both physical and mental health. The burden of care that arises in this process increases th...

Background BEYNEX (version 2.0) is an online application for tracking cognitive abilities using gamified follow‐up tests designed in eight different cognitive categories by Neurologists and psychologists. In this study, we aimed to determine and monitor the cognitive level of the person using this application by establishing an early alarm system,...

Background Family caregiving in Alzheimer’s Disease (AD) has been associated with a variety of negative psychological and social processes, including social isolation. Besides, it has been shown that the caregiver’s physical activity level is one of the factors associated with the burden of care. The negative impact of physical inactivity on genera...

Human immunodeficiency virus (HIV) continues to be a serious public health problem in our country in the world and has serious effects on the central and peripheral nervous system. HIV‑associated dementia (HAD), which may develop due to HIV infection, causes subcortical dementia that can progress with marked slowdown in reaction time and psychomoto...

Background & Objective: Tension-type headache (TTH) is the most common primary headache. TTH worsens quality of life and is related to various psychosocial factors. We aimed to examine the severity of headache (intensity, frequency, and duration), analgesic use, quality of life (QoL), and the impact of COVID pandemic-induced stress in TTH patients....

Aim: Coronavirus disease 2019 (COVID-19) related lockdown may have a negative effect on the neuropsychiatric status of Alzheimer’s Disease (AD) cases. In this study, it was aimed to find future implications by evaluating the neuropychiatric conditions of AD cases during total and partial lockdown periods. Methods: It is a prospective, cross-section...

Epilepsia partialis continua is characterized by continuous clonic contractions of a certain area of the body. One of the most common causes of Epilepsia partialis continua in adults is cerebrovascular events. Other causes include meningoencephalitis, Rasmussen encephalitis, diabetic nonketotic hyperosmolar coma, central nervous system malignancies...

Background: To date, it has been suggested that there may be many genetic, environmental, and vascular factors that affect hand preference. In previous studies evaluating the relationship between cerebral dominance and hand preference, carotid and vertebral artery (VA) Doppler ultrasonography (USG) was generally preferred; and these studies only m...

Background: Autoimmune encephalitis (AIE) and paraneoplastic syndromes (PNS) are both rare groups of neurological diseases that are difficult to diagnose. Aim: We aimed to determine the common and distinct aspects of these two aetiologies of encephalitis as well as the characteristics of our patient group. Methods: We respectively analysed the...

Amaç: COVID-19 pandemi süreci birçok kesimin yaşam kalitesini farklı şekillerde ve düzeylerde etkilemiştir. Stresin gerilim tipi baş ağrısında önemli bir rol oynadığı düşünülür. Bu çalışmada gerilim tipi başağrısı (GTBA) olan hastaların pandemi döneminde başağrısının şiddeti, sıklığı, süresi gibi özellikleriyle birlikte günlük yaşam değişikliklerin...

Introduction: Cognitive impairment is common in Parkinson's Disease, but the impact of predictive factors on incidence and rate of cognitive decline is incompletely understood. We aimed to determine the effects of sex and APOE allele status on cognitive performance in patients with Parkinson's Disease (PD). Material and methods: We conducted a r...

Introduction and aim: Stroke is the leading cause of disability in adults and the second most common cause of death, at a rate of 11.8% worldwide. The purpose of this study was to examine the etiological, demographic, and clinical characteristics of patients admitted to hospital due to acute strokes. Materials and methods: This multi-center stud...

Aim of Study The NLR is a simple and inexpensive parameter that is useful as a marker of subclinical inflammation. The purpose of this study was to investigate the clinical characteristics of patients diagnosed with acute cerebral ischemia at the time of initial evaluation in the emergency department. Patients and Methods The study was designed as...

Amaç: Coronavirus disease-2019 (COVID-19) pandemisi sürecinde, Alzheimer Hastalığı (AH) ve diğer demanslılar gerek ileri yaşları, gerek eşlik eden komorbiditeleri gerekse infeksiyon korunma kurallarına uyum sorunları açısından büyük risk altındadır. Bu duruma ek olarak sosyal izolasyon veya karantina gibi halk sağlığı müdahalelerinin de, demans has...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects both upper and lower motor neurons and its etiology is not fully understood. The incidence of ALS is 2-3/100,000 people in the world. Although ALS occurs sporadically in most patients, 5-10% of patients are thought to have genetic inheritance. The most common gene...

Background: Patients with multiple sclerosis (MS) suffer from the repetitive yawning and sleep problems. Yawning is observed in MS and other central nervous system disorders and yawning and swallowing may be controlled by the network of the brain stem. Therefore it is important to investigate the MS patients with various clinical and radiological...

Migraine is a common neurological disorder with an uncertain pathogenesis. A pathophysiological link has been proposed between the migraine headache and patent foramen ovale (PFO). However, the data about the association of migraine with the presence of PFO are conflicting. The study aims to prospectively investigate the prevalence of PFO in patien...

Yawning and swallowing are fundamental physiological processes that are present from fetal stages throughout life and that involve sequential motor activities in the oropharyngo-larynx making it likely that they may share neuroanatomical pathways. We postulate that yawning and swallowing are controlled by a distributed network of brainstem regions...

The reliability and diagnostic value of Lhermitte's sign in multiple sclerosis (MS) has not been fully established. The purpose of this study was to determine the clinical, neurophysiological and neuroradiological correlations of Lhermitte's sign in a cohort of MS patients and reassess the relevance of this phenomenon in the clinical history of the...

Neuroleptic malignant syndrome (NMS) is a rare but life-threatening clinical manifestation induced by neuroleptic medication. Although NMS is regarded as a psychiatric diagnosis, its treatment requires a systematic approach and thus intensive care follow-up. In this paper, we report nine cases with NMS followed up in our Neurology Intensive Care Un...