Nazish Jaffar

• M.B.B.S, M.Phil Pathology PhD Scholar
• Professor (Assistant) at Sindh Medical College Jinnah Sindh Medical University

Objectives This study aimed to assess healthcare professionals’ awareness and acceptance of telemedicine residing in Pakistan. Materials and Methods A cross-sectional study was conducted across Pakistan from November 2021 to March 2022. Data entry was done through a self-administered questionnaire. In this survey, the non-probability purposive sam...

Fish oil has been known for its antioxidant, cardioprotective, anti-inflammatory, and neuroprotective characteristics due to the presence of polyunsaturated fatty acids (PUFAs) that are essential for optimal brain function and mental health. The present study investigated the effect of Carcharhinus Bleekeri (Shark Fish) oil on learning and memory f...

Objective: To observe the spectrum of glial tumors in a resource-limited tertiary care setup of Karachi according to the modified WHO central nervous system tumor classification. Study Design: A retrospective analysis. Place and Duration of Study: The study was conducted at the Oncology Ward of Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pa...

Introduction: Breast cancer is the most common cancer in women; its early detection plays a crucial role in improving patient outcomes. Ki-67 is a biomarker commonly used for evaluating the proliferation of cancer cells in breast cancer patients. The quantification of Ki-67 has traditionally been performed by pathologists through a manual examinati...

Objective: To compare the diagnostic performance of direct microscopic techniques and culture media for detecting fungal isolates in hair specimens.Study Design: Cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Microbiology, Basic Medical Sciences Institute, Karachi, Pakistan, from January 2021 to June...

Objective: To validate the concordance of automated detection of Ki67 in digital images of breast cancer with the manual eyeball / hotspot method. Study design: Descriptive study. Place and Duration of the Study: Jinnah Sindh Medical University, Karachi, from 1st January to 15th February 2022. Methodology: Glass slides of cases diagnosed as in...

Objective: To assess the coagulation test abnormalities (prothrombin time, activated partial thromboplastin time and fibrin degradation products) in dengue fever patients and its impact on clinical outcomes of the patient. Study Design: Cross-sectional study. Place and Duration of Study: Hematology Department, Pakistan Naval Ship Shifa Hospital, Ka...

Objective: To identify the frequency and mode of pesticide application, its adverse health effects, and to assess farmers' knowledge and practice of precautionary measures. Methods: The cross-sectional study was conducted in Matli, Badin in the Sindh province of Pakistan from February to April 2020, and comprised farmers. Data was collected thro...

Background: The present study evaluated the chromosomal and molecular variations in patients of acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Methods and Materials: A cross-sectional study was conducted at the Department of Oncology at a tertiary care center between April 2018 and June 2021. A total of 314 cases of acute myeloid a...

Autologous platelet-rich plasma (PRP) and adipose tissues have proven beneficial in treating diabetic ulcer, eye infections, cataracts, and dermatologic conditions. We treated a patient with spinal cord injury with two consecutive platelet-rich plasma and stem cell therapies with an interval of 15 days. We assessed the patient's gait, posture, and...

Background: High-risk (HR) Human Papillomavirus (HPV) is an established cause of cervical cancer. HPV genotype detection is significant in preventing cervical cancers through targeted vaccination. Our study aimed to identify HRHPV16/18 and non 16/18 in cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC).

Thalassemia is a genetic disorder of hemoglobin synthesis. Every year 70,000 infants are born with beta thalassemia globally. Its incidence can be reduced by premarital thalassemia screening This review aims to focus on barriers to premarital thalassemia screening and to observe the current thalassemia practices in Asian countries. This study was c...

Background: Beta thalassaemia is an inherited disease that is a cause of continuous burden on the affected families and the society. The objective of the study was to evaluate the efficacy of Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) for the detection of beta thalassaemia trait when used for the screening in Pakistani populat...

Objective: Esophageal carcinoma is one of the most lethal and yet least studied malignancies in South Asian region. The aim of our study was to determine the frequency of Esophageal Carcinoma and to identify factors responsible for late stage diagnosis of this malignancy. Methods: A multi-institutional prospective cross-sectional study was conducte...

Background: Covid-19, a highly infectious disease was first reported in Wuhan, China on 31 December, 2019. It was declared a pandemic by World Health Organization on 11 March, 2020 when 118,326 cases were reported globally. The present study was designed to determine the knowledge, practices, availability of personal protective equipment to health...

Objectives: The aim of the study was to assess the knowledge of community pharmacies about recommended methods of drug disposal and hazardous effects of improper disposal of pharmaceutical waste and to determine the attitude as well as practice of community pharmacies about the proper disposal of pharmaceutical waste. Methods: A cross-sectional stu...

Proper training on the preventive measures against COVID-19 among health-care workers is crucial for mitigating the spread of viral infection. The present study evaluated the efficacy of a brief web-based module on the practice of hand hygiene and respiratory etiquette among respective health-care workers. A comparative study was conducted with a t...

Background and Objective: Hedera helix L. (Ivy) has been utilized as an alternative medicine for cough however, through extensive literature search; we found no reported activity of ivy on "-glucosidase inhibition, HbA1c levels and its protective effect on vital organs. Therefore, the present study aimed to evaluate the antidiabetic and protective...

Background: High-risk (HR) Human Papillomavirus (HPV) is an established cause of cervical cancer. HPV genotype detection is significant in preventing cervical cancers through targeted vaccination our study aimed to identify HRHPV16/18 and non 16/18 in cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC). Methods: A retrospecti...

ABSTRACT Objectives: To determine morphological spectrum of gall bladder diseases at a tertiary care centre of Karachi and to correlate with age and gender. Methodology: Data was collected from histopathological records between June 2017 to June 2019. Relevant data including registration number, age, gender of the patients and diagnosis were record...

Objectives: To determine the knowledge of MBBS students of a public sector medical university regarding hand hygiene and to assess the practical implication of their knowledge regarding hand hygiene during the clinical postings. Methodology: A total of 316 M.B.B.S students from first year to final year were included in the study. Students were equa...

Background: Regular voluntary unpaid blood donation assures safe blood supply in association with minimum infection transmission. The purpose of this study was to identify the frequency of regular voluntary blood donation and to evaluate the causes of donating blood as well as factors impeding blood donations among the medical and nonmedical studen...

Background: Penicillin resistance among Staphylococcus aureus commonly encountered in hospital admitted patients. Detection of antibiotic sensitivity in hospital-acquired methicillin-resistant Staphylococcus aureus infections is important as it has a great influence on empiric antibiotic prescription, successful control of infection, prevention of...

Health care workers are exposed to a number of occupational hazards including injury from needle stick, which puts workers at risk of transmission of as many as 30 pathogens, of which the most life-threatening are the Hepatitis B virus (HBV), Hepatitis C virus (HCV), and the Human Immunodeficiency Virus (HIV). This letter focuses on various factors...

Objective: To assess the frequency of various histopathological types of testicular germ cell tumor in our study population. The prime identification of testicular germ cell tumor is important to prevent the advance stage of cancers. The present study was designed to assess the frequency of different morphological types of testicular germ cell tumo...

Objectives: Basal cell carcinoma (BCC) is the most common cutaneous malignancy in white population. The pattern of exon specific p53 mutations in BCC and its subtypes remain undetected in our population. This study was designed to evaluate the prevalence and mutational spectrum of p53 mutations in basal cell carcinoma (BCC) and its subtypes in peop...

Background: Jinnah post graduate medical center is a major tertiary care hospital in Karachi. People of varying skin color from different ethnic groups in this cosmopolitan city present to this hospital. The current study was designed to determine the histopathological spectrum of non melanoma skin cancer including basal cell carcinoma and squamous...

Hydatid cyst of orbit is a rare disease constituting less than 1% of prevalence worldwide. It is a parasitic infestation by Echinococcus granulosus. It is prevalent in various regions of the world including South Asia. We, hereby, report a case of a 27-year-old male who was admitted to the ophthalmology ward of Jinnah Postgraduate Medical Centre. P...

Chemical induced liver injuries are among the most serious diseases in humans with a high global prevalence rate. The acute and chronic hepatoprotective effect of Hedera helix L. (Ivy) aqueous leaf extract was investigated in carbon tetrachloride (CCl4) induced rat model. It was evident by both acute and chronic study that pretreatment with Ivy pri...

ABSTRACT: Brenner tumors of ovary are relatively uncommon neoplasms and constitute about 1.4-2.5% of all tumors of ovary. Most of these tumors present as an incidental finding either on gross examination of ovary or as a microscopic finding. They are classified in surface epithelial tumors of ovary. We report here a case of a 50 year old woman who...