Nayim Paul

Nayim Paul
University of Dschang/ National Centre for Biological Science-TIFR

BSc, MSc, PhD

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34
Publications
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221
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Publications

Publications (34)
Chapter
In this chapter, a literature survey was performed to identify the best African plants and their derived phytochemicals with anti-Helicobacter pylori activity. Based on the established cut-off points for the classification of antibacterial activity of natural products, the most active African botanicals against Helicobacter pylori were identified a...
Article
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Background: Bacterial infections, especially those caused by multidrug-resistant (MDR) Gram-negative bacteria, remain a global health concern. Previous studies have reported the antibacterial activities of the methanol extract of the leaves of Acacia polyacantha Willd. (Fabaceae) (APL) as well as some of its phytoconstituents. In this study, APL an...
Article
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Background: The rise of multidrug-resistant (MDR) bacteria is a real public health problem worldwide and is responsible for the increase in hospital infections. Donella welwitschii is a liana or shrub belonging to the family Sapotaceae and traditionally used to cure coughs. Objective: This study was conducted with the objective to validate the m...
Article
Ethnopharmacological relevance: Enantia chlorantha is traditionally used to treat various ailments including rickettsia fever, cough and wounds, typhoid fever, infective hepatitis, jaundice, and urinary tract infections. Aim of the study: To isolate the antibacterial constituents of the hydro-ethanolic extract of the stem bark of E. chlorantha (...
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Background: The antibiotic resistance of pathogenic bacteria is one of the major health problems worldwide. The development of novel antimicrobial therapies based on natural products that greatly reduce this resistance is urgent. The present study aimed at evaluating the antimicrobial potential of four animal methanol extracts, Gryllus campestris,...
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Background: The rapid emergence of multidrug resistant (MDR) bacteria is occurring worldwide, endangering the efficacy of antibiotics, which have transformed medicine and saved millions of lives. Antibiotic-resistant infections are already widespread in the Sub-Saharan Africa and across the globe. To extend the search for new and more efficient ant...
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Imperata cylindrica is traditionally used to cure several diseases including cancer, wounds, and hypertension. The present study was designed to investigate the anticancer activity of the methanolic root extract of I. cylindrica (IC-MeOH). The water-soluble tetrazolium-1 and colony formation assays were used to check the proliferation ability of th...
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In this study, we examined the antibacterial and antibiotic-resistance reversal properties of methanol (MeOH) and ethyl acetate (EtOAc) extracts and compounds from Psychotria sycophylla aerial parts against drug-resistant bacteria. The tests were performed using the microdilution method. The mechanisms of action were investigated on growth kinetic...
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The local botanical Imperata cylindrica in Cameroon was investigated for its antibacterial potency. The methanol extract afforded a total of seven compounds, including five hitherto unreported compounds comprising three flavonoids (1–3) and two C-15 isoprenoid analogues (4 and 5) together with known derivatives (6 and 7). The novelty of the flavono...
Article
Background: Bacterial infections involving the multidrug resistant (MDR) strains are among the top leading causes of death throughout the world. Healthcare system across the globe has been suffering from an extra-ordinary burden in terms of looking for the new and more potent antimicrobial compounds. The aim of the present study was to determine th...
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Full-text available
Background: In recent years, drug resistance to human pathogenic bacteria has been commonly reported from all over the world. As antimicrobial activities of most medicinal plants and antibiotics have been already explored, it is more important to make investigations on animal species mainly invertebrates which could constitute an efficient source o...
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Bacterial multidrug resistance causes many therapeutic failures, making it more difficult to fight against bacterial diseases. This study aimed to investigate the antibacterial activity of extract, fractions, and phytochemicals from Plectranthus glandulosus (Lamiaceae) against multidrug-resistant (MDR) Gram-negative phenotypes expressing efflux pum...
Article
Ethnopharmacological relevance Infections due to multidrug-resistant (MDR) bacteria constitute a real problem in the public health worldwide. Hypericum roeperianum Schimp. ex A. Rich (Hypericaceae) is used traditionally for treatment of various ailments such as abdominal pains, constipation, diarrhea, indigestion, nausea, and bacterial diseases. A...
Article
Ethnopharmacological relevance Imperata cylindrica (L.) Raeusch (Gramineae) is a medicinal spice traditionally used in the treatment of hypertension and cancer. Aim of the study To assess the anti-metastatic potential of the methanol extract of I. cylindrica roots and determined its mechanisms of action. Material and methods The growth inhibition...
Article
Full-text available
Background: In recent years, drug resistance to human pathogenic bacteria has been commonly reported from all over the world. As antimicrobial activities of most medicinal plants and antibiotics have been already explored, it is more important to make investigations on animal species mainly invertebrates which could constitute an efficient source o...
Article
Full-text available
Background: Bacterial infections involving the multidrug resistant (MDR) strains are among the top leading causes of death throughout the world. Healthcare system across the globe has been suffering from an extraordinary burden in terms of looking for the new and more potent antimicrobial compounds. The aim of the present study was to determine the...
Article
Full-text available
Background: Multidrug-resistant (MDR) bacteria remain a major cause of morbidity and mortality globally. The present study was designed to investigate the in vitro antibacterial activities of crude methanol extract and constituents isolated by Column Chromatography (CC) from Cassia sieberiana bark (CSB) against ten MDR Gramnegative bacteria, as wel...
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Background: The cytotoxicity of the root's methanol extract of Imperata cylindrica (ICR). was previously reported in a panel of human cancer cell lines, including multi-drug resistant phenotypes. The aim of this study was to assess the acute and sub-chronic oral toxicity of methanol root extract of Imperata cylindrica. Methods: The acute toxicit...
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The emergence and persistence of multidrug-resistant (MDR) bacteria appears today as a serious threat of growing concern to human health. The aim of this present study was to investigate the antibacterial and antibiotic-modulating activity of the methanol extracts of Manilkara zapota (L.) P. Royen (Sapotaceae) against pathogenic strains belonging t...
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Acacia polyacantha is a medicinal plant traditionally used to treat livestock diseases and gastrointestinal infections; our study was undertaken to evaluate the antistaphylococcal activities of the methanolic leaf, bark, and root extracts, fractions, and compounds from Acacia polyacantha against a panel of 14 multidrug-resistant Staphylococcus bact...
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A new caffeate derivative from the ethanol extract of the stem bark of Cassia sieberiana DC. is described herein along with the known secondary metabolites spectaline (2), iso-6-cassine (3), 3-O-methyl-chiro-inositol (4), monobehenin (5), octyl nonadecyloate (6), β-sitosterol (7), stigmasterol (8) and sitosterol 3-O-β-D-glucopyranoside (9). The che...
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Background: The increase resistance of Staphylococcus aureus clinically, propels the search of novel approaches to treat staphylococcal infections. This study aims to investigate the anti-staphylococcal activity and antibiotic-modulating effects of the methanol extracts of five Cameroonian dietary plants namely Cinnamomum zeylanicum, Fagara xanthox...
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This work was designed to investigate the antibacterial activities of methanol extracts from thirteen Cameroonian edible plants and their antibiotic-potentiating effects against Gram-negative multidrug-resistant (MDR) phenotypes. The broth microdilution method was used to evaluate the minimal inhibitory concentration (MIC) and minimal bactericidal...
Data
Supplementary file.docx. Table S1: information on the studied plants; Table S2: further details on the antibiotic resistance profiles of tested Gram-negative bacteria; Table S3: results of preliminary evaluation of antibiotic resistance modulatory activity of selected extracts at subinhibitory concentrations against Pseudomonas aeruginosa PA124.
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Background: In this study, we evaluated the anti-staphylococcal and antibiotic-potentiating activities against resistant phenotypes of seven Cameroonian dietary plants: Arachis hypogaea; Cola pachycarpa; Curcuma longa; Lycopersicon esculentum; Manihot esculenta; Passiflora edulis and Rubus fellatae. Methods: The liquid broth microdilution method w...
Article
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Abstract Background: In this study, we evaluated the anti-staphylococcal and antibiotic-potentiating activities against resistant phenotypes of seven Cameroonian dietary plants: Arachis hypogaea; Cola pachycarpa; Curcuma longa; Lycopersicon esculentum; Manihot esculenta; Passiflora edulis and Rubus fellatae. Methods: The liquid broth microdilut...
Article
Full-text available
Background In this study, 18 methanol extracts from Cameroonian edible plants were tested for their antibacterial activities against 26 strains of S. aureus; the role of efflux pumps in the resistance of tested bacteria and the antibiotic resistance-modulating activities against selected multidrug-resistant (MDR) phenotypes were also investigated....
Data
Preliminary evaluation of antibiotic resistance modulatory activity of extracts against S. aureus SA88 (Table S1); antibiotic resistance modulatory activity of the bark methanol extract from Dacryodes edulis bark (DEB) (Table S2); the leaf methanol extract from Dacryodes edulis leaves (DEL) (Table S3); the seed methanol extract from Dacryodes eduli...
Article
Allanblackia genus, an endless source of bioactive compounds, was investigated for its antibacterial properties. The chemical study of the methanol extract from the fruits of Allanblackia gabonensis resulted in the isolation of the undescribed guttiferone BL (1) along with the known kaempferol (2), morelloflavone (3), morelloflavone 7″-O-β- d-glucopy...
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In order to contribute to the fight against infectious diseases, the in vitro antibacterial activity and the antibiotic-potentiating effects of Tristemma hirtum and five other Cameroonian edible plants have been evaluated against Gram-negative multidrug-resistant (MDR) phenotypes. The microdilution method was used to evaluate the bacterial suscepti...
Data
Table S1: Gram-negative bacteria used and their features and further details on the antibiotic-resistance profiles of tested Gram-negative bacteria.
Article
Full-text available
The present study was designed to evaluate the antibacterial activities of methanol extracts of bark and leaves of Syzygium jambos , as well as their synergistic effects with selected antibiotics against drug-resistant Gram-positive and Gram-negative bacteria. The crude extracts were subjected to qualitative phytochemical screening; broth microdilu...
Data
Table S1: Staphylococcus aureus strains and features. Table S2: Gram-negative bacteria and features.

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