Navid Banafshe

Navid Banafshe
King's College London | KCL · Department of Neuroscience (IoP)

About

5
Publications
125
Reads
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3
Citations
Introduction
PhD graduate of Neuroscience with a strong interest in the diagnostic value of auditory electrophysiological responses. Techniques: Auditory Electrophysiology, Scanning Electron Microscopy, Immunohistochemistry, Confocal Microscopy, image and data processing using Imaris and Matlab.

Publications

Publications (5)
Article
Full-text available
Age-related hearing loss in humans (presbycusis) typically involves impairment of high frequency sensitivity before becoming progressively more severe at lower frequencies. Pathologies initially affecting lower frequency regions of hearing are less common. Here we describe a progressive, predominantly low-frequency recessive hearing impairment in t...
Preprint
Full-text available
Age-related hearing loss in humans (presbycusis) typically involves impairment of high frequency sensitivity before becoming progressively more severe at lower frequencies. Pathologies initially affecting lower frequency regions of hearing are less common. Here we describe a progressive, predominantly low-frequency hearing impairment in two mutant...
Presentation
Abstract selected for a podium presentation at the ARO conference 2021. A reduction of the Auditory Brainstem Response (ABR) wave 1 (W1) amplitude has been suggested as an indicator for noise-induced cochlear synaptopathy. However, noise exposure damages multiple sites in the cochlea including the stria vascularis and inner and outer hair cells. We...
Presentation
This abstract has been chosen for a talk by the Basic Auditory Science Programme Committee: Following a large-scale screen of new mouse mutants using Auditory Brainstem Response (ABR) recording, we discovered an allele of the Klhl18 gene, Klhl18lowf, with progressive hearing loss predominantly affecting low frequencies. Klhl18lowf was a spontaneous...
Poster
Following a large-scale screen of new mouse mutants using Auditory Brainstem Response (ABR) recording, we discovered an allele of the Klhl18 gene, Klhl18lowf, with progressive hearing loss predominantly affecting low frequencies. Klhl18lowf was a spontaneous missense mutation of Klhl18 (9:110455454 C>A; V55F), predicted to have a damaging effect on...

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Projects

Project (1)
Project
Previously published papers have revealed an association between a selective loss of synapses at the modiolar side of the inner hair cells and a reduction of the Auditory Brainstem Response (ABR) wave I amplitude. Using transgenic mouse lines with known cochlear defects, my aim is to clarify whether the ABR wave I amplitude is a sufficient diagnostic tool for synaptic damage or whether we need more advanced electrophysiological metrics to diagnose cochlear synaptopathy.