Naufal Zagidullin

• PhD, Professor, Fellow ESC, International Member of ACC
• Head of Department at Bashkir State Medical University

Psoriasis is a chronic immune-inflammatory dermatological disease that affects not only the skin, but can also cause systemic inflammation, increasing cardiovascular endpoints. Aim: To examine long-term cardiovascular endpoints in patients with coronary heart disease (CHD), psoriasis and their combination in a prospective observational study. Mater...

Introduction — Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is used for ablation of various solid tumors and treatment of neurological diseases. During ablation, brain tissue is injured, resulting in the formation of necrosis and edema zones. Therefore, strategies to minimize brain damage are highly relevant. The goal of our resear...

Precise temperature regulation is essential for effective and safe magnetic resonance imaging-guided focused ultrasound (MRgFUS) treatments. Several variables influence the target temperature during sonication, with the energy delivered being a pivotal physical determinant. The skull density ratio (SDR) is utilized to evaluate the feasibility of tr...

Idiopathic pulmonary fibrosis (IPF) is a rapidly progressive interstitial lung disease of unknown pathogenesis with no effective treatment currently available. Given the regulatory roles of lncRNAs (TP53TG1, LINC00342, H19, MALAT1, DNM3OS, MEG3), miRNAs (miR-218-5p, miR-126-3p, miR-200a-3p, miR-18a-5p, miR-29a-3p), and their target protein-coding g...

Coronary restenosis is a pressing challenge in cardiovascular diseases with an annual incidence of 3-4%. The aim of the study was to assess the influence of known risk factors in predicting coronary restenosis in a systematic analysis and an original retrospective survey. In the first stage, we performed a systematic review of restenosis risk facto...

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease resulting from dynamic, cumulative gene-environment interactions that cause lung tissue injury, alteration of its normal function and acceleration of cellular senescence. Long non-coding RNAs (lncRNAs) function as critical epigenetic regulators of various aspects of cellular sen...

Background: Increased mortality and occurrence of cardiovascular (CV) outcomes during hospitalization and in short-term follow-up for moderate to severe SARS-CoV-2 infection have been associated with male sex, yet data regarding long-term outcomes by sex and COVID-19 variant (Alpha, Delta, and Omicron) are limited. Methods: This prospective study o...

Highlights We propose serum biomarkers as risk assessment tools for patients with COVID-19. J-waves are a common ECG finding, detected in 4–6% of the population, and are a risk factor for ventricular tachycardia and mortality in COVID-19 patients. Aim. To evaluate the prognostic potential of a combination of cardiac-specific biomarkers and ECG J-w...

Chronic obstructive pulmonary disease (COPD) is a multifactorial heterogeneous chronic inflam-matory respiratory disease. The molecular pathogenesis of COPD may include dysregulation of the stress responses that are associated with cell senescence and involve a wide range of signaling pathways and their epigenetic regulators, such as long noncoding...

SARS-CoV2, responsible for the COVID-19 pandemic, is still relevant for the medical system throughout the world. In addition to the effect on the respiratory system, cardiac manifestations of COVID-19 are also known in the acute and post-COVID-19 period, including known coronary heart disease, proarrhythmogenic effects including impact on sick sinu...

Editorial on the Research Topic Nutraceuticals in cardiovascular diseases and their associated risk conditions

The coronavirus infection (COVID-19) pandemic remains a hot topic of study to this day. According to studies, mortality in patients with COVID-19 and a history of diabetes mellitus (DM) is 2-3 times higher than in patients without DM. The purpose of the study is to analyze the course of coronavirus infection in patients with T2DM. Material and meth...

Aim. To study serum biomarker profile in patients with coronary artery disease (CAD) and psoriasis and the impact on the incidence of hospitalization for cardiovascular reasons and psoriasis. Material and methods. The study included 90 patients divided into following 3 groups: with psoriasis (n=30), coronary artery disease (CAD) (n=30) and CAD+psor...

These authors contributed equally to this work. Abstract: With the onset of the coronavirus pandemic, it has become clear that patients with diabetes are at risk for more severe and fatal COVID-19. Type 2 diabetes mellitus (T2D) is a major risk factor for adverse COVID-19 outcomes. The goal of study was to assess the characteristics and outcomes of...

During the pandemic of coronavirus infection (COVID-19) caused by a virus SARS-CoV-2 there has been significant variability in symptoms of the disease over time, severity of the course and in particular hospital mortality. Several SARS-CoV-2 variants have been identified such as Alpha, Delta, Omicron and others. Aim was to investigate the hospital...

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease of unknown origin with an average life expectancy of 3-5 years after diagnosis. The disease is accompanied by progressive pulmonary fibrosis, decreased lung function, poor response to therapy and early mortality. Various biomarkers, including serum biomarkers, ar...

Accumulating evidence indicates a high prevalence of long-term negative consequences of COVID-19. Their final assessment is possible only after their complete disappearance, which, given the ongoing registration of negative assessments of the health status of some hospitalized COVID-19 patients, is impossible in the near future. Taking this into ac...

Due to the large number of complications and decreased quality of life after coronavirus disease (COVID-19), physical and psychological rehabilitation of patients is relevant. However, the effectiveness of rehabilitation on endpoints has not yet been demonstrated. Aim. To determine the effectiveness of different rehabilitation options in hospitaliz...

Backrgound. Magnetic resonance-guided focused ultrasound (MR-FUS) is a new non-invasive technology for the surgical treatment of extrapyramidal movement disorders for such pathologies as essential tremor, Parkinson’s disease, etc. In these cases, the brain is injured and a zone of ischemia is formed. Arterial hypertension (AH) is one of the most co...

The viral infection and pandemic of coronavirus infection 2019 (COVID-19) was characterized not only by high morbidity and in-hospital mortality, but also by an increase in the mortality of patients after hospital discharge. At the same time, differences were noted in hospitalization rate, the number of complications and mortality of patients, and...

Introduction. Idiopathic pulmonary fibrosis (IPF) comprises an interstitial lung disease with unclear pathogenesis, rapid progression, and no effective treatment. Pulmonary fibrosis is reported to be one of the most severe complications induced by a new coronavirus infection COVID-19. The mechanisms triggering pulmonary fibrosis and leading to its...

Introduction. Extent of social losses due to the COVID-19 pandemic is still evaluated incompletely fully assessed despite its declared end. Aim. To study the socioeconomic burden of the novel coronavirus (COVID-19) in the Republic of Bashkortostan. Materials and Methods. In this study, we used the method of accounting for the economic burden caused...

The study goal was to evaluate the possibility of automating of optic coherent (OCT) images analysis and to develop a model for precise differentiation of nature of intracoronary atherosclerotic plaques using deep neural networks. At the first stage of the study, special software was developed that allows the experts to mark 16 different types of p...

Background COVID‐19 limitations have hindered the implementation of new technologies by preventing proctors from coming to the site. We share our first experience of magnetic resonance imaging (MRI)‐guided focused ultrasound (MRgFUS) treatment with an international remote online proctorship, and develop and evaluate the methodology of remote MRgFUS...

on behalf of the Committees of the Russian Society of Cardiology for work with medical schools of the Russian Federation and for educational activities and youth policy Cardiovascular diseases take a leading place in the morbidity pattern worldwide, and therefore improving the cardiology education in medical schools is very relevant. In addition, t...

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease of the respiratory system which develops as a result of a complex interaction of genetic and environmental factors closely related to lifestyle. We aimed to assess the combined effect of the PI3K/AKT/mTOR signaling pathway ( PIK3R1, AKT1, MTOR, PTEN ) and sirtuin ( SIRT1, SIRT...

Chronic obstructive pulmonary disease (COPD) is a complex lung disease characterized by progressive airflow limitation and abnormal inflammatory response of the lungs to inhaled noxious particles or gases. COPD pathogenesis has been linked to oxidative stress and systemic inflammation. We aimed to assess the association of cytokines and inflammator...

Introduction. Cardiovascular disease has been the leading cause of death and disability worldwide for many years. The widespread use of percutaneous coronary intervention has significantly improved clinical outcomes in patients with cardiovascular diseases. However, inflammatory reactions that occur in response to mechanical stretch, endothelial ex...

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease of the respiratory system that affects the lung parenchyma and airways; it is one of the leading causes of death in the world, which explains the constant search for new approaches to diagnosis, treatment and prevention of the disease. The molecular pathogenesis of COPD may in...

Introduction: While acute Coronavirus disease 2019 (COVID-19) affects the cardiovascular (CV) system according to recent data, an increased CV risk has been reported also during long-term follow-up (FU). In addition to other CV pathologies in COVID-19 survivors, an enhanced risk for arrhythmic events and sudden cardiac death (SCD) has been observed...

This article is about the experience in organizing and conducting the first Russian cardiology hackathon Cardio data hack UFA 2022 which took place in Ufa in November 2022. It describes the preparation stages and organizational conditions of the hackathon conducting, the ways of interacting between the event organizer and participants, and the meth...

Visceral obesity is a key link in the metabolic syndrome and can affect the development of cardiovascular diseases. Objective . The aim of the study was to identify the clinical, laboratory and instrumental characteristics of patients with coronary artery disease, to analyze adverse cardiovascular events after coronary bypass surgery, according to...

(1) Background: Heart failure with reduced ejection fraction (HFrEF) remains a major health burden. Angiotensin-Receptor-Neprilysin-Inhibitors (ARNIs) are an established HFrEF therapy which increases natriuretic peptide levels by inhibiting neprilysin. Leptin is a lipid metabolism parameter, which is also involved in glucose metabolism and is sugge...

A cardiac contractility modulation device is a new treatment used in patients with heart failure. CCM therapy is associated with an increase in physical activity tolerance, improved quality of life, reduced hospitalizations due to heart failure, and reverse remodeling of the left ventricle in patients with systolic heart failure. In this case, the...

Significant atherosclerotic stenosis of the carotid arteries can provoke ischemic stroke and is one of the factors considered when assessing eligibility for carotid endarterectomy (CEE). Objective . To identify risk factors for the development of adverse vascular events (AVE) after undergoing CEA in the medium-term (5 and 7 years) and long-term (10...

Chronic obstructive pulmonary disease (COPD) is a complex lung disease characterized by progressive airflow limitation and abnormal inflammatory response of the lungs to inhaled noxious particles or gases. COPD pathogenesis was linked to oxidative stress and systemic inflammation. We aimed to assess the association of cytokines and inflammatory gen...

Aim. To evaluate the effect of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization. Material and methods. This prospective, randomized, single-center study included two following groups: experimental group — 25 patients in the perioperative period of coronary artery...

Chronic obstructive pulmonary disease (COPD) is a multifactorial heterogeneous chronic inflammatory disease of the respiratory system. Oxidative stress plays a central role in the pathophysiology of COPD. The goal of the study is the identification of new molecular markers of COPD based on the analysis of the expression profile of genes involved to...

The COVID-19 epidemic is being revealed from a new angle every month. In particular, with the appearance of the delta strain, mucormycosis began to manifest in some patients, which had previously been extremely rare. Mucormycosis is a rare, aggressive infection caused by filamentous fungi of the Mucorales family and associated with high morbidity a...

Relevance . The proportion of angiotensin receptor blockers has increased significantly among prescribed antihypertensive agents. To a large extent, this is facilitated by the emergence of new high-quality generic drugs available to the widest range of patients. Study objectives . Evaluation of effectiveness and safety of Telmista® (Telmisartan 40...

Due to the rather specific course of COVID-19, the question of what day after the start of hospitalization should be expected to be the maximum risk of death in patients both during hospitalization and after discharge is relevant. Aim. The aim of the study was to determine the time of maximum risk of death during hospitalization of patients with CO...

Due to the rather specific course of COVID-19, the question of what day after the start of hospitalization should be expected to be the maximum risk of death in patients both during hospitalization and after discharge is relevant. Aim. The aim of the study was to determine the time of maximum risk of death during hospitalization of patients with CO...

Introduction: COVID-19 survivors reveal an increased long-term risk for cardiovascular disease. Biomarkers like troponins and sST-2 improve stratification of cardiovascular risk. Nevertheless, their prognostic value for identifying long-term cardiovascular risk after having survived COVID-19 has yet to be evaluated. Methods: In this single-center s...

Background. The sudden emergence and rapid spread of the novel coronаvirus infection (COVID-19) caused tremendous burden on the health care system including the economic one. In this regard, many questions concerning the prioritization of funding for various restrictive and preventive procedures have arisen; also the introduction of various inter...

The objective of our study was the analysis of using immunosuppressive therapy in patients with COVID-19 at the Clinic of the Bashkir State Medical University. Material and methods — We conducted the analysis of clinical and laboratory parameters of inflammatory response in 322 patients with COVID-19 who received tocilizumab, baricitinib, high dose...

Idiopathic pulmonary fibrosis (IPF) is the most common form of fibrosis of internal organs. The etiology and pathogenesis of IPF are still not well understood. However, a growing line of evidence shows that both genetic and non-genetic factors contribute to IPF development. The release of pro-inflammatory cytokines activates the immune cells. The e...

Introduction: Cardiovascular events are common in COVID-19. While the use of anticoagulation during hospitalization has been established in current guidelines, recommendations regarding antithrombotic therapy in the post-discharge period are conflicting. Methods: To investigate this issue, we conducted a retrospective follow-up (393 ± 87 days) of 1...

Introduction. Treatment with MRI-guided focused ultrasound (MRgFUS) is a new, non-invasive surgical technique for treating extrapyramidal movement disorders. This article presents the first use of MRgFUS in Russia for treating patients with essential tremor (ET). Materials and methods. Patients (n = 26; 17 men and 9 women) aged 2182 years (median...

AimsWhile COVID-19 affects the cardiovascular system, the potential clinical impact of cardiovascular biomarkers on predicting outcomes in COVID-19 patients is still unknown. Therefore, to investigate this issue we analyzed the prognostic potential of cardiac biomarkers on in-hospital and long-term post-discharge mortality of patients with COVID-19...

Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease that is characterized by partly reversible airflow limitation, chronic inflammation, fibrosis of small airways, and destruction of lung parenchyma. We aimed to assess the association of the inflammatory gene loci singly and in combinations with COPD in smokers an...

Background. The COVID-19 pandemic is associated with significant number of complications and mortality and a burden on the healthcare system. In 1015% of hospitalized patients, the invasive and non-invasive mechanical ventilation (IMV/NIMV) is required. At the same time, it is important to stratify the risk of mechanical ventilation upon admission...

Epicardial adipose tissue (EAT) has unique properties due to its special anatomical structure, thermoregulation, and metabolic activity. Dysregulated EAT provokes the synthesis of pro-inflammatory cytokines, disorders in the metabolism of fats and glucose, as well as contributes to fatty degeneration of the myocardium and heart failure development....

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease affecting primarily distal respiratory pathways and lung parenchyma. This study aimed to determine possible genetic association of chemokine and chemokine receptor genes polymorphisms with COPD in a Tatar population from Russia. SNPs of CCL20, CCR6, CXCL8, CXCR1, CX...

Objective: To analyze the relationship between electrocardiogram (ECG) parameters in the acute period of hemorrhagic stroke and its poor outcome within 90 days. Material and methods: ECG data of 133 patients with hemorrhagic stroke recorded upon admission to the primary vascular department were analyzed. Results: Eighteen percent out of 133 pa...

The coronavirus disease 2019 (COVID-19) pandemic is associated with high virulence, mortality and healthcare burden around the world. One of its features is procoagulant activity, which leads to a high incidence of thromboembolic events in the lungs and other organs. Therefore, from the very onset of the moderate COVID-19, low molecular weight hepa...

With the high morbidity and mortality rates, cardiovascular diseases have become one of the most concerning diseases worldwide. The heart of adult mammals can hardly regenerate naturally after injury because adult cardiomyocytes have already exited the cell cycle, which subseqently triggers cardiac remodeling and heart failure. Although a series of...

Background J-waves represent a common finding in routine ECGs (5–6%) and are closely linked to ventricular tachycardias. While arrhythmias and non-specific ECG alterations are a frequent finding in COVID-19, an analysis of J-wave incidence in acute COVID-19 is lacking. Methods A total of 386 patients consecutively, hospitalized due to acute COVID-...

Due to the population aging and the accumulation of concomitant diseases, the prevalence of atrial fibrillation (AF) as the most common arrhythmia is increasing. On the other hand, 14% of the population has chronic kidney disease (CKD). These conditions are often combined with each other causing a prothrombogenic effect, which significantly increas...

The coronavirus disease 2019 (COVID-19) affects not only the respiratory system, but also the cardiovascular system in 20-28% of cases, causing endothelial dysfunction, vasculitis, hyper- and hypocoagulation, myocarditis, endothelial dysfunction and other adverse effects. The presence of cardiovascular risk factors and diseases has been shown to wo...

Aim. To evaluate the dynamics of left atrial volume (LAV), strain (S) during the reservoir phase and strain rate (SR) in patients with paroxysmal and persistent atrial fibrillation (AF), scheduled for catheter radiofrequency ablation (RFA), as well as to compare the predictive value of S and SR as a marker of maintaining sinus rhythm. Material and...

to perform its pacemaker function. Our aim was to identify genetic predictors of SSS in a prospective cohort of patients admitted to the clinic for pacemaker implantation using single-locus and multilocus approaches. We performed genotyping for polymorphic markers of CLCNKA (rs10927887), SCN10A (rs6795970), FNDC3B (rs9647379), MIR146A (rs2910164),...

The classic Osborn wave in the form of characteristic changes at the depolarization end or ventricular repolarization beginning is more often associated with hypothermia (body temperature below 35,6° C). Some researchers have noticed Osborn wave at normal body temperature, various pathological conditions and diseases: hypercalcemia, myocardial isch...

Osteosarcoma (OS) is the most common primary malignant bone tumour in adolescence. Lately, light-emitting diodes (LED)-based therapy has emerged as a new promising approach for several diseases. However, it remains unknown in human OS. Here, we found that the blue LED irradiation significantly suppressed the proliferation, migration and invasion of...

Aims Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin on cardiovascular and non-cardiovascular causes of death. Methods and results DAPA-CKD was an international, randomized, placebo-controlled trial with a median...

N⁶-methyladenosine (m⁶A) RNA modification, a dynamic and reversible process, is essential for tissue development and pathogenesis. However, the potential involvement of m⁶A in the regulation of cardiomyocyte (CM) proliferation and cardiac regeneration remains unclear. In this study, we aimed to investigate the essential role of m⁶A modification in...

2Bashkir State Medical University, Ufa, Russian Federation, 450000. Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease affecting primarily distal respiratory pathways and lung parenchyma. An abnormal inflammatory response to inhaled harmful particles and tobacco smoke leads to airway remodeling and is thought to be...

A multi-marker approach for assessing the prognosis of patients with ST-segment elevation myocardial infarction (STEMI) is a promising strategy.Aim. To assess the potential prognostic power of soluble growth stimulation gene-2 (sST2), pentraxin 3 (PTX3), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in stratification of the risk of major...

The COVID-19 pandemic has had a huge impact on the health of millions of people around the world on an unprecedented scale. Unfortunately, the process of creating effective antiviral drugs and vaccines is being delayed. Therefore, drugs that are already available and may have an effect on COVID-19 are being investigated. Due to the fact that viral...

Background: Patients with chronic kidney disease have a high risk of adverse kidney and cardiovascular outcomes. The effect of dapagliflozin in patients with chronic kidney disease, with or without type 2 diabetes, is not known. Methods: We randomly assigned 4304 participants with an estimated glomerular filtration rate (GFR) of 25 to 75 ml per mi...

The new coronavirus infection (COVID‑19) is a serious threat to humanity. Although its pathogenesis has not been fully studied, angiotensin-converting enzyme 2 (ACE 2) has recently been identified as a receptor for entry into the cell of the coronavirus SARS-CoV‑2, thereby contributing to the spread of infection in the body. The goal of the review...

A new coronavirus infection (CVI) is a challenge to the medical system of the Russian Federation and requires precise flow forecasting to take the necessary measures on time. The article provides an overview of modern mathematical tools for predicting the course of CVI in the world. The created CVI forecasting project office allowed to determine th...

Psoriasis is a chronic immuno-inflammatory skin disease characterized by impaired proliferation and differentiation of epidermal keratinocytes involving both innate and adaptive immunity. The prevalence of psoriasis in the population is 1—4%. Recently, in connection with new data on the pathogenesis of the disease and the emergence of modern method...

Objective To study the prognostic role of current serum biomarkers in patients with myocardial infarction (MI) by constructing a multifactorial model for prediction of cardiovascular complications (CVC) in remote MI. Acute coronary syndrome is a major cause of death and disability in the Russian Federation. Introduction of current biomarkers, such...

ST-elevation myocardial infarction (STEMI) is one of the main reasons for morbidity and mortality worldwide. In addition to the classic biomarker NT-proBNP, new biomarkers like ST2 and Pentraxin-3 (Ptx-3) have emerged as potential tools in stratifying risk in cardiac patients. Indeed, multimarker approaches to estimate prognosis of STEMI patients h...

Neonatal mammalian heart maintains a transient regeneration capacity after birth, whereas this regeneration ability gradually loses in the postnatal heart. Thus, the reactivation of cardiomyocyte proliferation is emerging as a key strategy for inducing heart regeneration in adults. We have reported that a highly conserved long noncoding RNA (lncRNA...

Psoriasis is a chronic immuno-inflammatory skin disease characterized by impaired proliferation and differentiation of epidermal keratino-cytes involving both innate and adaptive immunity. The prevalence of psoriasis in the population is 1—4%. Recently, in connection with new data on the pathogenesis of the disease and the emergence of modern metho...

We present a case report of a patient with a previously identified cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), who was admitted due to coronavirus disease 2019 (COVID-19), confirmed by polymerase chain reaction and computed tomography. Examination and treatment of these patients presents cer...

Cardiac arrhythmias constitute a major health problem with a huge impact on mortality rates and health care costs. Despite ongoing research efforts, the understanding of the molecular mechanisms and processes responsible for arrhythmogenesis remains incomplete. Given the crucial role of Ca²⁺-handling in action potential generation and cardiac contr...