Nathaniel B. Klooster

Nathaniel B. Klooster
University of Pennsylvania | UP · Department of Neurology

Ph.D.

About

15
Publications
1,422
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
104
Citations
Introduction
I am interested in the neuroscience of memory and language broadly. At Penn, I study semantic memory and figurative language. Examining patients with neurodegenerative disease or focal lesions allows me to establish the necessity of brain regions in their support of cognition. Identifying experimental measures sensitive to the earliest cognitive changes in neurodegenerative disease promises to impact early diagnoses and evaluation of potential treatments.
Education
August 2002 - May 2006
Kenyon College
Field of study
  • Philosophy

Publications

Publications (15)
Article
Background: Sensitive measures of cognition are needed in preclinical and prodromal Alzheimer's disease (AD) to track cognitive change and evaluate potential interventions. Neurofibrillary tangle pathology in AD is first observed in Brodmann Area 35 (BA35), the medial portion of the perirhinal cortex. The importance of the perirhinal cortex for se...
Article
Recent findings point to a role for hippocampus in the moment-by-moment processing of language, including the use and generation of semantic features in certain contexts. What role the hippocampus might play in the processing of semantic relations in spoken language comprehension, however, is unknown. Here we test patients with bilateral hippocampa...
Article
Despite the ubiquity of metaphor in cognition and communication, it is absent from standard clinical assessments of language, and the neural systems that support metaphor processing are debated. Previous research shows that patients with focal brain lesions can display selective impairments in processing metaphor, suggesting that figurative languag...
Preprint
Despite the ubiquity of metaphor in cognition and communication, it is absent from standard clinical assessments of language, and the neural systems that support metaphor processing are debated. Previous research shows that patients with focal brain lesions can display selective impairments in processing metaphor, suggesting that figurative languag...
Preprint
Sensitive measures of cognition are needed in preclinical and prodromal Alzheimer’s disease (AD) to track cognitive change and evaluate potential interventions. We hypothesize that measures of semantic richness and figurative language are sensitive to cognitive impairment in prodromal AD. The neurofibrillary tangle (NFT) pathology of AD is first ob...
Article
Creative language is defined as linguistic output that is both novel and appropriate. Metaphors are one such example of creative language in which one concept is used to express another by highlighting relevant semantic features. While novelty is an inherent property of unfamiliar metaphors, appropriateness depends on the context. The current study...
Article
Full-text available
Embodied cognition theories propose that the semantic representations engaged in during language comprehension are partly supported by perceptual and motor systems, via simulation. Activation in modality-specific regions of cortex is associated with the comprehension of literal language that describes the analogous modalities, but studies addressin...
Preprint
Creative language is defined as linguistic output that is both novel and appropriate. Metaphors are one such example of creative language in which one concept is used to express another by highlighting certain semantic features. While novelty is an inherent property of unfamiliar metaphors, appropriateness depends on the context. The current study...
Article
Full-text available
Introduction: Relational memory is the ability to bind arbitrary relations between elements of experience into durable representations and the flexible expression of these representations. It is well known that individuals with traumatic brain injury (TBI) have declarative memory impairments, but less is known about how TBI affects relational memor...
Article
Full-text available
The impact of traumatic brain injury (TBI) on procedural memory has received significantly less attention than declarative memory. Although to date studies on procedural memory have yielded mixed findings, many rehabilitation protocols (e.g., errorless learning) rely on the procedural memory system, and assume that it is relatively intact. The aim...
Article
Full-text available
Hand gesture, a ubiquitous feature of human interaction, facilitates communication. Gesture also facilitates new learning, benefiting speakers and listeners alike. Thus, gestures must impact cognition beyond simply supporting the expression of already-formed ideas. However, the cognitive and neural mechanisms supporting the effects of gesture on le...

Network

Cited By