Nathan Long- PhD
- Kingston University
Nathan Long
- PhD
- Kingston University
Synthesis of squaric acid analogues as bioisosteric replacements of carboxylic acids
About
3
Publications
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Introduction
Current institution
Additional affiliations
September 2019 - July 2020
Education
September 2016 - July 2020
Publications
Publications (3)
Herein, we present a synthetic compound library comprising of 13 structurally diverse heterocyclic monosquarate-amide derivatives. The compounds featured in this library were designed as potential bioisosteric replacements carboxylic acid moiety’s. A good selection of the compounds presented exhibit unique molecular architecture and have shown prom...
Herein, we present a synthetic compound library comprising of 28 anilino and benzylamino monosquarate-amide derivatives. Members of this library were designed as bioisosteric replacements for groups such as the ubiquitous carboxylic acid moiety. Further to their synthesis, we have shown the potential of these chemical building blocks for the genera...
2,4‐Thiazolidinedione (TZD) is a privileged and highly utilised scaffold for the development of pharmaceutically active compounds. This sulfur‐containing heterocycle is a versatile pharmacophore that confers a diverse range of pharmacological activities. TZD has been shown to exhibit biological action towards a vast range of targets interesting to...
Questions
Question (1)
I need 4.0 equivelents of BBr3 for a reaction. my starting material is 0.55mmol. My BBr3 is sold as 1M in DCM and has a vol of 100mL.
How do i start to work this out
