Nathalie Alves da Paixão

• University of São Paulo

Introdução: A insuficiência cardíaca (IC) é a via final comum da maioria das cardiomiopatias e outras doenças do aparelho circulatório. Além do comprometimento funcional, portadores de IC apresentam perda excessiva da massa muscular que pode culminar em caquexia cardíaca (caquexia oriunda de uma doença cardíaca) sendo o treinamento físico aeróbico...

Background: We previously reported that exercise training (ET) facilitates the clearance of damaged proteins in heart failure. Here, we characterized the impact of ET on cardiac protein quality control during compensated ventricular hypertrophy in spontaneously hypertensive rats (SHR). Methods and results: SHR were randomly assigned into sedenta...

Heart failure (HF) is known to lead to skeletal muscle atrophy and dysfunction. However, intracellular mechanisms underlying HF-induced myopathy are not fully understood. We hypothesized that HF would increase oxidative stress and ubiquitin-proteasome system (UPS) activation in skeletal muscle of sympathetic hyperactivity mouse model. We also teste...

Representative histological images of untrained wild type (WT) and α2A/α2CARKO (ARKO) mice at 3, 5 and 7 months of age and trained α2A/α2CARKO mice (ARKOT) at 7 months of age. Muscle sections were prepared and analyzed as described in the Methods section of the manuscript. Dashed lines represent the location of plantaris muscle. Same magnification...

CONSORT checklist for non-pharmacological trials. (DOC)

Primer sequence used for real-time PCR. (DOC)

Cumulative survival of wild type (WT), untrained α2A/α2CARKO (ARKO) and trained α2A/α2CARKO mice (ARKOT) after starting experimental protocol, when mice were 5 month-old. ***p = 0.002 vs. WT. (DOC)

Aerobic exercise training (AET) is an important mechanical stimulus that modulates skeletal muscle protein turnover, leading to structural rearrangement. Since the ubiquitin-proteasome system (UPS) and calpain system are major proteolytic pathways involved in protein turnover, we aimed to investigate the effects of intensity-controlled AET on the s...

Cardiomyocyte hypertrophy occurs in response to a variety of physiological and pathological stimuli. While pathological hypertrophy in heart failure is usually coupled with depressed contractile function, physiological hypertrophy associates with increased contractility. In the present study, we explored whether 8 weeks of moderate intensity exerci...