Nathalie Maria Malewicz

Nathalie Maria Malewicz
Ruhr-Universität Bochum | RUB · Klinik für Anästhesiologie, Intensiv- und Schmerzmedizin

Dr. med. & M. Sc.

About

42
Publications
16,489
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
405
Citations
Introduction
I am a resident in Anesthesiology, Intensive Care and Emergency Care Medicine in Germany with my research focus on pain and itch. I finished my medical studies at Ruhr-University Bochum and my doctoral thesis at Professor Maiers laboratory (Bochum) uncovering treatment predictors in neuropathic pain patients using Quantitative Sensory Testing (QST). I had the opportunity to work with great collaborators in the fields of sepsis, pain pathways and programming solutions for analysing immunoflourescence and histology (Focinator, Stripenator). Supported by a grant from the German Research Foundation (DFG) I was able to work on itch and pain in projects based on psychophysical human and behavioral rodent experiments as a postdoc at Professor LaMotte’s laboratory at Yale Medical School.
Additional affiliations
August 2019 - present
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil
Position
  • PostDoc Position
March 2017 - March 2019
Yale University
Position
  • PostDoc Position
Description
  • Our laboratory mainly studies sensory psychophysics to study the peripheral neural mechanisms of acute and chronic pain and itch in humans and animals.
January 2015 - June 2019
University Hospital Essen
Position
  • Medical Doctor
Education
March 2018 - December 2018
Harvard T.H. Chan School of Public Health
Field of study
  • Principles and Practice of Clinical Research (PPCR)
January 2015 - January 2017
University Hospital Essen
Field of study
  • Anesthesology
June 2011 - December 2015
Ruhr-Universität Bochum
Field of study
  • Pain Medicine

Publications

Publications (42)
Article
Full-text available
Background: Capsaicin, the hot pepper agent, produces burning followed by desensitization. To treat localized itch or pain with minimal burning, low capsaicin concentrations can be repeatedly applied. We hypothesized that alternatively controlled release of capsaicin from poly(lactic-co-glycolic acid) (PLGA) nanoparticles desensitizes superficially...
Article
Background: Ficin, a cysteine protease derived from fig-tree latex, has been reported to elicit itch and nociceptive sensations, though quantitative sensory studies are lacking. Cowhage containing the pruritic cysteine Mucunain, on the other hand, has been widely studied as activating polymodal nociceptors and eliciting a histamine-independent itc...
Article
Background: Chronic posttraumatic/postsurgical pain (CPSP) is common after traumatic or surgical damage. Exposure to both trauma and surgery, with the potential for repeated bone and nerve damage, may increase the risk of CPSP after fracture-related surgery. But the (long-term) incidences of CPSP and neuropathic CPSP and the ensuing burdens are unk...
Article
Objectives This study aimed to discover the active compounds of Sophora flavescens Ait. (SF), the anti-itch effects and underlying mechanisms of oxymatrine (OMT), one of the bioactive compounds from SF. Methods Dorsal root ganglion cell membrane immobilized chromatography was used to screen potential anti-pruritic active compounds from SF. The scr...
Article
Objectives Inhalative anesthesia is of common use, but is generally known to potentiate postoperative nausea and vomiting (PONV). With an internal change of anesthesia regimen from total intravenous anesthesia (TIVA) to isoflurane (in terms of myocardial protection) in cardiac anesthesia a higher incidence of PONV was to be expected. Therefore, we...
Article
Full-text available
In humans, intradermal administration of β-alanine (ALA) and bovine adrenal medulla peptide 8-22 (BAM8-22) evokes the sensation of itch. Currently, it is unknown which human dorsal root ganglion (DRG) neurons express the receptors of these pruritogens, MRGPRD and MRGPRX1, respectively, and which cutaneous afferents these pruritogens activate in pri...
Article
Full-text available
We report a systematic review and meta-analysis of studies which assessed the antinociceptive efficacy of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators on pain-associated behavioural outcomes in animal models of pathological or injury-related persistent pain. In April 2019, we systematically searched 3 online databas...
Article
Full-text available
Background: High-dose opioids are conventionally used for cardiac anesthesia, but without monitoring of nociception. In non-cardiac surgical procedures the intra - operative dose of opioids can be individualized and reduced with pupillometric monitoring of the pupillary pain index (PPI; scale 1-9). A randomized controlled trial was carried out to...
Preprint
Full-text available
In human, intradermal administration of β-alanine (ALA) and bovine adrenal medulla peptide 8-22 (BAM8-22) evokes the sensation of itch. Currently, it is unknown which human dorsal root ganglion (DRG) neurons express the receptors of these pruritogens, MRGPRD and MRGPRX1 respectively, and which cutaneous afferents these pruritogens activate in prima...
Article
Full-text available
Background: Sepsis remains a major health challenge with high mortality. Adequate volume administration is fundamental for a successful outcome. However, individual fluid needs differ between patients due to varying degrees of systemic vasodilation, circulatory flow maldistribution, and increased vascular permeability. The current fluid resuscitati...
Article
Purpose Intensive care unit-acquired weakness (ICUAW) can manifest as muscle weakness or neuropathy-like symptoms, with diagnosis remaining a challenge. Uncertainties surround the long-term cause and sequelae. Therefore, the purpose was to assess incidence, time course and long-term influence on quality of life (QoL) of symptoms in ICU survivors M...
Article
Full-text available
Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Several modulators of ligand-gated ion channels have recently been identified, suggesting that there are P2XR f...
Conference Paper
61. Jahrgang - Supplement Nr. 11 - Mai 2020 Abstracts der Jahrestagung der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin 2020 https://www.ai-online.info/images/ai-ausgabe/2020/05-2020/Supplement_11-2020_DAC_Abstracts_1.pdf
Preprint
Background: Critically ill patients are at risk for sepsis and immunosuppressive mechanisms may prevail. Whether functional tests are helpful to detect immune alterations is largely unknown. Therefore, we tested the hypotheses, that reactivity of peripheral blood mononuclear cells (PBMCs) to secrete interferon-g (IFNγ) following stimulation in vit...
Article
Full-text available
Introduction: Irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) are inflammatory skin diseases accompanied by itch and pain. Irritant contact dermatitis is caused by chemical irritants eliciting an innate immune response, whereas ACD is induced by haptens additionally activating an adaptive immune response: After initial expo...
Preprint
Full-text available
BACKGROUND Sepsis remains a major health challenge with high mortality. Adequate volume administration is fundamental for a successful outcome. But with varying degree of systemic vasodilation, circulatory flow maldistribution and an increase in vascular permeability, the individual fluid need differs between patients. The current fluid resuscitati...
Article
Full-text available
DNA- and histone-related research frequently comprises the quantitative analysis of protein modifications, such as histone phosphorylation. Analysis of accumulation and disappearance of protein foci are used to monitor DNA damage and repair kinetics. If the protein of interest doesn’t accumulate in foci, laser micro-irradiation of single nuclei pro...
Article
Full-text available
Animals and humans display two types of response to noxious stimuli. The first includes reflexive defensive responses that prevent or limit injury; a well-known example of these responses is the quick withdrawal of one’s hand upon touching a hot object. When the first-line response fails to prevent tissue damage (for example, a finger is burnt), th...
Poster
Full-text available
Aim of Investigation: Persistent irritant and allergic contact dermatitis (ICD and ACD) are inflammatory diseases of the skin accompanied by itch and nociceptive sensations that diminish the quality of life. ICD is caused by chemical irritants activating innate immune cells, whereas ACD is a delayed-type hypersensitivity reaction mediated by hapten...
Poster
The quantitative analysis of cells and foci plays a key role in various cell biological methods. In the field of radiation biology and molecular radiation oncology, the effect of ionizing radiation, chemotherapy or molecularly targeted drugs on DNA damage induction is detected by the analysis of protein clusters or phosphorylated proteins recruited...
Article
Full-text available
Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B(Akt) are observed with high frequency during malignant transformation and cancer progression. Oncogenic gene mutations coding for the upstream regulators or Akt, e.g., growth factor receptors, RAS and phosphatidylinositol-3-kinase (PI3K), or for one of the three...
Conference Paper
To recognize and manage an emergency situation using an ABCDE (Airway, Breathing, Circulation, Disability, Environment), ISBAR ( Identity, Situation, Background, Awareness, Response). Medical students expressed difficulty in the recognition and management of emergency situations and requested a structured method for successfully dealing with such...
Article
Full-text available
The quantitative analysis of foci plays an important role in various cell biological methods. In the fields of radiation biology and experimental oncology, the effect of ionizing radiation, chemotherapy or molecularly targeted drugs on DNA damage induction and repair is frequently performed by the analysis of protein clusters or phosphorylated prot...
Conference Paper
Full-text available
The quantitative analysis of cells and foci plays an important role in various cell biology methods. In the fields of radiation biology and molecular radiation oncology, the effect of ionizing radiation, chemotherapy or molecularly targeted drugs on DNA damage induction is performed by the analysis of protein clusters or phosphorylated proteins rec...
Article
Full-text available
Background The quantitative analysis of foci plays an important role in many cell biological methods such as counting of colonies or cells, organelles or vesicles, or the number of protein complexes. In radiation biology and molecular radiation oncology, DNA damage and DNA repair kinetics upon ionizing radiation (IR) are evaluated by counting prote...
Article
Topical high-dose capsaicin acting on TRPV1 receptors and inducing an intraepidermal decrease in the small nerve fibre count is effective in treating neuropathic pain (NP). Sensory changes after capsaicin application, their correlation with pain relief and their role as possible predictors of response have been insufficiently analysed. We hypothesi...
Conference Paper
Ein neuer Ansatz in der Therapie peripherer neuropathischer Schmerzen ist die topische Applikation von hochdosiertem Capsaicin (8%) mit Responseraten zwischen 17,6% bis 47,8% [1]. Das Wirkprinzip beruht auf einem Funktionsverlust und einer Reduktion der C-Fasern in der Epidermis [2]. Daher wurde angenommen, dass die Schmerzlinderung nach Capsaicin...

Network

Cited By

Projects

Projects (4)
Project
Optimization of - pain assessment and - pain management.
Project
-Incidence of ICU-survivors with CIPNM -neurophysiological profiles of ICU-survivors with CIPNM
Project
Part of group project during the principles and practice of clinical research course (delivered via Harvard T.H Chan school of public health) we wanted to come with new ways of tailoring fluid therapy in patients with sepsis. The protocol is finalized, awaiting publication, looking for a fund and a hospital to run the actual trial.