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Introduction
Marine biotechnology
Seaweed biorefinery
Screening for anti-herpetic activities
Publications
Publications (166)
We investigated the fatty acid composition of the total lipids from the red alga Schizymenia dubyi (Gigartinales, Gymnophlaeaceae) harvested in Sicily. Twenty-four fatty acids were identified as methyl esters, including C14C28 saturated acids (77% of total acid mixture) and three hydroxylated acids. Four novel midchain methoxylated fatty acids (16...
An organic extract of the marine diatom Skeletonema costatum was studied in vitro for its effect on asynchronous cells of a human non-small-cell bronchoplumanory carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the G1 phase of the cell cycle, and kinetic studies in pretreated cells showed that this growth arrest was irreversible....
The aim of this study was to identify the presence of antimicrobial activities in the hemolymph of commercially important mollusc species. Acidic extracts were prepared from whole Cerastoderma edule (Cardiidae), Ruditapes philippinarum (Veneridae), Ostrea edulis (Ostreidae), Crepidula fornicata (Calyptraeidae) and Buccinum undatum (Buccinidae) and...
An unusual sulfated heteropolysaccharide containing uronic acids, previously isolated from the red alga Schizymenia dubyi, was studied in vitro for its effect on asynchronous cells of a human non-small-cell-bronchopulmonary carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the G1 phase of the cell cycle, and kinetic studies in pret...
We report here an efficient synthesis for pyrimidine nucleoside analogues by [4 + 2] cycloaddition reaction. These compounds were obtained by convergent chemistry from glycosyl isothiocyanates 3a-f (pyranoses, furanoses, and dissaccharides) and diazadienium salt 5. In fact, diazapentadienium iodide 5 prepared from vinylthioamide 4 is an efficient i...
Although the density and diversity of seaweeds in Madagascar is particularly high, these resources are underexploited and they are not part of the local population’s eating habits. No study has been carried out on the nutritional properties and seasonal variation of Eucheuma species harvested in Madagascar. In this study, Eucheuma denticulatum was...
The agricultural sector plays a crucial role in sustaining population growth and ensuring our well-being. However, as this sector faces numerous challenges due to environmental conditions and the increasing population, it is essential to identify natural alternatives that promote sustainable farming practices and protect the environment. Seaweed-ba...
Depuis les années 2010-2011, des échouages massifs de Sargassum spp. se produisent de façon récurrente dans les Caraïbes et le Golfe du Mexique et semblent prendre de l'ampleur d'année en année. Une fois échouée sur les plages, cette biomasse pose de nombreux problèmes d'un point de vue économique, sanitaire et environnemental. En effet, ces algues...
Depuis 2010-2011, des échouages massifs de Sargassum spp. sont récurrents dans les Caraïbes et le Golfe du Mexique. Ces algues sont riches en métaux lourds car elles ont la capacité d'absorber ceux présents dans l'eau de mer. Sargassum a une teneur en arsenic total (As) comprise entre 50 et 200 ppm et contient une fraction élevée en arsenic inorgan...
The effects of the Instant Controlled Pressure Drop (DIC) technology on the recovery of natural compounds from the brown seaweed Sargassum muticum (Yendo) Fensholt 1955 (Ochrophytina, Fucales) were investigated. Fresh biomass of S. muticum was collected on the Brittany Coast, France. Both fresh and Air Impingement-Dried (AID) thalli of 3 and 10 cm...
Gracilaria cornea was exposed to different irradiance intensities (low, moderate, and high) and light qualities (white and white + blue) in experimental cultures. Photosynthetic physiology was measured through daily growth rate, maximum photosynthesis, maximum photochemical efficiency, pigment content (chlorophyll a, phycobiliproteins, carotenoids)...
Red seaweed carrageenans are frequently used in industry for its texturizing properties and have demonstrated antiviral activities that can be used in human medicine. However, their high viscosity, high molecular weight, and low skin penetration limit their use. Low-weight carrageenans have a reduced viscosity and molecular weight, enhancing their...
Brown seaweeds of the Fucus genus represent a rich source of natural antiviral products. In this study, a Fucus ceranoides hydroalcoholic extract (FCHE) was found to inhibit 74.2 ± 1.3% of the proteolytic activity of the free SARS-CoV-2 3CL protease (3CLpro), an enzyme that plays a pivotal role in polyprotein processing during coronavirus replicati...
Herpes viruses (HSV) are among the most common viruses that infect humans. They cause blisters and inflammation of the oral and genital mucosa as well as severe symptoms such as blindness, hearing impairment and fatal encephalitis. Although acyclovir (ACV) and its derivatives are highly effective in treating recurrent lytic infections, the emergenc...
Macroalgae are a potentially novel source of nutrition and biologically active molecules. Proliferative species such as Eucheuma denticulatum, Solieria chordalis (red algae) and Sargassum muticum (brown alga) constitute a huge biomass that can be exploited. In this study, we focus on the extraction of polysaccharides from these three macroalgae spe...
In Brittany, invasive algae represent a real problem, unbalancing local ecosystems and threatening the economy and tourism, with massive stranding’s, especially in summer. The valorization of invasive algae in green processes and materials such as ecological building materials could represent a real opportunity to try to control the spread of these...
Even after hundreds of clinical trials, the search for new antivirals to treat COVID-19 is still relevant. Carrageenans are seaweed sulfated polysaccharides displaying antiviral activity against a wide range of respiratory viruses. The objective of this work was to study the antiviral properties of Halymenia floresii and Solieria chordalis carragee...
Marine macroalgae are present in the ocean and more particularly in the coastal zone. Their distribution is related to biotic and abiotic factors. Considered as sustainable raw materials for a wide range of value-added products and energy production, they are valued in the fields of human and plant health, agriculture, food or construction (Baghel...
Solieria spp. (Solieriaceae, Gigartinales, Rhodophyta) can be found in various habitats ranging from the marine environment to low-salinity estuarine environments. Of the commercially exploited carrageenophytes, some of the most abundant belong to the Solieriaceae family as, Kappaphycus, Eucheuma and Solieria. The supply of these seaweeds is ensure...
In this study, zinc oxide nanoparticles (ZnO NPs) were biosynthesized with the use of an extract derived from seaweed (Sargassum sp.) and used as a sorbent for the removal of Cr(III) ions from wastewater. The biosorption properties of the seaweed itself as well as of the post-extraction residue were investigated for comparison. ZnO NPs were charact...
Seaweed surface provides a suitable substratum for the settlement of microorganisms (bacteria, viruses, and plankton). These microbial partners may have either beneficial or detrimental effects on the host since surface microbiota can act either as a protective layer to the macroalgae (symbiotic beneficial relations) or, under changing environmenta...
Seaweeds represent a promising and sustainable feedstock for biofuel production which raises increasing research interests. Their high availability, easy fermentable composition, and good degradation potential make them a suitable candidate for alternating fossil fuels as an advantageous energy resource. This comprehensive review aims to summarize...
Polyopes lancifolius is an introduced species of Halymeniales (Rhodophyta) from Asia, discovered on the North Atlantic coast in 2008. In this study, a first biochemical description of the species from the Gulf of Morbihan (France) is presented. The overall biochemical analysis of the algal raw material showed levels of neutral sugars (25.14% dw), p...
Sargassum muticum is an invasive brown alga, which proliferates on European coasts. The composition of this biomass could represent a valuable input for the biorefinery concept but the algae have to be stabilized before a valorization process. Four drying processes were applied on S. muticum at the moderate temperature of 40 °C. Drying kinetics, th...
The underexploited biomass of red seaweed Solieria chordalis (C.Agardh) J.Agardh 1842 represents a potential source for biotechnological development. Extracts obtained from S. chordalis by enzyme-assisted extraction using Protamex® and Neutrase® were evaluated as potential biostimulants of plant growth. Additionally, this alga, as well as post-extr...
Herpes simplex virus 1 (HSV-1) remains a prominent health concern widespread all over the world. The increasing genital infections by HSV-1 that might facilitate acquisition and transmission of HIV-1, the cumulative evidence that HSV-1 promotes neurodegenerative disorders, and the emergence of drug resistance signify the need for new antiviral agen...
The current cultivation practices mainly use fertilizing products in order to increase crop yield and to improve soil structure and quality. However, short- and long-term negative impacts on the environment of some fertilizing products of mineral origin have already been described. Thus, the challenge is to search for a new generation of sustainabl...
The impact of air velocity and temperature on the drying curves of the invasive brown alga Sargassum muticum was studied. An air impingement dryer was used at five air velocities (7, 14, 21, 28 and 35 m s⁻¹) at 40 °C and at four air temperatures (40, 50, 60 and 70 °C) at 35 m s¹. Equilibrium moisture content was properly modeled by Oswin, Halsey an...
Ulva sp. is known to be a source of bioactive compounds such as ulvans, but to date, their biological activity on skin commensal and/or opportunistic pathogen bacteria has not been reported. In this study, the effects of poly- and oligosaccharide fractions produced by enzyme-assisted extraction and depolymerization were investigated, for the first...
Le procédé de séchage est utilisé depuis des centaines voire des milliers d'années afin de conserver les produits, principalement les denrées alimentaires. Les procédés de séchage modernes cherchent un compromis entre l'efficacité maximale du procédé et la qualité optimale du produit fini. Les chercheurs de l'IUT de Lorient-Pontivy développent depu...
Algae are organisms with an enormous biodiversity and contain manifold fatty acid molecular structures and ratios. This chapter presents information about the structure and distribution of fatty acids in algae whether microalgae or macroalgae. The parameters affecting lipid and fatty acid contents as well as distribution are also discussed. Methods...
Le littoral et la mer sont des ressources naturelles environnementales. C’est-à-dire des ressources qui, sans être un produit de l’activité humaine, influent ou pourraient influer sur
l’économie des pays ou le bien-être de leurs habitants. Partout dans le monde, ces zones concentrent des populations croissantes et des activités multiples. Les impac...
Marine algae known as one producers of bioactive compounds. This study aims to analyze the cytotoxicity and antiviral activity in Sargassum polycystum and Sargassum ilicifolium tested with Herpes Simplex Virus (HSV). The polysaccharides extract of algae was used in this study, as sulfated polysaccharides have been reported has bioactivity. Cytotoxi...
During the experimental cultivation of the red alga Halymenia floresii under Integrated MultiTrophic Aquaculture (IMTA), the establishment of opportunist green algae and the colonization of sessile invertebrates, which were usually disturbing the cultivation, were not observed. The culture tanks were clean and the surface of the H. floresii was rem...
Polysaccharides, lipids and amino acid profiles were investigated to understand the nutritional value of Caulerpa racemosa and Ulva fasciata from the Philippines. The results revealed that both species contain high amounts of proteins (8.8–19.9% for C. racemosa and 8.0–11.1% for U. fasciata). The portions of the total amino acids that were essentia...
The aims of this work are to isolate bacterial symbionts from nudibranchs and subsequently to determine anti-Methicillin resistant Staphylococcus aureus (MRSA), cytotoxicity and anti-Herpes simplex virus type 1 (HSV-1) activities of bio compounds. A total of 15 species of nudibranchs were collected from Karimunjawa and five species from Bali, respe...
Historically, enzyme-assisted extraction was applied to seaweeds to find a new ecofriendly way for phycocolloid extraction. A first evolution in the use of this novel extraction method leads to active fractions from seaweeds (not only polysaccharides) for agriculture, health, food, feed, or cosmetic applications. Since 2015, a second evolution has...
Indonesia is known for its marine biodiversity, including the richness of its brown seaweed, Sargassum. This genus has attracted many attention as it produces active compounds showing potential for the food, pharmacology and cosmetic industries. In this study, a mixture of S. duplicatum, S. echinocarpum and S. polycystum extracts was applied as an...
There is an urgent need to discover new compounds with antibacterial activity, which can be developed into lead structures for the treatment of human disease caused by multidrug-resistant (MDR) bacteria. In this study, we focussed on bryozoan-associated bacteria to screen them toward antibacterial activities, since the microbiome of these organisms...
Rhodymenia pseudopalmata lives in the intertidal zone receiving high doses of solar radiation, including the potentially harmful UVR. Previous studies proved it ability to adapt to different artificial light intensities and salinity concentrations. The aim of this study was to describe the differences on the Mycosporine-like amino acids (MAAs), phe...
The aim of this work was to isolate bacterial symbionts from nudibranchs and subsequently to determine anti-Methicillin resistant Staphylococcus aureus (MRSA), cytotoxicity and anti-HSV-1 activities of bio-compounds. Fifteen species of nudibranchs were collected from Karimunjawa and five species from Bali, respectively. A total of 245 bacteria isol...
The aim of this work was to isolate bacterial symbionts from nudibranchs and subsequently to determine anti-Methicillin resistant Staphylococcus aureus (MRSA), cytotoxicity and anti-HSV-1 activities of bio-compounds. Fifteen species of nudibranchs were collected from Karimunjawa and five species from Bali, respectively. A total of 245 bacteria isol...
Given the current interest to reach sustainable protein supplies, seaweed proteins represent a potential source for pharmaceutical, nutraceutical, cosmeceutical, or food and feed applications. Some species are reported to contain high quantities of protein with original amino acid composition, which has been comparable to the values reported for ot...
Macroalgae surfaces are considered as a potentially suitable substratum present underwater for the dynamic epibiotic microbiome. They secrete various organic substances as nutrients for the multiplication of bacteria and the formation of microbial biofilms. The microbial biofilm itself acts as a biological defence mechanism to prevent the establish...
Marine macroalgae (seaweed) are an excellent source of novel bioactive metabolites. The biorefinery concept applied to seaweed facilitates the extraction of many chemical constituents from the same biomass ensuring that the resource is used fully, generating few residues through a succession of extraction steps. In the present study, the biomass of...
Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total p...
In vitro antioxidant activities of the lipid fractions from two selected seaweeds, Solieria chordalis and Sargassum muticum were investigated according to the extraction methods. The activity of neutral lipids, glycolipids and phospholipids, thanks to extraction by chloroform/methanol (1/1 v/v; CM) mixture, pure supercritical carbon dioxide (sc-CO2...
The potential of Indonesian bays as alginate producers was assessed by determining the stock of wild brown algae and exploring their biomass as alginophytes at the scale of entire bay, using a combination of field observations, remote sensing high resolution data and GIS tools. Ekas Bay in Lombok Island presented a stock of brown macroalgae which v...
Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this study. The antiviral activity against Herpes Simplex Virus type 1 (HSV-1) was done on Vero cell lines by cell viability. Only two plants extracts; namely Euphorbia coopire (Euphorbiaceae) and Morus alba (Moraceae) showed potent anti-herpetic ac...
Lipid extraction yields and lipid class distribution from two seaweeds Solieria chordalis (Rhodophyceae) and Sargassum muticum (Phaeophyceae) were investigated using different extraction methods. Supercritical carbon dioxide extraction with or without co-solvent and chloroform/methanol extractions were applied to S. chordalis and S. muticum. Total...
Seaweeds are potentially excellent sources of bio-active metabolites that could represent useful leads in the development of new functional ingredients in pharmaceutical and cosmetic industries. In the last decade, new marine bioprocess technologies have allowed the isolation of substances with biological properties. The brown alga Sargassum muticu...
Carrageenan yield, physicochemical properties, and antiviral activity of the carrageenan from Solieria chordalis (Rhodophyceae, Solieriaceae) harvested at the Brittany coast (France) were investigated. S. chordalis carrageenan was extracted by conventional and the microwave assisted extraction (MAE) methods. The effect of different parameters durin...