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Natasha M Maurits

Natasha M Maurits
University Medical Center Groningen · Department of Neurology

Professor of Clinical Neuroengineering

About

275
Publications
27,981
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Introduction
I work in Clinical Neuroengineering: I translate clinical neurological problems to physico-mathematical problems, find a solution using state-of-the-art mathematical techniques and translate this solution back to neurology for application by neurologists and other researchers. A project can cover any one or more of these steps. I strongly believe in cross-disciplinary research and work together with researchers from neurology, psychology, physiology, computer science and applied mathematics.

Publications

Publications (275)
Article
Full-text available
Overlapping phenotypic features between Early Onset Ataxia (EOA) and Developmental Coordination Disorder (DCD) can complicate the clinical distinction of these disorders. Clinical rating scales are a common way to quantify movement disorders but in children these scales also rely on the observer’s assessment and interpretation. Despite the introduc...
Article
Full-text available
Older age is associated with worsened outcome after mild traumatic brain injury (mTBI) and a higher risk of developing persistent post-traumatic complaints. However, the effects of mTBI sequelae on brain connectivity at older age and their association with post-traumatic complaints remain understudied. We analyzed multi-echo resting-state functiona...
Article
Full-text available
Self-reported complaints are common after mild traumatic brain injury (mTBI). Particularly in the elderly with mTBI, the pre-injury status might play a relevant role in the recovery process. In most mTBI studies, however, pre-injury complaints are neither analyzed nor are the elderly included. Here, we aimed to identify which individual pre- and po...
Article
Objective To explore to what extent neuronal coupling between upper and lower limb muscles during gait is preserved or affected in patients with Parkinson’s Disease (PD). Methods Electromyography recordings were obtained from the bilateral deltoideus anterior and bilateral rectus femoris and biceps femoris muscles during overground gait in 20 heal...
Article
Full-text available
Background Human bipedal gait benefits from arm swing, as it drives and shapes lower limb muscle activity in healthy participants as well as patients suffering from neurological impairment. Also during gait initiation, arm swing instructions were found to facilitate leg muscle recruitment. Research question The aim of the present study is to explo...
Preprint
Older age is associated with worsened outcome after mild traumatic brain injury (mTBI) and a higher risk of developing persistent post-traumatic complaints. However, the effects of mTBI sequelae on brain connectivity at older age and their association with post-traumatic complaints remain understudied. We analyzed multi-echo resting-state functiona...
Article
Full-text available
Cerebral perfusion may be altered in sepsis patients. However, there are conflicting findings on cerebral autoregulation (CA) in healthy participants undergoing the experimental endotoxemia protocol, a proxy for systemic inflammation in sepsis. In the current study, a newly developed near-infrared spectroscopy (NIRS)-based CA index is investigated...
Article
Background: The supplementary motor area (SMA) is implicated in stereotypic multi-limb movements such as walking with arm swing. Gait difficulties in Parkinson's Disease (PD) include reduced arm swing, which is associated with reduced SMA activity. Objective: To test whether enhanced arm swing improves Parkinsonian gait and explore the role of t...
Article
Full-text available
Background In clinical practice, eye movements can provide an early diagnostic marker for early onset ataxia (EOA). However, quantitative oculomotor assessment is not included in the most frequently used and age-validated ataxia rating scale in children, the Scale for the Assessment and Rating of Ataxia (SARA). We aimed to investigate the applicabi...
Article
Full-text available
Background: Walking is characterized by stable antiphase relations between upper and lower limb movements. Such bilateral rhythmic movement patterns are neuronally generated at levels of the spinal cord and brain stem, that are strongly interconnected with cortical circuitries, including the Supplementary Motor Area (SMA). Objective: To explore...
Article
Full-text available
Background Early Onset Ataxia (EOA) and Developmental Coordination Disorder (DCD) share several phenotypical characteristics, which can be clinically hard to distinguish. Aim To combine quantified movement information from three tests obtained from inertial measurements units (IMUs), to improve the classification of EOA and DCD patients and health...
Article
Objective Age-related differences in neural strategies for motor learning are not fully understood. We determined the effects of age on the relationship between motor network connectivity and motor skill acquisition, consolidation, and interlimb transfer using dynamic imaging of coherent sources. Methods Healthy younger (n = 24, 18 – 24 y) and old...
Article
Full-text available
Background: Long-term tremor recording is particularly useful for the assessment of overall severity and therapeutic interventions in tremor patients. The purpose of this paper is to investigate the optimal number of days needed to obtain reliable estimates of tremor percentage, tremor frequency variability and tremor intensity in tremor patients...
Article
Full-text available
Although a general age-related decline in neural plasticity is evident, the effects of age on neural plasticity after motor practice are inconclusive. Inconsistencies in the literature may be related to between-study differences in task difficulty. Therefore, we aimed to determine the effects of age and task difficulty on motor learning and associa...
Article
Full-text available
Key points: Gait related arm swing in humans supports efficient lower limb muscle activation, indicating a neural coupling between the upper and lower limbs during gait. Intermuscular coherence analyses of gait related electromyography from upper and lower limbs in twenty healthy participants identified significant coherence in alpha and beta/gamm...
Article
Full-text available
Objective Cognitive reserve (CR) is the capacity to adapt to (future) brain damage without any or only minimal clinical symptoms. The underlying neuroplastic mechanisms remain unclear. Electrocorticography (ECOG), electroencephalography (EEG), and magnetoencephalography (MEG) may help elucidate the brain mechanisms underlying CR, as CR is thought t...
Article
Full-text available
Alzheimer’s continuum biological profiles (A⁺T⁻N⁻, A⁺T⁺N⁻, A⁺T⁻N⁺, and A⁺T⁺N⁺) were established in the 2018 National Institute on Aging and Alzheimer's Association (NIA-AA) research framework for Alzheimer’s disease (AD). We aim to assess the relation between AT(N) biomarker profiles and brain functional connectivity (FC) and assess the neural corr...
Article
Full-text available
Introduction Cognitive complaints are common shortly after mild traumatic brain injury (mTBI) but may persist up to years. Age-related cognitive decline can worsen these symptoms. However, effects of age on mTBI sequelae have scarcely been investigated. Methods Fifty-four mTBI patients (median age: 35 years, range 19–64 years, 67% male) and twenty...
Article
Full-text available
While the difficulty of a motor task can act as a stimulus for learning in younger adults, it is unknown how task difficulty interacts with age-related reductions in motor performance and altered brain activation. We examined the effects of task difficulty on motor performance and used electroencephalography (EEG) to probe task-related brain activa...
Article
Full-text available
Background: After transfemoral amputation, many hours of practice are needed to re-learn walking with a prosthesis. The long adaptation process that consolidates a novel gait pattern seems to depend on cerebellar function for reinforcement of specific gait modifications, but the precise, step-by-step gait modifications (e.g., foot placement) most l...
Article
The Organization for Human Brain Mapping (OHBM) has been active in advocating for the instantiation of best practices in neuroimaging data acquisition, analysis, reporting and sharing of both data and analysis code to deal with issues in science related to reproducibility and replicability. Here we summarize recommendations for such practices in ma...
Article
Full-text available
Background: The supplementary motor area (SMA) is implicated in both motor initiation and stereotypic multi-limb movements such as walking with arm swing. Gait in Parkinson's disease exhibits starting difficulties and reduced arm swing, consistent with reduced SMA activity. Objective: We tested whether enhanced arm swing could improve Parkinson...
Article
Full-text available
Muscle ultrasound density (MUD) is a non-invasive parameter to indicate neuromuscular integrity in both children and adults. In healthy fetuses and infants, physiologic MUD values during development are still lacking. We therefore aimed to determine the physiologic, age-related MUD trend of biceps, quadriceps, tibialis anterior, hamstrings, gluteal...
Chapter
Machine-learning algorithms can be used for data classification on EEG-based Brain-computer interfaces (BCIs). Here, we used an algorithm based on linear support vector machine (SVM) to identify the presence of the P300 component in datasets from 15 young adult participants with autism spectrum disorder that were provided for the IFMBE Scientific C...
Article
Full-text available
Aims: To investigate the accuracy of phenotypic early-onset ataxia (EOA) recognition among developmental conditions, including developmental coordination disorder (DCD) and hypotonia of central nervous system origin, and the effect of scientifically validated EOA features on changing phenotypic consensus. Method: We included 32 children (4-17y)...
Article
Full-text available
Functional neuroimaging techniques (i.e. single photon emission computed tomography, positron emission tomography, and functional magnetic resonance imaging) have been used to assess the neural correlates of anosognosia in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). A systematic review of this literature was performed, following t...
Article
Background A previous study reported a dramatic mismatch in objectively detected and self-reported tremor duration in patients with functional tremor. As these findings have an important and widespread impact in both clinical care and research, we conducted a validation study with a longer study duration and a larger sample of patients. Methods Fo...
Article
Full-text available
Background: Neuromodulation is nowadays investigated as a promising method for pain relief. Research indicates that a single 30-minute stimulation with transcranial pulsed electromagnetic fields (tPEMF) can induce analgesic effects. However, it is unknown whether tPEMF can induce analgesia in neuropathic pain patients. Objective: To evaluate the ef...
Article
Full-text available
A child's school achievement is influenced by environmental factors. The environmental factors, when represented by socioeconomic status (SES) of the family, have been demonstrated to be related to the reading skills of a child. The neural correlates of the relation between SES and reading have been less thoroughly investigated. The present study e...
Article
Over the last years convolutional neural networks (CNNs) have shown remarkable results in different image classification tasks, including medical imaging. One area that has been less explored with CNNs is Positron Emission Tomography (PET). Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is a PET technique employed to obtain a representat...
Article
Background: Human gait benefits from arm swing, which requires four-limb co-ordination. The Supplementary Motor Area (SMA) is involved in multi-limb coordination. With its location anterior to the leg motor cortex and the pattern of its connections, this suggests a distinct role in gait control. Research question: Is the SMA functionally implicated...
Method
Full-text available
The aim of this review is to collect and synthesis the main findings of research employing electroencephalographic methodology and paradigms to study cognitive reserve.
Chapter
Brain connectivity datasets are usually represented as networks in which nodes represent brain regions and links represent anatomical tracts or functional associations. Measuring similarity or dissimilarity among brain networks is useful for exploring connectivity relationships within individual subjects, or between groups of subjects under differe...
Article
Full-text available
The rapid automatic specialized processing of printed words is signalled by the left‐lateralization of the N1 component in the visual event‐related potential (ERP). In the present study, we have investigated whether differences in N1 lateralization can be observed between Dutch children with and without (a familial risk of) dyslexia around the age...
Conference Paper
An electroencephalography (EEG) coherence network is a representation of functional brain connectivity. However, typical visualizations of coherence networks do not allow an easy embedding of spatial information or suffer from visual clutter, especially for multichannel EEG coherence networks. In this paper, a new method for data-driven visualizati...
Article
Introduction Aassessing movement disorders in daily life can provide information that might not be available during a short clinical visit. This review provides an overview of the currently available ambulatory registration methods to assess motor symptoms. Methods A systematic review was performed of ambulatory registration methods, registering m...
Article
Full-text available
Electroencephalography (EEG) coherence networks represent functional brain connectivity, and are constructed by calculating the coherence between pairs of electrode signals as a function of frequency. Visualization of such networks can provide insight into unexpected patterns of cognitive processing and help neuroscientists to understand brain mech...
Article
Full-text available
It is poorly understood how healthy aging affects neural mechanisms underlying motor learning. We used blood-oxygen-level dependent (BOLD) contrasts to examine age-related changes in brain activation after acquisition and consolidation (24 h) of a visuomotor tracking skill. Additionally, structural magnetic resonance imaging and diffusion tensor im...
Article
Assessment of coordination disorders is valuable for monitoring progression of patients, distinguishing healthy and pathological conditions, and ultimately aiding in clinical decision making, thereby offering the possibility to improve medical care or rehabilitation. A common method to assess movement disorders is by using clinical rating scales. H...
Article
Full-text available
We analysed mean arterial blood pressure, cerebral blood flow velocity, oxygenated haemoglobin and deoxygenated haemoglobin signals to estimate dynamic cerebral autoregulation. We compared macrovascular (mean arterial blood pressure-cerebral blood flow velocity) and microvascular (oxygenated haemoglobin-deoxygenated haemoglobin) dynamic cerebral au...
Article
Background: During childhood, many conditions may impact coordination. Examples are physiological age-related development and pathological conditions, such as early onset ataxia and developmental coordination disorder. These conditions are generally diagnosed by clinical specialists. However, in absence of a gold phenotypic standard, objective rep...
Article
Full-text available
An electroencephalography (EEG) coherence network is a representation of functional brain connectivity, and is constructed by calculating the coherence between pairs of electrode signals as a function of frequency. Typical visualizations of coherence networks use a matrix representation with rows and columns representing electrodes and cells repres...
Preprint
Neuroimaging methods, including magnetoencephalography and electroencephalo- graphy (MEEG), allow non-invasive collection of neural data in healthy people and in individuals with neurological or psychiatric disorders, with the aim of advancing the understanding of brain function in health and disease. Currently, scientific practice is undergoing a...
Article
A brain–computer interface (BCI) is a system that allows communication between the central nervous system and an external device. The BCIs developed by various research groups differ in their main features and the comparison across studies is therefore challenging. Here, in the same group of 19 healthy participants, we investigate three different t...
Article
Full-text available
The present study investigates whether grade 6 reading outcomes, reading fluency, and reading comprehension can be predicted by grade 3 reading fluency, familial risk of dyslexia (FR), and grade 3 reading related skills: rapid automatized naming (RAN), phonological awareness (PA), and vocabulary. In a sample of 150 children, of whom 83 had a parent...
Presentation
Full-text available
Lateralization in the N1 component in adults and children using a linguistic judgement task
Article
The interaction between the somatosensory and motor systems is important for normal human motor function and learning. Enhancing somatosensory input using somatosensory electrical stimulation (SES) can increase motor performance, but the neuronal mechanisms underlying these effects are largely unknown. With electroencephalography (EEG), we examined...
Article
Methods: We created a brain substitute using agar that simulates the brain's conductivity, placed it in a human skull, and performed EEG recordings with CIs from three different manufacturers. As stimuli, we used simple and complex non-speech stimuli, as well as naturally produced continuous speech. We examined the effect of manipulating device se...
Article
Objective: An 'optimal' cerebral perfusion pressure (CPPopt) can be defined as the point on the CPP scale corresponding to the greatest autoregulatory capacity. This can be established by examining the pressure reactivity index PRx-CPP relationship, which is approximately U-shaped but suffers from noise and missing data. In this paper, we present...
Article
Digital games controlled by body movements (exergames) have been proposed as a way to improve postural control among older adults. Exergames are meant to be played at home in an unsupervised way. However, only few studies have investigated the effect of unsupervised home-exergaming on postural control. Moreover, suitable methods to dynamically asse...
Article
Objective: Plasticity of the central nervous system likely underlies motor learning. It is however unclear, whether plasticity in cortical motor networks is motor learning stage-, activity-, or connectivity-dependent. Methods: From electroencephalography (EEG) data, we quantified effective connectivity by the phase slope index (PSI), neuronal ac...
Article
Improving balance performance among the elderly is of utmost importance because of the increasing number of injuries and fatalities caused by fall incidences. Digital games controlled by body movements (exergames) have been proposed as a way to improve balance among older people. However, the assessment of balance performance in real-time during ex...
Article
Full-text available
Methods to identify an autoregulation guided 'optimal' cerebral perfusion pressure (CPPopt) for traumatic brain injury patients (TBI) have been reported through several studies. An important drawback of existing methodology is that CPPopt can be calculated only in approximately 50-60% of the monitoring time. In this study, we hypothesized that the...
Article
Background Patients with severe knee osteoarthritis are evaluated for total knee replacement (TKR), whose main indications are persistent pain and severe functional limitations substantially affecting mobility. However, evaluation of pain intensity and functional disability is difficult to standardize. Objective To evaluate the relationship betwee...
Article
Full-text available
Background The present study investigated differences in reading and spelling outcomes in Dutch and English as a second language (ESL) in adolescents with a high familial risk of dyslexia, of whom some have developed dyslexia (HRDys) while others have not (HRnonDys), in comparison to a low familial risk control group without dyslexia (LRnonDys). Th...
Data
Original raw data Variables are described in the variable labels. The dataset contains the original data, as well as the imputed and standardized data used for the final analysis.
Data
Descriptive statistics of the unstandardized data
Article
Objective: To distinguish tremor subtypes using wavelet coherence analysis (WCA). WCA enables to detect variations in coherence and phase difference between two signals over time and might be especially useful in distinguishing functional from organic tremor. Methods: In this pilot study, polymyography recordings were studied retrospectively of...
Article
Graphical tasks can provide objective measures of important motor symptoms of movement disorders such as Parkinson's disease (PD). These tasks could potentially be useful in clinical settings for (early) diagnosis and monitoring of such diseases. However, before such tasks can be used clinically, reproducibility needs to be investigated. The presen...
Chapter
what matrices are and how they can be used
Chapter
After reading this chapter you know:what vectors are and how they can be used,how to algebraically perform and geometrically represent addition and subtraction of vectors,how to algebraically perform and intuitively understand common forms of vector multiplication andhow vector relationships can be expressed and what their use is.
Chapter
After reading this chapter you know:what numbers are and why they are used,what number classes are and how they are related to each other,what numeral systems are,the metric prefixes,how to do arithmetic with fractions,what complex numbers are, how they can be represented and how to do arithmetic with them,the most common mathematical symbols andho...
Chapter
After reading this chapter you know:what the three main trigonometric ratios are and how they can be calculated,how to express angles in degrees and radians,how to sketch the three main trigonometric functions,how to sketch functions of the form A sin(Bx + C) + D and how to interpret A, B, C and D,what Fourier (or spectral or harmonic) analysis is...
Book
This book reviews math topics relevant to non-mathematics students and scientists, but which they may not have seen or studied for a while. These math issues can range from reading mathematical symbols, to using complex numbers, dealing with equations involved in calculating medication equivalents, the General Linear Model (GLM) used in e.g. neuroi...
Article
Full-text available
Methods to identify an autoregulation guided 'optimal' cerebral perfusion pressure (CPPopt) for traumatic brain injury patients (TBI) have been reported through several studies. An important drawback of existing methodology is that CPPopt can be calculated only in approximately 50-60% of the monitoring time. In this study, we hypothesized that the...