Natasha Anwar

Aga Khan University Hospital, Lahore Outreach Lab · Clinical and Laboratory Medicine

Ensuring United Nations Sustainable Development Goals are met collectively for the protection of women, requires a broadening of discussion and efforts from reproductive health to investigate ethical challenges facing women during COVID-19. The aim of this paper is to discuss issues of ethics, equity, and rights for the health access of socioeconom...

Objective: The purpose of our study was to determine the frequency of BRCA1 promoter hypermethylation and its association with expression changes of BRCA1 and main morphological features in sporadic breast cancer. Methods: A retrospective review of cases was performed to select those with specific morphological features suggestive of breast canc...

Robust standardized methods to extract DNA from formalin-fixed paraffin-embedded tissues are required for accurate bisulfite conversion based methylation analysis.Despite many different protocols are published, extraction of sufficient quantity of intact DNA from formalin-fixed paraffin-embedded (FFPE) tissues is still challenging. We compared two...

Purpose/Objective: BRCA1 sporadic breast cancers are associated with particular morphological features, decreased protein expression and features such as early onset, poor histological differentiation and hormone receptor negativity. The present study explored BRCA1 protein expression and morphological features in small cohort of sporadic breast tu...

Purpose/Objective: Methylation of the BRCA1 gene promoter region is associated with decreased BRCA1 protein expression. The objective of the following study was to determine promoter methylation and loss of protein expression in a small cohort of sporadic breast cancer cases. Material/Methods: The study was reviewed by the ethics review committee a...