Natasa Milic

Natasa Milic
University of Novi Sad · Faculty of Medicine

PhD, pharmaceutical sciences

About

104
Publications
47,820
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2,844
Citations
Additional affiliations
January 2009 - September 2020
University of Novi Sad
Position
  • Professor
September 1997 - January 2009
University of Naples Federico II
Position
  • Research Assistant

Publications

Publications (104)
Article
Full-text available
Silymarin is a bioflavonoid complex extract derived from dry seeds of Milk thistle [(Silybum marianum(L.) Gaernt. (Fam. Asteraceae/Compositaceae)] whose hepatoprotective effect has clinically been proved. Low toxicity, favorable pharmacokinetics, powerful antioxidant, detoxifying, preventive, protective and regenerative effects and side effects sim...
Article
Background Anxiety and depression are the most common psychological disorders found in Inflammatory Bowel Disease (IBD) patients. Accurate measuring of these disorders should be proposed for a prompt management. Patient-reported outcome measurements (PROMs) allow patients to self-report their psychological symptoms. Objective To highlight the pres...
Article
Non-alcoholic fatty liver disease (NAFLD) presents the most common chronic liver disease globally; it is estimated that 25.24% of the world's population has NAFLD. NAFLD is a multi-factorial disease whose development involves various processes, such as insulin resistance, lipotoxicity, inflammation, cytokine imbalance, the activation of innate immu...
Article
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The novel SARS-CoV-2 virus has led to a severe pandemic, starting from early 2020. Intensive care (ICU) management of the COVID-19 disease is difficult with high morbidity and mortality. Early nutritional support, especially with whey protein, seems to be crucial in this medical case. Thus, we aimed to assess the effects of an adequate nutritional...
Article
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Whereas the etiology of non-alcoholic fatty liver disease (NAFLD) is complex, the role of nutrition as a causing and preventive factor is not fully explored. The aim of this study is to associate dietary patterns with magnetic resonance imaging (MRI) parameters in a European population (Greece, Italy, and Serbia) affected by NAFLD. For the first ti...
Article
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Humans are exposed to the variety of emerging environmental pollutant in everyday life. The special concern is paid to endocrine disrupting chemicals especially to triclosan which could interfere with normal hormonal functions. Triclosan could be found in numerous commercial products such as mouthwashes, toothpastes and disinfectants due to its ant...
Article
Nonprenylated rotenoids isolated from Boerhaavia diffusa are identified as new class of breast cancer resistance protein inhibitors (ABCG2). The recent determination of high-resolution structure of ABCG2 (with chemotherapeutics mitoxantrone or Ko143) enables the investigation of molecular interaction capacities of boeravinones. In this research pha...
Article
Mastiha is a natural nutritional supplement with known anti-inflammatory properties. Non-alcoholic fatty liver disease (NAFLD) and Inflammatory bowel disease (IBD) are immune mediated inflammatory diseases that share common pathophysiological features. Mastiha has shown beneficial effects in both diseases. MicroRNAs have emerged as key regulators o...
Article
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Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with no therapeutic consensus. Oxidation and inflammation are hallmarks in the progression of this complex disease, which also involves interactions between the genetic background and the environment. Mastiha is a natural nutritional supplement known to possess antioxidant a...
Article
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Hyperlipidemia is currently listed as one of the leading problems associated with the increased risk of coronary and extra-coronary atherosclerosis and cardiovascular diseases worldwide. Since the effectiveness of the existing medications differ, the potential use of herbs and their effects on the hyperlipidemia is of great interest. This review su...
Article
Scope Non‐alcoholic fatty liver disease (NAFLD) is the most common liver disease with poor therapeutic strategies. Mastiha possesses antioxidant/anti‐ inflammatory and lipid lowering properties. We investigated the effectiveness of Mastiha as a non‐pharmacological intervention in NAFLD. Methods and Results 98 patients with NAFLD in three countries...
Article
Pinus nigra Arn. bark extracts from Mokra gora (MG) and Tara mountains were analyzed with regard to their polyphenolic profile and antioxidative and antiproliferative activity. The ethanol extract from MG showed the highest phenolic, flavonoid, tannin, and proanthocyanidin content when compared with the acetone and methanol extracts from both sites...
Article
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Recycling of electric and electronic waste products (e-waste) which amounted to more than 50 million metric tonnes per year worldwide is a massive and global operation. Unfortunately, an estimated 70-80% of this waste has not been properly managed because the waste went from developed to low-income countries to be dumped into landfills or informall...
Article
Background Bisphenol A (BPA), a widespread industrial substance is recognized as endocrine disrupting chemical and therefore could be associated with polycystic ovary syndrome (PCOS) related metabolic disturbances. Patients In this study 29 women of reproductive age with diagnosed PCOS were enrolled. Methods BPA in urine samples was analyzed by ga...
Article
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In the study, 305 patients of both genders were enrolled and divided into three groups: obese (BMI > 30 kg/m2), patients who were diagnosed type 2 diabetes mellitus (T2DM), and control, normal weight healthy volunteers. At least one of ten different phthalate metabolites was determined in the urine samples of 49.84% all enrolled participants. In th...
Article
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INTRODUCTION: Phthalates are recognized as endocrine disrupting compounds and are extensively present in variety of every day products. The chronic exposure to phthalates is suspected to be associated with range of health disorders. The study aim was to examine the abundance of phthalate metabolites in the urine samples among adults in the Province...
Article
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Phthalates represent a group of chemicals that are present in many consumer products being used on a day-to-day basis. They are known to act as endocrine disruptors which distort endocrine system function due to competition with endogenic hormones by adhering to the receptors or by changing the synthesis and metabolism of hormones. Potential ways o...
Article
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The key elements of serendipity are luck and contemplation. The discovery process includes the recognition of the finding potential based on knowledge and experience. Serendipitous discoveries are common in biomedical sciences. A significant number of pharmaceuticals is the result of serendipity. Drugs belonging to antimicrobial agents, central ner...
Article
Introduction: Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 25% of adult people worldwide. Nowadays, there is no definite treatment for NAFLD. International guidelines define an approach based on lifestyle changes, included a health alimentary regimen. The Mediterranean diet (MD) represents the gold standard in preventive medicin...
Article
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In states of intestinal dysbiosis, a perturbation of the normal microbiome composition, the intestinal epithelial barrier (IEB) permeability is increased as a result of the disruption of the epithelial tight junction protein network, in which occludin is mostly affected. The loss of IEB integrity promotes endotoxemia, that is, bacterial lipopolysac...
Article
LiverMultiScan1 is a non-invasive diagnostic tool which uses multiparametric Magnetic Resonance Imaging to characterize liver tissue. It provides: • accurate measurements of % Proton Density Fat Fraction (PDFF) • tissue T1-relaxation time, corrected for liver iron (cT1), standardized as the Liver Inflammation and Fibrosis score (LIF) To elucidate...
Article
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Background/Aim. Plant polyphenols are well known to show antimutagenic, anticarcinogenic, antiviral and antioxidative activity. The aim of this study was to investigate bio-active potential of Armoracia rusticana root juice and extracts: their polyphenol content, as well as in vitro antitumor activity and cell-death mechanism. Methods. Liquid-liqui...
Article
Pycnogenol® (PYC) has already being used as a food supplement and herbal medicine due to its potent antioxidant properties. The aim of the present study was to examine the protective effect of PYC on acetaminophen‐induced acute liver injury in rats. The effect of PYC on acetaminophen‐induced hepatotoxicity in rats was examined by determining bioche...
Article
Background: In obesity, low levels of vitamin D (VD) and vitamin B12 (VB12), may be the result of different pathophysiological mechanisms, but the possible association between them has not yet been defined. The aim of this cross-sectional analysis was to investigate the possible relationship between serum 25-hydroxyvitamin D (25(OH)D) and VB12 lev...
Article
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Polyphenols, including anthocyanins, flavonoids and stilbenes, which constitute one of the most abundant and ubiquitous groups of plant metabolites, are an integral part of the human diet. Resveratrol (3,5,4’-trihydroxystilbene), a naturally occurring polyphenol produced by some plants as a self-defence agent, has an antifungal activity. Resveratro...
Article
Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main component. This article reviews the chemistry of MT, the pharmacokinetics and bioavailability, th...
Article
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Background: The liver is involved in the metabolism of vitamin D. The prevalence of osteopenia in alcoholic liver disease (ALD) patients is between 34-48%, and the prevalence of osteoporosis is between 11-36%. Advanced liver disease is considered a risk factor for osteoporosis development. Aim of our study was to establish the relationship between...
Article
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Having in mind that there is a general lack of monitoring plans and precaution measures in the developing countries and that the Danube is the second longest river in Europe, the estimation of the relevant concentration levels of unregulated xenobiotics is a topic of interest both on local and international level. The selected pharmaceuticals, caff...
Chapter
Silybum marianum or milk thistle (MT) is the most well-researched plant in the treatment of liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristine), collectively known as silymarin. Silybin is the component with the greatest d...
Article
Full-text available
Phthalates are ubiquitous environmental contaminants, massively used in industry as plasticizers and additives in cosmetics, which may impair the human endocrine system inducing fertility problems, respiratory diseases, obesity, and neuropsychological disorders. The aim of this study was to examine the influence of the monoethyl phthalate (MEP) and...
Article
The use of herbal therapy in pregnancy is common for pregnancy related nausea, vomiting, gestational diabetes, anxiety, insomnia, and preparation for labor, as well as for treating infections. Many conventional drugs may interfere with fetal development and herbal products are considered to be safe. However, herbal therapy requires competent health...
Article
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Nonalcoholic fatty liver disease (NAFLD) affects 25–30% of the general population worldwide and this high prevalence is linked with lifestyle and dietetic changes, not only in Western countries, but also in the urban areas of developing countries. Several pharmacological approaches were proposed in the treatment of NAFLD, but the reported results a...
Article
Full-text available
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by liver fatty acid accumulation and fibrosis, not due to the excessive alcohol consumption. Notably, nutritional habits have been reported to be implicated in the onset and severity of the hepatic damage, while the Mediterranean diet has shown benef...
Article
Introduction: Hepatitis C virus (HCV) infection is a global health problem with 150 million infected people worldwide. Liver can be greatly affected by changes in gut microbiota due to increased intestinal permeability with passage of microbial antigens into the liver through the portal circulation. The concept of “gut-liver” axis is important to u...
Article
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The prevalence of obesity and type 2 diabetes mellitus epidemics presents a great health problem worldwide. Beside the changes in diet and decreased physical activity, there is growing interest in endocrine disrupting chemicals that may have effects on these conditions. Among them, the role of certain phthalates and bisphenol A is confirmed. We hav...
Article
The liver has the crucial role in the regulation of various physiological processes and in the excretion of endogenous waste metabolites and xenobiotics. Liver structure impairment can be caused by various factors including microorganisms, autoimmune diseases, chemicals, alcohol and drugs. The plant kingdom is full of liver protective chemicals suc...
Article
Design of a new drug entity is usually preceded by analysis of quantitative structure activity (properties) relationships, QSA(P)R. Six newly synthesized succinimide derivatives have been determined for i) in silico physico-chemical descriptors, pharmacokinetic and toxicity predictors, ii) in vitro biological activity on four different carcinoma ce...
Article
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The roles of the pharmacist were transformed throughout the history and modern pharmacist as we know now beside providing products and playing in optimization of medicines has a crucial role in ensuring the efficacy and safety of applied drugs. A better life quality, global health and safety is the major goal of the 21st century and to achieve that...
Article
Bisphenol A (BPA) is a ubiquitous environmental pollutant which is often associated with various health issues. In this study 103 healthy female volunteers in reproductive age from Serbian north province Vojvodina were enrolled and examined for the BPA exposure in the urine samples after 12 h of fasting. BPA was found in 35.92 % (37/103) of subject...
Article
Full-text available
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease and it encompasses a spectrum from simple steatosis to steatohepatitis, fibrosis, or cirrhosis. The mechanisms involved in the occurrence of NAFLD and its progression are probably due to a metabolic profile expressed within the context of a genetic predisposition and...
Article
Alcoholism is currently listed as the third leading cause of death. Chronic alcohol consumption brings serious medical complications like gastrointestinal, cardiovascular, musculoskeletal, respiratory system disorders. Liver can be seriously damage by alcohol misuse. Alcoholic Liver Disease (ALD) is the first important warning sign of alcohol abuse...
Article
Introduction: Obesity is a global health problem. More than half (54%) of the adult population in Serbia and 58.5% of adult population in the north province, Vojvodina is obese or overweight. Hence, it is urgent to identify environmental factors which may contribute obesity. Bisphenol A (BPA) is one of the most extensively used chemical in producti...
Article
The aim of the present work was to examine if hydrogen peroxide treatment of sugar beet fibre that aimed at improving its physicochemical properties would impair its antioxidant potential. Three different sugar beet fibres were obtained from sugar beet - non-treated fibre (NTF) from sugar beet cossettes extracted with sulphurous acid, treated fibre...
Article
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Introduction. Polycystic ovary syndrome is the most frequent endocrine disturbance in the reproductive period of women’s life and the most frequent cause of anovulatory infertility. Ovulation and pregnancy in patients having polycystic ovary syndrome may be a result of a wide range of therapeutic options, and the treatment assumes a gradual approac...
Article
The wastewater from meat processing industry is an important source of organic pollution in natural water bodies. In order to enable the identification and determination of concentration levels of pollutants the adaptation of analytical methods is necessary. During the research GC-MS was selected as conventional method for screening analyses of org...
Article
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Caffeine is odorless, bitter taste substance which can be naturally found in coffee, cocoa, tea leaves, and is intentionally added in food and pharmaceutical products. It can also be found in surface water in small concentrations where is often used as an excellent indicator of human waste. The aim of the work is determination of caffeine content i...
Article
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Due to numerous side effects of synthetic remedies, people are turning increasingly to phytotherapy, which is based on the use of medicinal herbs. Pharmaceutical industry shows great interest in the usage of plants as raw materials in the remedy production. In the past ten years, a large number of in vitro and clinical studies focused on the therap...
Article
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Therapeutic properties of cannabis have been known since ancient times, although the application has been limited mainly due to narcotic characteristics of this plant. Nowadays, the pharmacologically active substance in cannabis-cannabinoids, presents a very interesting group of compounds with potentially significant applications in medicine and ph...
Article
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Aim: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the general population. Overweight is a common condition in patients with NAFLD, and body composition (BC) assessment is useful to evaluate nutritional status and the efficacy of nutritional strategies. A valid tool for assessing BC is dual-energy X-ray abso...
Article
Full-text available
The aim of our study was to stablish the possible alternations in fatty acid composition of brain phospholipids in rats on a standard and high-fat diet supplemented with buckwheat leaf and flower mixture (BLF) and subsequent possible beneficial effects of BLF. Four months old male Wistar rats were randomly divided into five experimental groups fed...
Article
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The emission of untreated or insufficiently treated wastewater is very common in developing countries and consequently has harmful effects on the environment. The aim of this study was to analyse 24 physico-chemical parameters in raw wastewater and effluent after tertiary treatment (denitrification and disinfection) derived from meat-processing pla...
Article
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The study objective was to determine if the healthy participants were exposed to diethyl phthalate (DEP) and di (2-ethylhexyl) phthalate (DEHP) and if this exposure could be linked to the development of metabolic syndrome. The study included 103 healthy volunteers of similar age with normal BMI values, waist circumference, total cholesterol, HDL, L...
Article
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The goal of this cross-sectional study was to examine the occurrence of bisphenol A (BPA) in the morning spot urine taken from 145 female volunteers of various ages. Total urine BPA concentration was detected in 38.6% samples in the 0.92-70.96 μg/g Cr range. The majority of BPA+ women belonged to the 25+ body mass index (BMI) group (54.5% were over...
Article
BACKGROUND: “VITALPLANT” medicinal plant mixture, aimed at body weight regulation and metabolism enhancement was formulated in order to be incorporated as an ingredient in functional food formulations on the basis of known biological activity of the alder buckthorn bark, peppermint, caraway and parsley. METHODOLOGY: The body weight-lowering potenti...
Article
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Hepatic steatosis is commonly seen in the patients with chronic hepatitis C virus (HCV) infection. HCV is closely associated with lipid metabolism, and viral steatosis is more common in genotype 3 infection owing to a direct cytopathic effect of HCV core protein. In non-genotype 3 infection, hepatic steatosis is considered largely to be the result...
Article
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Background: Non-alcoholic fatty liver disease is the most common liver disease worldwide. Aim: The aim of this study is to compare the metabolic effects of the Mediterranean diet versus the diet associated with silybin, phosphatidylcholine and vitamin E complex in overweight patients with non-alcoholic fatty liver disease. Methods: Thirty Cauc...
Article
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Non-alcoholic fatty liver disease (NAFLD) is a relevant issue in public health owing to its epidemiological burden. It represents the most common chronic liver disease in the general population and is expected to increase in future as a result of an ageing population. The only currently recommended treatment for NAFLD is lifestyle modification. How...
Article
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Seasonal variations of bisphenol A (BPA) were investigated in the Danube along the Novi Sad bank, Serbia using solid-phase extraction followed by gas chromatographic mass spectrometric method. The obtained results confirmed the presence of BPA above the limit of quantification (6 ng/L) in 22 out of 32 water samples at all eight sampling sites. Тhe...
Article
Non-alcoholic fatty liver disease (NAFLD) is a global problem and one of the most common liver diseases in the world. Various pharmacological and non-pharmacological therapies seem to be non-effective and the patients are often advised not to expect a positive outcome. Hence, even in the modern Western society many patients reach for traditional he...
Article
Full-text available
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The mechanisms of the underlying disease development and progression are awaiting clarification. Insulin resistance and obesity-related inflammation status, among other possible genetic, dietary, and lifestyle factors, are thought to play the key role. There is no...
Article
Full-text available
Hepatitis C virus (HCV) infection is a common chronic liver disease worldwide. Non-alcoholic fatty liver disease and insulin resistance (IR) are the major determinants of fibrosis progression and response to antiviral therapy. The pathogenetic link between IR and chronic HCV infection is complex, and is associated with HCV genotype. Liver steatosis...
Article
Seasonal variations of caffeine and antibiotic concentrations were investigated along the selected sites of the Danube using solid phase extraction followed by HPLC (HPLC). The potential risks on the aquatic organisms were evaluated. HPLC methods for caffeine and antibiotic determination were modified and validated showing good accuracy, repeatabil...
Article
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Recognition of the adverse effects of medicinal herbs is not routine and the reports on such effects are even less frequent in clinical practice. Potential herb-drug interactions are of a major safety concern, especially for drugs with narrow therapeutic indices like warfarin, which can lead to severe adverse reactions that are sometimes life-threa...
Article
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The wastewater (municipal and industrial) discharged directly into the Danube in the vicinity of Novi Sad. Danube surface water, wastewater and raw water used for drinking water production were analyzed. Sampling campaigns during summer and autumn in 2012 were conducted. The research activities were planned within NATO International Project in orde...