Nataliya Pasyechnikova

Nataliya Pasyechnikova
Filatov Institute of Eye Diseases

About

44
Publications
4,067
Reads
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217
Citations
Citations since 2016
30 Research Items
206 Citations
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2016201720182019202020212022010203040
2016201720182019202020212022010203040

Publications

Publications (44)
Article
Full-text available
The paper describes the design and technical parameters of a medical thermoelectric device developed for diagnosing and monitoring the ophthalmic diseases. The main elements of the device are a specially designed thermoelectric heat flux sensor and a thermocouple temperature sensor connected to a data acquisition unit. The sensor is a thermoelectri...
Article
Full-text available
Introduction The use of near-infrared (NIR) light enables to transilluminate the eye non-invasively through the eyelid as opposed to visible light. Purpose To determine the possible use of NIR light-emitting-diode (LED) radiation for imaging intraocular tumours by transpalpebral transillumination. Material and methods This study was a pilot, open...
Article
Purpose To investigate efficacy and safety of photodynamic therapy (PDT) with chlorin e6-polyvinylpyrrolidone (Ce6-PVP) complex in patients with chronic central serous chorioretinopathy (CSC). Methods In this prospective, interventional, single-centre clinical pilot study included 28 patients (28 eyes) with chronic CSC. Patients received an intrav...
Article
Purpose To study the temperature and heat flux (HF) density of the ocular surface of healthy individuals depending on the thickness of the choroid. Methods This pilot study included 22 healthy individuals (44 eyes). The age of the studied healthy individuals ranged from 18 to 86 years. In all cases, measurement of temperature and HF density were p...
Article
Purpose To investigate the heat flux (HF) density from the ocular surface in healthy individuals. Methods This pilot study included 32 healthy individuals (64 eyes). Participants were divided into three age groups. They underwent a bilateral eye examination which included measurements of intraocular pressure, temperature of the external corneal su...
Article
Purpose To study the dynamics of epibulbar and intraocular temperature during vitreoretinal surgery. Methods This pilot study included 20 patients with rhegmatogenous retinal detachment (10 eyes) and proliferative diabetic retinopathy (10 eyes). All patients underwent vitreoretinal surgery with room temperature irrigation solution. In all cases, t...
Article
Full-text available
Currently, there are no clear recommendations about the safety of certain temperature conditions for intraocular structures during vitreoretinal surgery; instructions on the safe rate of rewarming of the vitreous cavity; and the advisability of monitoring ocular temperature in the postoperative period. The purpose was to study the dynamics of epibu...
Article
Zusammenfassung Hintergrund Trotz der Verbesserung der Diagnosetechnologien bleibt die Detektion von intraokularen Fremdkörpern (IFK), die sich in der Projektion des Ziliarkörpers befinden, eines der aktuellen Probleme der Augentraumatologie. Ziel Untersuchung der möglichen Visualisierung intraokularer Fremdkörper (IFK) in der Projektion des Ziliar...
Article
Full-text available
Bleeding in vitreoretinal patients during and early after vitrectomy is still a challenge that needs to be addressed. Purpose: To assess the effect of irrigation fluid temperature on intraocular bleeding time in rabbits during vitrectomy. Material and Methods: Twelve Chinchilla rabbits (24 eyes) were included in this study and divided into four gro...
Article
Full-text available
The paper presents the results of the development of a thermoelectric device in the form of a monocular dressing for contact cooling of the human eye through the eyelids. The developed device allows controlled local contact cooling of the eye structures through the eyelids and is designed to treat the acute and chronic eye diseases, reduce intraocu...
Article
Full-text available
Background: Heat exchange characteristics include not only temperatures and temperature distribution, but also heat flux (HF). Purpose: To examine temperature of and density of HF from the ocular surface in the eyes of patients with diabetic retinopathy (DR). Material and Methods: Sixty-two patients (123 eyes) with DR were under observation. Of the...
Article
Therapeutic hypothermia currently is successfully in various fields of medicine to protect biological tissues from ischemia. However the issue of changes in intraocular temperature under hypothermia remains poorly understood. Purpose. To study the dynamics of intraocular temperature in conditions of local hypothermia and on the basis of the obtaine...
Preprint
Full-text available
Currently, the only widely accepted corneal blindness treatment is to replace it by transplantation with a human donor cornea. However, increasing the shortage of donor corneas, as well as high risk of rejection in some corneal diseases, remain two major problems, which limit the success of corneal transplantation. Corneal neovascularization is con...
Article
Full-text available
Background: Assessment of heat exchange processes in the human body is based on temperature and heat flux measurements. Today, there is no instrument for measuring the heat flux density from the eye. Purpose: To investigate the heat flux density from the ocular surface in healthy individuals using the developed thermoelectric device. Materials and...
Article
Full-text available
Background: Intraoperative intraocular media and irrigation fluid temperature monitoring is not performed during vitreoretinal surgery in current clinical practice. Purpose: To investigate intraoperative changes in intraocular temperature at the major steps of vitreoretinal surgery with irrigating solutions differing in temperature. Materials and M...
Article
Full-text available
The severe worldwide shortage of donor organs, and severe pathologies placing patients at high risk for rejecting conventional cornea transplantation, have left many corneal blind patients untreated. Following successful pre-clinical evaluation in mini-pigs, we tested a biomaterials-enabled pro-regeneration strategy to restore corneal integrity in...
Poster
Introduction: One of the actual problems of ophthalmotraumatology remains the problem of detection and removal of intraocular foreign bodies. Purpose: To study the possibilities of the method of transpalpebral infrared transillumination for imaging of intraocular foreign bodies in the projection of the ciliary body. Materials and methods: Under sup...
Article
Full-text available
Background: It remains poorly understood what should be the temperature of the irrigating solution for intraocular surgery and how long it is reasonable to use irrigating solutions during vitrectomy. Purpose: To investigate the structure of the rabbit chorioretinal complex after vitrectomy with the use of irrigating solutions having different tempe...
Article
Full-text available
Background: Ciliary body size may be objectively assessed by ultrasound scanning and near-infrared transpalpebral transillumination. Purpose: To investigate the dimensions of ciliary body structures in various axial eye lengths in patients with rhegmatogenous retinal detachment (RRD). Materials and Methods: This study included 35 RRD patients (35 e...
Article
Full-text available
Korol AR, Zborovska O, Kustryn T, et al. Intravitreal aflibercept for choroidal neovascularization associated with chorioretinitis: a pilot study. Clin Ophthalmol. 2017;11:1315–1320.The Acknowledgement implies that Bayer Pharmaceuticals sponsored the study, this is not correct. The acknowledgment should state: The authors take full responsibility f...
Article
Full-text available
Purpose The purpose of this study was to evaluate the potential benefits of intravitreal aflibercept injections for the treatment of choroidal neovascularization (CNV) secondary to chorioretinitis. Methods In this uncontrolled, prospective cohort study, 15 eyes of 14 consecutive patients affected by CNV associated with ocular toxoplasmosis were tr...
Article
Purpose To assess safety and efficacy of biosynthetic collagen-phosphorylcholine implants as corneal substitutes in patients with severe pathologies for whom human donor cornea transplantation carries a high risk of rejection. Methods Recombinant human collagen type III and 2-methacryloyloxyethyl-phosphorylcholine were fabricated into collagen-MPC...
Article
Purpose To study ocular temperature distribution in the rabbit in dependence on ambient temperature in experiment. Methods To measure ocular temperature a thermoelectric device was developed; the latter consisted of a temperature recording microprocessor module, polytetrafluoroethylene microprobes (diameter – 0.6 mm) with thermocouple sensors, com...
Article
Purpose To study the possibilities of transpalpebral near-infrared LED transillumination for intraocular tumors imaging. Methods This study was conducted on 35 people (35 eyes) with intraocular tumors of the ciliary body and iris. In all cases a color photo of the anterior eye segment, transpalpebral near-infrared LED transillumination, ultrasound...
Article
Full-text available
Background: Near-infrared light is known to pass through human tissues better than visible light. With invisible infrared light, the eye can be illuminated not only through the cornea or the sclera, but also through the eyelid, which can be beneficial in some cases. Purpose: To determine possible use of near-infrared radiation in visualizing ciliar...
Article
Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of...
Article
Full-text available
Purpose: It was the aim of this study to determine the efficacy of intravitreal ranibizumab as treatment of choroidal neovascularizations associated with pathologic myopia. Materials and methods: In an uncontrolled, prospective time series cohort study, 65 eyes of 64 consecutive patients with choroidal neovascularization associated with patholog...
Conference Paper
Type: Free Paper Purpose: To determine the feasibility of using synthetically produced collagen-phosphorylcholine hydrogels as corneal stroma substitutes in patients with persistent noninfectious corneal ulcers (NCU). Methods: Interpenetrating networks of recombinant human collagen type III and methacryloyloxyethyl-phosphorylcholine (MPC) were fa...
Article
We have previously shown that recombinant human collagen (RHC)-based hydrogels fabricated into cell-free corneal implants are able to induce regeneration of the corneas of 10 patients in a Phase 1 clinical study. At four years post-operative, all implants were stably integrated without the use of sustained immunosuppression. Corneal tissue and nerv...
Article
Purpose To estimate the possibility of using of high-frequency electric welding of biological tissues for iridoplasty and trabeculectomy in the experiment. Methods In experiment we used devices and instruments made by the original method in the E.O.Paton Electric Welding Institute. Experimental studies in vitro were performed on the isolated porcin...
Article
Purpose The aim of this study was to construct a rabbit anterior cornea replacement with an acellular human cornea matrix (AHCM) as a scaffold Methods Cornea was taken from the enucleated eye from patient with melanoma of choroidea. Before the decellularization process, human corneas were washed 3 times in sterile phosphate buffered saline. To remo...
Article
Purpose To study the macro- and microscopic changes in the structures of fundus and sclera in the experiment after exposure of femtosecond laser radiation with a wavelength of 800 nm. Methods As a source of laser radiation we used Ti: sapphire laser oscillator «Coherent», which allows to obtain a sequence of pulses of duration 130 fs and a repetiti...
Article
Full-text available
To evaluate the effects of intravitreal triamcinolone acetonide (TA) as a monotherapy of serous Pigment Epithelial Detachment (PED) associated with AMD (Age-Related Macular Degeneration), this study has been performed. Seventeen patients (19 eyes) with serous PED associated with AMD were observed. All patients received 0.1ml (4mg) of intravitreal T...
Article
Full-text available
To fabricate donor corneal substitutes based on carbodiimide cross-linked porcine collagen, to study their in vitro and in vivo properties, and to elaborate new implantation techniques for the donor corneal collagen-based substitutes, this study had been performed. Bioengineered substitutes of corneal stroma (BSCS) were fabricated by cross-linking...
Article
Full-text available
The study had to define influence of combined applications of laser radiation and methylene blue (MB) on pathogenic culture of Candida albicans in vitro. The experimental study was done at standard techniques of method of cultivations in a broth. The laser irradiation of cultures was done at once after addition of MB in concentration 0.05%, 0.1% an...
Article
Full-text available
To increase the quality, diagnostic value and use of non-invasive fundus examination with transscleral or transpalpebral long-wave (red and near infrared) illumination. For fundus visualization we used red light diode sources at 660 nm and near infrared light diode sources at 810, 940 nm. Light radiation from diode sources penetrates into the globe...

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