Nataliya Kutsevol

• PhD, Dr.Chem Sci.
• Head of Faculty at Taras Shevchenko National University of Kyiv

Copolymers obtained by grafting polyacrylamide (PAA) onto polydextran (DEX) have been synthesised by ceric-ion-reduced redox initiation method. These copolymers have been characterized by light scattering, self-exclusion chromatography and viscometry in aqueous solutions. The short range molecular structure has been studied by small-angle X-ray sca...

Introduction Tumor drug resistance and systemic toxicity are major challenges of modern anticancer therapy. Nanotechnology makes it possible to create new materials with the required properties for anticancer therapy. Methods In this research, Dextran-graft-Polyacrylamide/ZnO nanoparticles were used. The study was carried out using prostate (DU-14...

Synthesis of metal oxide nanoparticles–polymer nanocomposites is an emerging strategy in nanotechnology to improve targeted delivery and reduce the toxicity of nanoparticles. In this study, we report biological effects of previously described hybrid nanocomposites containing dextran-graft-polyacrylamide/zinc oxide nanoparticles (D-PAA/ZnO NPs) prep...

Photodynamic therapy (PDT) is a non-invasive anticancer treatment that uses special photosensitizer molecules (PS) to generate singlet oxygen and other reactive oxygen species (ROS) in a tissue under excitation with red or infrared light. Though the method has been known for decades, it has become more popular recently with the development of new e...

The application of a biocompatible polymer nanocarrier can provide target delivery to tumor tissues, improved pharmacokinetics, controlled drug release, etc. Therefore, the proposed strategy was to use the water-soluble star-like copolymers with a Dextran core and Poly(N-isopropylacrylamide) grafts (D-g-PNIPAM) for conjugation with the widely used...

A comparative study of in vitro anti-cancer photodynamic activities of three-component zinc-tetraphenylporphyrin photosensitizer/dextran-graft-polyacrylamide copolymer/Au(Ag) nanoparticle (ZnTPP/D-g-PAA/Au(Ag)NP) nanohybrids on LNCaP prostate cancer cells was carried out under 420 nm light irradiation with low power. A significant cytotoxic effect...

Interpenetrating polymer networks (IPNs) were synthesized when acrylamide was subjected to radical polymerization and simultaneous cross-linking in the presence of chitosan. IPN samples were prepared as hydrogels using ammonium cerium (IV) nitrate as a redox initiator and N,N′-methylene-bis-acrylamide as a cross-linking agent. The structure of the...

Background. The search for new methods of cancer treatment and diagnosis are important. The disadvantages of chemotherapy drugs are the rapid acquisition of resistance and high toxicity. 8-hydroxyquinoline derivatives have a wide spectrum of biological activity and have the necessary properties for fluorescent cancer diagnosis. The aim of the study...

The toxicity of drugs for chemotherapy and cell resistance to their action are the main obstacles in anticancer therapy. Advances in nanotechnology may offer an alternative to traditional methods of anticancer therapy and overcoming drug resistance. The study was carried out on doxorubicin-resistant MCF-7/Dox breast cancer cells and BALB/3T3 clone...

Aim. In this study, blood compatibility of ZnO nanoparticles-nanocomplex (D-PAA/ZnONPs(SO42-)) synthesized in situ into dextran-graft-polyacrylamide (D-PAA) using zinc oxide nanoparticles produced from zinc sulphate (D-PAA/ZnONPs(SO42-)) as a precursor was tested using hemolysis, osmotic fragility and eryptosis assays. Materials and methods. Dose-d...

The thermal properties of cross-linked polymers based on chitosan and polyacrylamide were studied. Samples of the resulting network polymers, which included chains of polyacrylamide and chitosan, were obtained as hydrogel materials by radical polymerization of acrylamide in the presence of chitosan using the redox system of cerium (IV) ammonium nit...

Search for new antimicrobial agents is of great significance due to the issue of antimicrobial resistance, which nowadays has become more important than many diseases. The aim of this study was to evaluate the toxicity and biological effects of a dextran-graft-polyacrylamide (D-PAA) polymer-nanocarrier with/without silver or gold nanoparticles (AgN...

Introduction Cancer chemotherapy faces two major challenges – high toxicity of active substances and tumor resistance to drugs. Low toxic nanocarriers in combination with anticancer agents can significantly increase the effectiveness of therapy. Modern advances in nanotechnology make it easy to create materials with the necessary physical and chemi...

The possibility of usage of polymer nanocomposites is being intensively studied today with a purpose of their application in medicine, espessialy in oncology. At the experimental stage it is important to determine the mechanisms of the influence of such compounds on the body and their own possible undesirable effects. Aim – to study the effect of t...

Polyacrylamide-based hydrogels were loaded with cephalosporin antibiotics to obtain antimicrobial wound and burn dressings. At the stage of synthesis, small additives of dextrans of different molecular weights were used to affect the internal structure of the final polyacrylamide-based hydrogels. The control of antibiotic content, as well as its re...

This review shows the possibility of modeling the structure of chemically cross-linked hybrid dextran-graft-polyacrylamide hydrogels, as well as their physicochemical properties. Morphological, spectral, swelling, and sorbtion/desorbtion characteristics of hydrogels depending on initional chemical substances and cross-linking density are described....

Background: The combination of zinc oxide (ZnO) nanoparticles (NPs) with carriers enhances the anticancer effect of nanocomposites. Aim: To explore the mechanisms of cytotoxic action of dextran-graft-polyacrylamide (D-g-PAA/ZnO) NPs against prostate cancers cell lines in vitro. Materials and methods: Dextran-polyacrylamide was used as a matrix...

The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer sys...

The development of precision cancer medicine relies on novel formulation strategies for targeted drug delivery to increase the therapeutic outcome. Biocompatible polymer nanoparticles, namely dextran-graft-polyacrylamide (D-g-PAA) copolymers, represent one of the innovative non-invasive approaches for drug delivery applications in cancer therapy. I...

The synthesis and physico-chemical properties of chemically cross-linked hydrogels based on polyacrylamide and chitosan, which form interpenetrating polymer networks, are considered in the work. The strategy of obtaining cross-linked networks of both polyacrylamide and polyacrylamide grafted on chitosan by radical polymerization was used. The equil...

A triple thermosensitive polymer Dextran-g-Poly(N-isopropylacrylamide)/Au nanoparticles/Perylenediimide (D-g-PNIPAM/AuNPs/PDI) hybrid nanosystem was formulated in aqueous solution for potential use as thermoresponsive fluorescent optical switch and label. The completely reversible effect of sharp enhancement-quenching of the photoluminescence of D-...

Background. Open wound treatment requires a use of bandage material to prevent the development of pathogenic microflora and to provide the necessary conditions for tissue regeneration. The aim of the study was to compare the effectiveness of polyacrylamide (PAA) and dextran-graft-polyacrylamide (D-PAA) hydrogels loaded with silver nanoparticles (A...

We explored two approaches to recover uranium and plutonium from aqueous solutions at pH 4 and pH 7 using water-soluble star-like polyacrylamide polymers with a dextran core. In the first approach, a solution comprising a neutral or ionomer polymer was mixed with a radionuclide solution to form polymer–metal complexes that were then retained by ult...

The thermoresponsive Zinc TetraPhenylPorphyrin photosensitizer/Dextran poly (N-isopropylacrylamide) graft copolymer/Au Nanoparticles (ZnTPP/D-g-PNIPAM/AuNPs) triple hybrid nanosystem was synthesized in aqueous solution as a nanodrug for potential use in thermally driven and controlled photodynamic therapy applications. The aqueous solution of the n...

Luminescent O, N-containing carbon nanoparticles (O, N-CNPs) were synthesized by the one-step method. Their surface chemistry was studied by TPD-MS, TGA, and H NMR. Different groups, e.g., carboxyl, imide, and amide, were found. The small (O, N)-CNPsdispersed in water have a high quantum yield of 0.26 with respect to quinine sulfate in 0.05 M sulfu...

Now polymeric sorbents are used as basic environmental protection agents. They are used as filter elements for air and water purification. The application of stimulus-dependent polymers opens up new possibilities for the adsorption and desorption of different classes of substances. It was shown that the phase change behavior of dextran70-poly(N-iso...

The new methacrylic monomers with side chain styrylquinoline containing moiety were synthesized by reaction alcohols with methacryloyl chloride; and the polymers were synthesized by free radical polymerization. Polymers were characterized by ¹H NMR spectroscopy. The results of photochemical and optical activities of the corresponding polymers are p...

The present article describes the synthesis, characterization, and sorption/desorption properties of cross-linked hybrid dextran–graft-polyacrylamide hydrogels. Polymers were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The sorption/desorption ability of Methylene blue, Brilliant green, and Basic fuchsi...

A zinc tetraphenylporphyrin photosensitizer/dextran graft polyacrylamide anionic copolymer/Au nanoparticles (ZnTPP/D-g-PAAan/AuNPs) triple hybrid nanosystem was synthesized in water-based solution as a nanodrug for potential photodynamic therapy applications. Dynamic light scattering studies showed that the nanosystem is stable against aggregation...

Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV method. It is shown that cefuroxime-loaded Dextran/Su...

Novel monomers based on (2Z)-2-(benzylidene)-6-hydroxy-1-benzofuran-3 (2H)-one with different substituents were synthesized by reaction of acylation with methacryloyl chloride. Kinetic of homopolymerization was investigated by dylatometric method. The synthesis of copolymers based on novel aurone containing monomers and methylmethacrylate was condu...

Cadmium sulfide nanoparticles were synthesized in situ in polymer matrix Dextran-g-Polyacrylamide at several pH values. In the present work, it is reported the effect of concentration and pH value on Cadmium sulfide nanoparticle size. The CdS sols were characterized using the Dynamic light scattering, UV–Visible spectroscopy, and Transmission elect...

Hydrogel absorbents were synthesized based on cross-linking of Polyacrylamide grafted on Dextran or Dextran sulfate sodium salt. It was found that the swelling capacity of hydrogels depends on cross-linker concentration as well as Dextran component. FT-IR studies of hydrogels were carried out to analyze its structure. Methylene blue dye as model ca...

A new water-soluble thermosensitive star-like copolymer, dextran-graft-poly-N-iso-propilacrylamide (D-g-PNIPAM), was created and characterized by various techniques (size-exclusion chromatography, differential scanning calorimetry, Fourier-transform infrared (FTIR) spectroscopy, and dynamic light scattering (DLS) spectroscopy). The viability of can...

The combination of hydrogels with broad-spectrum antibacterial agents makes it possible to create a universal analogue of tissue dressing material with the necessary properties for the treatment of wounds and ulcers. Chlorhexidine-saturated (0.05%) hydrogels based on polyacrylamide polymers, dextran-grafted polyacrylamide and dextran sulfate-grafte...

Recently, it has been proved that polymers with a dextran core and grafted polyacrylamide chains dextran–polyacrylamide are effective in photodynamic chemotherapy, which gives confidence in the prospect of drug nanosystem. However, further research is needed to determine the effect of the treatment on male reproductive function. Experiments have be...

Chlorin e6 and its derivatives are the basis of a number of drugs used in medicine in the treatment of various diseases, including cancer, by photodynamic therapy. Nonpolar derivatives of Chlorin e6—dimethyl ether of Chlorin e6 (DME Ce6) and trimethyl ether of Chlorin e6 (TME Ce6)—are actively studied for application during photodynamic therapy. In...

We report on the structure and properties of dextran-graft-polyacrylamide star-lake polymers, which are efficient flocculant aids. Demonstrated in this paper is that these polymers form complexes with three common radionuclide contaminants: uranium, strontium, and cesium. Application of these polymers as flocculant aids together with inexpensive ka...

Methylene blue as photosensitizer was used for antimicrobial photoinactivation of Staphylococcus aureus in suspension. The antimicrobial activity of methylene blue was activated by red light of low energy density. Determination of CFU in bacterial suspensions was performed in the Goryaev chamber after staining an aliquot of the suspension with Acri...

The hydrogels based on cross-linked dextran-graft-polyacrylamide (D-g-PAA) and polyacrylamide (PAA) with different densities of chemical cross-links were synthesized by radical polymerization. They were used as nanoreactors for the photochemical synthesis of silver nanoparticles (AgNPs). The polymer hydrogels and nanocomposites with loaded AgNPs we...

The multi-component nanosystems based on the branched copolymer dextran-graft-polyacrylamide in an anionic form (D-g-PAAan) with gold nanoparticles (AuNPs), photosensitizer Chlorine e6 (Ce6), and chemotherapeutic agent Doxorubicin (Dox) were developed for use in complex breast cancer therapy. The synthesized nanosystems were characterized by Quasi...

The temperature-driven plasmon-exciton coupling in thermoresponsive dextran-graft-PNIPAM/Au nanoparticle/CdTe quantum dot (D-g-PNIPAM/Au NPs/CdTe QDs) hybrid nanosystem was studied. A significant (0.84 eV) splitting of the absorption peak was observed in the absorption spectrum of the nanosystem, which reflects the fact of formation of plexcitons,...

The method of holographic interferometry is based on observation in real-time value of the change of the refractive index of solution during and after its illumination with laser light. This method was used to compare the effects of laser illumination on nanosystems containing polymer (in nonionic and anionic form), Au nanoparticles (AuNPs), and ph...

Skin damage is accompanied by bacterial infection of the wound. Different materials are used for accelerate tissue regeneration and minimize bacterial contamination. Also it is prevent the penetration of bacteria to damaged tissues. After the emergence of antibiotic-resistant strains of microorganisms began the search for alternative means of their...

Development and characterization of hybrid hydrogels loaded with methylene blue, which are designed to apply for photodynamic therapy, are presented. Hybrid hydrogels were synthesized by grafting polyacrylamide onto dextran/dextran sulfate sodium salt using N, N′-methylene-bis-acrylamide as a cross-linker. The differences in microstructure of synth...

Series of hydrogels based on polyacrylamide and copolymer dextran-graft-polyacrylamide with various cross-linking density and various molecular weight of dextran component were prepared using N,N′-methylene-bis-acrylamide as cross-linking agent. The comparative equilibrium swelling capacity of synthesized hydrogels was studied. The swelling behavio...

Polymer nanoparticles have gained significant attention as nanoplatform for drug delivery. Water-soluble smart polymers with special characteristics can be used therapeutically as nanocarrier in which the active ingredient is entrapped, encapsulated, adsorbed, or chemically attached. For preparation of nanocomposites for chemotherapy and photodynam...

Water-soluble polymers with special characteristics can be used as carriers in which the active ingredients are entrapped, encapsulated, adsorbed, or chemically attached. The understanding of the processes occurring during the formation of multicomponent nanosystems is the urgent task for the synthesis of antitumor nanocomposites. Gold nanoparticle...

Thermosensitive polymer poly-N-isopropylacrylamide (PNIPAM) having a conformational transition in the interval of physiological temperatures was discussed last years as a novel drug delivery system. Chlorin e6 (Ce6) is a photosensitizer used in the photodynamic anticancer therapy. The comparative study of the encapsulation of Ce6 and its derivative...

Background: recently, it has been proved that copolymers with dextran cores and grafted polyacrylamide are effective in photodynamic and chemotherapy. However, further research is needed to define correct dosage and to assess the risks. Thus, animal studies are becoming more relevant to determine the effect of the treatment of such drug nano-system...

Polyacrylamide and dextran-graft-polyacrylamide hydrogels are prepared and used as nanoreactors and networks for the synthesis of silver nanoparticles (AgNPs). Photochemical generation of AgNPs is carried out under UV-irradiation of Ag+ ions in swollen hydrogels of different cross-linking densities. The obtained hydrogels and hydrogel/AgNPs composi...

Multicomponent nanocomposites for anticancer therapy were prepared, characterized, and tested for their antitumor efficacy. The water-soluble star-like dextran-graft-polyacrylamide copolymer was used as a nanoplatform for the creation of polymer-based multicomponent drug delivery systems for photodynamic and combined (photodynamic+chemotherapy) ant...

Cross-linked dextran-graft-polyacrylamide hydrogels with different cross-linking density loaded with methylene blue was prepared as light-activated antimicrobial materials. Sorption/desorption properties of hydrogels were studied by estimating the change in the absorption maximum of MB solutions. The sorption/desorption rate of MB into/out of hydro...

In this work, we investigated the influence the effect of ZnO nanoparticles (NPs) sizes on nonlinear optical response of doped methacrylic aurone-based polymer. The thin films containi ng aurone-based polymer and ZnO nanoparticles were spin-deposited on glass substrates and their optical and nonlinear optical features were studied using the Maker-f...

The laser-induced aggregation in the thermosensitive dextran grafted-poly(N-isopropylacrylamide) copolymer/Ag nanoparticles (D–g–PNIPAM/AgNPs) hybrid nanosystem in water has been observed. The laser-induced plasmonic heating of Ag NPs causes the Lower Critical Solution Temperature (LCST) conformation transition in D–g–PNIPAM/AgNPs macromolecules wh...

Chlorin e6 is a known photosensitizer used in photodynamic therapy of cancer as a component of existing formulations and in development of novel ones. Upon the increase of pH, chlorin e6 is known to overcome the molecular transition (considered to be the molecule deprotonation) at about pH 6.1-6.4; effect of this transition on singlet oxygen genera...

The thermostability of polysterene with/without new styrylquinoline containing methacrylic fragments has been described in the present work. Polystyrene and copolymers based on styrene and new methacrylic styrylquinoline containing monomers were synthesized by free radical thermoinitiated polymerization in the presence of 2,2′-azobisisobutyronitril...

The viability of cancer cell lines (human transformed cervix epithelial cells, HeLa, and osteoblastic cell line from a C57BL/6 mouse calvaria, MC3T3, as models for cancer cells) was studied using MTT and live/dead assays after incubation with a branched copolymer dextran-graft polyacrylamide in anionic form (D-g-PAAan) as nanocarrier for drugs, dox...

Poly-N-isopropylacrylamide (PNIPAAm) is a biocompatible thermosensitive polymer that is promising for use in nanobiotechnology applications since this polymer has a phase transition temperature (LCST) in the physiological temperature range. LCST can be regulated by changing the hydrophilic-hydrophobic balance of the PNIPAAm-containing macromolecule...

Hydrogels were synthesized by grafting polyacrylamide onto dextran using N,N′-methylene-bis-acrylamide as a cross-linker. The hydrogels were converted into polyelectrolytes by alkaline hydrolysis, and samples having various concentrations of ionic groups were obtained. The swelling behavior of the hydrogels in distilled water at room temperature wa...

Hydrogel-silver nanocomposites are found to be excellent materials for antibacterial applications. For developing of these сomposites, the hydrogel matrices are synthesized first by polymerizing of acrylamide in the presence of cross-linker N,N-methylene-bis-acrylamide using redox initiating system cerium(IV) ammonium nitrate. Silver nanoparticles...

The comparative refractive index analysis for two systems, Au sol synthesized into solution of dextran-graft-polyacrylamide (D-g-PAA) starlike copolymer and solution of D-g-PAA under laser illumination, has been carried out. It was established that Au nanoparticles (AuNPs) are 1.5–6 nm in size. The size of individual polymer molecule in solution wa...

During the last decade, stimuli-responsible polymers based on poly(N-isopropylacrylamide) having conformational transition in the range of physiological temperature have been discussed as novel drug delivery nanosystems. A star-like copolymer with a dextran core and grafted poly(N-isopropylacrylamide) arms (D-g-PNIPAM) was synthesized, characterize...

During the last decade, stimuli-responsible polymers based on poly(N-isopropylacrylamide) having conformational transition in the range of physiological temperature have been discussed as novel drug delivery nanosystems. A star-like copolymer with a dextran core and grafted poly(N-isopropylacrylamide) arms (D-g-PNIPAM) was synthesized, characterize...

One of the ways to improve the efficiency of photodynamic therapy is to enhance the accumulation of the photosensitizer (PS) in the tumor; for this, either polymers or metal nanoparticles (NP) could be used. Here we studied the effect of Au and Ag nanoparticles (AuNPs and AgNPs, respectively) synthesized in situ in solution of non-charged and anion...

Introduction: The aim of this research was to study the impact of various doxorubicin (Dox)-containing nanofluids, e.g. singlewalled carbon nanotube (SWCNT)+Dox, graphene oxide (GO)+Dox and DextranPNIPAM (copolymer)+Dox mixtures on HeLa cells (human transformed cervix epithelial cells, as a model for cancer cells) depending on their concentration....

This work was devoted to the study of the photothermal and photochemical processes occurring under laser irradiation of the nano-systems consisting of gold nanoparticles incorporated into polymer nano-carriers in a non-ionic and anionic form. The UV-vis spectroscopy demonstrated that the intensity of the surface plasmon resonance band is higher for...

Polystyrene (PS)-diphenyloxazole (PPO) nanoparticles with attached cross-linked poly-N-isopropylacrylamide (PNIPAM) chains were obtained resulting in PS-PPO-PNIPAM hybrid nanosystems (NS). Fluorescence spectra of chlorin e6 added to PS-PPO-PNIPAM hybrid NS revealed electronic excitation energy transfer (EEET) from PS matrix and encapsulated PPO to...

Laser induced structural transformations in a dextran grafted-poly(N-isopropylacrylamide) copolymer/Au nanoparticles (D-g-PNIPAM/AuNPs) hybrid nanosystem in water have been observed. The laser induced local plasmonic heating of Au NPs leads to Lower Critical Solution Temperature (LCST) phase transition in D-g-PNIPAM/AuNPs macromolecules accompanied...

Thermally responsive polymers based on poly (N-isopropylacrylamide) (PNIPAM) with lower critical solution temperature (LCST) in the region of physiological temperatures become a subject of a study as promising material for biomedical application. In the present work, the star-like dextran-graft-PNIPAM with incorporated gold nanoparticles (AuNPs) in...

Two thiazine dyes were used for quantitation of anionic surfactants. The analytical procedure consists in titration of surfactant solution with cationic dye, registering absorbance at specific wavelength. Optimal wavelengths are 640 nm for the o-Toluidine Blue dye and 666 nm for the Methylene Blue dye. The registered absorbance values are dependent...

Hybrid hydrogels based on polyacrylamide were prepared by using N,N’-methylene-bis-acrylamide as cross-linker during radical polymerization of two component Dextran/Acrylamide system. It was found that the swelling capacity of hydrogels depends on cross-linker concentration as well as Dextran component. SEM, TGA and DSC studies of hybrid polyacryam...

Feasible method of quantitative determination of anionic polymers in aqueous solutions was described using poly(styrene sulfonate) and poly(acrylate) sodium salts as an example. The method consists in absorbance measurements while titrating with thiazine dye. Volume of dye solution needed to attain specified value of absorbance is linearly dependen...

The purpose of the present study was to evaluate the toxicity of gold nanoparticles (AuNPs) incorporated into branched polymer matrices Dextran-graft-Polyacrylamide on cancer cells of different origin. The study was performed on breast cancer MCF-7 cell line and its two sublines MCF-7/Dox and MCF-7/DDP resistant to Dox and DDP, respectively and MT-...

Branched dextran-graft-polyacrylamide copolymers with different surface properties (charged and uncharged, pure and loaded by Ag or Au nanoparticles) were created in order to drug delivery usage. By means of differential scanning calorimetry, membranotropic action of the polymers was revealed in a set of model lipid membranes, both charged and unch...

Hybrid nanosystems consisting of star-like copolymer Dextran-graft-Polyacrylamide in the anionic form (D-g-PAA(PE)), silver nanoparticles (AgNPs), and cisplatin (cis-Pt) have been synthesized in water and characterized by TEM, DLS, FTIR, and UV-Vis spectroscopies. It is shown that cis-Pt forms a complex with carboxylate groups of the polymer. For t...

This paper reports mechanical properties and thermal stability of the PVA hydrogels. An electron beam radiation method was used for polymer cross-linking. Hydrogels were prepared at various polymer concentrations. Mechanical and thermal properties were analyzed. It was shown that efficiency of the irradiation was depending on initial polymer concen...

The triple system with berberine, silver nanoparticles and polymeric matrix was studied optical spectroscopy methods. Silver nanoparticles were synthesized in situ in water solution of branched copolymers Dextran-graft-polyacrylamide. An adding the berberine to a solution of nanoparticles leads to the changes in the absorption spectra: the optical...

Photodynamic therapy is a procedure that uses a photosensitizing drug to apply light therapy selectively to target cancer treatment. This study is focused on a synthesis and characterization of a new hybrid nanocomposites based on the branched copolymers dextran–polyacrylamide in nonionic, D-g-PAA and anionic D-g-PAA(PE) form, with incorporated gol...

The isoquinoline quaternary alkaloid Berberine possesses a variety of pharmacological properties that suggests its promising application for an anticancer delivery system design utilizing its ability to intercalate DNA. In the current work, we have investigated the effects of Berberine on the human T cell leukemia cell line in vitro. Fluorescent mi...