Nataliya Dolgushina

Nataliya Dolgushina
Research Center for Obstetrics, Gynecology and Perinatology · R&D

About

48
Publications
1,578
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123
Citations
Citations since 2017
27 Research Items
97 Citations
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20172018201920202021202220230510152025
20172018201920202021202220230510152025

Publications

Publications (48)
Article
Investigation of the effect COVID-19 mediated with autoantibodies has on reproductive outcomes is important. This study aimed to evaluate the profile of antiphospholipid antibodies (aPL) and their association with the outcomes of assisted reproductive technology (ART) programs in patients with a history of COVID-19. The study included 240 patients:...
Article
In the context of the COVID-19 pandemic, scientific interest is growing in studying the impact of the proposed vaccination on women’s reproductive health. As is known, alterations in the state of the immune system and activation of an autoimmune response can lead to reproductive failure in women and potential complications of subsequent pregnancy....
Article
Androgens play a key role in the physiology of the female body and the reproductive system. Androgen receptor expression in the various tissues points to the importance of androgens in the regulation of the female sexual and social functioning. The study aimed to evaluate sexual functioning in women with infertility and diminished ovarian reserve (...
Article
Androgen concentrations in follicular fluid samples collected from patients undergoing in vitro fertilization (IVF) may provide useful clinical indicators. This study aimed to analyze possible associations of the androgen levels in follicular fluid and blood plasma in patients with diminished ovarian reserve (POR) in IVF programs. Cross-sectional s...
Article
A number of factors, the key one of which is the quality of the embryo transferred into the uterine cavity, influence the effectiveness of assisted reproductive technology programs. The embryo quality is most commonly assessed on the basis of morphological criteria and the results of preimplantation genetic testing for aneuploidy (PGT-A). However,...
Article
COVID-19, a severe acute respiratory syndrome caused by SARS-CoV-2, may predispose to thrombotic events, especially when combined with antiphospholipid antibodies (aPL). However, there are limited data on prevalence and antigenic specificity of aPL in COVID-19. Complement activation is assumed to play an important role in pathogenesis of COVID-19-a...
Article
Full-text available
Objective: To investigate the feasibility of using quantitative assessment of the MT-ND1 gene copy number in culture medium as a marker of successful implantation and embryo quality. Materials and methods: We analyzed the level of MT-ND1 gene copy number in the spent culture medium as a function of embryo quality, maternal age, and the outcome of e...
Article
Autoimmune mechanisms have been implicated in the negative effects of vaccines on female reproductive health. This study evaluates the endogenous levels of self-reactive antibodies and ovarian reserve-associated hormones before and after immunization with the domestically developed Gam-COVID-Vac combined vector vaccine to check for possible reprodu...
Article
Introduction . Vitamin D administration is recommended for women with vitamin D insufficiency, who are planning to undergo assisted reproductive treatment (ART). The action of the active form of vitamin D is mediated through its vitamin D receptor (VDR). The presence of VDR in the cells and tissues of the female reproductive system suggests that vi...
Article
Introduction . Infertility, i.e. the inability to achieve a clinical pregnancy within 12 months of a regular sexual life without contraception, is a current medical problem and affects up to 15-25% of married couples in Western countries. Objective . To evaluate the efficacy of prophylactic prescription of antioxidants in preparation for cycles of...
Article
Full-text available
The aim of the work was to determine frequency of lupus anticoagulant (LA) detection in patients at various degrees of COVID-19 severity as well as duration of LA circulation after the infectious disease. The study included 103 patients with COVID-19. The patients were observed during the hospital care and in ambulance, if required. The patients we...
Article
Folic acid (vitamin B9) is a water-soluble vitamin, essential for the growth and development of the blood and immune systems. Its deficiency is a significant risk factor for fetal neural tube defects. The widespread implementation of drugs and food supplements containing folic acid in preparation for pregnancy and in its first trimester has signifi...
Article
The association between levels of trace elements, endocrine diseases and reproductive impairments is actively investigated currently. In this connection, it seems relevant to study elemental status (elemental composition of blood and amounts of elements therein) of infertile patients enlisted in programs employing assisted reproductive technologies...
Article
Objective. To analyze the relationship between blood bisphenol A levels in men, sperm quality and in vitro fertilization (IVF) out-comes. Material and methods. Infertility treatment of 154 married couples was performed using ART. The level of bisphenol A in the blood of patients was determined by gas chromatography-mass spectrometry. The effect of...
Article
Follicular fluid (FF) contains blood coagulation factors and extracellular vesicles (EVs), but their role in coagulation processes is still unclear. Objective. To evaluate the presence of coagulation factors and EVs in FF, and analyze their role in coagulation hemostasis. Materials and methods. fibrinogen, coagulation factors V, VII, X, XII, anti-f...
Article
We summarized the data on the role and efficiency of mechanical microvibration during embryo culturing in assisted reproduction protocols. The efficiency of culturing systems with microvibration in assisted reproduction programs and possible mechanisms of microvibration effect on the preimplantation development of human embryos are discussed.
Article
We analyzed the effect of cryopreservation on the expression of glutathione peroxidase (GPX1) and glutathione reductase (GSR) genes in human sperm cells (15 sperm samples from fertile donors and 10 samples from infertile patients). The relative expression of GPX1 and GSR genes was determined by real-time PCR. The rate of post-thaw recovery was 2.1...
Article
It is known that the main pathogenetic factor of hypertensive conditions is endothelial activation which may be associated with the production of antiendothelial cell antibodies (AECAs). The aim of this study was to evaluate the rate and to estimate the diagnostic value of AECAs in patients with hypertensive disorders in pregnancy (HDP). A cross-se...
Article
Full-text available
The aim of the study was to study the effectiveness of assisted reproductive technologies (ART) programs in patients of different age groups, taking into account clinical and laboratory data. Materials and methods. A prospective cohort study included 188 patients with infertility of various genesis who were stratified according to age: group 1 (n=...
Article
Polyamines, especially spermine and spermidine, are found in all living beings, and due to their unique po-lycationic structures they interact with a variety of cellular negatively charged targets, primarily nucleic acids, polyphosphates, basic proteins and phospholipids. Extremely wide range of targets for polyamines suggests their critical role i...
Article
The aim was to identify cell and genetic predictors of human blastocyst hatching success in assisted reproduction programmes via a prospective case–control study. Blastocysts, donated by couples in assisted reproduction programmes were used. Hatching success assessment was performed after 144–146 h post-fertilization. The mRNA expression levels of...
Article
The human oocyte is surrounded by the zona pellucida—an elastic, transparent extracellular matrix consisting of specific glycoproteins. The zona pellucida is preserved after fertilization and surrounds the developing human embryo for a few days. The embryo needs to get out of the zona pellucida before implantation to establish cell contacts between...
Article
Objective. To evaluate the clinical cost-effectiveness of preimplantation genetic screening (PGS) in patients of late reproductive age in in vitro fertilization programs (IVF). Subjects and methods. The prospective cohort study included 85 childless couples of late reproductive age, who were divided into groups according to the use of PGS on 3 and...
Article
Full-text available
The problem ofdecreased fertility in women of advanced reproductive age is important today. The number of women of advanced age with infertility is increasing constantly, however efficiency of infertility treatment (even with the use of artificial reproductive technologies) remains low. There are many biological and other causes ofageassociated inf...
Article
Full-text available
There are controversial data about the effect of different controlled ovarian hyperstimulation (COS) protocols on embryological stage and in vitro fertilization (ivf) outcomes. The aim of our study was to evaluate embryological and clinical outcomes according to COS protocol.Material and methods. This prospective cohort study included 521 patients...
Article
In this review, we provide basic facts about maternity care services within the health care system in Russia. We give a short overview of such key aspects as the demographic situation, reproductive behaviour, regulatory framework for providing health care for women and children, maternal and perinatal mortality, and the availability of medical pers...
Article
Background: The poor ovarian response (POR) to ovarian stimulation significantly decreases the efficiency of assisted reproduction technologies. The genesis of POR is not well understood, and can result from various genetic and immune factors.Purpose: To determine the role of genetic (number of CGG repeats in the FMR1-gene) and autoimmune factors (...
Article
Purpose: To evaluate the aneuploidy rates of 13, 18, and 21 and the X and Y chromosomes in embryos from patients with morphologically normal oocytes and different oocyte dysmorphisms. Methods: This prospective cohort study included 84 patients treated with in vitro fertilization (IVF) at a single academic center. The patients were divided into the...
Article
A large proportion of human oocytes received from exogenous gonadotropin-stimulated cycles have different morphological attributes, or dysmorphisms. The presence of dysmorphism can affect the fertilization rate, the embryo quality and subsequently the frequency of occurrence of implantation and pregnancy. Special attention is paid to oocytes with c...
Article
Objective: To investigate the role of matrix metalloproteinases (MMP-2, MMP-9) and their inducer (CD147) in premature rupture of membranes (PROM) at term labor. Methods: In a cross-sectional study, 24 women aged 19–39, with 37–40-week pregnancy, and no clinical and histological signs of chorioamnionitis, were divided into two groups with and withou...
Article
Full-text available
Background: Poor ovarian response represents a major negative contribution to the efficacy of In vitro fertilization programs. It has been shown that specific nucleotide sequence variants of BMP15 gene, which encodes the growth factor specifically expressed by oocytes to regulate follicle development, are related to certain forms of ovarian dysfunc...
Article
Infertility in women, poor ovarian response (POR) to hormonal stimulation of ovulation, failures in cycles of in vitro fertilization (IVF) are often associated with autoantibodies: anti-ovarian, anti-phospholipid (APA), against gonadotropins and their receptors. Objective: to study the spectrum of autoantibodies against hormones and phospholipids i...
Article
Full-text available
Ovarian stimulation protocol and other potential risk factors of poor ovarian response (POR) were analyzed in retrospective case-control study. Due to ESHRE criteria (2011) 150 infertile women of IVF department were divided into the group of cases with POR and the control group with the normal ovarian response. The elder age of the women and the ea...
Article
Purpose: To identify the role of both genetic (number of CGG repeats in the FMR1 gene) and autoimmune factors (anti-ovarian antibodies) in premature ovarian failure (POF). Methods: In cross-sectional study, 78 women with POF were divided into 3 groups by the number of CGG repeats (less than 28, 28-36, more than 36) in any of the FMR1 gene allele...
Article
The main reasons of fetus loss as observed in pregnant women with chronic viral infection are discussed in the paper. The role of the immune system and different mechanisms of endothelial lesions inherent in the genesis of the discussed phenomenon are analyzed. An approach to management of pregnancy in patients with viral infections targeted at the...
Article
Antithrombotic therapy is often used during pregnancy for the treatment and prevention of venous thromboembolism, the prevention of systemic embolism in patients with heart valve prostheses and the prevention of foetal loss in patients with antiphospholipid syndrome. Low-molecular-weight heparins (LMWHs), including nadroparin, have largely replaced...

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