Natalie Vande Pol

Natalie Vande Pol
Michigan State University | MSU · Department of Microbiology and Molecular Genetics

Bachelor of Science

About

19
Publications
3,520
Reads
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268
Citations
Citations since 2016
18 Research Items
268 Citations
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2016201720182019202020212022010203040506070
2016201720182019202020212022010203040506070
Introduction
Natalie Vande Pol is a doctoral candidate in the Department of Microbiology and Molecular Genetics at Michigan State University. Natalie does research in Bioinformatics, Molecular Biology and Microbiology. Her current research project is "Plant-fungal-bacterial interactions: Elucidating mechanisms of plant growth promotion by fungi in the Mortierellaceae" and includes phylogenetics, plant fungal symbiosis, transcriptomics, and metabolomics.
Education
September 2012 - June 2014
Stanford University
Field of study
  • Biology

Publications

Publications (19)
Article
Full-text available
Mutualistic interactions between free-living algae and fungi are widespread in nature and are hypothesized to have facilitated the evolution of land plants and lichens. In all known algal-fungal mutualisms, including lichens, algal cells remain external to fungal cells. Here, we report on an algal–fungal interaction in which Nannochloropsis oceanic...
Article
Mutualistic interactions between free-living algae and fungi are widespread in nature and are hypothesized to have facilitated the evolution of land plants and lichens. In all known algal-fungal mutualisms, including lichens, algal cells remain external to fungal cells. Here, we report on an algal-fungal interaction in which Nannochloropsis oceanic...
Article
Full-text available
Background One of the most crucial steps in high-throughput sequence-based microbiome studies is the taxonomic assignment of sequences belonging to operational taxonomic units (OTUs). Without taxonomic classification, functional and biological information of microbial communities cannot be inferred or interpreted. The internal transcribed spacer (...
Article
Full-text available
Endogonales is a lineage of early diverging fungi within Mucoromycota. Many species in this order produce small sporophores (“sporocarps”) containing a large number of zygospores, and many species form symbioses with plants. However, due to limited collections, subtle morphological differentiation, difficulties in growing these organisms in vitro,...
Conference Paper
Full-text available
Association mapping (AM) methods are used in genome-wide association (GWA) studies to test for statistically significant associations between genotypic and phenotypic data. The genotypic and phenotypic data share common evolutionary origins -- namely, the evolutionary history of sampled organisms -- introducing covariance which must be distinguishe...
Preprint
Full-text available
Association mapping (AM) methods are used in genome-wide association (GWA) studies to test for statistically significant associations between genotypic and phenotypic data. The genotypic and phenotypic data share common evolutionary origins – namely, the evolutionary history of sampled organisms – introducing covariance which must be distinguished...
Article
Full-text available
Endosymbiosis of bacteria by eukaryotes is a defining feature of cellular evolution. In addition to well known bacterial origins for mitochondria and chloroplasts, multiple origins of bacterial endosymbiosis are known within the cells of diverse animals, plants, and fungi. Early-diverging lineages of terrestrial fungi harbor endosymbiotic bacteria...
Presentation
Full-text available
The Mortierellales comprise a polyphyletic lineage of early diverging, globally distributed, soil fungi. Several Mortierella species are known to interact with roots and promote plant growth, even though they do not make traditional mycorrhizal structures. Mortierella also harbor bacterial endosymbionts and have unique oleaginous biology that makes...
Presentation
Full-text available
Some background on my thesis project and an outline of two non-rDNA approaches I’m taking to resolving the phylogeny of the Mortierellaceae.
Poster
Full-text available
Mortierella species belong to a diverse lineage of early diverging, plant-associated fungi. These chitinolytic fungi are globally distributed and ubiquitous in soils. They are also of biological interest because they harbor obligate bacterial endosymbionts, promote plant growth, and have unique oleaginous (oil-producing) features. Inter- and intra-...

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Projects

Projects (2)
Project
I am interested in the mechanism of Mortierellales-plant interactions and whether these plant associations are phylogenetically conserved. To answer those questions, I must first resolve the phlyogenetic structure of this lineage, for which classical rDNA loci are inadequate. To that end, I am working with single-copy exonic loci and low-coverage genomes.
Project
I am interested in how trans-kingdom symbioses are established and evolve over time. My current research is focused on plant associated, fungal-bacterial interactions. Specifically I am studying a group of bacteria in the Burkholderiaceae and how they interact with plant associated Zygomycete fungi in the genus Mortierella. These microbes were all isolated from around Poplar (genus Populus) tree roots (the rhizosphere). One example are endobacteria related to Candidatus Glomeribacter. In collaborations with colleagues I have used full genome sequencing of both microbes, and created fungal strains with and with out these endobacteria to study the functional basis of their interactions. Other research groups have established that this symbiosis is ancient and co-evolved. I have addressed the functional questions using comparative physiological, transcriptomic, metabolomic, and proteomic approaches. A second example are free-living Burkholderia species also found in the Populus rhizosphere which impart significant growth-increase phenotypic effect on Mortierella. In an attempt to understand the mechanisms and signals exchanged in this so called 'mycorrhizal helper' symbiosis effect we have designed a microfluidic co-culture system to make time lapse microscopy videos which allow us to observe single cell interactions. This project also includes using combined -omics approaches to elucidate signaling and materials trade in a transient symbiosis.