Natália Yumi Noronha

Natália Yumi Noronha
University of São Paulo | USP · Departamento de Clínica Médica (Ribeirão Preto)

Bachelor of Science
PhD candidate at The University of São Paulo - Brazil, Medical School of Ribeirão Preto - FMRP/USP.

About

47
Publications
3,312
Reads
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193
Citations
Additional affiliations
April 2021 - present
DG lab: Affordable Nutritional Genetic Testing
Position
  • P&D intern
Description
  • This is a non-academic internship from the PhD, approved from the post-graduation service. I am currently working on methodologies validation of SNP microarrays in clinical practice.
April 2020 - present
University of São Paulo
Position
  • Discipline Monitor - PhD educational activities
Description
  • The objective of my position is to assist the students from the Improvement Course in Sports Nutrition and Obesity. During my experience, I was involved in activities as online class tutor, preparing educational activities and evaluations.
February 2014 - June 2014
University of Ribeirão Preto
Position
  • Discipline Monitor
Description
  • The monitoring activity of the Practical Microbiology discipline was carried out under the supervision of Professor Ana Lucia Fachin Saltoratto. The activity included the preparation of materials for practical classes such as microbiological inocula, culture media, various solutions and material autoclaving. I also participated during the practical classes to assist both the professor and the students.

Publications

Publications (47)
Article
Full-text available
This study investigated the ability of the Brazilian Caffeine Expectancy Questionnaire (CaffEQ-BR), full and brief versions, to differentiate genetic profiles regarding the polymorphisms of the CYP1A2 (rs 762551) and ADORA2A (rs 5751876) genes in a cohort of Brazilian athletes. One-hundred and fifty participants were genotyped for CYP1A2 and ADORA2...
Article
Full-text available
Background Pre-diabetes precedes Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially for menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated the role of physical exercise in epigenetic reprogramming to modulate the gene expression patt...
Article
Full-text available
“Nutrition transition” describes the shifts in dietary consumption and energy expenditure influenced by economic, demographic, and epidemiological changes at a population level. This phenomenon has been associated with rising obesity rates worldwide, especially in developed countries. In Brazil, the historical analysis of temporal trends between ma...
Article
Full-text available
Obesity is directly connected to lifestyle and has been associated with DNA methylation changes that may cause alterations in the adipogenesis and lipid storage processes contributing to the development of the disease. We demonstrate a complete protocol from selection to epigenetic data analysis of patients with and without obesity. All steps from...
Article
Full-text available
AimThe aim of this study was to analyze the association and susceptibility of Single Nucleotide Polymorphisms (SNPs) in the DRD2 and BDNF genes with BED in patients with weight regain in the postoperative period of bariatric surgery.Methods One hundred and seventy-seven individuals who underwent bariatric surgery with weight regain were evaluated a...
Article
Full-text available
Introduction Nutriepigenetic markers are predictive responses associated with changes in “surrounding” environmental conditions of humans, which may influence metabolic diseases. Although rich in calories, Western diets could be linked with the deficiency of micronutrients, resulting in the downstream of epigenetic and metabolic effects and consequ...
Article
Full-text available
Matrix metalloproteinases (MMP) and their endogenous inhibitor, the tissue inhibitor of metalloproteinases (TIMP), are expressed in many different cell types and play an important role in physiologic and pathological degradation of extracellular matrix (ECM). Starting from these observations and considering the activation state of peripheral blood...
Article
Full-text available
Genes involved in the regulation of metabolism, adipose tissue deposition, inflammation, and the appetite-satiety axis may play an important role in fetal development, and possibly induce permanent metabolic changes and fat accumulation. In this study we investigated: (1) obesity-related gene expression in maternal and cord blood of overweight/obes...
Preprint
Background: Telomere length (TL) shortening process is associated with several known environment and individual determinants. DNA methylation is the most studied epigenetic process and may be associated with TL. We investigated the associations between DNA methylation and TL in peripheral blood. Methods: Methylation wide association study was condu...
Article
Full-text available
Background Telomeres are structures located at the ends of chromosomes associated with a protein complex, known as the shelterin complex. In individuals with obesity, excess adipose tissue plays a key role in inducing a chronic and systemic inflammatory state, which can cause TL shortening. In this context, bariatric surgery is one of the most effe...
Article
Full-text available
Background & Aims The worldwide outbreak of the coronavirus disease 2019 (COVID-19) has already caused a substantial public health burden. Increasing numbers of studies linked obesity to more severe COVID-19 consequence and mortality, challenging health systems worldwide, especially in emerging countries like Brazil. Herein, we aimed to search the...
Article
Full-text available
Background & aims Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19. Methods We analyzed gene expression profiles of a...
Preprint
Full-text available
Objectives: Verify the frequency of polymorphisms related to obesity and Binge Eating Disorder (BED) in DRD2 and BDNF genes in patients undergoing bariatric surgery with weight regain above 10% of the weight lost. Methods: Evaluation of 177 individuals undergoing bariatric surgery with weight regain, divided into two groups: Group 1: individuals wi...
Preprint
Full-text available
Aim: To analyze the association and susceptibility of Single Nucleotide Polymorphisms (SNPs) in the DRD2 and BDNF genes with BED in patients with weight regain in the postoperative period of bariatric surgery. Methods: 177 individuals who underwent bariatric surgery with weight regain were evaluated and divided into two groups according to the BED...
Article
Full-text available
Background: Beta-alanine has become a dietary supplement widely used by athletes due to its ergogenic effect. However, there is still no consensus on the performance benefit of beta-alanine on exercise lasting longer than ten minutes. The present study aimed to evaluate the effect of beta-alanine supplementation on running performance and the expr...
Article
Full-text available
We aimed to investigate the effects of short-term hypocaloric diet-induced weight loss on DNA methylation profile in leukocytes from women with severe obesity. Eleven women with morbid obesity (age: 36.9 ± 10.3 years; BMI: 58.5 ± 10.5 kg/m²) were assessed before and after 6 weeks of a hypocaloric dietary intervention. The participants were compared...
Article
Full-text available
Weight regulation and the magnitude of weight loss after a Roux-en-Y gastric bypass (RYGB) can be genetically determined. DNA methylation patterns and the expression of some genes can be altered after weight loss interventions, including RYGB. The present study aimed to evaluate how the gene expression and DNA methylation of PIK3R1, an obesity and...
Article
Full-text available
DNA methylation could provide a link between environmental, genetic factors and weight control and can modify gene expression pattern. This study aimed to identify genes, which are differentially expressed and methylated depending on adiposity state by evaluating normal weight women and obese women before and after bariatric surgery (BS). We enroll...
Article
Full-text available
Background: Telomere length is inversely associated with the senescence and aging process. Parallelly, obesity can promote telomere shortening. Evidence suggests that physical activity may promote telomere elongation. Objective: This study's objective is to evaluate the effects of combined exercise training on telomere length in obese women. De...
Article
Full-text available
The coronavirus disease 2019, referred to as COVID-19 by the World Health Organization (WHO), is an ongoing viral pandemic caused by the influenza-like virus strain SARS-CoV-2 (1). According to WHO (2020), SARS-CoV-2 infection has been responsible for approximately 10,185,374 confirmed cases of COVID-19 and more than 500,000 deaths worldwide (2). I...
Article
Full-text available
Introduction: obesity is associated with high levels of oxidative stress (OS) and inflammation. There is a lot of evidence that some polyphenols, such as green tea, have a positive impact on the OS state and consecutively, on inflammation. Objectives: the purposes of this study were: a) evaluate OS biomarkers in both obese and normal weight wome...
Article
Telomeres are structures located at the ends of chromosomes associated with proteins, from the shelterin complex, which are responsible for the protection and preservation of the genetic material. The telomere length (TL) progressively decreases with each cell division, and recent evidence suggests that lifestyle can lead to telomere shortening. In...
Article
Full-text available
INTRODUCTION epigallocatechin-3-gallate (EGCG) is the most abundant catechin contained in green tea (Camellia sinensis) and has been associated with anti-obesity and anti-cancer effects, but the exact molecular mechanisms remain elusive. In this context, this study was designed to improve the understanding of the EGCG anti-obesity and anti-cancer a...
Article
Objectives: Genetic predisposition and epigenetic signatures could explain why some individuals regain the weight lost after different obesity treatments. Major facilitator superfamily domain 3 (MFSD3) is a family of membrane-bound solute carriers whose expression has been recently associated with nutrient intake and adipose tissue homeostasis. Th...
Article
Full-text available
Introduction: inflammation and oxidative stress are factors that may play a substantial role in telomere attrition. In line of this, obesity is associated with telomere shortening. Green tea had anti-inflammatory and antioxidant effects and may alter telomere length (TL). Objectives: we evaluated the effect of decaffeinated green tea supplementa...
Article
Objective After bariatric surgery, modifications to signaling pathway networks, including the signaling pathways of the metabolic regulator mTOR (mammalian, or mechanistic, target of rapamycin), may lead to molecular alterations related to energy source availability, systemic nutrients, and catabolic and anabolic cellular processes. This study aime...
Article
This study aims (i) to verify expression of the UCPs, PLIN1, PPARG2, and ADRB3 genes in the abdominal subcutaneous adipose tissue of obese women at baseline and after 8 weeks of supplementation with decaffeinated green tea extract, and (ii) to associate findings with clinical parameters. This is a longitudinal study during which 11 women with obesi...
Article
Full-text available
Background: Differential gene expression in peripheral blood mononuclear cells (PBMCs) after Roux-en-Y gastric bypass (RYGB) is poorly characterized. Markers of these processes may provide a deeper understanding of the mechanisms that underlie these events. The main goal of this study was to identify changes in PBMC gene expression in women with o...
Article
Objective Resting metabolic rate (RMR) is an important parameter to guide the nutritional therapy of class III obese patients. The aims of the present study were to develop a predictive equation for RMR estimation in class III obese women using anthropometric indicators and to compare indirect calorimetry with other predictive equations. Methods T...
Article
Full-text available
Introduction: Gene expression analyses from peripheral blood mononuclear cells (PBMC) and white adipose tissue are conflicting. It seems that results from single tissue are not enough to explain how changes affect humans as a complex biological system. Objective: The aim of this study was to compare, from obesity subjects, PBMC and white adipose t...
Article
Full-text available
Background/Objectives In addition to environmental and psychosocial factors, it is known that genetic factors can also influence the regulation of energy metabolism, body composition and determination of excess weight. The objective of this study was to evaluate the influence of UCP3, PLIN1 and PPARG2 genes on the substrates oxidation in women with...
Article
Full-text available
Background Analysis of the expression of genes related to the energy metabolism can elucidate the understanding of physiological and genetic factors that contribute to obesity. This study aimed to evaluate the expression of genes and its influence on resting metabolic rate and weight loss in obese patients before and after bariatric surgery. Method...
Article
Background/objectives: Although energy restriction contributes to weight loss, it may also reduce energy expenditure, limiting the success of weight loss in the long term. Studies have described how genetics contributes to the development of obesity, and uncoupling proteins 1 and 2 (UCP1 and UCP2) and beta-3-adrenoceptor (ADRB3) have been implicat...
Article
Full-text available
Background/objective: Uncoupling proteins (UCPs) are located in the inner membrane of mitochondria. These proteins participate in thermogenesis and energy expenditure. This study aimed to evaluate how UCP1 and UCP3 expression influences substrate oxidation and elicits possible changes in body composition in patients submitted to bariatric surgery....
Data
Status of anthropometry, body composition, oxidation of substrates, and gene expression. (XLS)

Questions

Question (1)
Question
I have been concerned about pollution. I would like to know other people interested in developing practical solutions to our big world. I think showing society the molecular effects of toxic compounds can help in this journey. But sure I need and want something more effective.

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Projects

Projects (2)
Project
Systematically review and critically appraise published clinical practice guidelines (CPGs) for Bariatric-Metabolic Surgery (BMS) in children and adults.
Project
Obesity is a chronic and multifactorial disease whose prevalence is high worldwide. Factors related to the environment, such as eating patterns and sedentary lifestyle, can directly influence its progression. In addition, substances known as obesogens can act as endocrine disruptors, altering the expression of genes related to energy metabolism. Those targets can be regulated by epigenetic mechanisms like DNA methylation. In this sense, large-scale genomic studies allow thousands of regions to be evaluated thus simultaneously providing a global analysis for clinical studies. The objective of my PhD project is to identify the DNA methylation patterns of obese and non obese women and correlate the obtained Beta values with the serum concentration of toxic and essential metals.