Natalia Jimenez

Natalia Jimenez
University of Chile · Centro de Modelamiento Matemático (CMM)

PhD in Chemical Engineering and Biotechnology

About

7
Publications
1,306
Reads
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193
Citations
Citations since 2016
5 Research Items
191 Citations
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
Introduction
Natalia does research in Bioengineering, Systems Biology and Biotechnology. Their most recent publication is 'A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism'.

Publications

Publications (7)
Article
Full-text available
Arboviral diseases such as Zika and Dengue have been on the rise mainly due to climate change, and the development of new treatments and strategies to limit their spreading is needed. The use of Wolbachia
Article
Full-text available
Extensive use of antibiotics has been the primary treatment for the Salmonid Rickettsial Septicemia, a salmonid disease caused by the bacterium Piscirickettsia salmonis. Occurrence of antibiotic resistance has been explored in various P. salmonis isolates using different assays; however, P. salmonis is a nutritionally demanding intracellular facult...
Article
Full-text available
Wolbachia are alpha-proteobacteria known to infect arthropods, which are of interest for disease control since they have been associated with improved resistance to viral infection. Although several genomes for different strains have been sequenced, there is little knowledge regarding the relationship between this bacterium and their hosts, particu...
Article
Full-text available
Objective Over-express galactokinase (Galk1) in tissue plasminogen activator (tPA) producing CHO cells as a potential strategy to improve cell growth and product synthesis. Results tPA producing CHO cells were transfected with the galactokinase (Galk1) gene. CHO-Galk1 cells showed a 39% increase of the specific growth rate in galactose. Moreover,...
Article
Highlights •A consensus genome-scale model of CHO cell metabolism was constructed •Model has 1,766 genes and 6,663 reactions describing metabolism and protein production •Integration of omic data reveals amino acid auxotrophy bases in various cell lines •Cell engineering can yield more efficient resource allocation than bioprocess methods Summary...

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