Natalia Egorova-Brumley

Natalia Egorova-Brumley
University of Melbourne | MSD · Melbourne School of Psychological Sciences

PhD

About

74
Publications
11,176
Reads
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1,273
Citations
Additional affiliations
August 2018 - present
University of Melbourne
Position
  • PostDoc Position
April 2016 - present
The Florey Institute of Neuroscience and Mental Health
Position
  • Analyst
January 2014 - January 2016
Harvard Medical School
Position
  • PostDoc Position
Education
October 2010 - November 2013
University of Cambridge
Field of study
  • Cognitive Neuroscience

Publications

Publications (74)
Article
Full-text available
The relationship between pain and depression is thought to be bidirectional and the underlying neurobiology ‘shared’ between the two conditions. However, these claims are often based on qualitative comparisons of brain regions implicated in pain or depression, while focused quantitative studies of the neurobiology of pain-depression comorbidity are...
Article
Full-text available
Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper‐limb sensorimotor impairment. We investigated associations between non‐l...
Preprint
Full-text available
Sensorimotor performance after stroke is strongly related to focal injury measures such as corticospinal tract lesion load. However, the role of global brain health is less clear. Here, we examined the impact of brain age, a measure of neurobiological aging derived from whole brain structural neuroimaging, on sensorimotor outcomes. We hypothesized...
Preprint
Diffusion-weighted imaging has produced useful biomarkers of verbal fluency post-stroke but acquiring diffusion data is not always clinically feasible. Further, it has been demonstrated that subcortical regions may contribute to verbal fluency, though the predominant focus in the literature has been on cortical contributions to verbal fluency. Fina...
Article
Full-text available
Dynamic whole-brain changes occur following stroke, and not just in association with recovery. We tested the hypothesis that the presence of a specific behavioural deficit after stroke would be associated with structural decline (atrophy) in the brain regions supporting the affected function, by examining language deficits post-stroke. We quantifie...
Article
Full-text available
Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic stimulation to these same circuits may modulate these symptoms. To determine whether these circuits converge, we studied depression severity after brain lesions (n = 461, five datasets), transcranial magnetic stimulation (n = 151, four datasets) and deep bra...
Article
We aimed to chart white matter integrity over 3 years after stroke, to examine if post‐stroke loss of white matter continues to be accelerated compared to control participants. We applied a longitudinal “fixel”‐based analysis, sensitive to fibre tract‐specific differences within a voxel, to assess axonal loss in stroke (N=71, 22 women) compared to...
Article
Background The structural integrity of hippocampal subfields has been investigated in many neurological disorders and was shown to be better associated with cognitive performance than whole hippocampus. In stroke, hippocampal atrophy is linked to cognitive impairment, but it is unknown whether the hippocampal subfields atrophy differently. Purpose...
Preprint
Full-text available
Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is involved in sensorimotor behavior but has not been widely studied within the context of post-stroke upper limb sensorimotor impairment. The hippocampus is vulnerable to secondary degeneration after stroke, and damage to this region could furth...
Article
Full-text available
Background: Stroke survivors are at high risk of dementia, associated with increasing age and vascular burden and with pre-existing cognitive impairment, older age. Brain atrophy patterns are recognised as signatures of neurodegenerative conditions, but the natural history of brain atrophy after stroke remains poorly described. We sought to determi...
Preprint
Full-text available
Background: Stroke survivors are at high risk of dementia, associated with increasing age and vascular burden and with pre-existing cognitive impairment, older age. Brain atrophy patterns are recognised as signatures of neurodegenerative conditions, but the natural history of brain atrophy after stroke remains poorly described. We sought to determi...
Article
Full-text available
Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-vivo data sensitive to microstructural features of white matter, up to 3 orders of magnitude smaller than typical voxel sizes. The key to extracting such valuable information lies in complex modelling techniques, which form the link between the rich diffusion M...
Data
Supplementary Document 3 for Dhollander, T., Clemente, A., Singh, M., Boonstra, F., Civier, O., Duque, J. D., Egorova, N., Enticott, P., Fuelscher, I., Gajamange, S., Genc, S., Gottlieb, E., Hyde, C., Imms, P., Kelly, C., Kirkovski, M., Kolbe, S., Liang, X., Malhotra, A., Mito, R., Poudel, G., Silk, T.J., Vaughan, D.N., Zanin, J., Raffelt, D., Caey...
Data
Supplementary Document 2 for Dhollander, T., Clemente, A., Singh, M., Boonstra, F., Civier, O., Duque, J. D., Egorova, N., Enticott, P., Fuelscher, I., Gajamange, S., Genc, S., Gottlieb, E., Hyde, C., Imms, P., Kelly, C., Kirkovski, M., Kolbe, S., Liang, X., Malhotra, A., Mito, R., Poudel, G., Silk, T.J., Vaughan, D.N., Zanin, J., Raffelt, D., Caey...
Data
Supplementary Document 4 for Dhollander, T., Clemente, A., Singh, M., Boonstra, F., Civier, O., Duque, J. D., Egorova, N., Enticott, P., Fuelscher, I., Gajamange, S., Genc, S., Gottlieb, E., Hyde, C., Imms, P., Kelly, C., Kirkovski, M., Kolbe, S., Liang, X., Malhotra, A., Mito, R., Poudel, G., Silk, T.J., Vaughan, D.N., Zanin, J., Raffelt, D., Caey...
Data
Supplementary Document 1 for Dhollander, T., Clemente, A., Singh, M., Boonstra, F., Civier, O., Duque, J. D., Egorova, N., Enticott, P., Fuelscher, I., Gajamange, S., Genc, S., Gottlieb, E., Hyde, C., Imms, P., Kelly, C., Kirkovski, M., Kolbe, S., Liang, X., Malhotra, A., Mito, R., Poudel, G., Silk, T.J., Vaughan, D.N., Zanin, J., Raffelt, D., Caey...
Article
Full-text available
Introduction: Hippocampal subfield volumes are more closely associated with cognitive impairment than whole hippocampal volume in many diseases. Both memory and whole hippocampal volume decline after stroke. Understanding the subfields' temporal evolution could reveal valuable information about post-stroke memory. Methods: We sampled 120 partici...
Article
Objective/Background Sleep-wake dysfunction is bidirectionally associated with the incidence and evolution of acute stroke. It remains unclear whether sleep disturbances are transient post-stroke or are potentially enduring sequelae in chronic stroke. Here, we characterize sleep architectural dysfunction, sleep-respiratory parameters, and hemispher...
Preprint
Full-text available
Background and Purpose. Fatigue is associated with poor functional outcomes and increased mortality following stroke. Survivors identify fatigue as one of their key unmet needs. Despite the growing body of research into post-stroke fatigue, the specific neural mechanisms remain largely unknown. Methods. This observational study included 63 stroke s...
Article
Cardiovascular risk factors and stroke are associated with increased risk of all‐cause dementia. More than one third of stroke patients will develop dementia, but mechanisms are unclear. Vascular brain burden from accumulated risk factors may contribute to cognitive impairment at the time of stroke, with the stroke being yet another manifestation o...
Preprint
Full-text available
The final peer reviewed version of this work was published in NeuroImage. The full text and supplementary documents are available open access via https://doi.org/10.1016/j.neuroimage.2021.118417 — Abstract: Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-vivo data sensitive to microstructural features of whi...
Preprint
Full-text available
Objective To identify associations between atrophy of spared subcortical nuclei and sensorimotor behavior at different timepoints after stroke. Methods We pooled high-resolution T1-weighted MRI brain scans and behavioral data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects mo...
Article
Full-text available
Executive dysfunction affects 40% of stroke patients, but is poorly predicted by characteristics of the stroke itself. Stroke typically occurs on a background of cerebrovascular burden, which impacts cognition and brain network structural integrity. We used structural equation modelling to investigate whether measures of white matter microstructura...
Article
Study objectives: Sleep-wake dysfunction is bidirectionally associated with the pathogenesis and evolution of stroke. Longitudinal and prospective measurement of sleep after chronic stroke remains poorly characterised due to a lack of validated objective and ambulatory sleep measurement tools in neurological populations. This study aimed to valida...
Article
Background and Purpose Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerated brain atrophy is described following ischemic stroke, but it is not known whether atrophy rates vary over the poststroke period. Examining rates of brain atrophy allows the identification of potential therapeutic window...
Article
Full-text available
Objective Executive dysfunction affects 40% of stroke patients and is associated with poor quality of life. Stroke severity and lesion volume rarely predict whether a patient will have executive dysfunction. Stroke typically occurs on a background of cerebrovascular burden, which impacts cognition and brain network structural integrity. We investig...
Article
Full-text available
Introduction Long sleep duration in aging populations has recently been proposed as a key modifiable risk factor and sequela of stroke. It is unclear whether the pathogenesis of post-stroke sleep-wake dysfunction is due to focal infarction to regional sleep-wake hubs in the brain, or to accelerated whole-brain neurodegeneration. We utilise a novel...
Article
Background and Purpose— We examined if ischemic stroke is associated with white matter degeneration predominantly confined to the ipsi-lesional tracts or with widespread bilateral axonal loss independent of lesion laterality. Methods— We applied a novel fixel-based analysis, sensitive to fiber tract–specific differences within a voxel, to assess a...
Article
Full-text available
White matter hyperintensities (WMHs) are frequently observed on brain scans of older individuals and are associated with cognitive impairment and vascular brain burden. Recent studies have shown that WMHs may only represent an extreme end of a diffuse pathological spectrum of white matter (WM) degeneration. The present study investigated the micros...
Article
Sleep-wake disruption is a key modifiable risk factor and sequela of stroke. The pathogenesis of post-stroke sleep dysfunction is unclear. It is not known whether post-stroke sleep pathology is due to focal infarction to sleep-wake hubs, or to accelerated post-stroke neurodegeneration in subcortical structures after stroke. We characterise the firs...
Article
Full-text available
Aging is a known non-modifiable risk factor for stroke. Usually, this refers to chronological rather than biological age. Biological brain age can be estimated based on cortical and subcortical brain measures. For stroke patients, it could serve as a more sensitive marker of brain health than chronological age. In this study, we investigated whethe...
Article
Background: In experimental placebo and nocebo studies, neutral control treatments are often administered for comparison with active treatments, but are of little interest, as, on average, they result in little change. Yet, when considered at an individual level, they fluctuate between baseline and subsequent measurements and may reveal important...
Article
Full-text available
We assessed first-year hippocampal atrophy in stroke patients and healthy controls using manual and automated segmentations: AdaBoost, FIRST (fsl/v5.0.8), FreeSurfer/v5.3 and v6.0, and Subfields (in FreeSurfer/v6.0). We estimated hippocampal volumes in 39 healthy controls and 124 stroke participants at three months, and 38 controls and 113 stroke p...
Article
Background: Focal brain lesions can lend insight into the causal neuroanatomical substrate of depression in the human brain. However, studies of lesion location have led to inconsistent results. Methods: Five independent datasets with different lesion etiologies and measures of postlesion depression were collated (N = 461). Each 3-dimensional le...
Article
Background: The apolipoprotein E (APOE) gene ɛ4 allele is a risk factor for Alzheimer's disease and cardiovascular disease. However, its relationship with cognition and brain volume after stroke is not clear. Objective: We compared cognition and medial temporal lobe volumes in APOEɛ4 carriers and non-carriers in the first year after ischemic str...
Conference Paper
White matter hyperintensities (WMH) are a key feature of small vessel cerebrovascular disease and are highly prevalent in the elderly. WMH are associated with cognitive decline, a high risk of dementia and stroke. Despite accumulating evidence implicating WMH as a neurodegenerative marker, its pathological mechanisms remain unclear. Moreover, the h...
Conference Paper
Ischaemic stroke leads not only to focal lesions in the region of infarction but can also result in neurodegeneration remote to infarction. While loss of gray matter distal to the lesion and disruptions in global functional connectivity have been characterised, little is known about remote and global white matter degeneration. Previous studies have...
Article
Full-text available
Background: Cerebrospinal fluid circulation is crucial for the functioning of the brain. Aging and brain pathologies such as Alzheimer's disease have been associated with a change in the morphology of the ventricles and the choroid plexus. Despite the evidence from animal models that the cerebrospinal fluid system plays an important role in neuroi...
Article
Introduction Sleep-wake dysfunction contributes to the pathogenesis and progression of ischemic stroke. Lesions to sleep-wake circuitry may compromise post-stroke recovery; however, the neuroanatomical correlates of post-stroke sleep-wake disruption remain unclear. We hypothesized that sleep-wake dysfunction after stroke, characterized by prolonged...
Article
Classical theories suggest placebo analgesia and nocebo hyperalgesia are based on expectation and conditioned experience. Whereas the neural mechanism of how expectation modulates placebo and nocebo effects during pain anticipation have been extensively studied, little is known about how experience may change brain networks to produce placebo and n...
Article
Full-text available
Manual quantification of the hippocampal atrophy state and rate is time consuming and prone to poor reproducibility, even when performed by neuroanatomical experts. The automation of hippocampal segmentation has been investigated in normal aging, epilepsy, and in Alzheimer's disease. Our first goal was to compare manual and automated hippocampal se...
Article
We are used to talking to our patients about pain. As neurologists, we talk to people with unusual pain syndromes every day. We talk to them about their trigeminal neuralgia, about their headaches, and about the diverse pains associated with Guillain-Barre syndrome. We talk with people who have complex regional pain syndromes requiring multidiscipl...
Article
Full-text available
The multilingual brain implements mechanisms that serve to select the appropriate language as a function of the communicative environment. Engaging these mechanisms on a regular basis appears to have consequences for brain structure and function. Studies have implicated the caudate nuclei as important nodes in polyglot language control processes, a...
Preprint
Full-text available
The multilingual brain implements mechanisms that serve to select the appropriate language as a function of the communicative environment. Engaging these mechanisms on a regular basis appears to have consequences for brain structure and function. Studies have implicated the caudate nuclei as important nodes in polyglot language control processes, a...
Article
Introduction Apolipoprotein E (APOE) ε4 allele is a known risk factor for the development of cognitive impairment. APOE ε4 carriers have been reported as having lower hippocampal volume in Alzheimer’s disease, mild cognitive impairment, and in healthy cohorts, 1 but this is not well investigated in stroke. Here, we compared the regional volume in...
Article
Full-text available
Around one-third of people develop depression following ischaemic stroke, yet the underlying mechanisms are poorly understood. Post-stroke depression has been linked to frontal infarcts, mainly lesions in the left dorsolateral prefrontal cortex (DLPFC). But depression is a network disorder that cannot be fully characterised through lesion-symptom m...
Article
Full-text available
Age-related cognitive decline is a significant public health concern. Recently, non-pharmacological methods, such as physical activity and mental training practices, have emerged as promising low-cost methods to slow the progression of age-related memory decline. In this study, we investigated if Tai Chi Chuan (TCC) and Baduanjin modulated the frac...
Article
Disruptions to functional connectivity in subsystems of the default mode network are evident in Alzheimer's disease (AD). Functional connectivity estimates correlations in the time course of low-frequency activity. Much less is known about other potential perturbations to this activity, such as changes in the amplitude of oscillations and how this...
Chapter
This chapter is intended as a primer to the most widely used neuroimaging methods available in the prediction, diagnosis and monitoring of the neurodegenerative diseases. We describe the imaging methods that allow us to examine brain structure, function and pathology and investigate neurodegenerative mechanisms in vivo. We describe methods to inter...
Article
Full-text available
Depression is a common outcome following stroke, associated with reduced quality of life and poorer recovery. Despite attempts to associate depression symptoms with specific lesion sites, the neural basis of post-stroke depression remains poorly understood. Resting state fMRI has provided new insights into the neural underpinnings of post-stroke de...
Poster
Full-text available
Amplitude of low-frequency oscillations and episodic memory dysfunction in Alzheimer’s Disease
Article
Full-text available
Background. Visual cue conditioning is a valuable experimental paradigm to investigate placebo and nocebo effects in pain. However, little attention has been paid to the cues themselves and potential variability of effects (their quantity and quality) stemming from the choice of stimuli. Yet, this seemingly methodological question has important imp...
Article
Full-text available
Cognitive impairment is one of the most common problem saffecting older adults. In this study, we investigated whether Tai Chi Chuan and Baduanjin practice can modulate mental control functionand the resting state functional connectivity (rsFC) of the cognitive control network in older adults. Participants in the two exercise groups practiced eithe...
Article
Full-text available
Transcutaneous vagus nerve stimulation (tVNS), a non-invasive method of brain stimulation through the auricular branch of the vagus nerve, has shown promising results in treating major depressive disorder (MDD) in several pilot studies. However, the neural mechanism by which the effect on depression might be achieved has not been fully investigated...
Article
Full-text available
Previous studies provide evidence that aging is associated with the decline of memory function and alterations in the hippocampal (HPC) function, including functional connectivity to the medial prefrontal cortex (mPFC). In this study, we investigated if longitudinal (12-week) Tai Chi Chuan and Baduanjin practice can improve memory function and modu...
Article
Full-text available
Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA). Over a period of 4 weeks (six treatments), we collected resting state...
Article
Full-text available
Our experience with the world is shaped not only directly through personal exposure but also indirectly through observing others and learning from their experiences. Using a conditioning paradigm, we investigated how directly and observationally learned information can affect pain perception, both consciously and non-consciously. Differences betwee...
Article
Full-text available
Subthreshold depression (StD) is a prevalent condition associated with social morbidity and increased service utilization, as well as a high risk of developing into a major depressive disorder (MDD). The lack of well-defined diagnostic criteria for StD has limited research on this disorder, with very few brain-imaging studies examining the neurobio...