Nasser Alhajj

Nasser Alhajj
South East Technological University · Science

Master of Science (Pharmaceutics)

About

8
Publications
2,742
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65
Citations
Introduction

Publications

Publications (8)
Article
Full-text available
Nano spray drying has emerged as an outstanding platform for engineering micro- and nanoparticles, with growing applications in various areas of drug delivery. As a new technology involving distinct technical design, parameters of the nano spray drying process are not fully elucidated. In a quality-by-design approach, the aim of the current study w...
Article
Spray drying is an increasingly used particle engineering technique for the production of dry powders for inhalation. However, the amorphous nature of most spray-dried particles remains a big challenge affecting both the chemical and the physical stability of the dried particles. Here, we study the possibility of producing co-amorphous ciprofloxaci...
Article
Cystic fibrosis (CF) is an inherited multisystem disease affecting the lung which leads to a progressive decline in lung function as a result of malfunctioning mucociliary clearance and subsequent chronic bacterial infections. Pseudomonas aeruginosa is the predominant cause of lung infection in CF patients and is associated with significant morbidi...
Article
Full-text available
Pulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 μm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glycol (PEG) microparticles with different sizes, morph...
Article
Leucine is a promising excipient with several applications in the development of inhalable spray-dried powder of high- and low-dose drugs. The addition of leucine has exhibited significant enhancing effects on the aerosolization and physical stability of the produced particles. Here, we focus not only on the applications of leucine in inhalable spr...
Article
Spray drying is a constructive single-step manufacturing technique used to produce dry powder. Spray drying plays a remarkable role in producing inhalable powder formulations due to its ability to engineer particles with optimized characteristics for inhalation. However, the complexity of drying kinetics and particle formation process coupled with...
Article
Full-text available
Chitosan nanoparticles are exhalation prone and agglomerative to pulmonary inhalation. Blending nanoparticles with lactose microparticles (∼5 µm) could mutually reduce their agglomeration through surface adsorption phenomenon. The chitosan nanoparticles of varying size, size distribution, zeta potential, crystallinity, shape and surface roughness w...
Article
Introduction: Pulmonary drug delivery is organ-specific and benefits local drug action for lung cancer. The use of nanotechnology and targeting ligand enables cellular-specific drug action. Combination approaches increase therapeutic efficacy and reduce adverse effects of cancer chemotherapeutics that have narrow therapeutic index window and high c...

Questions

Question (1)
Question
Hi,
I notice that several publications in developing dry powder for inhalation mention the FPF of the dry powder without the ED. I think that can cause mislead readers. For example if FPF value is 90% might sounds excellent but if the hidden ED was only 10% then the story will be different.
I am not sure if I am right or I missed some facts. I would be glad to find opinions of other researchers in the field.
Best regards

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