Nasrin Ziamajidi

• PhD in Clinical Biochemistry
• Professor at Hamadan University of Medical Sciences

Background: Various effects, such as oxidative stress and the induction of apoptotic genes, have been reported regarding selenium nanoparticles (SeNPs) on human cell lines. Objectives: This report studied the effects of SeNPs on SW480, a human colon cancer cell line. Methods: The effects of nanoparticles on the SW480 cell lines were investigated us...

This study explores the role of LINC00839 and its potential interaction with the miR-195-5p/cyclin E1 (CCNE1) axis in oral squamous cell carcinoma (OSCC). Using The Cancer Genome Atlas, we analyzed lncRNA, miRNA, and mRNA sequencing data for OSCC. Different online tools were applied to detect lncRNA-related miRNAs and their target mRNAs, forming a...

Background: The outbreak of the COVID-19 pandemic started in Wuhan, China, in December 2019 and spread rapidly around the world. Effective indicators to evaluate the severity and clinical progress of the disease need to be further investigated so that they can be used to reduce mortality. We sought to analyze the laboratory findings of some cases o...

Background: Gold nanoparticles (AuNPs), a new cancer treatment, have few side effects. Objectives: This study aimed to investigate the effect of AuNPs on oxidative stress in HCT-116 colon cancer cells. Methods: The viability of HCT-116 cells was evaluated using the 3-(4,5-dimethylthiazol-2,5-diphenyl) tetrazolium bromide (MTT) assay after 24 and 48...

Background Selenium nanoparticles (SeNPs) have special applications in biochemistry and physics that enable various effects, such as oxidative stress or antioxidant activity. In the present study, the effect of SeNPs on SW480 cell lines via MTT assay, determination of ROS and stress oxidative enzymes activities, and gene expression of Bax, Bcl2, an...

Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in the field of cancer research. The goal of this research was to explore the oxidative stress, apoptosis, and angiogenesis in SKBR3 breast cancer cells after exposure to AgNPs. The survival rate of SKBR3 cancer cells and MCF-10A normal br...

Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in the field of cancer research. The goal of this research was to explore the oxidative stress, apoptosis, and angiogenesis in SKBR3 breast cancer cells after exposure to AgNPs. The survival rate of SKBR3 cancer cells and MCF-10A normal br...

This study aimed to evaluate the protective effects of All-trans retinoic acid, Alpha-tocopherol, and vitamin C against ZnO-NP-induced kidney damage. Fifty-four rats were divided into nine groups, including Groups Con1 (deionized water), Con2 (olive oil), VitA (All-trans retinoic acid 1000 IU/kg), Group VitE (Alpha-tocopherol 100 IU/kg), VitC (Vita...

Objective(s): Breast cancer is the most common malignancy in women. MiRNAs modulate the PI3K/AKT/mTOR (PAM) pathway, functioning as either tumor suppressors or oncogenes. This research explores the impact of AgNPs on breast cancer cells while emphasizing the interplay between miR-133a and the PAM pathway and uncovering regulatory mechanisms. Materi...

Breast cancer is particularly severe in women. Research highlights the crucial role of miRNAs in key cellular processes, showcasing their intricate interactions with the oncogenic PI3K/AKT/mTOR (PAM) signaling pathway and underscoring their significant role as tumor suppressors. The effect of silibinin on cell growth and survival was evaluated usin...

Introduction This study aimed to evaluate the protective effects of All-trans retinoic acid, Alpha-tocopherol, and vitamin C against on ZnO-NP-induced kidney damage. Material and methods Fifty-four rats were divided into nine groups including Groups Con1 (deionized water), Con2 (olive oil), VitA (All-trans retinoic acid 1000IU/Kg), Group VitE (Alp...

Background The use of nanoparticle drug delivery systems to enhance the therapeutic efficacy and reduce the side effects of anticancer drugs is taken into consideration. Astaxanthin (ATX) is a natural xanthophyll carotenoid with antioxidant, anti-inflammatory, and antiapoptotic properties used to prevent and treat some cancers. Objectives In the p...

Background The association between metabolic syndrome (MetS) and breast cancer may significantly impact the mortality and incidence of breast cancer. This study aimed to assess the association between MetS risk factors and immunohistochemical (IHC) profiles in women with breast cancer. Methods This cross-sectional study used the medical records of...

Background TiO2 nanoparticles is a transition and heat resistant metal used in medicine, dentistry, and bone fixators. Objective The effect of TiO2 nanoparticles on oxidative stress and apoptosis in HCT116 colon cancer cells was studied. HCT116 cells were cultured in DMEM supplemented with 10% FBS. Free radicals were assessed using a fluorimeter....

Background: Bladder cancer (BC) is known as the most frequent neoplasm of the urinary system, whose prevalence has significantly increased over the past three decades. Successful treatment of BC is a highly challenging task. In this regard, several studies have demonstrated that increased level of oxidative stress may cause cancer cells death. Furt...

Some reports emphasize that zinc oxide nanoparticles (ZnO NPs) are detrimental to the reproductive organs of animals. As such, this research aimed at exploring the apoptotic potential of ZnO NPs on testis along with the beneficial role of Vitamins (V) A, C, and E against ZnO NP-induced damage. To this aim, a population of 54 healthy, male Wistar ra...

The outbreak of the COVID-19 infection has led to the rapidity of vaccine usage in recent years. Emerging data indicate that the efficacy of vaccination against COVID-19 was about 95% in the general population, though its impact is impaired in patients with hematologic malignancies. As such, we decided to research the publications in which the auth...

Purpose MicroRNAs (miRNAs) are regulatory molecules capable of positively or negatively regulating signaling pathways, and are involved in tumorigenesis as well as various aspects of cancer. The purpose of this study was to investigate the expression levels of miR-133a, miR-637, and miR-944 in serum and tumor tissues as well as their relationship w...

One of the most often utilized nanoparticles (NPs) in several technologies is zinc oxide (ZnO) NPs. However, these NPs are said to have harmful effects on the reproductive system. Thus, we designed this study to specify the potential preventive activity of vitamins (Vits) A, C, and E, as antioxidants, against toxicity of ZnO NPs in the testes of ra...

Background The rapidly increasing applications of zinc oxide nanoparticles (ZnO NPs) in various industries have led to growing concerns about their damaging influence on human health. The present research was designed to determine the protective action of vitamins (Vits) A, C and E on the heart toxicity induced by ZnO NPs.Methods Fifty-four male Wi...

Objective: Pulmonary toxicity induced by CCl4, a model of idiopathic pulmonary fibrosis (IPF), leads to tissue remodeling and inflammation. Human umbilical cord mesenchymal cell-conditioned medium (hMSC-CM) is a potent anti-inflammatory, antioxidative, and antifibrotic agent. Methods: Forty male Wistar rats were assigned to the control (C), oliv...

Background: MicroRNA (miRNA) is a regulatory molecule capable of positively or negatively regulating signaling pathways and furthermore assumes a part tumorigenesis and various aspects of cancer. The purpose of this study is to investigate the expression level of miR-133a, miR-637 and miR-944 genes in serum and tumor tissue and their relationship w...

Cu nanoparticles (CuNPs) have various applications in biomedicine, owing to their unique properties. As the effect of CuNPs on the induction of oxidative stress and apoptosis in the human colorectal cancer cell line SW480 has not yet been studied, we investigated the toxicity and mechanism of action of these NPs in SW480 cells. MTT assay was perfor...

Breast cancer is a multifactorial disease, and among the many factors which are involved in the onset, progression, and invasion of the disease, oxidative stress plays a significant role. The concentration and activity of enzymatic antioxidants are proportional to the concentration of trace elements, and the concentration of trace elements is often...

Background: Breast cancer is one of the leading causes of death in women worldwide. This causes an increase in free radicals, resulting in oxidative stress. The aim of this study was to determine the effect of breast cancer on oxidative stress and its relationship with hematological indices. Methods: This case-control study included 43 women wit...

Bladder cancer is defined as a urinary tract malignancy that threatens men's and women's health. Due to the side effects of common chemotherapies, novel therapeutic strategies are necessary to overcome the issues concerning bladder cancer treatments. Nanotechnology has been suggested as a means to develop the next-generation objectives of cancer di...

Objective: The current study was designed to investigate the protective effects of curcuma caplet against titanium dioxide nanoparticles (nTiO2)-induced damage in liver and kidney of male Wistar rats. Materials and methods: Thirty adult (7-8 week old) male rats (200 g) were randomly divided into 5 groups of 6 each. The first and second groups re...

Introduction: Nanomedicine has recently been known as an emerging research area with promising applications in cancer diagnosis and treatment. Aside from this, gold nanoparticles (AuNPs), as one of the important components of nanomedicine, have attracted considerable attention due to their special physicochemical properties and lower toxicity than...

The beneficial role of glutathione (GSH), as an important component of antioxidant defense system, on sperm parameters in rats following exposure to ZnO NPs

Background: Pharmacotherapy with medicinal plants is a promising approach to treat cancer. Cinnamon is a medicinal plant whose properties have been proven in various fields of medical sciences. Among its biological activities, its antioxidant and antiviral effects can be mentioned. In this study, the antitumor effects of Cinnamon with a focus on g...

Introduction This study aimed to investigate the apoptotic and anti-cancer effect of gold nanoparticles (AuNPs) on apoptosis in HCT-116 colon cancer cells. Materials and methods The level of ROS and apoptosis were determined by fluorimetric method and flow cytometry and Hoechst 33,258 staining, respectively. Furthermore, the mRNA expression of Bax...

Cu nanoparticles (CuNPs) have various applications in biomedicine, owing to their unique properties. As the effect of CuNPs on the induction of oxidative stress and apoptosis in the human colorectal cancer cell line SW480 has not yet been studied, we investigated the toxicity and mechanism of action of these NPs in SW480 cells. An MTT assay was per...

Breast carcinoma is a heterogeneous disease that affects millions of women worldwide. Wilms’ tumor 1 (WT1) is an oncogene that promotes proliferation, metastasis and reduces apoptosis. MicroRNAs (miR) are short noncoding RNAs with a major role in cancer metastasis. In present study, we investigated the association of serum level of WT1 with oxidati...

In recent years, morbid obesity cases have increased. Inflammation and oxidative stress levels are also elevated in these people, and many obesity-related diseases arise from high levels of these factors in obesity. Therefore, in the present study, the effect of gastric bypass surgery on the oxidative and antioxidant status of morbidly obese people...

Background and objectives Obesity is known as a disease with a chronic low-grade state of inflammation and high levels of oxidative stress. Given the challenges and consequences caused by obesity, obesity therapy is an essential subject to address. For sustainable weight loss, gastric bypass surgery is the most successful and essential option. Met...

Nanoparticles are vastly exploited in today’s technology. However, it is realized that exposure to high concentrations of nanoparticles (NPs) may have adverse effects on human health. According to previous reports, zinc oxide (ZnO) NPs cause toxic effects in tissues via inducing apoptosis. The current work was designed to evaluate possible protecti...

Background: Oxidative stress has been shown to be an important factor, which plays a significant role in the pathogenesis of neurodegenerative disorders. Heat Shock Protein-27 (HSP-27) has been implicated in antioxidant responses against oxidative stress. Trehalose is a natural disaccharide widely used in a variety of food products with demonstrate...

The in vitro effects of insulin-loaded trimethyl chitosan nanoparticles (nano-insulin) in HepG2 cells were explored in this study. Its toxicity, along with glucomodulatory effects, was measured to evaluate its potential at the cellular level. Different concentrations of insulin and nano-insulin were evaluated on HepG2 cultured cells to study their...

Background & Objective: Retinopathy is a common difficulty in diabetic subjects. Hyperglycemia damages the tissues through stimulation of oxidative stress and inflammation. Since the antioxidant function of garlic has been proven, in the current report the activity of aqueous garlic extract (AGE) upon the oxidative stress and inflammation in the re...

The ever-increasing use of zinc oxide nanoparticles (ZnO NPs) in industrial and consumer products leads to concerns about their safety. Liver is one of the most important target organs of nanoparticles after entering the body. As such, the aim of this study was to evaluate the protective effects of vitamins (Vit) A, C, and E on ZnO NPs-induced live...

Background and purpose One of the most important complications of diabetes mellitus (DM) is liver damage. Hyperglycemia-induced inflammation is a major cause of diabetic complications. Therefore, compounds with hypoglycemic properties can be useful in controlling the complications of diabetes. The purpose of the current report was to evaluate the i...

Background: Hyperglycemia damages various tissues such as the testes through oxidative stress and inflammation, which can eventually lead to infertility. Objective: Garlic extract effects on the testicular tissue of diabetic rats were investigated. Materials and methods: In this experimental study, 36 male Wistar rats (8-wk old, weighing 230-3...

Titanium dioxide nanoparticles (nTiO2) can accumulate in different tissues and damage them with oxidative stress induction. Different components with antioxidant capacity can protect the tissues. So in this study, the protective effects of vitamin A and E on the nTiO2-induced oxidative stress in rats’ spleen tissues were examined. Thirty-six male W...

AimsType 2 diabetes mellitus (T2DM) is a highly prevalence disease that has a close relation with secretory factors such as adipokines and myokines. C1q tumor necrosis factor-α (TNF-α)-related protein 15 (CTRP15) is a paralogue paralogue of adiponectin that has a close relation with insulin resistance and inflammation. The present study aimed to as...

Nanotechnology is a developing and revolutionary science that has been widely recommended for diagnosis and treatment of cancer. Among the various nanoparticles used in nanotechnology, gold nanoparticles (AuNPs) have attracted much attentions due to their promising anticancer properties. Despite the potential advantages of AuNPs, their apoptotic an...

Background The growing prevalence of bladder cancer worldwide has become a major concern for the researchers, and the side effects of chemotherapy drugs have always been a major problem in cancer treatment. Cinnamaldehyde, the active ingredient in the Cinnamon plant, has long been considered with anti-oxidant and anti-inflammatory effects. Methods...

This report was aimed to study the validity of vitamins A and E on the spermatogenesis disorders caused by titanium dioxide nanoparticles (TiO2 NPs). Thirty-six male Wistar rats were randomly divided into six groups. Two groups as controls received bi-distilled water and olive oil for three weeks, respectively. The third group treated with 300 mg/k...

This study aimed to evaluate the effects of iron and ω-3 polyunsaturated fatty acids (PUFA) supplementations in the heart tissue of Wistar male rats with T2DM. After diabetes induced by High fat diet and streptozotocin (HFD-STZ) in animals, oxidative stress markers, including TOS, TAC, OSI (oxidative stress index), MDA, expression of RAGE, ICAM-1,...

BACKGROUND: This study aimed to evaluate the effects of iron and ω-3 polyunsaturated fatty acids (PUFA) supplementations in the heart tissue of Wistar male rats with T2DM. After diabetes induced by HFD-STZ in animals, oxidative stress markers, including TOS, TAC, OSI (oxidative stress index), MDA, expression of RAGE, ICAM-1, VCAM-1, TNF-α, tissue l...

Aim: The study aimed to explore miR-600 and WT1 expression and its potential clinical significance in breast cancer. Materials & methods: The expression of miR-600 and WT1 in tumor and non-tumor adjacent tissues in 45 breast cancer patients as well as serum level of miR-600 in these patients and 45 healthy group were analyzed. Results: The expressi...

Retinopathy is one of the most common complications of diabetes. Hyperglycemia damages to the tissues through induction of oxidative stress and inflammation. In this study, the effects of garlic extract on the oxidative stress status and interleukin-1 beta (IL-1β) mRNA and protein levels in the retinal tissue of diabetic rats were investigated. Twe...

The effects of human umbilical cord blood mesenchymal stem cells conditioned medium (hMSC-CM) on Lysyl oxidase (LOX) family gene expression and proteins were evaluated. Fifty-four male Wistar rats were divided into nine groups. The control groups received olive oil and phosphate-buffered saline (PBS) while untreated groups received CCl4. The treate...

Carbon tetrachloride (CCl4) as environmental toxin induces tissue damage through oxidative stress. In the present study, the effect of treatment with Human Umbilical Cord Blood Mesenchymal Stem Cell Conditioned Medium (hMSC-CM) was evaluated on improvement of chronic injectable CCl4-induced oxidative stress. Fifty-four male rats were divided into n...

Non-alcoholic fatty liver disease (NAFLD) is associated with lipid accumulation and lipotoxicity. The main aim of this study is to evaluate the synergistic treatment effect of fish oils (FOs) and chicoric acid (CA) in palmitate (PA)-induced NAFLD HepG2 model. HepG2 cells were pre-treated with palmitate (0.75 mM) for 24 h, and then were exposed to C...

Bac Coronary artery disease (CAD) is the leading cause of death worldwide and most commonly develops as a result of atherosclerosis. ANGPTL8 is a secreted adipokine that regulates lipid metabolism and is associated with cardiometabolic diseases, including type 2 diabetes and CAD. However, the association between circulating ANGPTL8 levels and CAD i...

In the present study, the simultaneous carrier ability of natural antioxidant of astaxanthin (ATX) and chemotherapeutic drug of 5-fluorouracil (5-FU) by whey protein of β-lactoglobulin (β-LG) using various spectroscopic techniques (UV–visible, fluorescence, circular dichroism (CD) and dynamic light scattering) in combination with molecular docking...

Aims: Receptor for advanced glycation end products (RAGE) production is induced by diabetes. Microglial cells are activated by RAGE and produce inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and oxidative stress markers. Persistent production of TNF-α can provide a link between diabetes and Alzheimer's disease (AD). The purpose of...

Background and objective: In spite of therapeutic effect of tamoxifen on the breast cancer, it has some side effects on the liver including non-alcoholic fatty liver disease. In this study the effects of Rosa canina distilled water on the tamoxifen-induced fatty liver and oxidative stress status in male rats were investigated. Materials and metho...

Targeting irisin as a myokine/adipokine is a new therapeutic approach in the improvement of insulin-resistance (IR) during type 2 diabetes (T2D). In present study we evaluated the effects of palmitate and chicoric acid (CA) on irisin production in peripheral blood mononuclear cells (PBMCs) of patients with T2D. This study performed on 20 newly diag...

Purpose: Breast cancer (BC) is globally the main reason of cancer-related deaths in women. Omentin-1, an anti-inflammatory and antioxidant adipokine, plays different roles in tumorigenesis and anti-oncogenic pathways. In present study, we investigated the association of omentin-1 with oxidative stress and clinical significances in healthy controls...

Background Diabetes mellitus is a chronic metabolic disorder that undesirably affects both central and peripheral nervous systems through the apoptosis of neurons. Insulin and insulin-like growth factors (IGFs) inhibit apoptosis of oligodendrocytes. The objective of this study was to determine whether oral insulin in the form of nanoparticles may h...

Objective Oxidative stress and inflammation play an important role in the pathogenesis of diabetes and its complication. In this study, we aimed to evaluate and compare oxidative stress markers and antioxidant enzymes activity, as well as Interleukin 6 (IL-6) level in newly diagnosed type 2 diabetes mellitus (T2DM) patients and healthy subjects. M...

Abstract In the current study, we developed resveratrol (RES)-loaded solid lipid nanoparticle (SLN-RES) in order to improve insulin resistance through the upregulation of SNARE protein complex in rats with type 2 diabetes. The SLN-RES characteristics include the following: the average size of 248 nm, the zeta potential of − 16.5 mV, and 79.9% RES e...

The increasing application of titanium dioxide nanoparticles (NTiO2) in life and the toxicity potential of these nanoparticles have raised concerns about their detrimental effects on human health. This study was conducted to investigate the hepatoprotective effects of vitamin E and vitamin A against hepatotoxicity induced by NTiO2 in rats. Thirty-s...

Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patients and healthy subjects and expl...

Background Liver dysfunction is a predominant complication of diabetes. Herbal remedies such as garlic are commonly used for reducing diabetic complications. In this study the effect of garlic extract on glucose level, liver enzymes activities in the serum and nitric oxide (NO) level, oxidative stress status, and histology in the liver tissues of s...

Objective(s) Chronic hyperglycemia leads to activation of the advanced glycation end products (AGE)-receptor (RAGE) for AGE axis and oxidative stress, which promote diabetic renal damage. This study examines the effect of insulin-loaded trimethyl chitosan nanoparticles on the kidney tissue of diabetic rats. Materials and Methods Twenty-five male W...

In diabetes, the increasing blood glucose levels through oxidative stress, with increase in inflammatory cytokines and growth factors, such as TGF-β1, can cause long-term complications, including nephropathy. Subcutaneous injection of insulin is a common method used to treat Type 1 diabetes, which can lead to problems such as hypoglycemia and edema...

Background: Subcutaneous injection of insulin can lead to problems such as hypoglycemia and edema. Objective: The purpose of this research was to evaluate the effect of oral insulin-coated trimethyl chitosan nanoparticles on control of glycemic status, IGF-1 and IGF-2 levels, and apoptosis in the hippocampus of rats with diabetes mellitus. Meth...

The objective of this study was to investigate the effect of free tamoxifen and tamoxifen-loaded solid lipid nanoparticles (SLN) on cytochrome P450 (CYP3A2) and flavin-containing monooxygenase1 (FMO1) genes expression in the liver of female Wistar rats. Thirty female Wistar rats aged 7–8 weeks, were divided into six groups of six rats each. The fir...

Background Diabetic nephropathy and liver damage are important complications of diabetes mellitus (DM). Various factors, such as sirtuins (silent information regulators or SIRTs) are associated with these complications. Sirtuins are a family of NAD ⁺ -dependent proteins, and seven types of these can be found in mammalians. In this study, we evaluat...

Background: An in vivo study was carried out to study of telomerase reverse transcriptase and Uterine-Ovarian-specific genes expression in the endometrial tissue of ovariectomized female Sprague-Dawley rats. Material and methods: Twenty-four female Sprague-Dawley rats divided into 4 groups of six rats. The first and second groups were ovariectom...

Introduction: Tamoxifen (TMX) has harmful dose-dependent long-term side effects such as liquid retention in postmenopausal breast cancer patients. Although, encapsulation of low-dose TMX in colloidal delivery systems have been effective, an in vivo study is needed to survey the effect of TMX-loaded Solid Lipid Nanoparticles (TMX-loaded SLN) on the...

Objective: The aim of this study was to explore the efficacy of insulin-loaded trimethylchitosan nanoparticles on certain destructive effects of diabetes type one. Materials and methods: Twenty-five male Wistar rats were randomly divided into three control groups (n=5) and two treatment groups (n=5). The control groups included normal diabetic r...

Introduction: Retinopathy is one of the most important complications of diabetes mellitus that results from chronic hypeglycemia, oxidative stress and inflammation. Tumor necrosis factor-beta2 (TGF-β2) is an important factor in the inflammation pathway due to hyperglycemia. Garlic is one of the most frequently used plants in Iranian diets that has...

Diabetes mellitus (DM) is one of the most prevalent diseases in the world, which is strongly associated with liver dysfunction. Hyperglycemia, through an oxidative stress pathway, damages various tissues. Herbal medicine is a good candidate to ameliorate hyperglycemia and oxidative stress. In this study, the effects of aqueous Allium sativum (garli...

Introduction: Zinc is part of the antioxidant system; so, zinc deficiency impairs the body's antioxidant defense system and leads to increased oxidative stress. The objective of this study was to investigate the effect of zinc oxide on antioxidant level in rats. Methods: Twenty-five male Wistar rats of 5-8 weeks old were divided into five groups of...

Hexokinase (HK) is the first enzyme of glycolysis pathway. In brain, most dominant form of HK, HK-I, binds reversibly to the outer mitochondria membrane. Those metabolites that affect binding or releasing of the enzyme from the mitochondria have regulatory effect on glucose consumption of the cell. In this study destructive effect of phenylalanine...

Background: Diabetes mellitus (DM) is a common metabolic disorder with disruption of glucose and lipid metabolism. Many herbal extracts are used for treatment of diabetes. Allium sativum, (garlic), is one of a plant that is routinely used in Iranian population. In this study we investigated the effects of aqueous garlic extract on biochemical param...

Context: Allium sativum L. (Liliaceae) (garlic) is a medicinal plant that is widely used in herbal medicine. Nephropathy is a complication of diabetes that is induced by long-term hyperglycaemia. Objective: The effects of aqueous extract of garlic (AGE) on the expression of tumour necrosis factor-alpha (TNF-α) and oxidative stress status were studi...

Background: The effect of tamoxifen on endometrial carcinogenesis stems from its estrogen agonist effect. An in vivo study was carried out to compare the effect of tamoxifen-loaded solid lipid nanoparticles and free drug on the ER-α and VEGF-A genes expression. Material and methods: Twenty-four female Sprague-Dawley rats divided into 4 groups of...

Blood and urine biochemistry screening tests are important for initial detection of diabetes, determination of severity of its complications, and monitoring of therapy. We evaluated the effects of aqueous chicory seed extract (CSE), on renal biochemical parameters, histology, and Na+/glucose cotansporters, SGLT1 and SGLT2 expression levels using me...

One of the most important complications of diabetes is nephropathy. This study investigates the effects of aqueous garlic extract on inflammation and oxidative stress status in the kidneys of diabetic rats. Male rats were divided into four groups- control rats, diabetic rats, garlic extract-treated diabetic rats, garlic extract-treated normal rats....

Some medications may change trace element levels in the body. Extracts of various plants, due to having the several elements, can have beneficial effects. Consumption of herbal extracts with chemical drugs may reduce adverse effects of medication. The goal of this study was to evaluate copper (Cu), zinc (Zn), and manganese (Mn) concentrations in se...

Increased c-Cbl associated protein (CAP) level in adipose tissue can facilitate glucose uptake via GLUT 4 in adipocytes. Increased level of CAP results from activation of PPARγ transcription factor. Biochanin A, soy isoflavonoid, is a PPARγ agonist. Present study was designed to investigate the influence of Biochanin A supplementation on CAP gene e...

Increased plasma level of adiponectin can improve insulin resistance in skeletal muscle cells. Activation of PPARγ transcription factor can increase the expression of adiponectin gene and adiponectin level. Biochanin A, a natural compound, is a PPARγ agonist. The aim of this study was to investigate the effect of Biochanin A administration on adipo...

Background: Recently tamoxifen-loaded solid lipid nanoparticles were introduced as innovative drug delivery system for the treatment of hormone-sensitive breast cancer. An in vitro study was conducted to determine the antioxidant status induced by tamoxifen-loaded solid lipid nanoparticles in female Wistar ovariectomized rats. Materials and Methods...

Background: Inflammation is an early event in the development of diabetes type 2 (T2D). Cichorium intybus L. (chicory) possesses anti-inflammatory action. We compared the anti-inflammatory aspect of aqueous chicory seed extract (CSE) in early and late stage T2D in rats. Methods: Wistar albino rats were divided into nine final groups (n = 6). Thr...