Nasrin Saki

• Associate professor of dermatology
• Professor (Associate) at Shiraz University of Medical Sciences

Introduction: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Topical corticosteroids as the mainstay of treatment have many side effects, both cutaneous and systemic. Sertaconazole is an antifungal cream with anti-inflammatory, antipruritic and antistaphylococcal activity. In this study, the authors compare the effect of hyd...

Introduction Acne vulgaris is a common disease involving adolescents predominantly, which can lead to scar formation. This study aimed to compare the efficacy of fractional CO2 laser therapy, alone or combined with topical Timolol or insulin, for acne scar treatment, which has not been yet rigorously investigated. Method In this Randomized Control...

Epidermolysis bullosa (EB) is an inherited disease that causes widespread symptoms characterized by extreme epithelial fragility. This study examined traditional, complementary, and integrative medicine (TCIM) usage among EB patients referred to clinics at Shiraz University of Medical Sciences between 2019 and 2020. We enrolled the patients with EB...

Introduction Melasma, also known as chloasma, is a common skin disorder characterized by acquired hyperpigmentation. Many patients with this condition prefer using herbal remedies instead of chemical agents. This study aims to review clinical trials conducted on the effectiveness of herbal remedies in treating melasma. Methods In this scoping revi...

Background Solar lentigines are common hyperpigmented lesions typically appearing after 50 years of age and associated with negative psychological effects in affected individuals. Topical depigmenting products, such as hydroquinone and even the Kligman's formula, are usually ineffective for treating lentigines. Stabilized cysteamine has been recent...

Introduction Infraorbital hyperpigmentation represents one of the most prevalent conditions in cosmetic dermatology. To treat this condition, many patients prefer natural remedies. This study explored the efficacy of topical castor oil cream in treating patients with infraorbital hyperpigmentation. Methods We conducted an exploratory single‐arm cl...

Introduction Epidermolysis Bullosa EB is an inheritable bullous disorder characterized by massive blistering of the skin in response to minor trauma.

Introduction: Palmar hyperhidrosis or excessive palmar sweating can reduce one's quality of life as it is associated with significant physical and occupational disabilities. We compared the gel and nanoemulgel of oxybutynin in treating these patients. Materials and methods: This pilot study was performed as a double-blind controlled randomized c...

Objective: Vulvovaginal symptoms are common in postmenopausal women and can affect their quality of life and sexual function. Using a sample of postmenopausal Iranian women, we evaluated a Persian translation of the Vulvovaginal Symptoms Questionnaire (VSQ). Methods: This study included 201 postmenopausal Iranian women referred to dermatology an...

Objective: Brimonidine is a vasoconstrictive agent used to treat several dermatologic disorders. Here, we review the uses of brimonidine in different aspects of dermatology. Methods: We searched keywords including rosacea, erythema, topical brimonidine, dermatology, and skin disease in PubMed, Cochrane, and Google Scholar to collect the related...

Background: Non-melanoma skin cancer (NMSC) is the most common type of cancer in the world. In traditional Persian medicine (TPM), various types of temperament (Mizaj) are considered to diagnose, treat, and prevent a variety of illnesses. The present study aimed to evaluate the temperament of patients with NMSC in comparison with a control group....

Although antibiotics are among the most commonly used treatments of acne, there are refractory cases, or they can cause some complications. Recently, leukotriene B4 has been found to play a major role in inflammatory acne lesions. This double‐blind, randomized clinical trial was conducted on 108 patients with acne who needed systemic therapy and re...

A 56-year-old with pustular lesions on extensor areas: what is your diagnosis? CLINICAL PRESENTATION The patient was a 56-year-old woman with a history of hypertension and hyperlipidemia from one year ago. About two years ago, papule and pustular lesions emerged in the extensor area of both elbows; the lesions were accompanied by purulent discharge...

Pruritus is a symptom that adversely affects the quality of life of patients with epidermolysis bullosa (EB). Although studies indicate the positive effect of gabapentin on some types of pruritus, its effect on pruritus due to EB remains unexplored. Hence, this study investigated the efficacy of topical gabapentin in treating EB pruritus. We pilote...

Background Immunization against the coronavirus disease 2019 (COVID-19) began in January 2021 in Iran; nonetheless, due to a lack of vaccination among children under 12, this age group is still at risk of SARS-CoV-2 infection and its complications. Case presentation SARS-CoV-2 infection was diagnosed in a 6-year-old girl who had previously been he...

Various conditions, including infections, can cause telogen effluvium (TE). One of them is coronavirus disease 2019 (COVID‐19), where hair loss usually begins between 2 and 12 weeks after the illness. TE can be acute or chronic, and the chronic type can be intermittent. Here, we present the case of a 17‐year‐old girl with severe and widespread hair...

Introduction: Epidermolysis bullosa (EB) is a rare inherited genetic skin disorder with severe skin itching and recurrent blisters and erosion. There is no effective and specific therapy for all types of EB. Objective: The aim of this study was to evaluate a topical formulation of henna (Lawsonia inermis L.) in the management of wounds and the itc...

Primary cutaneous CD4+ small to medium T-cell lymphoproliferative disorder is rare, accounting for only 2-3% of all primary cutaneous lymphomas. In this report, we describe the case of a 50-year-old man with an asymptomatic, small, round nodule on his temple area.

Various conditions, including infections, can cause telogen effluvium (TE). One of them is coronavirus disease 2019 where hair loss usually begins between two and twelve weeks after the illness. Here, we present the case of a 17-year-old girl with having a history of such attacks since childhood.

With the investigation of the efficacy of laser therapy in primary localized amyloidosis(PLCA) only recently starting to materialize, we aimed to review the currently available studies of laser therapy in the management of the disease. We searched PubMed, Scopus, Embase, Web of Science, Cochrane, and ProQuest online databases with a specified searc...

Objectives: Striae distensae (SD) are common skin condition that have posed a significant challenge regarding their assessment and treatment. The present study aimed to evaluate the efficacy of microneedling in comparison to Fractional CO2 laser therapy. Methods: Similar striae were selected and photographed. Each side was randomly assigned to b...

Materials and methods: This cross-sectional study was performed on patients with pemphigus vulgaris referred to Faghihi Hospital and Shiraz Dental Faculty in 2017-2018. The participants included 26 women with histopathologically confirmed pemphigus vulgaris and 26 healthy age-matched controls. The serum levels of luteinizing hormone (LH), follicle...

Introduction Melasma remains a recurrent, chronic, therapeutically challenging, and psychologically burdening condition. Several different modalities and approaches have been utilized, and some with notable success to experimentally manage the condition. Cysteamines, with their depigmentation properties, have only recently been intensely studied. O...

Association of functional dyspepsia with selected dermatology complaints and sleep disturbances based on traditional Persian medicine Background: Functional dyspepsia (FD) is a common disorder of the upper gastrointestinal tract. Several documents in conventional medicine claim an association between FD, sleep disturbance, and some dermatological c...

CLINICAL PRESENTATION A 41-year-old man referred to our dermatology clinic with an asymptomatic 2 by 1.5 cm erythematous firm nodule on his scalp. He stated that it had been growing in size gradually over the past three years. The patient had a history of pruritus but never felt any pain at the site of the nodule. In his physical exam, lymphadenopa...

A great deal of scientific evidence have focused on the peculiar erythematous and purpuric violaceous acral lesions in young and healthy individuals resembling chilblains (pernio), leading the scientific community to investigate the association between these lesions and SARS-CoV-2. Furthermore, this is suggestive that some COVID-19 skin manifestati...

Background: Skin cancer is the most common cancer in the world. The aim of this study was to evaluate the quality of life (QoL) of both patients with non-melanoma skin cancer and their relatives. Methods: This is an analytical cross-sectional study on patients with non-melanoma skin cancer and their first-degree relatives referred to dermatology cl...

Background Psychodermatology is an interdisciplinary field in dermatology which involves the interaction between mind and skin. Studies from various parts of the world demonstrate generalized lack of knowledge regarding psychocutaneous disorders among dermatologists. We provide this survey to evaluate the knowledge, awareness, and practice patterns...

Background and aims: Pemphigus vulgaris is a rare autoimmune intraepidermal vesiculobullous disease involving the skin and mucosa. It impacts the quality of life of both patients and their families. Methods: A total of 70 patients with pemphigus vulgaris (either outpatient or hospitalized) were enrolled using the simple sampling method between 2...

Ma'aljobon, a handmade substance, is the liquid portion of coagulated milk after adding vinegar to the heated milk. In traditional Persian medicine (TPM) it has been known as a useful remedy for the treatment of some skin disorders. The aim of this study was to review the applications of Ma'aljobon for skin diseases according to the sages of TPM an...

Ma'aljobon, a handmade substance, is the liquid portion of coagulated milk after adding vinegar to the heated milk. In traditional Persian medicine (TPM) it has been known as a useful remedy for the treatment of some skin disorders. The aim of this study was to review the applications of Ma'aljobon for skin diseases according to the sages of TPM an...

Several types of human papillomaviruses (HPV) induce warts. Warts are one of the most common infections in childhood with a reported prevalence of up to 20%. Warts are divided clinically into genital and non‐genital forms. Plantar warts are common non‐genital warts. In this series five pediatric cases treated with C02 laser for their plantar warts...

Context: Although etiopathogenesis of frontal fibrosing alopecia (FFA) is not fully discovered, it seems that hormonal factors play a role. Aims: The aim of this study was to investigate the serum level of sex hormones in patients with FFA compared to a control group. Settings and design: This was a case-control study. Subjects and methods:...

Primary localized cutaneous amyloidosis (PLCA) is a recalcitrant sporadic dermatological condition and most treatments have failed so far. We studied the efficacy of topical Dimethyl sulfoxide (DMSO) 50% solution in comparison with tretinoin 0.5% cream in treatment of macular amyloidosis. In this split‐side within‐person single‐blinded randomized c...

Background: Pemphigus vulgaris (PV) is a chronic autoimmune disease. Dyslipidemia, increased risk of atherosclerosis and higher cardiovascular morbidity, and mortality have been reported in several autoimmune conditions. It has been hypothesised that there might be an association between dyslipidemia and PV. Therefore, the objective of this study...

Presenter: Abstract Introduction: Acne vulgaris is one of the most common skin disorders, which various factors are involved in its pathogenesis. Recent investigations on intracellular signaling pathway show that the over expression of mTORC1 complex (mammalian target of rapamycin), leads to increased sebum production and altered keratinization, th...

Background: Antibiotics are commonly used in the treatment of acne vulgaris. Considering the rise of antibiotic resistance, alternative medications may be used in the main anti-acne armamentarium. The aim of this study was to investigate the efficacy of oral azithromycin in the treatment of acne vulgaris. Methods: Database searches were performe...

Background: Keloid management remains a challenging clinical problem despite numerous therapies reported until now. The efficacy of corticosteroids in the treatment of keloids has been well established. The most commonly used corticosteroid is intralesional triamcinolone. Sporadic reports on the use of intralesional verapamil suggest its efficacy....

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology. There is evidence that bacteria may contribute to initiating the inflammatory response in HS patients. To date, data on bacteria found in HS lesions and their resistance rates are rare. Methods: The results of bacterial cultures and antibiotic susc...

Background and objective: Psoriasis is a common chronic inflammatory skin disorder affecting any age and gender. The clinical presentation of the nail disease depends on the location of the pathology: nail bed or nail matrix. We aimed to compare the therapeutic effects of triamcinolone acetonide iontophoresis (TI) and topical calcipotriol/betameth...

It is a challenging task to diagnose mycosis fungoides (MF), a type of primary cutaneous lymphoma, in the early stages of its development, due to the unspecific presentations associated with the disease. Histopathology and immunohistochemistry conduce to a more definite diagnosis. Presence of atypical T-cells in epidermis and upper dermis is the mo...

Background: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are 2 inflammatory indicators that increase in many pathologic and physiologic conditions. Pemphigus vulgaris (PV) is an autoimmune skin disease in which autoantibodies against desmogleins cause acantholysis. In this study we have measured ESR and CRP levels in patients w...

The Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two ends of the spectrum of severe immunobullous state characterized by keratinocyte apoptosis. The present study aimed to draw attention to various epidemiological features of SJS and TEN diseases such as causative drugs, underlying diseases, duration of hospitalization, a...

Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. The aim of this study is to assess the preval...

A 14-year-old boy presented with an asymptomatic solitary skin-colored plaque on the frontal area that had been present for five years. In the beginning, the plaque was small but gradually progressed to a large 4 x 4 cm plaque on the forehead (Figure 1a). On the dermatological examination, two café-au-lait macules on the trunk were found. General p...

Introduction: Melasma is a benign, acquired, and chronic hypermelanosis. Topical hydroquinone (HQ) is a conventional choice to treat melasma. Tranexamic acid (TA) is a relatively new brightening agent that interferes with keratinocyte- melanocyte interactions. The aim of the present study was to compare the efficacy and safety of TA intradermal in...

Butterfly Patients in Iran Waiting to Specific Attention from Authorities

Diaper dermatitis is a common disorder. Coriandrum sativum is a herbal remedy with anti-inflammatory, analgesic, anti-microbial and anti-oxidant activities effects. In this non-randomised clinical trial which was performed on 58 infants with diaper dermatitis referred to Faghihi Hospital, Shiraz University of Medical Sciences, the efficacy and safe...

Background Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND). Objective The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients. Method...

Cutaneous leishmaniasis (CL) is one of the most common endemic diseases in Iran. It has a diverse spectrum of clinical manifestations. Herein we present a woman with leishmanial dactylitis, which is a very rare clinical form of CL. Successful treatment consisted of parenteral pentavalent antimonials for two months. Leishmanial dactylitis can be eas...

Background Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin dis...

span lang="EN-US">Clinical trials have reported the efficacy and safety of PS lasers in the treatment of multicolored and recalcitrant tattoos.</span

Pentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cr...

Background: Malignant melanoma, one of the most deadly skin cancers, is a skin tumor that arises from the epidermal melanocytes. The aim of this study is to evaluate the demographic and clinical data of malignant melanoma patients in a referral dermatology center in the south of Iran. Methods: In this retrospective study, we have reviewed files of...

A 52-year-old woman sought medical attention because of several annular erythematous lesions with central clearing on her body since seven months ago. No pruritus or burning sensations were noted. Her medical and family history was unremarkable. Her Fitzpatrick skin photo-type was II. On dermatological physical examination, there were several annul...

Tinea incognito is a dermatophyte infection of the skin with an atypical presentation attributed to inappropriate treatment with immunosuppressive medications. In this report, we have presented the case of a middle-aged lady with tinea incognito that mimicked dermatitis herpetiformis. She had good response to antifungal treatments.

Background: Wart is a common skin disease that can occur at any age. While they are usually benign and self-limited, they can become irritating and cosmetically disabling to patients. The objective of this study is to compare the effectiveness of a topical 85% formic acid preparation with a combination of topical salicylic acid and lactic acid. Met...

Skin manifestations, including scalded skin, desquamation, and chronic periorificial dermatitis, are rare clinical signs in patients with methylmalonic acidemia. This condition may be due to enzyme deficiency or multi-nutrient deficiency because of nutritional restriction. Bullous skin lesion is very rare in these patients and consequently, this ty...

Background: Myocardial infarction remains one the leading causes of mortality and morbidity and involves a high cost of care. Early prediction can be helpful in preventing the development of myocardial infarction with appropriate diagnosis and treatment. Artificial neural networks have opened new horizons in learning about the natural history of di...

Background: Lichen Planus is a common mucocutaneous disease with unknown etiology. Immunodeficiency is a known predisposing factor to this disease. Oral Candidiasis which is an opportunistic fungal infection, commonly affects healthy and immune-compromised patients. Candida has different species bearing different treatments. In this study, research...

Bilateral ear canal eruptive skin tags in an otherwise healthy young lady: a case report Cutaneous skin tags are common skin growths, usually harmless, which protrude from the skin and may have a short, narrow stalk. Typically, they are the same color as the skin or a little darker and appear mostly in the axilla, groin, and cervical area. In this...

Multiple firm, reddish-brown papules and nodules on shoulder and arm The reported case is a 39-year old man who was referred to dermatology clinic with a 10 years history of multiple papules and nodules on his lateral aspect of upper shoulder and the whole right arm (Figure 1). The lesions became larger and increased in number during this period. T...

Pemphigus vulgaris (PV) is one of the most common and studied autoimmune disorders of skin. The knock down of desmogleins in the skin by IgG antibodies will eventually leads to mucocutaneous problems in both genders. Targeting the cardinal molecules involved in the pathways of immune response is the main goal of given therapy. With regard to the si...

Skin manifestations, including scalded skin, desquamation, and chronic periorificial dermatitis, are rare clinical signs in the patients with methylmalonic acidemia. This condition may be due to enzyme deficiency or multi--nutrient deficiency because of nutritional restriction. Bullous skin lesion is very rare in these patients and consequently, th...

Background: As the early and accurate diagnosis of all diseases, including skin disorders directly influences the duration of treatment and its costs, which may be a significant burden, it is very important for physicians to be familiar with all types of diseases, especially those with a higher incidence in population. Considering that disease patt...

Hand eczema is a common distressing skin problem. It is an immune reaction to haptens. Thus, substances that inhibit Immune system can be effective in the treatment of hand eczema. In this study, topical fumaric acid 5% cream is compared with topical steroid in the treatment of hand eczema. Patients with hand eczema were randomly divided into two g...

Alopecia areata is a chronic disease with a great impact on the patient's quality of life. In this study we reviewed the frequency of psychological disorders in patients with alopecia areata in comparison to a control group. We enrolled 40 patients with alopecia areata and a 40-volunteer random age-sex matched control group. The study is based on a...

Background. Psoriasis is a chronic inflammatory skin disease affecting approximately 1-3% of Caucasians. Prolactin has proliferative effects on human keratinocytes, a dominant feature of psoriasis, and it is thought that this hormone may play a role in the pathogenesis of the disease. This study was conducted to confirm or refute these findings in...

Cutaneous metastasis is a rare complication of visceral malignancies. We present a very unusual case of a 33 year-old seemingly healthy man with a sudden and rapidly enlarging skin lesion that was diagnosed as a skin metastasis of his visceral malignancy. Abdominopelvic CT scan revealed thickening of the anterior wall of the urinary bladder and the...

A 12 years old boy, diagnosed with psoriasis since childhood was referred to the dermatology clinic of Aleppo University Hospital,Syria with the chief complaint of erythematous hyperkeratotic lesions on the palms and soles (Figure 1). Similar symmetrical hyperkeratotic areas were extended on the dorsal surfaces of the extremities as well as on knee...

Cutaneous epithelioid angiomatous nodule (CEAN) is regarded as a very rare entity of benign vascular hyperplasia that clinically manifests as mainly single, small, rapidly-growing reddish to bluish nodules or papules, mainly on the head and neck of adults. Most patients present with solitary lesions. We present a 39-year-old female with multiple, r...

Diffuse normolipemic plane xanthoma is characterized by the presence of yellowish-orange plaques on the eyelids, neck, upper trunk, buttocks and flexural surfaces of the extremities in patients with a normal lipid profile. It mainly affects adults of both sexes. Diffuse normolipemic plane xanthomas are usually associated with reticuloendothelial sy...

Background: Hirsutism is defined as the presence of terminal hairs with a male-like pattern in women, due to the increased levels of androgens or increased responses of the target organs to androgens. Facial hirsutism has a negative effect on the quality of life in female patients. Among the many therapeutic modalities for hirsutism, laser therapy...

A 12 years old boy, diagnosed with psoriasis since childhood was referred to the dermatology clinic of Aleppo University Hospital,Syria with the chief complaint of erythematous hyperkeratotic lesions on the palms and soles.

A 60-year-old man was referred with a 1-month history of angina and dyspnea to a cardiology clinic. In physical examination, there was a rough, low-pitched crescendo-decrescendo systolic murmur that was best heard at the second intercostal space at the right upper sternal border. Echocardiography showed severe aortic stenosis and left ventricular h...

We report a 42-year-old woman with an asymptomatic solitary targetoid patch on her shin of 1 month duration. Histopathologic evaluation revealed intact epidermis with vascular proliferation in the papillary dermis. Vascular channels were irregular, thin walled, and dilated. They were lined by prominent endothelial cells having plumped protruding nu...

Traumatic brain injury (TBI) is an important cause of death and disability in young adults ,and may lead to physical disabilities and long-term cognitive, behavioral psychological and social defects. There is a lack of definite result about the effect of thyroid hormones after traumatic brain injury in the severity and no data about their effect on...

In this report, we describe a patient with drug-induced liver failure who developed endogenous endophthalmitis after liver transplantation. Our patient's clinical course was so fulminant that the eye was lost in less than 1 month, without any response to therapy. Recognition of this infection is important because many patients die of disseminated A...

Nasolacrimal duct obstruction is a common ophthalmic problem, comprising 3% of clinic visits in some series. Primary acquired dacryostenosis results from inflammation of unknown cause that eventually leads to occlusive fibrosis. Helicobacter pylori is a microaerophilic, Gram-negative spiral organism that has been shown to be the causative factor in...

This study presents a modification of tibial inlay technique in posterior cruciate ligament (PCL) reconstruction and evaluates the structural properties of tibial side fixation of the graft, comparing tibial inlay technique and a new modification, that is interference screw fixation of tibial side of the graft in suggested supine position which is...