About
29
Publications
5,618
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
187
Citations
Introduction
Research based on Functional Genomics, Transcriptomics, single cell transcriptomics, Metagenomics, Epigenetic regulation, 3D genomics, non-coding RNA, Gene family identification, Enrichment and Network studies
Current institution
Additional affiliations
January 2017 - January 2019
January 2019 - March 2022
Education
May 2013 - May 2015
Publications
Publications (29)
The tree bean (Parkia timoriana (DC). Merr) is an underutilized legume and is abundantly found in Southeast Asia. It is valued for its nutritious pods and cultivated for food and timber. Despite of the presence of several nutrients, the regulatory networks involved in secondary metabolite biosynthesis in the tree bean remain largely unexplored. Rec...
During B-cell development, cells progress through multiple developmental stages, with the pro-B-cell stage defining commitment to the B-cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression functions. We found here that knockout of YY1 at the pro-B-cell stage eliminates B lineage commitment. YY1 kn...
Histone deacetylase 2 (HD2) proteins play an important role in the regulation of gene expression. This helps with the growth and development of plants and also plays a crucial role in responses to biotic and abiotic stress es. HD2s comprise a C2H2-type Zn²⁺ finger at their C-terminal and an HD2 label, deacetylation and phosphorylation sites, and NL...
The basic helix-loop-helix (bHLH) is the second largest TF family in plants that play important roles in plant growth, development, and stress responses. In this study, a total of 100 bHLHs were identified using Hidden Markov Model profiles in the Nicotiana tabacum genome, clustered into 15 major groups (I-XV) based on their conserved domains and p...
Abiotic stress tolerance is an intricate feature controlled through several genes and networks in the plant system. In abiotic stress, salt, and drought are well known to limit cotton productivity. Transcriptomics meta-analysis has arisen as a robust method to unravel the stress-responsive molecular network in crops. In order to understand drought...
Immune cell development relies on intricate transcriptional and epigenetic mechanisms dictating lineage specification. YY1, a transcription factor with dual transcriptional roles, manages lineage-specific chromatin interactions despite its ubiquitous expression. In, our study, conditional YY1 knock-out in the B cell lineage resulted in the loss of...
Transcription Factor Ying Yang 1 (YY1) regulates epigenetic modifications and gene expression. We found that YY1 knockout (KO) pro-B cells lose B lineage commitment and gain the ability to develop into alternative hematopoietic lineages (Genes & Dev, in press). To explore the mechanism of this unusual lineage plasticity, we conducted scRNA-seq, scA...
The present study investigates the flower-anthesis mechanism in two closely related plant species, Cestrum diurnum and Cestrum nocturnum. These plants are morphologically similar, but exhibit distinct flowering times: C. diurnum flowers during the day, whereas C. nocturnum blooms at night. This contrast in flowering time makes them ideal subjects f...
During B cell development, cells progress through multiple developmental stages with the pro-B cell stage defining commitment to the B cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression functions. We find here that knockout of YY1 at the pro-B cell stage eliminates B lineage commitment. YY1 knoc...
Glutaredoxins (Grxs) are glutathione (GSH)-mediated, small (10–15 kDa) oxidoreductases. In the present investigation, transgenic Arabidopsis thaliana over-expressing a glutaredoxin gene [LOC101493651 (CaGrx)] of chickpea (Cicer arietinum L.) has been evaluated against drought, and further transcriptomic studies were performed to know the effect of...
The impact of fungicide residues on non-target soil bacterial communities is relatively unexplained. We hypothesize that the persistence of fungicide residues in the soil will affect the soil bacterial populations. Persistence depends on biotic and abiotic factors, primarily determined by agricultural activities. Activities such as fallow soil (F),...
Phosphate starvation is one of the major factors limiting plant productivity globally. Soil microflora with an inherent trait of phosphate accumulation directly influences soil phosphorus level by regulating its labile form in soil solution. However, the detailed mechanism involved during their interaction with plants under phosphate deficient cond...
In plants, abiotic stress tolerance is controlled by a number of genes and networks. In abiotic stress condition, drought, and salt are well known to limit the productivity of cotton. To unravel the stress-responsive molecular network in crops, transcriptomics meta-analysis has emerged as a powerful method. This method is crucial to understand the...
Winged bean (Psophocarpus tetragonolobus (L.) DC.) is an underexploited tropical legume whose tuberous-roots contain 12-19% of proteins. The species has excellent drought tolerance ability thus making it a prospective climate-smart future crop. However, the underlying defense mechanism(s) of the species against the drought stress are not yet unders...
Salinity tolerance has been documented as one of the main abiotic stresses, disapprovingly impeding the growth and fertility of core food crops including rice in the ecosphere. We have evaluated 24 varieties exposed to salt stress (150-300 mM NaCl; for 48-72 h) at the vegetative stage. The cellular-level physiological response was observed by asses...
Tubby-like proteins (TLPs) transcription factors are found in single-celled to multi-cellular eukaryotes in the form of large multigene families. TLPs are identified through a specific signature of carboxyl terminal tubby domain, required for plasma membrane tethering and amino terminal F-box domain communicate as functional SCF-type E3 ligases. Th...
Crop losses due to various insects are a global problem. For decades, several types of research have been ongoing on this issue with limited success due to co-evolving insect pests. In this study, the modified Cocculus hirsutus trypsin inhibitor (ChTI), a serine proteinase inhibitor gene encoding a natural plant defense protein, inhibiting the dige...
Endophytes are plant inhabitants acting as its extended genome. The present study highlights the importance of maintaining plant endophytes for sustainable disease resistance in plants.
Heat shock transcription factors (HSFs) function under heat and other abiotic stresses to combat stress. Few HSFs have been reported to function in plant development under unstressed conditions. In tomato, 26 HSFs were identified based on highly conserved functional domains. The HSF gene family expansion in tomato is attributed to segmental and tan...
To understand drought tolerance mechanism(s) in clusterbean (Cyamopsis tetragonoloba), we conducted physiological,
biochemical, and de novo comparative transcriptome analysis of drought-tolerant (RGC-1002) and drought-sensitive (RGC-
1066) genotypes subjected to 30 days of drought stress. Relative water content (RWC) was maintained in tolerant geno...
MicroRNAs (miRNAs) are small, highly conserved non-coding RNA molecules and products of primary miRNAs that regulate the target gene expression. Homology-based approaches were employed to identify miRNAs and their targets in Cestrum nocturnum L. and Cestrum diurnum L. A total of 32 and 12 miRNA candidates were identified in C. nocturnum and C. diur...
Drought, a major abiotic limiting factor, could be modulated with in-built reprogramming of plants at molecular level by regulating the activity of plant developmental processes, stress endurance and adaptation. The transgenic Arabidopsis thaliana over-expressing metallothionein 1 (MT1) gene of desi chickpea (Cicer arietinum L.) was subjected to tr...
Polyethylene terephthalate (PET) is a common single-use plastic which accumulated in the environment due to its non-degradable characteristics. In recent years, microbes from different environments were found to degrade plastics and suggested their capability to degrade plastics under varying environmental conditions. However, complete degradation...
The rhizospheric microbial communities and enzymes involved in nutrient mineralization play a vital role in plant and soil health particularly under abiotic stress conditions. Hence, the investigation has been made on the activities of enzymes involved in carbon, nitrogen, phosphorus, and sulfur cycles and metabolic potentials microbial communities...
Tubby-like proteins (TLPs) possess a highly conserved closed β barrel tubby domain at C-terminal and N-terminal F-box. The role of TLP gene family members has been widely discussed in numerous organisms; however, the detailed genome-wide study of this gene family in Gossypium species has not been reported till date. Here, we systematically identifi...
The basic helix-loop-helix (bHLH) superfamily is the second largest transcription factor family in plants that act as homo or hetero dimers to regulate the expression of their target genes. bHLH genes have a significant role in plant development and several stress responses. A total of hundred bHLHs was identified and all the identified Nicotiana t...
The endemic spread of plastic in the environment requires urgent need of a sustainable approach. Marine microbes found to have vast bioactivity and play a central role in biogeochemical cycling in the ocean; however, very few of them had been explored for biochemical cycling or plastic degradation. In the present study, we report the draft genome s...
The flowers of Cestrum nocturnum L. (CS1) and Cestrum diurnumL. (CS2) bloom at night and at day time, respectively. So, it is interesting to find out the responsible molecular factors especially miRNAs and their underlying mechanism governing the flower-anthesis in these two species. Homology-search based computational analysis was employed for the...
