Naser Abbasi

• Ph.D; Pharm D.
• Head of Department at Medical University of Ilam

Cholesterol and glucose are two important biomarkers that are linked to different human diseases. In this work, we have designed a turn-on fluorescent biosensor based on carbon dots hybridized by...

Introduction: Prostatitis is an inflammatory condition of the prostate gland caused by bacterial infections or non-infectious factors. This condition is typically characterized by symptoms such as pelvic pain, urinary frequency, and burning during urination. If left untreated, prostatitis may result in complications, including sexual dysfunction, i...

The diverse geographical regions of Iran have tribes with different cultures and customs in the medicinal use of plants in the control, prevention and treatment of diseases, and on this basis, to collect valuable ethnobotanical information in the field of medicinal plants, more studies are needed among different tribes. It is so that in the event o...

Safe chemicals for drug withdrawal can be extracted from natural sources. This study investigates the effects of clonidine and Thymbra spicata extract (TSE) on mice suffering from morphine withdrawal syndrome. Thymol, which is the active constituent in TSE, was also tested. A total of 90 mice were divided into nine groups. Group 1 was the control g...

Bread is a valuable food in Iranian families that is used as a source of energy, protein, minerals, and vitamins. Unfortunately, most bakeries process bread artificially to speed up the production process and inevitably resort to the use of harmful chemicals such as baking soda, and SDT (sodium hydrosulfite). In this study, the types of bread produ...

Background: In order to measure the plasma levels of Losartan and Bosentan, a sensitive Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) technique was developed. Methods: To compare bioavailability, the Area Under the Curve (AUC), peak plasma concentration (Cmax), and time to Cmax (Tmax) were employed. The standard curve (150-2400 ng/...

The aim of this study was the identification of luteolin in Prosopis farcta extract (PFE) and melatonin to evaluate its effect on THC withdrawal syndrome in mice. Luteolin was identified by high‐performance liquid chromatography (HPCL). Signs of toxicity of mice in PFE and luteolin were monitored for LD50 calculation. The behavioral symptoms of THC...

Background: Methadone poisoning intentionally or accidentally leads to a high rate of treatment burden and cost and deaths. The evaluation of the factors affecting the severity of poisoning can reduce recovery time, costs, and potential risks. Objectives: This study aimed to investigate the effect of intravenous vitamin C (ascorbic acid) administra...

Background In order to measure the plasma levels of Losartan and Bosentan, a sensitive Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) technique was developed. Methods To compare bioavailability, the Area Under the Curve (AUC), peak plasma concentration (Cmax), and time to Cmax (Tmax) were employed. The standard curve (150–2400 ng/m...

Designing biocompatible polymers using plant derivatives can be extremely useful in tissue engineering, nanomedicine, and many other fields of medicine. In this study, it was first looked into how chitosan/alginate scaffolds were made and characterized in the presence of berberine and barberry fruit extract. Second, the process of proliferation and...

Objectives: Alzheimer's disease (AD), the most common cause of dementia, is one of the leading causes of morbidity and death in the world. Currently, treatment mostly used to slow down the disease progression. Herbal remedies are considered by many in the community as a natural and safe treatment with fewer side effects. Silibinin, the active ingr...

Background and purpose: Today, implant treatment is one of the most popular dental

Background: Every year, drug poisoning is the most prevalent reason for referring patients to medical centers. This study aimed to evaluation of morphine, methadone, digoxin, and dronabinol poisoning in Shahid Mostafa Khomeini Hospital in Ilam. Methods: In this In this Cross-sectional study, patient samples suspected of morphine, methadone, digo...

Background: Menopause is a stage in woman's life that some women experience in middle age and some at a younger age (premature menopause). Low levels of ovarian hormones, during menopause can lead to various complications. Menopause is one of the factors that can affect a woman's sexual function. Objective: The present study was conducted to com...

Background and Aim: Diabetes is a metabolic disease with high blood sugar levels. Olfactory ensheathing cells (OECs) are able to express various growth factors and integrin-linked kinase (ILK) plays an important role in regulating various processes of cells. In this study, we investigated the effects of silybinin on the expression of vascular-endot...

Aims: Chitosan, like docosahexaenoic acid (DHA) and mesenchymal stem cells (MSCs), is used in medicine as a wound healing accelerator. Thus, in this study, chitosan-alginate (CA) membranes containing DHA and MSCs were produced, and their antibacterial and antibiofilm activities against burn infections caused by Pseudomonas aeruginosa were investiga...

Background Brain strokes are the cause of death in many people, among survivors; it can cause problems such as motor and cognitive impairment. The role of the hippocampus and its damage in ischemia has been assessed by researchers. One of the treatments commonly used today by researchers in cell therapy. Therefore, this study aimed to evaluate the...

The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years. Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3 nanoparticles (Fe2O3 NPs), and chitosan hydrogel beads in different concentrations. The chara...

Objective: Ultrasound (US) is an imaging procedure with various applications, such as checking the fetus during pregnancy. To the best of our knowledge no study have investigated the simultaneous effect of diagnostic US waves and ethanol exposure on intracellular calcium ([Ca2+]i) processes and reactive oxygen species (ROS). Thus, in the current st...

The drug delivery system is valuable in the treatment of the disease. A nanopolymer as a thymol and Thymbra spicata release system was synthesized and its effects on morphine withdrawal syndrome in comparison with clonidine in rats were studied. The nanopolymer was characterized by different methods, namely, IR, HNMR, CNMR, GPC, DLS, and AFM. Thymo...

Introduction: Cisplatin is a strong anticancer medicine, but its use is limited due to the potential nephrotoxicity induction. Objectives: The present study seeks to determine the impact of Hypericum hydroalcoholic extract on cisplatin-induced nephrotoxicity. Materials and Methods: Thirty-two male rats were assigned to groups 1 to 4. Group 1, contr...

Objective: Ultrasound (US) is a medical imaging technique with various therapeutic and diagnostic applications. This study aimed to investigate the effects of diagnostic US waves with a frequency of 3.5 MHz and intensity of 65 mW/cm2 on the threshold of neurons’ excitability and the apoptosis induced by pentylenetetrazole (PTZ) in rats. Materials a...

Objective: To evaluate the anti-bacterial activities of titanium dioxide (TiO) nanoparticles of Origanum (O.) vulgare and Hypericum (H.) perforatum extracts, carvacrol and hypericin against Staphylococcus (S.) aureus. Methods: In this study, TiOnanoparticles of O. vulgare and H. perforatum extracts, carvacrol and hypericin, were prepared and the...

Finding more efficient agents with fewer side effects for the treatment of burns has been a concern for researchers. The current study aims to assess Aloe vera (L.) Burm.f. and Vitis vinifera L. extract combination (AVEC) effects on wound healing in rats compared with silver sulfadiazine (SSD). Identification of individual polyphenols of the plant...

With the increase in the use of antibiotics and resistance against them, attention has been paid to natural remedies with the possibility of lower resistance and side effects. In this study, the essential oil of Loranthus europaeus Jacq. was identified chemically and the antimicrobial effects of the essential oil and extract on bacterial agents suc...

Background The choice of route of drug administration is given depends not only on the compliance but also on the drug’s pharmacokinetics pathway. In this study, the efficacy, and safety of nasal and oral administration of chloral hydrate in the pediatric ready for electroencephalography were evaluated. Methods 143 infants who had to undergo EEG fo...

Background: Ischemia plays an important role in increasing damage to the nervous system. This study aimed to evaluate the effect of Prosopis farcta (PFE) and its bioactive luteolin (Lu) and forced swimming exercise on the hippocampus of mice after induced ischemia reperfusion. Methods: The bioactive component of PFE (Lu) was identified by HPLC....

Introduction In the current study, silver nanoparticles were prepared and synthesized in aqueous medium using Scrophularia ‎striata leaf extract as stabilizing and reducing agents. Also, we investigated the anti-chronic myeloid leukemia ‎potentials of silver nanoparticles against BV173 (chronic myeloid leukemia in blast crisis), CML-T1 (chronic ‎my...

Introduction Recently, various nanoparticles containing medicinal plants have been specifically designed to deliver anticancer drugs and nucleic acids such as DNA and RNA to cancer cells and as a result, they open up new avenues in cancer treatment strategies. In this study, gold nanoparticles were synthesized in aqueous medium using Nigella damasc...

Peganum harmala is a plant that belongs to the family Zygophyllaceae. In traditional medicine, this plant has therapeutic effects such as repelling intestinal worms, increasing sexual potency, increasing milk secretion, anti-rheumatism, regularizing, anti-parasitic, hypnotic, diaphoretic, anti-cancer and analgesic. The aim of this study was to iden...

Background: Considerable increase in gut motility after probiotic supplementations consumption is indicated in recent studies. The present study conducted to clarify whether supplementation with Saccharomyces boulardii can palliate the abdominal pain frequency in children with Functional Abdominal Pain (FAP). Methods: The present clinical trial was...

Introduction Alternative medicine is important in cancer treatment. The apoptotic effect of Thymol and extracted Thymol from Thymbra spicata on non-small-cells lung cancer was studied. Material and methods Thymol was evaluated in Thymbra spicata extract by HPCL. Cell viability was assessed by MTT method. DCF and flu3-AM probe was used for ROS and...

Chitosan is a linear polysaccharide and non-toxic bioactive polymer with a wide variety of applications due to its functional properties such as ease of modification, and biodegradability. In this study, a green protocol for supporting of Cu(II) on chitosan-encapsulated magnetic Fe3O4 nanoparticles is described. The morphological and physicochemica...

Introduction Formulating new wound-healing ointments by natural compounds is the first research priority in the developing and developed countries. This study was intended to provide green formulation of Ag-NP ointment containing Citrus lemon leaf aqueous extract and examine its capability of healing cutaneous wounds and its antioxidant and cytotox...

Enhancing microbial resistance to antibiotics and their probable side effects leads to the popularity of medicinal plants, so the need for novel antibacterial compounds with plant origin is felt more than ever. The object of the recent study was to assess the antibacterial property of Stachys lavandulifolia Vahl aqueous extract (SLVAE) on Escherich...

Ethnomedicinal plants are considered recent resources for producing components that could treat wounds. Stevia rebaudiana is a native plant in Iran, which the plant has been used as an anti-inammatory, antioxidant, antibacterial, antifungal, antiparasitic, antiviral, and antidiabetic agent in Iran. In this study, the authors describe the property o...

Aims: Giardia lamblia (G. lamblia) is one of the most common intestinal parasites worldwide. There are some side effects and the reports of parasite resistance to metronidazole as the first line treatment of giardiasis. Therefore, it is essential to discover an effect and safe drug to treat giardiasis. Methodology: In this study, the anti-parasitic...

In this study, nickel nanoparticles (NiONPs) have been successfully synthesized in an aqueous medium using the aqueous extract from the leaves of Calendula officinalis. The synthesized NiONPs were characterized using different techniques. According to the XRD analysis, the mean crystal size for NiONPs was found to be 33.17 nm. In addition, SEM imag...

Wound healing is a process that starts with the inflammatory response after the occurrence of any damage. This process initiates by restoring the wound surface coating tissue, migrating fibro-blasts to form the required collagen, forming a healing tissue and finally, leading to contortion and extraction of the wound. Today, various drugs are used t...

Using a solid-phase extraction for the determination of VPA, this study aimed to prepare a valproic acid (VPA) imprinted silica gel adsorbent by surface molecular imprinting technique. VPA-imprinted silica adsorbent was characterized by FTIR spectroscopy. The VPA adsorption from solutions was studied in SPE mode. All influenced parameters on adsorp...

Introduction Persian medicine (PM) is one of the oldest branches of medicine in the world. The purpose of this research was to analyze published articles about PM in the PubMed indexed journals. Method Articles indexing in the PubMed database (2015-2019) searched for keywords "Iranian traditional medicine", "Iranian medicine", "Persian traditional...

In recent days, novel biomolecule stabilized nanocomposites have come into prominence as featured next generation materials. In this article we have green synthesized Au nanoparticles being deposited and stabilized over chitosan (CS) molecules. The electron rich polar functional groups of chitosan have been exploited to cap the Au NPs. The structur...

Cutaneous leishmaniosis is a major worldwide public health problem with annual incidence of 1.5 million cases across 98 countries. Treatment still relies on the use of chemical drugs with increasing resistance and side effects. The aim of this study was to investigate the anti-leishmanial effect of the hydroalcoholic Thymbra spicata extract on Leis...

Satureja khuzistanica Jamzad (Lamiaceae) and Thymbra spicata L. (Lamiaceae) are medicinal plants belonging to the genera of Satureja and Thymbra, having many uses in traditional Iranian medicine. S. khuzistanica is used to treat different diseases such as cramps, nausea, and infectious diseases. Medicinal plants, extracts, and essential oils are of...

In recent days, novel biomolecule stabilized nanocomposites have come into prominence as featured next generation materials. In this article we have green synthesized Au nanoparticles being deposited and stabilized over chitosan (CS) molecules. The electron rich polar functional groups of chitosan have been exploited to cap the Au NPs. The structur...

Chamomile has several variants, such as Anthemis Susiana Nabelek, Matricaria chamomilla L., Chamomilla recutita (L.) Rauschert, Matricaria suaveolens Koch and etc. Medicinal herbs, extracts and essential oils are of particular importance in the pharmaceutical, cosmetic and food industries. The phytoanalysis of these compounds is of particular impor...

By this article, we are going to report results of one of works which has been performed on investigation of the binding and inhibition of catalase (CAT) by ascorbate (ASC). To achieve this goal, different electrochemical experiments have been performed and their data have been analyzed by conventional and chemometric methods. Conventional methods...

Themagnetically isolable nanobiocomposites have significant impact as themodified newgeneration catalysts in recent days. This has persuaded us to design and synthesis of a novel Ag NPs decorated biguanidine-chitosan (Bigua-CS) dual biomolecular functionalized core-shell type magnetic nanocomposite (Ag/Bigua-CS@Fe3O4). Bigua-CS could be introducing...

Introduction. After the Iraq war, the dust phenomenon has increased in western Iran. Our study aimed to evaluate the effect of the dust phenomenon on the content of heavy metals in raw milk in Ilam province. Study objects and methods. The dust samples were collected during one year. The concentrations of dust particles were determined with the Envi...

In Iranian traditional medicine Quercus brantii var. Persica (Oak) is considered warm-and dry-natured. It is used for gastric pain, ulcer, anemia, hemorrhoids and rickets, burns, indigestion, diarrhea, and infection. Oak is readily available and has a variety of medicinal and health effects in both traditional and modern remedies. The main objectiv...

In this study, a novel method was developed to measure acidic and basic drugs in biological and wastewater samples. The method used magnetic nanoparticles based on Vortex-Assisted Dispersive Micro-Solid Phase Extraction (SPE) and then identifying with HPLC-UV. The magnetic nanoparticle (Fe3O4@SiO2@[email protected]2) has been used as an efficient a...

In this study, from June 2019 to May 2019 aerial parts of Scrophularia striata Boiss. were collected from Ilam city and those of Scrophularia deserti Delile from Dehloran city, Ilam province in western Iran. The aerial parts of the medicinal plants were pulverized. The essential and volatile oils were extracted by headspace solid-phase microextract...

Stomach ache is one of the most chronic and debilitating abdominal pains. Medicinal plants are one of the most accessible sources for treating diseases like gastrointestinal disorders. In this review, we investigate and report the most important medicinal plants recommended by Persian medicine for treating stomach aches and comparing them with thei...

Essential oils are aromatic compounds widely used in the perfumery, pharmaceutical and food industries. There are several methods to extract essential oils and extracts. These methods include distillation, pressure or scraping, pressing and razor technique, headspace solid-phase micro extraction (HS-SPME), solvent extraction, extraction by bioactiv...

In the present research, salting out and vortex assisted dispersive liquid-liquid microextraction based on solidification of floating organic drop microextraction (SO-VADLLME-SFODME) for the extraction and determination of phenol and chlorophenols in water samples followed by HPLC have been studied through a novel, simple, low-cost, selectable and...

Hepatoxicity is a common complication of acetaminophen. This study was to evaluate the effects of Nectaroscordum tripedale extract (NTE) and its bioactive component tetramethylpyrazine (TMP) on acetaminophen-induced liver failure. The presence of TMP in NTE was determined by HPLC. The hepatoprotective effect of NTE and TMP (50, 100 and 200 mg/kg, r...

Background and Aim: Osteoporosis is one of the most common bone diseases that is caused by an imbalance between the activity of osteoblasts and osteoclasts. Osteoprotegerin (OPG) plays an active role in inhibiting osteoclasts by binding to the receptor activator of nuclear factor kappa-B ligand (RANKL). The balance in the OPG/RANKL ratio is importa...

Introduction: Thymbra spicata has flavonoid, alkaloid compounds and antioxidant properties. In the current study, the protective effect of hydroalcoholic extract of Thymbra spicata (TS) was investigated on acetaminophen-induced liver toxicity. Materials and Methods: The hydroalcoholic extract of the plant was extracted by Soxhlet extractor. In this...

The aim of the study was the rapid green synthesis of titanium nanoparticles using the aqueous extract of Falcaria vulgaris leaves (TiNPs@FV) and exploring their antioxidant, cytotoxicity, antifungal, antibacterial, and cutaneous wound healing activities under in vitro and in vivo condition. These nanoparticles were characterized by UV-Vis, Fourier...

Eucalyptus globulus Labill. belongs to the Myrtaceae family, which extracted essential oils uses for medicinal, nutritional, and ornamental purposes. The present study conducted to extract the essential oil of Dehloran native eucalyptus leaf and recognize its biochemical components by the HS-SPME method. The eucalyptus leaf collected from Dehloran...

Drug delivery systems have been of interest to researchers. The effects of synthesized nano-polymers as silibinin and silymarin extract drug delivery systems on olfactory ensheathing cells under normal and high-glucose conditions were studied. The structure of the nanopolymer was characterized by IR, HNMR, GPC, DLS, and AFM. The toxicity was evalua...

Chronic pain is a common problem that affects the quality of life of patients. Among chronic pains, headache is one of the most common pains. This study is an ethnobotanical study of headache treatment using medicinal plants in Shahrekord region, Chaharmahal and Bakhtiari province. This study was performed by collecting data using an ethnobotanical...

A novel, simple, sensitive and green ultrasonic-assisted liquid–liquid microextraction method based on a synthetic citric acid–glycerol nanopolymer solution was used for the extraction of antioxidant acids (ferulic, cinnamic, gallic acid and rutin) in five kinds of oil samples from vegetables. The synthetic nanopolymer from citric acid and glycerol...

Background Studies have shown that consumption of high levels of alcohol causes many negative effects on the liver and kidneys where antioxidant ingredients can be a proper solution to reducing the resulting damages. So, the present study investigated the effect of hydroalcoholic extract of Crocus sativus L. (saffron) petal with antioxidant propert...

URINARY tract stones are the third leading urinary tract disease. People with kidney stones suffer from severe colic pain, which is not often completely relieved with common analgesic medications and opioid drugs are used to relieve pain. The aim of this ethnobotanical study was to identify medicinal plants used by indigenous people of Shahrekord f...

BACKGROUND and objective: Hepatoprotection using herbal drugs and preventing very common liver disease is very necessary in today’s world. Therefore, this ethnobotanical study was conducted to identify and report medicinal plants in Shahrekord with hepatoprotective effect. Factors such as oxidative stress, free radicals, white alcohol, chemicals, p...

Background & objective, Brucellosis is a zoonotic disease whose most common complications include intermittent fever, headache, fatigue, weight loss, night sweats, joint pain, osteomyelitis, spondylitis, peripheral arthritis, sacroiliitis, etc. In this study, the epidemiology of brucellosis in Dehloran, Iran between 2015 and 2019 was studied. Metho...

Morphine is the most effective medication to relieve pain, antinociception and withdrawal syndrome, but clinical application of these compounds is greatly affected by the occurrence of addiction. The aim of this research was the influence of SE and curzerene (Cur) on withdrawal syndrome signs in mice contrasted with clonidine. Extraction of the S....

Objective: The aim of this study was to evaluate the effect of thymol and thymol nano polymer on the blood biochemical parameters and anti-diabetic activity in Streptozotocin (STZ)-induced diabetic rats. Methods: The synthesized nano polymer (NP) was characterized by using different spectroscopy methods, such as IR, HNMR and CNMR. Loading and relea...

Background: Mumie, as an inorganic and semi-solid herbal substance, could be obtained from crevice caves and is used for bone diseases in traditional medicine. This study investigated the effects of this substance on the expression of bone alkaline phosphatase (BALP) enzyme as well as proliferation and mortality rates of MG63 human osteoblast-like...

LamZiziphora clinopodioides Biosynthesis of metal nanoparticles using plant medicine is under exploration is due to wide biomedica applications and research interest in nanotechnology, the recent study was assessing green synthesis of zinc nanoparticle using ), the use of plant material Ziziphoraleaves extract (ZnNPs@ not only makes the process eco...

Objective: To focus a new chemoprevention approach that uses nanotechnology to deliver luteolin to human breast cancer cells (MCF-7), and its underlying mechanism. Methods: Water-soluble copolymer-encapsulated nanoparticle-luteolin (CENL) was formulated using the hydrophobic drug luteolin. The ability to load and release he anticancer drug into/...

Background Nowadays, the drug delivery system is important in the treatment of diseases. Purpose A polymeric nanoparticle modified by oleic acid (NPMO) as a Thymol (Thy) drug release system was synthesized from Thymbra spicata and its neurotrophic and angiogenic effects on rat’s olfactory ensheathing cells (OECs) in normal (NG) and high glucose (H...

Introduction: Cell therapy is known as one of the most common methods used for treating a spinal cord injury (SCI); particularly, olfactory ensheathing cells (OECs), which have attracted much more attention among scholars due to their properties such as promotion of axonal regeneration, remyelination, and angiogenesis. Thus, the present study compa...

Aim This study was designed to evaluate the synergistic activities of hydroalcoholic extracts of medicinal plants Origanum vulgare and Hypericum perforatum and their active components, carvacrol and hypericin against Staphylococcus aureus. Methods The synergistic effects of the plants, as well as carvacrol and hypericin, were examined using a chec...

HPLC

Background Today, the plant Prosopis farcta is frequently used for traditional medicinal purposes. The aim of this study was the identification of luteolin in P. farcta extract (PFE) and to evaluate its effect on morphine discontinuation syndrome in rats. Material/Methods Using high-performance liquid chromatography (HPCL), luteolin was evaluated...

Introduction: The purpose of this study was evaluating the effect of Smyrnium cordifolium extract (SCE) and curzerene (Cur) on withdrawal syndrome in mice compared with clonidine. Methods: High-performance liquid chromatography (HPLC) was used to determine the active ingredients of S. cordifolium. To evaluate the effects of SCE and Cur, 64 mice wer...

Leishmaniasis is a zoonotic parasitic disease that is caused by different Leishmania species. Most cases of leishmaniasis are reported from Afghanistan, Saudi Arabia, Algeria, Brazil, Iraq, and Iran. Antimony compounds have long been used as standard treatment and first line drugs for leishmaniasis, but Leishmania species have recently acquired dru...

Herbs have played an important role in the health and wellness of human. Nowadays, medicinal herbs are at the forefront of studies of medical science because of their importance in public health. Understanding the traditional and therapeutic effects of medicinal plants is important because they can be effective as a source of medication. Based on t...

The thyroid gland regulates a wide range of physiological activities such as growth, metabolism, homeostasis, and cell proliferation and differentiation through the secretion of thyroid hormones (THs). Thyroid diseases are among the most common endocrine disorders, hypothyroidism is the most common clinical thyroid dysfunction. Hyperthyroidism mean...

Introduction: Spinal cord injury (SCI) causes constant irreversible functional deficits. Poor prognosis of such a disease prompts scientists to work on an effective way of treatment. Stem cell transplantation provides a promising strategy for such researchers. Using olfactory ensheathed cells (OECs) has, so far, indicated very good results. Hensce,...

Introduction: The involvement of secreted frizzled-related protein5 (SFRP5) and adiponectin, two important adipokines produced by adipocytes, in cardiovascular diseases demand further assessment. Therefore, in this study the relation of the adipokines and atherosclerosis was evaluated in Rat. Materials and methods: For the study, thirty male Wistar...