
Narine ArabyanUniversity of California, Davis | UCD · Department of Population Health and Reproduction (VM)
Narine Arabyan
Ph.D. in Microbiology
About
15
Publications
2,022
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
175
Citations
Publications
Publications (15)
Chitinases are glycosyl hydrolases that catalyze the hydrolysis of the β-1,4 linkages in complex carbohydrates and those that contain GlcNAc. These enzymes are considered emerging virulence factors during infection because the host glycan changes. This is the release of four single chitinase deletion mutants in Salmonella enterica serovar Typhimuri...
Salmonella is a common food-associated bacterium that has substantial impact on worldwide human health and the global economy. This is the public release of 1,183 Salmonella draft genome sequences as part of the 100K Pathogen Genome Project. These isolates represent global genomic diversity in the Salmonella genus.
Lysozyme enzymes hydrolyze the β-1,4-glycosidic bond in oligosaccharides. These enzymes are part of a broad group of glucoside hydrolases that are poorly characterized; however, they are important for growth and are being recognized as emerging virulence factors. This is the release of four lysozyme-encoding-gene-deletion mutants in Salmonella ente...
Prebiotics and probiotics reduce and prevent GI infections by modulating the gut microbiome. Prebiotics proliferate beneficial gut bacteria while probiotics prevent the attachment and invasion of pathogens. However, the mechanisms of these intricate processes are inadequately understood that alter Salmonella infection dynamics. We hypothesized that...
Amylases catalyze the cleavage of α- d -1,4 and α- d -1,6-glycosidic bonds in starch and related carbohydrates. Amylases are widely distributed in nature and are important in carbohydrate metabolism. This is the release of four single and two double deletions in Salmonella enterica serovar Typhimurium LT2 that are important for glycan degradation d...
Sialidases, which are widely distributed in nature, cleave the α-ketosidic bond of terminal sialic acid residue. These emerging virulence factors degrade the host glycan. We report here the release of seven sialidase and one sialic acid transporter deletion in Salmonella enterica serovar Typhimurium strain LT2, which are important in cellular invas...
Listeria monocytogenes is a food-associated bacterium that is responsible for food-related illnesses worldwide. This is the initial public release of 306 L. monocytogenes genome sequences as part of the 100K Pathogen Genome Project. These isolates represent global genomic diversity in L. monocytogenes .
Campylobacter is a food-associated bacterium and a leading cause of foodborne illness worldwide, being associated with poultry in the food supply. This is the initial public release of 202 Campylobacter genome sequences as part of the 100K Pathogen Genome Project. These isolates represent global genomic diversity in the Campylobacter genus.
Although gut host-pathogen interactions are glycan-mediated processes, few details are known about the participating structures. Here we employ high-resolution mass spectrometric profiling to comprehensively identify and quantitatively measure the exact modifications of native intestinal epithelial cell surface N-glycans induced by S. Typhimurium i...
Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection. While glycan degradation is crucial for infection, this process is inadequately understood. Salmonella contains 47 glycosyl hydrolases (GHs) that may degrade the glycan. We hypothesi...
The host gut epithelial membrane is shielded by complex glycans to protect the cell. Gastroenteritis begins when invasive pathogens bind and degrade the glycans at the epithelial barrier to gain access of host membrane. While glycan degradation is crucial for infection, this process is poorly understood. We hypothesized that Salmonella deploys its...
Shearing of bacterial gDNA within a specific size range prior to sequencing library construction is a critical step in Next Generation Sequencing workflows. The quality control of the sheared bacterial gDNA is required in large multiplexed formats for large volume workflows, such as those used in the 100K Pathogen Genome Sequencing Project. Using t...
Sialidases, also known as neuraminidase, are glycosyl-hydrolases that cleave terminal sialic acid from complex glycans. Sialidases are widely distributed in nature and are found in organisms from Eukarya, Eubacteria, and viruses. Microbes use these enzymes to reveal the cell surface that holds sialic acid-containing cell membrane receptors that are...
Salmonella enterica spp. enterica sv Typhimurium infection accounts for 1.3 billion foodborne disease cases worldwide. Gastroenteritis is initiated at the epithelial barrier where Salmonella binds receptors to initiate infection. As a protective mechanism, the host membrane is covered with complex glycans including mucin (glycoproteins) and the gly...