Naram Khalayli

Al-Mouassat University Hospital · Psychiatry

Introduction Our study aimed to evaluate temporomandibular joint involvement in rheumatoid arthritis (RA) patients and healthy individuals Methods 142 participants were recruited in two groups: 72 patients with RA and 70 healthy controls. All participants were tested for seropositivity of rheumatoid factor and anticitrullinated protein antibodies....

Introduction and importance The interactions between the susceptibility of the host and some of the COVID-19 vaccine components happened. Viral infections, including COVID-19, are related to the pathogenesis of bipolar disorder (BD). These findings could trigger an initial bipolar episode. Case presentation A 48-year-old Syrian married female, pre...

Introduction IgA vasculitis is generally triggered by infections and vaccines. Herein, we report a case of a young man who was previously healthy and who developed IgA vasculitis after the first dose of the COVID-19 mRNA vaccine Pfizer-BioNTech. Case presentation The patient’s symptoms were mainly skin and joint without renal or other system invol...

Key Clinical Message Several reports of suspected oral and ocular manifestations of coronavirus disease 2019 (COVID‐19) has prompted investigations into ocular signs, symptoms, and transmission (5).11.2% of patients with COV19 infection had ocular symptoms, including ocular pain, conjunctivitis, dry eye, and floaters, meanwhile, many studies had do...

Introduction We aimed to study systemic lupus erythematosus (SLE) central neurological patterns and their correlations with the disease activity. Patients and Methods Our retrospective observational study was carried out on admitted SLE patients. The patients’ demographic data, clinical examinations, laboratory tests, imaging studies and systemic...

Background: This study aimed to examine the prevalence of menstrual cycle changes (MCs) and their patterns among healthy Syrian women following the administration of the first and second doses of a vaccine. Methods: A cross-sectional online survey following campaigns for COVID-19 vaccines was conducted in 2022 from June 26 to August 3. Data collect...

Introduction and importance The coexistence of Hashimoto’s thyroiditis and ulcerative colitis has been previously mentioned, as these diseases are autoimmune diseases. Limited data about the coexistence of rheumatoid arthritis in patients with Hashimoto’s thyroiditis have been published till now. Meanwhile, the coexistence of Sjogren’s syndrome dur...

Background Although humanity is important within the medical health field, the authors lack studies that address this topic. Objective The authors aimed to assess humanity among a sample of Syrian internal medicine interns. Methods The authors have used a validated scale based on the Medical Humanity Scale (MHS) categorized into seven human value...

Background Behçet’s disease is a chronic autoimmune disorder that affects various organs, including oral aphthae, genital ulceration, cutaneous manifestation, ocular involvement, and positive pathergy test according to the International Study Group for Behçet’s Disease criteria. This study aimed to investigate the oral health condition of patients...

Introduction and importance The COVID-19 pandemic has led to a post-acute syndrome that can persist for an extended period. The correlation between anorexia nervosa (AN) and some autoimmune diseases has been reported. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, presented with different clinical ions and periods, affecting a...

People with ankylosing spondylitis (AS) are vulnerable group to experience mood disorders. It is crucial to identify factors that contribute to depression and anxiety in order to improve outcomes. This study seeks to determine the rates of depression and anxiety in Syrian AS patients, as well as identify potential predictors for these conditions. T...

Introduction Systemic Lupus Erythematosus is a systemic immune disease that classically occurs in young to middle-aged women and may present with cutaneous, renal, hematologic, neurological, and/or other symptoms at the time of diagnosis. Late-onset Systemic Lupus Erythematosus or Systemic Lupus Erythematosus in the elderly is a subtype that differ...

Introduction The problem of infertility is common worldwide. IVF remains the most widely used technique of assisted reproductive technology. Embryo implantation failure is a common cause of unexplained infertility and recurrent miscarriages, thus the relationship between antiphospholipid antibodies and embryo implantation failure after IVF and embr...

Background Nintedanib was approved for the treatment of scleroderma and scleroderma-related interstitial lung disease, as it decrease the forced expiratory volume. Case presentation A 48-year-old Asian female patient with systemic scleroderma 6 years ago developed breathlessness, nausea, heart palpation, and sudden severe occipital headache over t...

Introduction and importance Systemic lupus erythematosus is a systemic immune disease, presented with a broad spectrum of clinical manifestations. The occurrence of interstitial lung disease as the initial manifestation of systemic lupus erythematosus is very rare. Case presentation We present the case of a 6-year-old girl who presented with sympt...

Introduction Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can involve any organ system, and may lead to significant morbidity and even mortality. Down’s syndrome (DS) is the most frequent genetic cause of intellectual disabilities, typically caused by the presence of an extra chromosome 21. Case presentation A 47-year-ol...

Introduction: Granulomatosis with polyangiitis (GPA) vasculitis typically involves upper and lower airways and kidneys. Gastrointestinal involvement is rare, clinically reported as esophageal involvement, gastrointestinal hemorrhage, intestinal perforation, colitis, and pancreatitis. Case presentation: We present a 36 old man, with intestinal perfo...

Introduction and importance Rhupus syndrome is a very rare combination of systemic lupus erythematosus and rheumatoid arthritis. It is characterized by the presence of erosive arthritis with symptoms and signs of systemic lupus erythematosus. Rheumatoid nodules and neurological and renal involvement are further complications of Rhupus syndrome, lea...

Background Mixed connective tissue disease is characterized by high titers of distinct antibodies: U1 ribonucleoprotein with variable clinical features seen in rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis, and dermatomyositis. Limited case reports revealed the association between MCTD and cancer, like lymphoma, lung...

Introduction and importance Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a rare co-occurrence with systemic sclerosis, in around 2.5–9% of patients. The clinical manifestations and prognosis of vasculitis in systemic sclerosis depend on organ involvement. It presented with rapidly progressive acute renal failure without malig...

Introduction Panuveitis is intraocular inflammation of all layers of the uvea and may be isolated or associated with systemic inflammatory diseases affecting one eye or both eyes. Uveitis and conjunctivitis are noted in coronavirus disease 2019 (COVID-19) infection but have been listed as a major adverse event in case reports for COVID-19. Importa...

Introduction and importance The diagnosis of sarcoidosis and Sjögren’s syndrome (SS) in the same patient is a challenge since sarcoidosis is considered an exclusion criterion for SS. Case presentation The authors described a 62-year-old woman, who had SS for 8 years and presented with dry mouth, dry eyes, dyspnoea, and erythema nodosum. High resol...

Introduction The prevalence of ocular abnormalities of COVID-19 is different according to different reports. However, currently available evidence on the presence of this virus in ocular secretions and its association with conjunctivitis is not well established. Objective To reveal the ocular features among COVID-19 patients and to describe them w...

Introduction and importance Calciphylaxis manifests clinically by skin ischemia and necrosis and histologically by calcification of dermal arterioles. Usually, it occurs in patients with end-stage renal disease on dialysis or in patients who had a kidney transplant. Here, we present a case of Calciphylaxis occurring in a patient with psoriasis and...

Introduction Systemic sclerosis is a connective tissue condition, presented with clinical manifestations including ocular involvement in a small percentage. A few cases of uveitis were described in the literature, especially in CREST syndrome. Case presentation We reported a case of a 48-year-old male with blurred vision of left eye that diagnosed...

Background AS Patients are a vulnerable group to mood disorders due to the high burden of their disease and its impact on physical function and quality of life. Identifying risk factors for depression and anxiety is essential for at-risk groups to better outcomes. This study aims to assess the prevalence of depression and anxiety among Syrian AS pa...

Introduction and importance The most common causes of infertility are idiopathic spermatogenetic disorders; occurring in multiple reproductive or systemic diseases. The underlying genetic disorders influence the treatment, and transmission of the disease to the offspring. Case presentation A 32-year-old Syrian male, married for 6 years, presented...

Key Clinical Message Guillain–Barré syndrome (GBS) is a rare immune status, which affects the nerves, leading to muscle weakness and tingling, and, in some cases, paralysis. Our case showed that GBS may happen after knee infectious arthritis.

Introduction: Erythema nodosum (EN) is a self-limited septal panniculitis that presents with fever, arthralgia, and arthritis. Tumor necrosis factor alpha (TNF-α) inhibitor such as golimumab has been found to treat EN in inflammatory bowel diseases (IBD). We herein report the paradoxical occurrence of EN following golimumab for ankylosing spondyli...

Introduction: In the United States, tocilizumab was approved for the treatment of scleroderma and scleroderma-related interstitial lung disease because it inhibited the decrease in forced expiratory volume, so scleroderma treatment is entering a new era. Case presentation: A 44-year-old female patient with systemic scleroderma, diagnosed 6 years...

Background: Behçet's disease is a chronic autoimmune disorder that affects various organs, including oral aphte, genital ulceration, cutaneous manifestation, ocular involvement, and positive pathergy test according to International Study Group for Behçet’s Disease criteria. This study aimed to investigate the oral health condition of patients with...

Introduction Low back pain related to pregnancy occurs in 60%–70% of pregnancies, at any time during pregnancy. During pregnancy, many factors such as weight gain, and others are the causes of the back pain. In Syria, due to the circumstances of the war, many pregnant women may be exposed to increase the risk of lower back pain, so this study will...

Background: Uveitis, a notable cause of severe visual impairment, is frequently characterized as infectious or non-infectious autoimmune uveitis (AU), the latter of which is commonly associated with younger individuals and systemic diseases. Despite the condition's widespread impact, there are substantial gaps in the comprehension of its pathogenes...

Unlabelled: Coronavirus disease 19 (COVID-19) has become the most serious public health crisis of our generation, and vaccines are effective in preventing its infection. Remitting seronegative symmetrical synovitis with pitting edema is an idiopathic rare benign syndrome, but it could be secondary to aautoimmune diseases. Here, the authors reporte...

Unlabelled: COVID-19 is a systemic viral disease complicated with medical conditions. Severe rhabdomyolysis during the COVID-19 course is not until now well known. Case presentation: The authors presented a 48-year-old female with fatal rhabdomyolysis caused by COVID-19 infection. She was referred to us with cough, generalized myalgia and arthra...

Unlabelled: The incidence of neurological injury in primary Sjogren's syndrome varies between 2.5 and 60%. The authors aimed to evaluate its prevalence and characteristics in patients with primary Sjogren's syndrome in a sample of the Syrian population. Patients and methods: Forty-eight patients with primary Sjogren's syndrome, attending outpati...

Unlabelled: Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology. It involves multiple organs and presents as varying clinical manifestations such as renal involvement (nephritis) and hematological disorders. Materials and methods: One hundred sixty people, divided equally into two groups: SLE patients, diagnosed acc...

Unlabelled: Although central nervous system demyelinating lesions as a side effect of tumor necrosis factor (TNF)-alpha inhibitors have been reported, this treatment is still used in some autoimmune diseases. Case presentation: A 34-year-old Syrian male presented with difficulty walking and tingling, and numbness on the left side of his body ove...

Unlabelled: Coronavirus infections have been responsible since 2019 for respiratory illnesses with varying severity worldwide. Worst outcomes from coronavirus (COVID-19) have been reported in older patients andthose with comorbidities like rheumatic diseases. Some drugs used for treating rheumatic diseases are used in patients with COVID-19. Based...

Background: Nurses are more predisposed to low back pain (LBP), due to the nature of their work. Its prevalence varies from 62% to 84%. We aimed to reveal low back pain prevalence, and its characteristics, including its relation with depressive symptoms among a sample of Syrian nurses. Methods: A cross-sectional study was conducted on 156 female nu...

Background: Osteoporosis is a progressive decline in the bone mass, which occurs with no alterations to the bone's composition. It is associated with increased bone fragility that may eventually lead to fractures. In this study, we aim to assess the level of awareness that Syrian women possess regarding osteoporosis and spread the knowledge about...

Background Fibromyalgia is a chronic disease with a high burden. We aim to be the first to investigate the prevalence of fibromyalgia (FM) in Syria and assess its risk factors. Methods A self-reported questionnaire was distributed to the public to identify fibromyalgia patients using the American College of Rheumatology (ACR) 2010 modified criteri...

Background The problem of infertility is common worldwide. In vitro fertilization remains the most widely used technique of assisted reproductive technology. Embryo implantation failure is a common cause of unexplained infertility and recurrent miscarriages, thus the relationship between antiphospholipid antibodies and embryo implantation failure a...

Background Severe acute respiratory syndrome coronavirus 2 continues to impose itself on all populations of the world. Given the slow pace of vaccination in the developing world and the absence of effective treatments, adherence to precautionary infection control measures remains the best way to prevent the COVID-19 pandemic from spiraling out of c...

Background Behçet's disease is a multisystem autoimmune disorder of unknown origin, characterized by frequent oral and genital ulcerations, ocular and cutaneous lesions, arthritis, and it may also involve the gastrointestinal, and central nervous system. In this paper we discuss a case of Behcet syndrome presenting with isolated oral aphthous initi...

Introduction Sjögren's syndrome is an autoimmune disease affecting exocrine glands and other organs. At the onset of the disease and during its course, it most commonly manifests as neuropsychiatric symptoms, most frequently, depression and anxiety. However, the association with bipolar disorder seems rare and not frequently documented. Case repor...

Sjögren’s syndrome is an autoimmune disease that affects multiple organs manifesting as different symptoms and signs. Neuropsychiatric manifestations are one of the symptoms and are common at the onset of the disease and during its course. The most frequent symptoms are depression and anxiety (5). However, the association with bipolar disorder seem...

Background Fibromyalgia is a chronic disease with a high burden. We aim to be the first to investigate the prevalence of fibromyalgia (FM) in Syria and assess its risk factors. Methods a self-reported questionnaire was distributed to the public to identify fibromyalgia patients using the American College of Rheumatology (ACR) 2010 modified criteri...

Background Severe acute respiratory syndrome coronavirus 2 continues to impose itself on all populations of the world. Given the slow pace of vaccination in the developing world and the absence of effective treatments, adherence to precautionary infection control measures remains the best way to prevent the COVID-19 pandemic from spiraling out of c...