Naomi Wright

Naomi Wright
Oxford University Hospitals NHS Trust | OUH NHS · Department of Paediatric Surgery

MBChB (Hons) BSc (Hons) MRCS DCH MSc PhD

About

103
Publications
98,883
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
3,609
Citations
Introduction
Naomi Wright is a Paediatric Surgery Registrar and Wellcome Trust Clinical PhD Fellow at King's Centre for Global Health and Health Partnerships in London, UK. She is the Principal Investigator for the Global PaedSurg and PaedSurg Africa Research Collaborations (@PaedsSurgeon), the Surgical Lead for the King's-Somaliland Partnership (@KingsSomaliland), an organiser for the Global Initiative for Children's Surgery (@GICSurgery, www.globalchildrenssurgery.org) and a representative for the British Association of Paediatric Surgeons International Affairs Committee (@BAPS_IAC). Her PhD is entitled: Developing and piloting an interventional bundle to reduce mortality from gastroschisis in low-resource settings and identifying priority congenital anomalies for further interventional studies.
Additional affiliations
October 2017 - October 2020
King's College London
Position
  • Fellow
September 2016 - present
King's College London
Position
  • Fellow
Description
  • Research Lead for the PaedSurg Africa Research Collaboration Surgical Lead for the King's-Somaliland Partnership
November 2008 - May 2009
Starship Children's Hospital
Position
  • House Surgeon

Publications

Publications (103)
Article
Full-text available
SARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri‐operative or prior SARS‐CoV‐2 were at further increased risk of venous thromboembolism....
Article
Background: This research adopted a care protocol from high-income countries in a level II/III hospital in a middle-income country to decrease morbidity and mortality associated with gastroschisis. Methods: We established a multidisciplinary protocol to treat patients with gastroschisis prospectively from November 2012 to November 2018. This inclu...
Article
Full-text available
Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates an...
Article
Full-text available
Introduction As childhood mortality from infectious diseases falls across sub-Saharan Africa (SSA), the burden of disease attributed to surgical conditions is increasing. However, limited data exist on paediatric surgical outcomes in SSA. We compared the outcomes of five common paediatric surgical conditions in SSA with published benchmark data fro...
Article
IntroductionAs childhood mortality from infectious diseasesfalls across sub-Saharan Africa (SSA), the burden of disease attributed to surgical conditions is increasing. However, limited data exist on paediatric surgical outcomes in SSA. We compared the outcomes of five common paediatric surgical conditions in SSA with published benchmark data from...
Article
Full-text available
Introduction: As childhood mortality from infectious diseases falls across sub-Saharan Africa (SSA), the burden of disease attributed to surgical conditions is increasing. However, limited data exist on paediatric surgical outcomes in SSA. We compared the outcomes of five common paediatric surgical conditions in SSA with published benchmark data fr...
Article
Full-text available
Purpose To describe the epidemiology and referral patterns of gastroschisis patients in northern Ghana. Methods A hospital-based retrospective review was undertaken at Tamale Teaching Hospital (TTH) Neonatal Intensive Care Unit (NICU) between 2014 and 2019. Data from gastroschisis patients were compared to patients with other surgical diagnoses. D...
Article
Introduction It is estimated that 28–32% of the global burden of disease can be treated with surgery. Most of this burden is concentrated in low and middle-income countries, underpinning the importance of the topic of global surgery (GS). The multidisciplinary principles of GS are increasingly recognised as being key to modern practice and as such,...
Article
Full-text available
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the s...
Article
Full-text available
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the se...
Article
Full-text available
Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes...
Article
Full-text available
Background: Congenital anomalies are the 5th leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the sev...
Article
Full-text available
Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes o...
Article
Background: congenital anomalies are the 5th leading cause of under-5 mortality, globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care. Limited literature exists on these conditions in low- and middle-income countries (LMICs). We compared the outcomes of the seven commonest gastrointestinal c...
Article
Full-text available
Background: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. Methods: This international cohort study included adult patients undergoing elective sur...
Article
Full-text available
Background In 2011 a consensus statement from the British Association of Paediatric Urologists recommended lowering the age at orchidopexy to under 1 year. There are concerns that a younger age at operation may increase postoperative testicular atrophy. The ORCHESTRA study aimed to establish the current age at orchidopexy in a multicentre, internat...
Article
Full-text available
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathw...
Article
Full-text available
Introduction: Congenital anomalies are the fifth leading cause of death in children under 5 years old globally (591 000 deaths reported in 2016). Over 95% of deaths occur in low-income and middle-income countries (LMICs). It is estimated that two-thirds of the congenital anomaly health burden could be averted through surgical intervention and that...
Article
Full-text available
Background: Congenital anomalies are the fifth leading cause of under-5 mortality globally. The greatest burden is faced by those in low/middle-income countries (LMICs), where over 95% of deaths occur. Many of these deaths may be preventable through antenatal diagnosis and early intervention. This systematic literature review investigates the use...
Article
Full-text available
Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods This inte...
Article
Full-text available
Background: The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19. Methods: A global expert-response study was conducted to elicit projections for the proportion of elective...
Research Proposal
Full-text available
Aim: To conduct a systematic review that identifies and analyzes cost-effectiveness of neonatal surgical interventions for congenital anomalies in LMICs. Objectives: 1. To systematically identify studies on cost-effectiveness of neonatal surgery for congenital anomalies in LMICs; 2. Evaluate the cost-effectiveness of neonatal surgery for congenital...
Article
Full-text available
Background Congenital anomalies have risen to become the fifth leading cause of under-five mortality globally. The majority of deaths and disability occur in low- and middle-income countries including Ghana. This 3-year retrospective review aimed to define, for the first time, the characteristics and outcomes of neonatal surgical conditions in nort...
Article
Full-text available
Introduction: Congenital anomalies are the 5th leading cause of mortality in children under 5 years globally. The greatest burden is faced by those in developing countries, where over 95% of deaths occur. Many of these deaths may have been preventable through antenatal diagnosis and early intervention. This study aims to conduct a systematic review...
Article
Full-text available
Introduction: Congenital anomalies are the 5th leading cause of death in children under 5-years of age globally, contributing an estimated half a million deaths per year. Very limited literature exists from low- and middle-income countries (LMICs) where most of these deaths occur. The Global PaedSurg Research Collaboration aims to undertake the fir...
Article
Full-text available
Introduction Congenital anomalies are the fifth leading cause of death in children <5 years of age globally, contributing an estimated half a million deaths per year. Very limited literature exists from low and middle income countries (LMICs) where most of these deaths occur. The Global PaedSurg Research Collaboration aims to undertake the first mu...
Article
Full-text available
Background: Gastroschisis is associated with less than 4% mortality in high-income countries and over 90% mortality in many tertiary paediatric surgery centres across sub-Saharan Africa (SSA). The aim of this trial is to develop, implement and prospectively evaluate an interventional bundle to reduce mortality from gastroschisis in seven tertiary p...
Article
Full-text available
The Optimal Resources for Children's Surgery (OReCS) Document provides details of what is required for children's surgical care at every level of healthcare in terms of infrastructure, service delivery, training and research. The full executive summary and OReCS documents are available open access/ free of charge via the following link: https://e...
Article
Full-text available
BACKGROUND: The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who ha...
Article
Full-text available
Background Recommendations by the Lancet Commission on Global Surgery regarding surgical care in low- and middle-income countries (LMICs) require development to address the needs of children. The Global Initiative for Children’s Surgery (GICS) was founded in 2016 to identify solutions to problems in children’s surgery by utilizing the expertise of...
Article
Background Recommendations by the Lancet Commission on Global Surgery regarding surgical care in low-and middle-income countries (LMICs) require development to address the needs of children. The Global Initiative for Children's Surgery (GICS) was founded in 2016 to identify solutions to problems in children's surgery by utilizing the expertise of p...
Article
Full-text available
Objective Outcome reporting heterogeneity impedes identification of gold standard treatments for children born with gastroschisis. Use of core outcome sets (COSs) in research reduces outcome reporting heterogeneity and ensures that studies are relevant to patients. The aim of this study was to develop a gastroschisis COS. Design and setting Systema...
Article
Full-text available
Background: The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who ha...
Article
Full-text available
Introduction There is a significant disparity in outcomes for neonates with gastroschisis in high-income countries (HICs) compared with low-income and middle-income countries (LMICs). Many LMICs report mortality rates between 75% and 100% compared with <4% in HICs. Aim To undertake a systematic review identifying postnatal interventions associated...
Article
Full-text available
This article and other global surgery articles can be viewed for free on the website: https://voices.one.surgery/issue-4-december-2018/
Research Proposal
Full-text available
Background: Gastroschisis has a great disparity in outcomes globally with less than 4% mortality in high-income countries (HICs) and over 90% mortality in many tertiary paediatric surgery centres across sub-Saharan Africa (SSA), including the study centres. Low-technology, cost-effective, evidence-based interventions are available with the potentia...
Article
This article describes the Global Surgery Symposium held within the 65th British Association of Paediatric Surgeons (BAPS) Annual Congress in 2018. Global surgery is a rapidly expanding and developing field and is of particular importance in paediatrics since children account for up to 50% of the population in low- and middle-income countries (LMIC...
Article
ABSTRACT There is great global disparity in the outcome of infants born with gastroschisis. Mortality approaches 100% in many low income countries. Barriers to better outcomes include lack of antenatal diagnosis, deficient pre-hospital care, ineffective neonatal resuscitation and venous access, limited intensive care facilities, poor access to the...
Method
Full-text available
A systematic review of pre-hospital and in-hospital postnatal interventions to improve outcomes for neonates with gastroschisis in low-and middle-income countries. PROSPERO 2018 CRD42018095349 Available from: http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018095349 Aim: To identify postnatal pre-hospital and in-hospital interve...
Article
Full-text available
Background: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-,...
Article
Full-text available
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort stu...
Article
Full-text available
Objective Outcome reporting heterogeneity impedes identification of gold-standard treatmentsfor children born with gastroschisis. Use of core outcome sets (COS) in research reducesoutcome reporting heterogeneity and ensures that studies are relevant to patients. Theaim of this study was to develop a gastroschisis COS.Design and SettingSystematic re...
Presentation
Full-text available
Background: Congenital anomalies have risen to become the 5th leading cause of death in children under 5-years of age globally, yet limited literature exists from low-and middle-income countries where most of these deaths occur.
Conference Paper
Full-text available
Background: Congenital anomalies are the 5th leading cause of death in under 5-year olds globally, yet there is a dearth of research from low- and middle-income countries (LMICs) where up to 90% of cases occur. There are only a handful of single institution, retrospective reviews on patients with congenital diaphragmatic hernia (CDH) from LMICs. Th...
Conference Paper
Full-text available
Background: Sub-Saharan Africa (SSA) has the highest unmet need for surgical care in the world with an estimated shortfall of 41 million cases/ year. Children constitute up to 50% of the population yet there is dearth of research on paediatric surgery from the region. Aim: To undertake a multi-centre prospective cohort study comparing outcomes of...