Naoki Katase

Naoki Katase
Nagasaki University · Department of Oral Patholgy

D.D.S., Ph.D.

About

116
Publications
7,894
Reads
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1,100
Citations
Introduction
Naoki Katase currently works at the Department of Oral Patholgy, Nagasaki University. Naoki does research in Oncology, Pathology and Dentistry. Their current project is functional analyses on DKK3 gene as a therapeutic target in head and neck squamous cell carcinomas. Please visit my website. https://www.dickkopf-katase.com/home
Additional affiliations
December 2016 - present
Nagasaki University
Position
  • Assistant Progessor
December 2016 - present
Nagasaki University
Position
  • Professor (Assistant)
April 2013 - November 2016
Kawasaki Medical School
Position
  • Professor
Education
April 2005 - March 2009
Graduate School of Medicine, Dentisry and Pharmaceutical Sciences, Okayama University
Field of study
  • Oral Pathology
April 1998 - March 2005
Okayama University Dental School
Field of study
  • Dentistry

Publications

Publications (116)
Article
Objective: We previously reported that dickkopf WNT signaling inhibitor 3 (DKK3) would modulate malignant potential of oral squamous cell carcinoma (OSCC) via activating Akt. Recently, cytoskeleton associated protein 4 (CKAP4) functions as receptor of DKK3, which activates Akt in esophageal squamous cell carcinoma, but its expression and function...
Article
Epithelioid hemangioendothelioma (EHE) is a rare non-epithelial tumor derived from vascular endothelial cells. A 70-year-old Japanese man was diagnosed with metastatic EHE of the mandible, which originally developed at the superior vena cava (SVC). He was already under best supportive care and intraoral care for pain relief and to maintain his qual...
Article
Full-text available
Lymphomatoid papulosis (LyP) is one of primary cutaneous CD30-positive large T-cell lymphoproliferative disorders (CD30 + PCLPD) that seldom arises in the oral region. We report here an extremely rare case of LyP arising on the lip. A 25-year-old female developed a painless mass on her right upper lip, which gradually grew and became painful. She v...
Article
Spindle cell lipoma is a rare subtype of lipoma in the oral cavity. Although simple lipoma is easily diagnosed by MRI, it is sometimes difficult to distinguish spindle cell lipoma from liposarcoma due to its similar MRI appearance. A 76-year-old man was referred to our department complaining of a painless mass at the right margin of his tongue. A 1...
Article
Hearing loss can be induced in the temporomandibular joint region by factors such as infection and tumors, because the mandibular fossa lies adjacent to the external ear canal. Here we report a case of conductive hearing loss that improved after condylectomy for condylar process hyperplasia. A 43-year-old man complained of a feeling of fullness in...
Article
Objective Most malignant tumors require remodeling extracellular matrices (ECMs) for invasive growth and metastasis. Cancer cells and stromal cells remodel ECM. We investigated the relationship between regional lymph node (LN) metastasis and expression of ECM remodeling factors in oral squamous cell carcinoma (OSCC). Methods Using primary OSCC and...
Article
Glandular odontogenic cyst (GOC) is a rare odontogenic cyst derived from odontogenic epithelium; GOC shows aggressive behavior, unpredictable recurrence and rarely, malignant transformation. We describe our experience with a case of GOC arising in the mandible. A 49-year-old woman was referred to our hospital because of tenderness of the right mand...
Article
Background: Cancer arises from cumulative genetic or epigenetic aberrations, or the destabilization of central signaling pathways that regulate cell proliferation, differentiation, cell cycle, gene transcription, migration, angiogenesis and apoptosis. Investigating the cancer-specific genetic background is important to get deeper apprehension of c...
Article
Traumatic osteomyositis is a disease in which bone forms ectopically in muscle owing to its traumatic damage caused by severe bruising, contusion, or recurrent weak stimuli. The femoral region and upper arm are the most common regions for the development of traumatic osteomyositis, while it rarely occurs in the head and neck region. Here we report...
Article
The purpose of this study was to evaluate computed tomography (CT) findings of radicular cysts with a focus on location, size, and condition of the surrounding bone. Subjects comprised 60 men and 86 women (mean age 47.2 years) with histopathologically confirmed radicular cysts who underwent CT examination between 2012 and 2014. Mesiodistal and bucc...
Conference Paper
Background & Aims: The new therapy for pancreatic cancer which has the poorest prognosis among malignant tumors is high demand nowadays. The overall 5-year survival rate in all stages of this type of cancer is less than 5%, even with the multimodality therapy, including surgery, chemotherapy and radiotherapy. Although gemcitabine (GEM) is a key dru...
Conference Paper
Background & Aims: The new therapy for pancreatic cancer which has the poorest prognosis among malignant tumors is high demand nowadays. The overall 5-year survival rate in all stages of this type of cancer is less than 5%, even with the multimodality therapy, including surgery, chemotherapy and radiotherapy. Although gemcitabine (GEM) is a key dru...
Article
Dickkopf-related protein 3 (DKK3), which is a member of the Dickkopf WNT signaling pathway inhibitor family, is considered to be a tumor suppressor, due to its reduced expression in cancer cells and its ability to induce apoptosis when overexpressed by adenovirus. However, our previous study demonstrated alternative functions for DKK3 in head and n...
Article
Hemangiomas are benign vascular soft tissue tumors, which most frequently occur in the skin or subcutaneous tissue. Intramuscular hemangiomas typically occur in the trunk and extremities and less frequently in the head and neck. Among these, those occurring in the temporalis muscle are extremely rare. The authors report the case of a 43-year-old Ja...
Article
DKK3, a member of the dickkopf Wnt signaling pathway inhibitor family, is believed to be a tumor suppressor because of its reduced expression in cancer cells. However, our previous studies have revealed that DKK3 expression is predominantly observed in head and neck/oral squamous cell carcinoma (HNSCC/OSCC). Interestingly, HNSCC/OSCC patients with...
Article
Background: Inhibition of KIT oncoproteins by imatinib induces clinical responses in most gastrointestinal stromal tumor (GIST) patients. However, many patients develop imatinib resistance due to secondary KIT mutations. The drug resistance mechanism has only been partially elucidated, and the sunitinib resistance mechanism is also unknown. In this...
Article
Full-text available
DKK3, a member of dickkopf WNT signaling pathway inhibitor family, is believed to be a tumor suppressor, because of itsreduced expression in cancer cells. However, our previous studies have revealed that DKK3 expression is predominantly observed in head and neck, and oral squamous cell carcinoma (HNSCC/OSCC). Interestingly, HNSCC/OSCC patients with...
Article
Full-text available
Background Migration of cancer cell correlates with distant metastasis and local invasion, which are good targets for cancer treatment. An optically accessible device ?TAXIScan? was developed, which provides considerably more information regarding the cellular dynamics and less quantity of samples than do the existing methods. Here, we report the e...
Article
Introduction: OSTEOTRANS MX (Takiron Co, Ltd, Osaka, Japan) is a resorbable osteosynthetic material composed of an unsintered hydroxyapatite/poly-l-lactide composite, and its osteoconductive capacity has been documented. The authors here report their clinical experience using OSTEOTRANS MX. Methods: The authors treated 35 patients (19 men, 16 wo...
Article
Background: Tumor parenchyma-stromal interactions affect the properties of tumors and their dynamics. Our group previously showed that secreted frizzled related protein (sFRP)-2 impairs bone formation and promotes bone invasion in ameloblastoma. However, the effects of the secreted growth factors CCN2, TGF-β, and BMP4 on stromal tissues in amelobl...
Article
Bisphosphonates (BPs) are useful drugs for the management of osteoporosis and metastatic bone disease, and are used to prevent skeletal-related events. However, the side effects of BPs, bisphosphonate-related osteonecrosis of the jaw (BRONJ), sometimes severely impairs patient quality of life. Here we report a case of severe BRONJ in the maxilla, w...
Article
Heat shock protein 90 (HSP90) has numerous cellular functions, including promotion of proper protein folding, and stabilizes a number of oncogenic proteins, many of which are overexpressed in cancers. The objective of this study is to evaluate an antitumor effect of HSP90 inhibitor, AUY922, in esophageal squamous cell carcinoma(ESCC) cell lines. ES...
Article
Full-text available
Skeletal muscle differentiation is a multistep, complex pathway in which several important signaling molecules are involved. Recently, microRNAs (miRNAs), endogenous non-coding small RNAs that regulate mRNAs, have been proposed to be involved in skeletal muscle differentiation. In this study, we identified skeletal muscle differentiation-associated...
Article
Full-text available
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare type of odontogenic carcinoma arising from the jawbone. Odontogenic cysts are true cysts that arise from the dental epithelium, which is associated with tooth formation. The epithelial lining of odontogenic cysts has the potential to transform into various types of odontogenic tumor; h...
Article
Squamous cell carcinoma throughout the epithelium of a lateral cervical cyst is considered extremely rare. This report describes an additional case of this very rare clinical condition. A 70-year-old man presented with a well-defined, immobile, painless mass in the left neck that was excised with a diagnosis of branchial cyst. Histologic findings o...
Article
Head and neck squamous cell carcinoma (HNSCC) is frequently occurring malignancy worldwide. It is believed that HNSCC may occur as the result of cumulative abnormalities on cancer related genes. However, the key genes or pathways that might serve an important role in HNSCC biology are yet to be investigated. Therefore, we previously performed genom...
Article
Full-text available
Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting an...
Article
We previously reported that dynamic contrast-enhanced MRI parameters and time–signal intensity curves (TICs; also known as contrast index curves) are useful for the differential diagnosis of jawbone lesions. In particular, odontogenic fibroma and ossifying fibroma, which possess similar histopathological features (i.e., a mixture of hard and soft t...
Article
Salivary glands are important exocrine glands for oral health and initial digestion. Salivary gland dysfunction resulting from irreversible glandular damage usually leads to poor life quality in patients. Recent investigations showed that bone marrow-derived cells (BMDCs) could be grafted into non-hematopoietic cells in multiple tissues. In this st...
Data
Expression profiles after clustering analysis for mouse whole transcripts. Messenger RNAs from C2C12 in proliferating medium (C2C12-PR), C2C12 in differentiation medium (C1C12-DF), and W4-08 in proliferating medium (C2C12-W4-08) were analyzed with the 3D-GeneTM mouse oligo chip 24K (Toray Industries, Inc., Tokyo).
Article
Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT...
Article
Tooth tissue engineering offers very attractive perspectives for elaboration of regenerative treatments, which enables to cure tooth loss and restore quality of life of the patients. To elaborate such treatment, isolation and culture of dental pulp cell must be achieved as a key element. In this article, we report the establishment of a stable cell...
Article
The purpose of this study was to evaluate the radiological and histopathological findings of 11 patients with unerupted first molars to verify the factors obstructing spontaneous eruption. The patients' clinical, radiological, and histopathological data were evaluated retrospectively to determine histopathological diagnosis, radiographic findings,...
Article
The object of this study was to determine the characteristics of central odontogenic fibroma (COF) in order to help achieve a correct diagnosis. Central odontogenic fibroma, which tends to be epithelium-poor, is an extremely rare type of odontogenic fibroma. The lack of data concerning COF, due to its low incidence, can make this entity difficult t...
Article
Objectives: To evaluate the diagnostic value of MRI for odontogenic tumours. Materials and methods: 51 patients with odontogenic tumours were subjected to pre-operative MRI examinations. For tumours with liquid components, i.e. ameloblastomas and keratocystic odontogenic tumours (KCOTs), the signal intensity (SI) uniformity of their cystic compo...
Article
The object of this study was to estimate the influence of radiation therapy (RT) and hyperbaric oxygen therapy (HBO) on osteoradionecrosis of the jaw (ORNJ). This retrospective study included patients who were diagnosed with ORNJ from 1998 to 2012 (15 years) and who recieved a total dose of RT (Gy) for the duration of the study. The duration of ORN...
Article
Full-text available
Oral squamous cell carcinoma (OSCC) is thought to arise as the result of cumulative genetic or epigenetic alterations in cancer-associated genes. We focused on the Dickkopf-3 (Dkk-3) gene as a candidate tumor suppressor in OSCC. Dkk-3 is a potential tumor suppressor, and its downregulation has been reported in various types of malignancies. However...
Article
Full-text available
Background. Wnt signaling is involved in muscle formation through β-catenin-dependent or -independent pathways, but interactions with other signaling pathways including transforming growth factor β/Smad have not been precisely elucidated. Results. As Wnt4 stimulates myogenic differentiation by antagonizing myostatin (GDF8) activity, we examined the...
Article
Full-text available
Purpose of the research Tooth germ development involves multiple events, including cell proliferation and cell differentiation. Connective tissue growth factor (CTGF/CCN2) is a signaling protein involved in tooth germ development, and we investigated how it is expressed and what roles it may have in primary cultures of mesenchymal cells derived fro...
Article
Bone healing is a complex and multistep process in which the origin of the cells participating in bone repair is still unknown. The involvement of bone marrow-derived cells in tissue repair has been the subject of recent studies. In the present study, bone marrow-derived cells in bone healing were traced using the GFP bone marrow transplantation mo...
Article
The aim of this study was to determine the expression of essential osteogenic genes related to the canonic WNT pathway, i.e., WDR5, sFRP-2, and their downstream genes, in ameloblastoma and to clarify their biologic impact on this neoplasm. Forty-six paraffin-embedded ameloblastoma samples and ameloblastic (AM-1) and preosteoblastic (KUSA/A1) cell l...
Article
Ossifying fibroma (OF), a rare nonodontogenic tumor, is defined as a bone-related jawbone lesion. The main histopathological feature of OF is the replacement of bone by benign connective tissue. Ossifying fibroma usually occurs in the second to fourth decades of life and shows a predilection for females. Ossifying fibroma most commonly occurs in th...
Article
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant odontogenic tumor arising from odontogenic epithelial remnants within the jawbones. PIOSCC is histopathologically divided into 3 types: solid-type carcinoma, carcinoma derived from a keratocystic odontogenic tumor, and carcinoma derived from an odontogenic cyst. In this artic...
Article
Adenoid cystic carcinoma (ACC) of the head and neck region is an uncommon epithelial tumor of the major and minor salivary glands. In the oral region, although ACC arising from the minor salivary glands is the second most commonly found tumor in the tongue base, its occurrence in the anterior part of the tongue is rare. Histopathologically, ACC is...
Article
Lymphoepithelial cysts, which are also known as branchial cleft cysts, commonly occur in the lateral cervical region. Lymphoepithelial cysts arising in the parotid gland are rare and must be distinguished from parotid gland tumors. Magnetic resonance imaging (MRI) is useful for diagnosing parotid gland lesions, and MR images of lymphoepithelial cys...
Article
Dens invaginatus is a deep surface invagination of the dentin that is lined by enamel and is easily affected by dental caries, thus resulting in pulpitis and apical periodontitis. This report presents an image analysis of rare dens invaginatus of the maxillary third molar in a 23-year-old man. A radiographic examination showed a radiopaque structur...
Article
The aim of this study was to compare the expressions of basal lamina (BL) collagen IV α chains and matrix metalloproteinases (MMP)-2 and MMP-9 in oral dysplasia (OED) and invasive carcinoma. Ten cases each of OEDs, carcinomas-in situ and oral squamous cell carcinomas (OSCCs) were examined by immunohistochemistry. Another 5 cases, each of normal and...
Article
The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI), especially dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), in extranodal non-Hodgkin lymphoma (NHL) of oral and maxillofacial regions. Thirteen cases with extranodal NHL were examined using MRI. T1-weighted images (T1WI) and T2-weight...
Article
Odontogenic fibroma (OF) is a rare nonepithelial benign tumor arising from the odontogenic mesenchymal tissue in the jawbone. OFs are topographically categorized into 2 types, the central type and peripheral type, and are histopathologically divided into the epithelium-poor type and epithelium-rich type. The radiological findings of central OF comm...
Article
To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) for differentiating between benign and malignant tumors in the palate. 26 patients with submucosal palatal tumors were preoperatively examined using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), and washout ratios (WR300 and WR600) were determined fro...
Article
Full-text available
Recent studies have established that, in benign tumors, a large number of cancer stem cells are present, which have great implications in tumor development. However, in ameloblastoma, a highly aggressive, locally invasive tumor with a high recurrence rate, whether or not cancer stem-like cells are present remains undetermined. Therefore, in this st...
Article
Full-text available
Head and neck squamous cell carcinoma (HNSCC) is one of the most frequently occurring types of cancer worldwide. We focused on the fact that the aberrant function of Wnt/β-catenin signaling is a frequent event in malignancies. Dickkopf (Dkk)-3 is a major negative regulator of Wnt/β-catenin signaling, which is a known tumor suppressor and is down-re...
Article
We report a case of focal oral mucinosis of the upper gingiva in an infant. A 19-month-old girl was referred to our clinic in 2010 because of a swelling of the left maxillary gingiva.We carried out tumor extirpation under general anesthesia. Histopathological examination showed spindle-shaped fibroblast-like cells in a loose mucoid stroma. We diagn...
Article
To evaluate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for minor salivary gland tumors in the oral cavity. Thirty-two patients with minor salivary gland tumors were examined preoperatively using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), Tpeak; i.e., the time that corresponded to...
Article
We examined the transplanted bone marrow-derived cell migration into periodontal tissues. Bone marrow cells from green fluorescent protein (GFP) transgenic mice were transplanted. The immunohistochemistry (IHC) revealed that GFP-positive cells were detected in the periodontal tissues. The GFP-positive cells histopathologically differentiated into s...
Article
Full-text available
Purpose of the researchLigneous gingivitis is a rare disease characterized by nodular gingival enlargement secondary to fibrin deposits induced by micro-injury in the gingiva, which disorder results from plasminogen (PLG) deficiency. Although none have investigated the association of wound healing factors with ligneous gingivitis. In this study, in...
Article
Full-text available
Oral mucosal melanoma (OMM) is a fatal sarcoma of unknown etiology. Histological morphology and genetic events are distinct from those of its cutaneous counterpart. Mutation and up-regulation of c-kit has been identified in OMM which may activate downstream molecules such as RAS and RAF. These molecules are involved in the mitogen-activated protein...
Article
Dickkopf (Dkk)-3, an inhibitor of the Wnt/β-catenin pathway, is reported as a potential tumor suppressor gene in many cancers. To gain a better comprehension of the mechanisms involved in the carcinogenesis of oral squamous epithelium, protein expression and localization of Dkk-3 and β-catenin was investigated in normal epithelium, dysplasias and s...
Article
Full-text available
Lymph node metastasis is considered a factor in determining the prognosis of squamous cell carcinoma (SCC). Both oral and cervical SCC tumor cells prefer lymph vessels as the route of metastasis. D2-40 is a specific marker of lymphatic endothelial cells. This study clarifies the distribution and characteristics of lymphatic vessels in oral and cerv...
Article
Malignant lymphoma is the second-most common malignancy in the head and neck region. Waldeyer's ring is the most common site of extranodal Hodgkin's lymphoma (NHL) in that region, and a small percentage of primary extranodal NHL occurs in the oral cavity. The most common sites of extranodal NHL in the oral region are the palate and maxilla, and nea...
Article
Teeth are important structures for masticatory and phonetic purposes. Loss of teeth decreases these functions leading to impaired quality of life. Missing teeth replaced by tooth regeneration may be possible with emerging advances in stem cell biology and tissue engineering. Recent investigations have demonstrated that bone marrow derived cells (BM...