Nancy Weiland-Bräuer

Nancy Weiland-Bräuer
Christian-Albrechts-Universität zu Kiel | CAU · Institute for General Microbiology

Private Lecturer/Akadämische Rätin
biofilms, quorum quenching, bacteriophages, phage therapy, fungi, host-microbe interactions, metaorganisms

About

42
Publications
7,835
Reads
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670
Citations
Additional affiliations
May 2010 - February 2016
Christian-Albrechts-Universität zu Kiel
Position
  • PostDoc Position
September 2006 - April 2010
Christian-Albrechts-Universität zu Kiel
Position
  • PhD Student

Publications

Publications (42)
Article
Full-text available
Microorganisms are present in nearly every niche on Earth and mainly do not exist solely but form communities of single or mixed species. Within such microbial populations and between the microbes and a eukaryotic host, various microbial interactions take place in an ever-changing environment. Those microbial interactions are crucial for a successf...
Article
Full-text available
All multicellular organisms are associated with a diverse and specific community of microorganisms; consequently, the microbiome is of fundamental importance for health and fitness of the multicellular host. However, studies on microbiome contribution to host fitness are in their infancy, in particular, for less well-established hosts such as the m...
Article
Full-text available
The associated microbiota of marine invertebrates plays an important role to the host in relation to fitness, health, and homeostasis. Cooperative and competitive interactions between bacteria, due to release of, for example, antibacterial substances and quorum sensing (QS)/quorum quenching (QQ) molecules, ultimately affect the establishment and dy...
Article
Full-text available
The cover image is based on the Original Article Cultivable microbiota associated with Aurelia aurita and Mnemiopsis leidyi by Cornelia Jaspers et al., https://doi.org/10.1002/mbo3.1094.
Article
Full-text available
The translocation of non-indigenous species (NIS) around the world, especially in marine systems, is increasingly being recognized as a matter of concern. Species translocations have been shown to lead to wide ranging changes in food web structure and functioning. In addition to the direct effects of NIS, they could facilitate the accumulation or t...
Article
Full-text available
The translocation of non-indigenous species around the world, especially in marine systems, is a matter of concern for biodiversity conservation and ecosystem functioning. While specific physical and ecological traits are often recognized to influence the success in the establishment of non-indigenous species, the impact of the associated microbiot...
Article
Full-text available
Background:The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution, and development of both players. These interdependencies inspired a new view of multicellular organisms as “metaorganisms.” The goal of the Collaborative Research Center “Origin and Function of Metaorganisms” is...
Article
Full-text available
Almost all animals and plants are inhabited by diverse communities of microorganisms, the microbiota, thereby forming an integrated entity, the metaorganism. Natural selection should favor hosts that shape the community composition of these microbes to promote a beneficial host-microbe symbiosis. Indeed, animal hosts often pose selective environmen...
Preprint
Full-text available
The associated microbiota of marine invertebrates plays an important role to the host in relation to fitness, health and homeostasis of the metaorganism. As one key chemically-mediated interaction, Quorum sensing (QS) and interference with QS among colonizing bacteria ultimately affects the establishment and dynamics of the microbial community on t...
Preprint
Full-text available
Background The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution and development of both players. These interdependencies inspired a new view of multicellular organisms as “metaorganisms”. The goal of the Collaborative Research Center “Origin and Function of Metaorganisms” is...
Preprint
Full-text available
The translocation of non-indigenous species around the world, especially in marine systems, is a matter of concern for biodiversity conservation and ecosystem functioning. While specific traits are often recognized to influence establishment success of non-indigenous species, the impact of the associated microbial community for the fitness, perform...
Article
Full-text available
Biofilm formation in the clinical environment is of increasing concern since a significant part of human infections is associated, and caused by biofilm establishment of (opportunistic) pathogens, for instance Candida albicans and Staphylococcus epidermidis. The rapidly increasing number of antibiotic-resistant biofilms urgently requires the develo...
Article
Full-text available
Abstract Multicellular organisms can be regarded as metaorganisms, comprising of a macroscopic host interacting with associated microorganisms. Within this alliance, the host has to ensure attracting beneficial bacteria and defending against pathogens to establish and maintain a healthy homeostasis. Here, we obtained several lines of evidence argui...
Article
Full-text available
Marine invasions are of increasing concern for biodiversity conservation worldwide. Gelatinous macrozooplankton contain members, which have become globally invasive, for example the ctenophore Mnemiopsis leidyi or the hydromedusae Blackfordia virginica. B. virginica is characterised by a large salinity tolerance, with a brackish-water habitat prefe...
Preprint
Full-text available
Almost all animals and plants are inhabited by diverse communities of microorganisms, the microbiota. The hosts often pose highly selective environments, which only a subset of the environmentally available microbes are able to colonize. From the host's perspective it seems useful to shape the community composition of these allowed microbes to prom...
Article
Full-text available
From protists to humans, all animals and plants are inhabited by microbial organisms. There is an increasing appreciation that these resident microbes influence the fitness of their plant and animal hosts, ultimately forming a metaorganism consisting of a uni- or multicellular host and a community of associated microorganisms. Research on host–micr...
Chapter
The marine environment covers more than 70 % of the world’s surface. Marine microbial communities are highly diverse and have evolved during extended evolutionary processes of physiological adaptations under the influence of a variety of ecological conditions and selection pressures. They harbor an enormous diversity of microbes with still unknown...
Article
Full-text available
Aiming to comprehensively survey the potential pollution of an alpine cryoconite (Jamtalferner glacier, Austria), and its bacterial community structure along with its biodegrading potential, first chemical analyses of persistent organic pollutants, explicitly polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) as well as polycycli...
Article
Full-text available
Bacterial cell-cell communication (quorum sensing, QS) represents a fundamental process crucial for biofilm formation, pathogenicity, and virulence allowing coordinated, concerted actions of bacteria depending on their cell density. With the widespread appearance of antibiotic-resistance of biofilms, there is an increasing need for novel strategies...
Article
Full-text available
Background Traditional medicinal plants have been used as an alternative medicine in many parts of the world, including Ethiopia. There are many documented scientific reports on antimicrobial activities of the same. To our knowledge, however, there is no report on the anti-Quorum Sensing (Quorum Quenching, QQ) potential of traditional Ethiopian med...
Article
Full-text available
Most bacteria are able to grow in biofilms in which they effectively resist antimicrobial agents. This leads to a general problem, since traditional treatments of bacteria and prevention strategies become mostly ineffective. Novel strategies for biofilm inhibition are thus urgently required. Compounds interfering with cell-cell communication (quoru...
Article
Full-text available
The scyphozoan Aurelia aurita is recognized as a key player in marine ecosystems, and a driver of ecosystem change. It is thus intensely studied to address ecological questions, although its associations with microorganisms remain so far undescribed. In the present study, the microbiota associated with A. aurita was visualized with fluorescence in...
Article
Full-text available
Two reporter strains were established to identify novel biomolecules interfering with bacterial communication (quorum sensing, QS). The basic design of these Escherichia coli-based systems comprises a gene encoding a lethal protein fused to promoters induced in the presence of QS signal molecules. Consequently, these E. coli strains are unable to g...
Article
The N-acyl-homoserine lactones (N-AHLs) play an important role in bacterial cell-cell signaling. Up to date, however, only a few different experimentally proven classes of N-AHL ring-cleaving enzymes are known. Here we report on the isolation and biochemical characterization of a novel hydrolase derived from the soil metagenome and acting on N-AHLs...
Article
Full-text available
Marine microbial communities are highly diverse and have evolved during extended evolutionary processes of physiological adaptations under the influence of a variety of ecological conditions and selection pressures. They harbor an enormous diversity of microbes with still unknown and probably new physiological characteristics. Besides, the surfaces...
Article
In this study, we investigated the ability of the fungus Neurospora crassa to produce and secrete two ribonucleases: the heterologous bovine RNase A and the endogenous RNase N(1). A set of expression vectors was constructed, each consisting of an RNase A open reading frame under the control of a specific promoter and each with a specific terminator...
Article
The bud emergence (BEM)46 proteins are evolutionarily conserved members of the alpha/beta-hydrolase super family, but their exact role remains unknown. To better understand the cellular role of BEM46 and its homologs, we used the model organism Neurospora crassa in conjunction with bem46 RNAi, over-expression vectors, and repeat induced point mutat...

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Projects

Projects (3)
Project
The ultimate goal of the Collaborative Research Center is to understand why and how microbial communities form long-term associations with hosts from diverse taxonomic groups. We are particularly interested in the specific functional consequences of the interactions, the underlying regulatory principles, and also the resulting impact on host life history and evolutionary fitness.
Project
All projects are focusing on cell-cell communication and its inhibition and the prevention/inhibition of harmful biofilms.