Nancy Mayo

Nancy Mayo
McGill University | McGill · School of Physical and Occupational Therapy

BSc(PT, MSc, PhD

About

442
Publications
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16,176
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Publications

Publications (442)
Article
Objective To understand the impact of pediatric multiple sclerosis (MS), health-related quality of life (HRQL) measures have been used. However, specific areas of concern of youths with MS are not known. The objective of this study was to contribute content for inclusion in a new condition-specific measure of the life impact of MS for children and...
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PurposeThe purpose of this study is to estimate the extent to which people aging with HIV meet criteria for successful aging as operationalized through HRQL and maintain this status over time. A second objective is to identify factors that place people at promise for continued successful aging, including environmental and resilience factors.Methods...
Chapter
This chapter provides an overview of the evidence linking mobility to quality of life (QoL). The findings showed that the operationalization of QoL varied across studies covering measures of physical or mental health, general health perception, life satisfaction, participation, illness intrusiveness, health-related QoL (HRQL) and global quality of...
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Introduction: Low motivation is frequent in older people with HIV, yet poorly understood. Effort-cost decision-making (ECDM) tasks inspired by behavioral economics have shown promise as indicators of motivation or apathy. These tasks assess the willingness to exert effort to earn a monetary reward, providing an estimate of the subjective "cost" of...
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Purpose Strongly framed research questions are clear as to the population (P), the exposures or interventions (E/I), comparison groups (C), outcomes (O), time when relevant (T), and what the investigator wants to know. A solid framework sets up the measurement model, analysis, and anticipated results. The purpose of this study was to estimate the e...
Article
Objective: To estimate the extent to which comorbidity and lifestyle factors were associated with physical frailty in middle-aged and older Canadians living with HIV. Design: Cross-sectional analysis of 856 participants from the Canadian Positive Brain Health Now cohort. Methods: The frailty indicator phenotype was adapted from Fried's criteri...
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Importance: Given the importance of apathy for stroke, we felt it was time to scrutinize the psychometric properties of the commonly used Starkstein Apathy Scale (SAS) for this purpose. Objectives: The objectives were to: (i) estimate the extent to which the SAS items fit a hierarchical continuum of the Rasch Model; and (ii) estimate the strength o...
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Purpose The Working Group undertook a critical, comprehensive synthesis of the response shift work to date. We aimed to (1) describe the rationale for this initiative; (2) outline how the Working Group operated; (3) summarize the papers that comprise this initiative; and (4) discuss the way forward. Methods Four interdisciplinary teams, consisting...
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Purpose The extant response shift definitions and theoretical response shift models, while helpful, also introduce predicaments and theoretical debates continue. To address these predicaments and stimulate empirical research, we propose a more specific formal definition of response shift and a revised theoretical model. Methods This work is an int...
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A correction to this paper has been published: https://doi.org/10.1007/s11136-021-02890-6
Article
Research on the psychosocial impact of COVID-19 has found significant levels of distress among the general population, and among those especially vulnerable due to chronic social or health challenges. Among these are individuals aging with HIV infection, who are encountering COVID-19 as a new infectious threat to their health and wellbeing. In a lo...
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Objective(1) To develop a personalized health outcome profile as a feedback tool to improve self-management in people living with chronic conditions such as HIV and (2) to evaluate the interpretability and usefulness of the feedback tool for setting specific goals.Methods The development of “My Personal Brain Health Dashboard” was inspired by the k...
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Background Older adults living with HIV may be at increased risk of experiencing distress during the COVID-19 pandemic. Methods We took advantage of a cohort study in older adults living with HIV in Canada (+BHN) to study the psychological impact of the first wave of the COVID-19 pandemic. A longitudinal study was conducted in which participants in...
Article
Background Recent evidence has suggested an existence of a multiple sclerosis (MS) prodrome. Hence, some young adults with MS are very likely to have had symptoms in childhood or adolescence. It is, therefore, reasonable to assume that people aged under 25 years with MS might have had pediatric-onset. In contrast, young people aged between 26 to 35...
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Objective This study used converging methods to examine the neural substrates of cognitive ability in middle-aged and older men with well-controlled HIV infection. Methods Seventy-six HIV+ men on antiretroviral treatment completed an auditory oddball task and an inhibitory control (Simon) task while time-locked high-density EEG was acquired; 66 ha...
Article
Incidence of cardiovascular disease in people living with HIV has increased as overall survival has improved because of combination antiretroviral therapy (cART). Arterial stiffness is a composite indicator of cardiovascular disease risk independent of traditional risk factors. We aimed to synthesize the evidence on the relation of HIV and of cART...
Article
Importance Postoperative recovery is difficult to define or measure. Research addressing interventions aimed to improve recovery after abdominal surgery often focuses on measures such as duration of hospital stay and complication rates. Although these clinical parameters are relevant, understanding patients’ perspectives regarding postoperative rec...
Preprint
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Given the importance of apathy for stroke, we felt it was time to scrutinize the commonly used Starkstein Apathy Scale (SAS) for psychometric evidence that it is fit for this purpose. The objectives were to: (i) estimate the extent to which the SAS items fit a hierarchical continuum of the Rasch Model; and (ii) estimate the strength of the relation...
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Full-text available
Purpose Many neuromotor conditions affect children from a young age through to adulthood, impacting their quality of life (QOL). For QOL to be accurately measured in these children, pediatric QOL must first be conceptualized. Some theoretical models and definitions have been proposed to understand QOL, but they were not developed for the pediatric...
Article
Objective: The ability to work is amongst the top concerns of people living with welltreated HIV. Cognitive impairment has been reported in many otherwise asymptomatic persons living with HIV and even mild impairment is associated with higher rates of occupational difficulties. There are several classification algorithms for HIV-Associated Neuroco...
Article
Background : The age of onset of MS appears to influence the course of disease progression and people with younger age of onset might have a different disability trajectory. Objectives : To identify longitudinal patterns of disability progression, as measured by changes in the Multiple Sclerosis Functional Composite (MSFC), of young people in MS d...
Article
Aim To identify generic measures used to measure quality of life (QoL) in pediatric multiple sclerosis research, estimate an overall score of children and adolescents with pediatric multiple sclerosis, and compare the scores to scores of typically developing children and adolescents. Method A systematic search was conducted on four databases. All...
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Purpose People living with HIV may experience some degree of mild cognitive impairment. They are best placed to report on their cognitive symptoms, but no HIV-specific questionnaire exists to elicit these concerns. This study aimed to validate a set of items to form a measure Methods 48 items were tested on an initial sample of 204 people with HIV...
Article
Safety guidelines resulting from the coronavirus disease 2019 pandemic may reduce physical activity participation of older adults, particularly prefrail and frail individuals. The objective was to explore older adults’ experiences with physical activity during the coronavirus disease 2019 pandemic. Using a qualitative descriptive approach, intervie...
Preprint
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Objective This study used converging methods to define the structural and functional characteristics of the neural substrates underlying variation in cognitive ability in older men with well-controlled HIV infection. Methods Seventy-six HIV+ men treated with combination antiretrovirals completed attention and inhibitory control tasks tapping diffe...
Article
Importance: Increased patient activation (PA) (ie, knowledge, skills, motivation, confidence to participate in care) may result in improved outcomes, especially in surgical settings. Objective: To estimate the extent to which PA is associated with 30-day postdischarge unplanned health care utilization after major thoracic or abdominal surgery....
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PurposeIn the context of identifying consequences and evaluating interventions for rare diseases, health-related quality of life (HRQL) measures are often used. Conclusions about HRQL are difficult to make as the participants are likely drawn from different countries. A global estimate of HRQL with estimates of variation would permit pooling of dat...
Article
Background Recent evidence has suggested an existence of a MS prodome, indicating that symptoms of neurodegeneration were present before the first clinical event. These early signs of MS are usually not recognized as a symptom of MS and some young adults with MS are very likely to have had these symptoms in their childhood or adolescence. It is thu...
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Background There is a lack of patient-reported outcome measures (PROMs) with robust measurement properties to assess postoperative recovery and support patient-centered care after abdominal surgery. The aim of this study was to establish a conceptual framework of recovery after abdominal surgery to support the development of a conceptually relevant...
Article
Objective To estimate, among people with multiple sclerosis, the extent to which a personally tailored exercise programme (MSTEP©) resulted in greater improvements in exercise capacity and related outcomes over 12 months in comparison with general exercise guidelines. Design Two-group randomized trial. Subjects Ambulatory and sedentary. Interven...
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Background: Goal setting is a crucial element in self-management of chronic diseases. Personalized outcome feedback is needed for goal setting, a requirement for behavior change. This study contributes to the understanding of the specificity of patient-formulated self-management goals by testing the effectiveness of a personalized health outcome pr...
Article
Background: Ecological validity is an important psychometric property when assessing function. How a person with multiple sclerosis (MS) performs in clinical settings and in natural environments can be quite different. Walking is the most frequently assessed and recommended way to maintain health in a progressive disease such as MS. The objective...
Article
Objective: To estimate the extent to which staff-directed facilitation of early mobilization impacts recovery of pulmonary function and 30-day postoperative pulmonary complications (PPCs) after colorectal surgery. Summary background data: Early mobilization after surgery is believed to improve pulmonary function and prevent PPCs; however, adhere...
Article
Background: People aging with HIV are at risk for loneliness, with stigmatization and economic marginalization added to the health challenges arising from chronic infection. This study provides evidence for the extent, contributors, and consequences of loneliness in people living with HIV, focusing on brain health and quality of life. Setting: C...
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Objective To estimate the extent to which HIV-related variables, cognition, and other brain health factors interrelate with other HIV-associated symptoms to influence function, health perception, and QOL in older HIV+ men in Canada. Design Cross-sectional structural equation modelling (SEM) of data from the inaugural visit to the Positive Brain He...
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Physical activity is an important health behaviour in reducing morbidity and mortality in individuals with chronic obstructive pulmonary disease (COPD). Accurate measurement of the characteristics of physical activity is essential to understanding the impact of COPD on physical activity. In a previous article, we reported on the cross-cultural adap...
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Importance Frailty represents a multidimensional syndrome that is increasingly being used to stratify risk in surgical patients. Current frailty risk models are limited among those undergoing thyroid or parathyroid surgery. Objective To develop and compare preoperative risk indices to determine factors associated with short-term major postoperativ...
Article
RÉSUMÉ Les facteurs de protection retrouvés chez des octogénaires atteints de sclérose en plaques (SP) vivant à domicile ont été comparés à ceux d’individus sans SP du même groupe d’âge et de personnes moins âgées atteintes de SP. Les données provenant des octogénaires atteints de SP ( n = 23) et d’un groupe de répondants plus jeunes avec cette mal...
Article
Background: Confusion exists among neurosurgeons when choosing and implementing an appropriate study design and statistical methods when conducting research. We noticed particular difficulty with mislabeled and inappropriate case-control studies in the neurosurgical literature. Objective: To quantify and to rigorously review this issue for appro...
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Introduction: A theory-based, task-oriented, community walking programme can increase outdoor walking activity among older adults to optimise functional independence, social participation and well-being. The study objective is to determine if there is a difference in the change in outdoor walking activity from baseline to 10 weeks, 5.5 months and...
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Background: Mild cognitive impairment is common in chronic HIV infection and there is concern that it may worsen with age. Distinguishing static impairment from on-going decline is clinically important, but the field lacks well-validated cognitive measures sensitive to decline and feasible for routine clinical use. Measures capable of detecting im...
Article
Objective: Investigate whether cerebral small vessel disease (CSVD) is more common in virologically-suppressed HIV-positive participants compared to HIV-negative controls and examine the potential synergistic effects of HIV and CSVD on brain structure and cognition. Design: Cross-sectional analysis of 119 treated, virologically-suppressed HIV-po...
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Background: Aging and neurological conditions like Multiple Sclerosis (MS) and Parkinson's disease (PD) make people vulnerable for gait impairments, limit function, and restrict sustained walking needed for health promotion. Walking to meet physical activity guidelines requires adequate cadence which is difficult to achieve for gait vulnerable pop...
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Objective:: To estimate the construct validity of the Preference-Based Stroke Index and its value added over a generic measure, the EuroQol-5D-3L at three months after stroke. Design:: This is a secondary analysis of an existing inception cohort. Pearson correlation coefficients were estimated to test construct validity and Generalized Estimatin...
Preprint
BACKGROUND Evidence shows that gait training in older adults is effective in improving gait pattern but effects abate with cessation of training. During gait training therapists use a number of verbal and visual cues to place the heel first when stepping. This simple strategy changes posture from stooped to upright, lengthens the stride, stimulated...
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Importance: Patients 65 years or older are the most frequent users of operative resources and are also the most vulnerable to postoperative adverse events (AEs). Frailty indices are increasingly being used for preoperative risk stratification within head and neck cancer surgery, but most models lack a multifactorial basis and cannot be directly ap...
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Background: While evidence supports early compared to delayed cholecystectomy as optimal management of acute calculous cholecystitis (ACC), significant variability in practice remains. The purpose of this study was to identify variables associated with early cholecystectomy, to target opportunities to improve adherence to best practices. Methods:...
Article
Objectives: To examine the course of recovery and resulting health-related quality of life (HRQL) after low-trauma hip fracture using two different definitions of recovery. Design: Inception cohort with eight assessments over one year. Setting: Participants were recruited from a tertiary-care hospital and followed in the community. Interventi...
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Objective: The overall aim of this study is to create an item pool reflecting the cognitive concerns expressed by people with HIV as a first step toward developing such a measure. Method: Semiqualitative interviews with 292 people with HIV were carried out. Their concerns were mapped to neurocognitive domains to identify concern content areas an...
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Background While disease progression can be readily monitored in early stage relapsing multiple sclerosis (MS), it is more challenging for secondary progressive multiple sclerosis (SPMS). This advanced stage of disease has distinct pathophysiology due to compartmentalization of neuroinflammatory activity within the central nervous system, resulting...
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Background The Stroke Canada Optimization of Rehabilitation by Evidence-Implementation Trial (SCORE-IT) showed that a facilitated knowledge translation (KT) approach to implementing a stroke rehabilitation guideline was more likely than passive strategies to improve functional walking capacity, but not gross manual dexterity, among patients in reha...
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Background and objective: Participants experiencing homelessness and mental illness who received housing and support through the At Home/Chez Soi trial showed modest gains in quality of life (QOL) compared to treatment as usual participants. Participants' QOL ratings over time may have been affected by either response shift triggered by new life c...
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Seniors are living longer and many experience what is called Healthy Aging, an aging process without significant impairment. However, the vast majority of older adults will have some degree of limitations. In order to develop successful healthcare strategiesit’s necessary to understand the dynamics of aging. The global aim of this study was to desc...
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After hospitalization, further disability among seniors could be prevented through exercise. Nonetheless, a one-on-one rehabilitation is not realistic for the volume of seniors that are experiencing disability. Currently available educational material for improving disability is so vast and non-specific that passive dissemination may pose a barrier...
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Across Canada, people over 75 years of age represent 16% of all hospital admissions. The admission rate per 100,000 seniors is 5 times higher for acute care and 22 times higher for complex continuing care than the rates for younger adults. After a hospital discharge, dealing with new disabilities can be difficult and even overwhelming. Understandin...
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Objectives The objectives of this study were to identify needs and to estimate whether self-reported health can be used as an indicator of service needs among seniors. Methods This was a cross-sectional survey. Age- and sex-adjusted logistic regression was used to estimate the link between functional status indicators and fair or poor self-reporte...
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Background The Stroke Canada Optimization of Rehabilitation by Evidence Implementation Trial (SCORE-IT) was a cluster randomized controlled trial that evaluated two knowledge translation (KT) interventions for the promotion of the uptake of best practice recommendations for interventions targeting upper and lower extremity function, postural contro...
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Background Comparisons of population health status using self-report measures such as the SF-36 rest on the assumption that the measured items have a common interpretation across sub-groups. However, self-report measures may be sensitive to differential item functioning (DIF), which occurs when sub-groups with the same underlying health status have...
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Purpose: To identify from the published literature the feasibility and the application of the individualized measures [Patient Generated Index (PGI), Schedule for the Evaluation of Individual Quality of Life (SEIQOL), and the short form of it (the direct weighting SEIQOL-DW)] in the context of cancer and to summarize the evidence on the psychometr...
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Objective: To estimate feasibility and potential for efficacy of an individualized, exercise-focused, self-management program (i.e. Managing Mobility Outcomes In Vulnerable Seniors ( MMOVeS)), in comparison to exercise information in improving mobility after six months among seniors recently discharged from hospital. Design: Randomized pilot stu...