Nancy E Lane

Nancy E Lane
University of California, Davis | UCD · School of Medicine

About

609
Publications
63,531
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
30,564
Citations
Citations since 2017
230 Research Items
12279 Citations
201720182019202020212022202305001,0001,5002,000
201720182019202020212022202305001,0001,5002,000
201720182019202020212022202305001,0001,5002,000
201720182019202020212022202305001,0001,5002,000

Publications

Publications (609)
Article
Full-text available
Objective: Metabolic dysregulation frequently co-occurs with obesity, which has been shown to be a risk factor for lower extremity osteoarthritis (OA). We evaluated the association between metabolic syndrome (MetS), alone and in combination with obesity, and hip OA. Methods: In two parallel cross-sectional analyses, we studied 403 women from the...
Article
Full-text available
Background To assess the compound effects of BMI and sustained depressive symptoms on changes in knee structure, cartilage composition, and knee pain over 4 years using statistical interaction analyses. Methods One thousand eight hundred forty-four individuals from the Osteoarthritis Initiative Database were analyzed at baseline and 4-year follow-...
Article
Introduction: Hyperkyphosis commonly affects older people but is not widely acknowledged as a clinically actionable problem, especially in men. There are several techniques to quantify kyphosis including the blocks and Cobb angle measurements. This study includes both kyphosis measures to investigate whether older men with accentuated kyphosis may...
Article
Background Older men with the worse alignment of activity and light may have lower levels of cognition and increased rates of cognitive decline. Methods This cohort consisted of 1 036 older men (81.1 ± 4.6 years) from the MrOS Sleep Study (2009–2012). Light and activity levels were gathered by wrist actigraphy. Phasor analysis was used to quantify...
Article
Background: Musculoskeletal pain, a possible marker of central sensitization, is associated with higher prevalence of lower urinary tract symptoms (LUTS) among older men. We investigated whether musculoskeletal pain is associated with LUTS progression. Methods: Participants were 5,569 men age ≥65 years enrolled in the prospective, multicenter Os...
Article
Full-text available
Age-related hyperkyphosis is associated with adverse health outcomes, such as falls, fractures, and mortality. However, few studies investigated the relationship between the severity of hyperkyphosis and physical endurance in older adults. This study examined whether a degree of hyperkyphosis curvature was independently associated with the 6-minute...
Article
Full-text available
Background: Several studies have examined gut microbiota and sarcopenia using 16S ribosomal RNA amplicon sequencing; however, this technique may not be able to identify altered specific species and functional capacities of the microbes. We performed shotgun metagenomic sequencing to compare the gut microbiome composition and function between indiv...
Article
Full-text available
Sleep disturbances increase with age and are predictors of mortality. Here, we present deep neural networks that estimate age and mortality risk through polysomnograms (PSGs). Aging was modeled using 2500 PSGs and tested in 10,699 PSGs from men and women in seven different cohorts aged between 20 and 90. Ages were estimated with a mean absolute err...
Preprint
Full-text available
Microgravity-induced bone loss is a main obstacle for long term space missions as it is difficult to maintain bone mass when loading stimuli is reduced. With a typical bone mineral density loss of 1.5% per month of microgravity exposure, the chances for osteoporosis and fractures may endanger astronauts' health. Parathyroid Hormone or PTH (1-34) is...
Article
Muscle strength and physical performance are associated with incident fractures and mortality. However, their role in the risk of subsequent fracture and post‐fracture mortality is not clear. We assessed the association between muscle strength (grip strength) and performance (gait speed and chair stands time) and the risk of subsequent fracture and...
Article
Full-text available
Background: Approximately 30% to 40% of older adults have hyperkyphosis, defined as excessive curvature of the thoracic spine. Hyperkyphosis is associated with increased morbidity and mortality. This study aimed to determine whether hyperkyphosis (Cobb's angle) and upper extremity tasks were independently associated with the 6-min walk test (6MWT)...
Article
Context Whether repeated bone mineral density (BMD) screening improves fracture prediction in men is uncertain. Objective Evaluate whether a second BMD 7 years after the initial BMD improves fracture prediction in older men. Methods 3,651 community-dwelling men (mean age 79.1 years) with total hip BMD at baseline and Year 7 (Y7). Self-reported fr...
Article
Chronic pain syndrome is a heterogeneous group of diseases characterized by several pathological mechanisms. One in five adults in Europe may experience chronic pain. In addition to the individual burden, chronic pain has a significant societal impact because of work and school absences, loss of work, early retirement, and high social and healthcar...
Article
Full-text available
Accurate quantification of bone, muscle, and their components is still an unmet need in the musculoskeletal field. Current methods to quantify tissue volumes in 3D images are expensive, labor-intensive, and time-consuming; thus, a reliable, valid, and quick application is highly needed. Tissue Compass is a standalone software for semiautomatic segm...
Article
Objective: To assess the effects of weight loss and weight gain on hip and knee radiographic changes, pain, and joint replacement over 4 years. Methods: Participants (n=2752) from the Osteoarthritis (OA) Initiative were classified as those with weight gain (>5% gain), weight loss (>-5% loss), or as controls (-3 to 3% change) over four years. Gen...
Article
Rationale and Objectives Osteoporosis affects 9% of individuals over 50 in the United States and 200 million women globally. Spinal osteoporotic compression fractures (OCFs), an osteoporosis biomarker, are often incidental and under-reported. Accurate automated opportunistic OCF screening can increase the diagnosis rate and ensure adequate treatmen...
Article
Background Muscle mass declines with age, while body adiposity increases. Sarcopenic obesity has been proposed to be particularly deleterious. However, previous methods for estimating muscle mass have been inadequate, and the relative contributions of total body fat vs. muscle fat to adverse outcomes have been unclear. Methods In a large cohort of...
Article
Full-text available
Objective To evaluate changes in bone turnover and bone mineral density (BMD) in subjects with rheumatoid arthritis (RA) on glucocorticoid (GC) after discontinuing denosumab for 12 months. Methods Randomized, double-blind, placebo-controlled phase 2 study of subjects with RA. Subjects received placebo, or denosumab 60 or 180 mg every 6 months for...
Article
Aims Features of central sensitization (CS) are present in almost all chronic pain conditions, including painful urinary conditions and back pain. Recently CS was proposed as a mechanism of nonpainful lower urinary tract symptoms (LUTS). Using musculoskeletal pain as an indicator of CS, we investigated whether the prevalence of musculoskeletal pain...
Article
Objectives There is still a large unmet need for novel osteoarthritis (OA) treatments that could provide clinically important effects on long-term pain relief (≥12 months). We examined the relation of bariatric surgery along with weight loss to analgesic prescription and all-cause mortality among individuals with OA. Methods We conducted a cohort...
Article
Background Cut-points to define slow walking speed have largely been derived from expert opinion. Methods Study participants (13,589 men and 5,043 women aged ≥65years) had walking speed (m/s) measured over 4-6 meters (mean ± SD: 1.20 ± 0.27 m/s in men and 0.94 ± 0.24 m/s in women.) Mobility limitation was defined as self-reported any difficulty wi...
Preprint
Full-text available
Background: Accurate quantification of bone, muscle, and their components is still an unmet need in the musculoskeletal field. Current methods to quantify tissue volumes in 3D images are expensive, labor-intensive, and time-consuming; thus, a reliable, valid, and quick application is highly needed. Methods: Tissue Compass is a standalone software f...
Article
Full-text available
Background Opioids are frequently prescribed for pain control in knee osteoarthritis patients, despite recommendations by current guidelines. Previous studies have investigated the chondrotoxicity of different opioid subtypes. However, the impact opioids may have on progression of osteoarthritis in vivo remains unknown. The aim of this study was th...
Article
Full-text available
How different measures of adiposity are similarly or differentially related to mobility limitation and mortality is not clear. In total, 5849 community-dwelling men aged ≥65 years (mean age: 72 years) were followed mortality over 10 years and self-reported mobility limitations (any difficulty walking 2–3 blocks or with climbing 10 steps) at six con...
Article
Chronic increases in pro-inflammatory cytokines in older adults, known as inflammaging, is an important risk factor for morbidity and mortality in the aging population. It has been suggested that circadian disruption may play a role in chronic inflammation, but there has been limited study that investigated the overall profile of 24-hour rest-activ...
Article
Full-text available
A Correction to this paper has been published: https://doi.org/10.1038/s42255-021-00377-9.
Article
Objective: The aim of this study was to investigate the associations between weight cycling and knee joint degeneration in individuals with overweight or obesity with different patterns of weight change over 4 years. Methods: A total of 2,271 individuals from the Osteoarthritis Initiative database were assessed (case-control study). Linear regre...
Article
Full-text available
Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical systems. Space agencies can no longer reduce the majority of the human health and performance risks through crew...
Article
Full-text available
Background Adipose tissue has recently gained interest as an independent imaging biomarker for osteoarthritis. Purpose To explore 1) cross‐sectional associations between local subcutaneous fat (SCF) thickness at the knee and the extent of degenerative changes in overweight and obese individuals and 2) associations between local fat distribution an...
Article
Full-text available
Background Hyperkyphosis is common in older adults and associated with low physical function and reduced health related quality of life (HrQol). Improved kyphosis has been previously established in kyphosis-targeted interventions in randomized controlled trials in older adults with hyperkyphosis; however, evidence for improved physical function is...
Article
Full-text available
Objective Lorecivivint (LOR; SM04690), an investigational Wnt pathway modulator, previously demonstrated patient-reported and radiographic outcome improvements versus placebo in clinically relevant subjects with moderate to severe knee osteoarthritis (OA). This study’s objective was to identify effective LOR doses. Design Subjects in this 24-week,...
Article
Full-text available
The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with age. We leverage three independent cohorts comprising over 9,000 individuals and find that composit...
Article
To assess the association of height loss in old age with subsequent risk of hip and any clinical fracture in men late in life while accounting for the competing risk of mortality, we used data from 3,491 community‐dwelling men (mean age 79.2 years). Height loss between baseline and follow‐up (mean 7.0 years between examinations) was categorized as...
Article
Full-text available
A Correction to this paper has been published: https://doi.org/10.1007/s00198-021-05828-3
Chapter
The systemic and focal joint inflammation that characterizes many of the rheumatologic disorders can also be accompanied by adverse effects on the skeleton. Much of the attention has focused on the focal bone resorption in articular and periarticular bone associated with disorders such as rheumatoid arthritis (RA), the prototypical inflammatory joi...
Article
Purpose Osteoarthritis (OA) is a frequently occurring, chronic condition; however, few studies describe the clinical characteristics of individuals with OA and the treatments they use to manage their symptoms. We conducted a study to characterize the OA population in the US and describe the nonsurgical management used by this population based on co...
Article
Full-text available
Objective To summarize available evidence on the association between hip shape as quantified by statistical shape modeling (SSM) and the incidence or progression of hip osteoarthritis. Design We conducted a systematic search of five electronic databases, based on a registered protocol (available: PROSPERO CRD42020145411). Articles presenting origi...
Article
Full-text available
Objective Hip shape is a well-recognized risk factor for hip osteoarthritis (OA) and hip fracture. We aimed to investigate whether the genetic variants known to be associated with adult hip shape were also associated with adolescent hip shape. Methods Hip DXA scans, obtained in offspring from the Avon Longitudinal Study of Parents and Children (AL...
Article
Full-text available
Glucocorticoids increase bone fragility in patients in a manner that is underestimated by bone mass measurement. We aimed to determine if the adult mouse could model this bone strength/bone mass discrepancy. Methods: Forty‐two thirteen week old BALB/cJ mice were randomized into vehicle and glucocorticoid groups, implanted with vehicle or 6‐methylpr...
Article
Full-text available
Background and Objectives Fatigue is a common complaint and shares many risk factors with falls, yet the independent contribution of fatigue on fall risk is unclear. This study’s primary aim was to assess the association between fatigue and prospective fall risk in 5,642 men aged 64-100 enrolled in the Osteoporotic Fractures in Men Study (MrOS). Th...
Article
Nerve growth factor (NGF) is a neurotrophin that activates nociceptive neurons to transmit pain signals from the peripheral to the central nervous system and that exerts its effects on neurons by signalling through tyrosine kinase receptors. Antibodies that inhibit the function of NGF and small molecule inhibitors of NGF receptors have been develop...
Preprint
Full-text available
Background: Hyperkyphosis is common in older adults and associated with low physical function and reduced health related quality of life (HrQol). Improved kyphosis has been previously established in kyphosis-targeted interventions in randomized controlled trials in older adults with hyperkyphosis however evidence for improved physical function is c...
Article
Full-text available
Background Currently, there are no effective medications to reverse periodontal disease (PD)-induced bone loss. The objective of this study was to test a new anabolic compound, LLP2A-Ale, or with the combination treatment of mesenchymal stromal cell (MSC), in the treatment of bone loss secondary to PD. Methods PD was induced in mice by placing a l...
Article
Full-text available
The use of bone turnover marker (BTM) testing for patients with osteoporosis in the USA has not been well characterized. This retrospective US-based real-world data study found BTM testing has some association with treatment decision-making and lower fracture risk in patients with presumed osteoporosis, supporting its use in clinical practice.Intro...
Article
Full-text available
Background: To assess the association of co-existing MRI lesions with knee pain at rest or on joint loading. Methods: We included participants from Osteoarthritis Initiative whose pain score, measured by WOMAC sub-scales, differed by ≥1 point at rest (in bed at night, sitting/lying down) or on joint loading (walking, stairs) between two knees. C...
Article
The associations between objective measures of sleep duration and bone outcomes in older men are unknown. No consistent, significant association was identified between sleep duration and bone mineral density (BMD) in the current analysis. However, future research should determine if vitamin D status modifies this relationship.IntroductionPrior stud...
Article
Objective: Disruption of rest-activity rhythms is cross-sectionally associated with metabolic disorders, including type 2 diabetes, yet it remains unclear whether it predicts impaired glucose metabolism and homeostasis. The aim of this study is to examine the cross-sectional and prospective associations between rest-activity rhythm characteristics...
Preprint
Full-text available
Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical system. Space agencies can no longer buy down the majority of human system risk through the crew member selection...
Article
Full-text available
Background and purpose: Treatments that prevent worsening kyphosis are important due to the progressive nature of kyphosis with aging. We assessed long-term efficacy of treatment effects after a short-term kyphosis exercise and posture training intervention in a cohort study among older adults with hyperkyphosis, and investigated whether long-term...
Article
Background: The extent of medial meniscal extrusion (MME) that is associated with structural and symptomatic progression of knee osteoarthritis has not been defined yet. Objective: To investigate MRI-based thresholds of MME that are associated with structural progression of knee degenerative disease and symptoms over a period of 4 years. Method...
Article
Full-text available
Background: Progesterone receptor (PR) affects immunomodulation, and lack of PR in osteoprogenitor cells primarily affects pathways associated with immunomodulation, especially in males. In this study, we selectively deleted PR from osteoprogenitor cells using Prx1-Cre to evaluate the tissue-specific effects of PR on the pathegenesis of inflammata...
Article
Full-text available
Objective This work aims to study (i) the relationship between body mass index (BMI) and knee synovial inflammation using non-contrast-enhanced MRI and (ii) the association of synovial inflammation versus degenerative abnormalities and pain.Materials and methodsSubjects with risk for and mild to moderate radiographic osteoarthritis were selected fr...
Article
Objectives Our aim was to determine the association between protein intake (overall and by source) and all-cause and cause-specific mortality among older men.DesignProspective cohort study.Setting5790 ambulatory community-dwelling older men from multicenter Osteoporotic Fractures in Men (MrOS) study.MeasurementsTotal energy and protein intake, and...
Article
Objectives To study the natural history of new horizontal meniscal tears and their association with progression of cartilage degeneration in individuals at risk for or with mild to moderate knee osteoarthritis over 4 years.Methods Individuals who developed a new meniscal tear in the right knee over 2 years were selected from the Osteoarthritis Init...
Article
Objective To identify joint structural risk factors, measured using quantitative compositional and semiquantitative magnetic resonance imaging (MRI) scoring, associated with the development of accelerated knee osteoarthritis (AKOA) compared with a more normal rate of knee osteoarthritis (OA) development. Design From the Osteoarthritis Initiative w...
Preprint
Full-text available
Aims. Currently, there are no effective medications that reverse periodontal disease (PD)-induced bone loss. The objective of this study was to test a new anabolic compound, LLP2A-Ale, or with the combination treatment of mesenchymal stromal cell (MSC), in the treatment of bone loss secondary to PD. Martials and Methods. PD was induced in mice by...
Preprint
Full-text available
Aims. Currently, there are no effective medications that reverse periodontal disease (PD)-induced bone loss. The objective of this study was to test a new anabolic compound, LLP2A-Ale, or with the combination treatment of mesenchymal stromal cell (MSC), in the treatment of bone loss secondary to PD. Materials and Methods. PD was induced in mice by...
Preprint
Full-text available
Background. Currently, there are no effective medications that reverse periodontal disease (PD)-induced bone loss. The objective of this study was to test a new anabolic compound, LLP2A-Ale, or with the combination treatment of mesenchymal stromal cell (MSC), in the treatment of bone loss secondary to PD. Methods. PD was induced in mice by placing...
Article
Objectives Adiposity is often approximated by body mass index (BMI), weight, and % fat from dual energy x-ray absorptiometry (DXA). We aimed to describe how different measures of adiposity and body composition are similarly or differentially related to mobility limitation and mortality. Methods Older community-dwelling men aged ≥65 yrs were follow...
Article
Background Concerns over the safety of available osteoarthritis (OA) treatments have led to revision of treatment guidelines and highlight the need for new therapies. Lorecivivint (LOR; SM04690) is an intra-articular (IA), small-molecule CLK/DYRK1A inhibitor that modulates the Wnt pathway and is in development as a potential disease-modifying treat...
Preprint
Full-text available
Background: To assess the association of co-existing MRI lesions with knee pain at rest or on joint loading. Methods: We included participants from Osteoarthritis Initiative whose pain score, measured by WOMAC sub-scales, differed by ≥1 point at rest (in bed and with sitting/lying down) or on joint loading (with walking and on stairs) between two k...
Preprint
Full-text available
Background: To assess the association of co-existing MRI lesions with knee pain at rest or on joint loading. Methods: We included participants from Osteoarthritis Initiative whose pain score, measured by WOMAC sub-scales, differed by ≥1 point at rest (in bed at night, sitting/lying down) or on joint loading (walking, stairs) between two knees. Cart...
Article
Full-text available
Background: Declines in bone, muscle and physical performance are associated with adverse health outcomes in older adults. However, few studies have described concurrent age-related patterns of change in these factors. The purpose of this study was to characterize change in four properties of muscle, physical performance, and bone in a prospective...
Article
Full-text available
Objective Statistical shape modelling (SSM) of hip dual-energy x-ray absorptiometry (DXA) scans has identified relationships between hip shape and radiographic hip OA (rHOA). We aimed to further elucidate shape characteristics related to rHOA by focusing on subregions identified from whole-hip shape models. Method SSM was applied to hip DXAs obtai...
Article
Full-text available
Objective To assess the safety and efficacy of the novel Wnt pathway modulator lorecivivint (SM04690) for treating pain and inhibiting structural progression in moderate‐to‐severe symptomatic knee osteoarthritis (OA). Methods Subjects in this 52‐week, Phase 2a, multicenter, randomized, double‐blind, placebo (PBO)‐controlled, dose‐ranging trial rec...