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Publications
Publications (23)
Purpose
Radiotherapy treatment planning (RTP) using MR has been used increasingly for the abdominal site. Multiple contrast weightings and motion‐resolved imaging are desired for accurate delineation of the target and various organs‐at‐risk and patient‐tailored planning. Current MR protocols achieve these through multiple scans with distinct contra...
Purpose
Widely used conventional 2D T2* approaches that are based on breath‐held, electrocardiogram (ECG)–gated, multi‐gradient‐echo sequences are prone to motion artifacts in the presence of incomplete breath holding or arrhythmias, which is common in cardiac patients. To address these limitations, a 3D, non‐ECG‐gated, free‐breathing T2* technique...
T 1 mapping is becoming a staple magnetic resonance imaging method for diagnosing myocardial diseases such as ischemic cardiomyopathy, hypertrophic cardiomyopathy, myocarditis, and more. Clinically, most T 1 mapping sequences acquire a single slice at a single cardiac phase across a 10 to 15-heartbeat breath-hold, with one to three slices acquired...
Introduction
Dynamic contrast-enhanced (DCE) MRI has important clinical value for early detection, accurate staging, and therapeutic monitoring of cancers. However, conventional multi-phasic abdominal DCE-MRI has limited temporal resolution and provides qualitative or semi-quantitative assessments of tissue vascularity. In this study, the feasibili...
Background and aims
Accurate differentiation of chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) is an area of unmet clinical need. In this study, a novel Multitasking dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) technique was used to quantitatively evaluate the microcirculation properties of pancreas in CP...
Purpose
To develop a novel 3D abdominal CEST MRI technique at 3 T using MR multitasking, which enables entire‐liver coverage with free‐breathing acquisition.
Methods
k‐Space data were continuously acquired with repetitive steady‐state CEST (ss‐CEST) modules. The stack‐of‐stars acquisition pattern was used for k‐space sampling. MR multitasking was...
Purpose
To develop an MR multitasking‐based dynamic imaging for cerebrovascular evaluation (MT‐DICE) technique for simultaneous quantification of permeability and leakage‐insensitive perfusion with a single‐dose contrast injection.
Methods
MT‐DICE builds on a saturation‐recovery prepared multi‐echo fast low‐angle shot sequence. The k‐space is rand...
Objectives:
The aims of the study are to evaluate the feasibility of using pH-sensitive magnetic resonance imaging, chemical exchange saturation transfer (CEST) in pancreatic imaging and to differentiate pancreatic ductal adenocarcinoma (PDAC) with the nontumor pancreas (upstream and downstream) and normal control pancreas.
Methods:
Sixteen CEST...
Purpose
To develop a free‐breathing, non‐electrocardiogram technique for simultaneous myocardial T1, T2, T2*, and fat‐fraction (FF) mapping in a single scan.
Methods
The MR Multitasking framework is adapted to quantify T1, T2, T2*, and FF simultaneously. A variable TR scheme is developed to preserve temporal resolution and imaging efficiency. The...
Purpose
To perform fast 3D steady‐state CEST (ss‐CEST) imaging using MR Multitasking.
Methods
A continuous acquisition sequence with repetitive ss‐CEST modules was developed. Each ss‐CEST module contains a single‐lobe Gaussian saturation pulse, followed by a spoiler gradient and eight FLASH readouts (one “training line” + seven “imaging lines”). T...
Purpose
To develop a new technique that enables simultaneous quantification of whole‐brain T1, T2, T2∗, as well as susceptibility and synthesis of six contrast‐weighted images in a single 9.1‐minute scan.
Methods
The technique uses hybrid T2‐prepared inversion‐recovery pulse modules and multi‐echo gradient‐echo readouts to collect k‐space data wit...
Purpose
To develop a 3D multitasking multi‐echo (MT‐ME) technique for the comprehensive characterization of liver tissues with 5‐min free‐breathing acquisition; whole‐liver coverage; a spatial resolution of 1.5 × 1.5 × 6 mm³; and simultaneous quantification of T1, water‐specific T1 (T1w), proton density fat fraction (PDFF), and R2∗.
Methods
Six‐ec...
Purpose
To address head motion in brain MRI with a novel motion‐resolved imaging framework, with application to motion‐robust quantitative multiparametric mapping.
Methods
MR multitasking conceptualizes the underlying multiparametric image in the presence of motion as a multidimensional low‐rank tensor. By incorporating a motion‐state dimension in...
High-field magnetic resonance imaging (MRI, 3.0T and above) offers numerous advantages for imaging the human body over lower-field strengths. However, it suffers from unwanted fast spatially-varying main (B 0 ) fields caused by the susceptibility mismatch at the tissue interfaces. When this is combined with the anatomical complexity of the human bo...
Purpose
To develop a low‐dose Multitasking DCE technique (LD‐MT‐DCE) for breast imaging, enabling dynamic T1 mapping–based quantitative characterization of tumor blood flow and vascular properties with whole‐breast coverage, a spatial resolution of 0.9 × 0.9 × 1.1 mm³, and a temporal resolution of 1.4 seconds using a 20% gadolinium dose (0.02 mmol/...
Purpose
To develop a 3D whole‐brain simultaneous T1/T2/T1ρ quantification method with MR Multitasking that provides high quality, co‐registered multiparametric maps in 9 min.
Methods
MR Multitasking conceptualizes T1/T2/T1ρ relaxations as different time dimensions, simultaneously resolving all three dimensions with a low‐rank tensor image model. T...
Purpose
To develop an MR multitasking‐based multidimensional assessment of cardiovascular system (MT‐MACS) with electrocardiography‐free and navigator‐free data acquisition for a comprehensive evaluation of thoracic aortic diseases.
Methods
The MT‐MACS technique adopts a low‐rank tensor image model with a cardiac time dimension for phase‐resolved...
Background
Current magnetic resonance imaging (MRI) of pancreatic disease is qualitative in nature. Quantitative imaging offers several advantages, including increased reproducibility and sensitivity to detect mild or diffuse disease. The role of multiparametric mapping MRI in characterizing various tissue types in pancreatic disease such as chroni...
Purpose
To develop a quantitative DCE MRI technique enabling entire‐abdomen coverage, free‐breathing acquisition, 1‐second temporal resolution, and T1‐based quantification of contrast agent concentration and kinetic modeling for the characterization of pancreatic ductal adenocarcinoma (PDAC).
Methods
Segmented FLASH readouts following saturation‐r...
Purpose
To develop a simultaneous T1, T2, and ADC mapping method that provides co‐registered, distortion‐free images and enables multiparametric quantification of 3D brain coverage in a clinically feasible scan time with the MR Multitasking framework.
Methods
The T1/T2/diffusion weighting was generated by a series of T2 preparations and diffusion...
Purpose
To develop a dynamic contrast‐enhanced (DCE) MRI method capable of high spatiotemporal resolution, 3D carotid coverage, and T1‐based quantification of contrast agent concentration for the assessment of carotid atherosclerosis using a newly developed Multitasking technique.
Methods
5D imaging with 3 spatial dimensions, 1 T1 recovery dimensi...
Quantitative cardiovascular magnetic resonance (CMR) imaging can be used to characterize fibrosis, oedema, ischaemia, inflammation and other disease conditions. However, the need to reduce artefacts arising from body motion through a combination of electrocardiography (ECG) control, respiration control and contrast-weighting selection makes CMR exa...