Namrita Lall

Namrita Lall
University of Pretoria | UP · Department of Plant and Soil Sciences

PhD

About

308
Publications
81,175
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5,694
Citations
Additional affiliations
January 2001 - present
University of Pretoria
Position
  • Professor (Full)

Publications

Publications (308)
Article
Gold nanoparticles from plant extracts and their bioactive compounds to treat various maladies have become an area of interest to many researchers. Acne vulgaris is an inflammatory disease of the pilosebaceous unit caused by the opportunistic bacteria Cutibacterium acnes and Staphylococcus epidermis. These bacteria are not only associated with infl...
Article
Background Phytochemicals and their derivatives/analogues represent over 50% of the current medicines in worldwide clinical use. Despite a significant contribution to the total bioactive natural plant products, the aquatic plants are underestimated, and several species are extinct and in endangered list. Objective The aim of this review article is...
Article
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Switchgrass is a bioenergy feedstock that potentially possesses multiple health benefits. However, the biological properties and associated bioactive compounds of switchgrass have not been adequately investigated. In the current study, we assessed the anti-inflammatory properties of switchgrass. Results from in vitro bioassays indicated that the me...
Article
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Polyphenols are one of the most abundant classes of secondary metabolites in plants and particularly relevant in leafy vegetables, fruits, berries, tea, and other beverages, with a wide range of health-promoting activities reported. They are also among the most widely studied natural products regarding their biosynthesis, chemical properties, and p...
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Angiogenesis is an essential mechanism in both physiological and pathological functions, such as wound healing and cancer metastasis. Several growth factors mediate angiogenesis, including vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF). This study evaluated the potential wound healing activity of Greyia radlkofe...
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Mupirocin has been reported for its role in the treatment of infected wounds through its antibacterial activity, however the role of mupirocin in promoting wound healing via alternative mechanisms has not been extensively evaluated. This study aimed to evaluate the potential effect of mupirocin to promote wound healing, not only through its antibac...
Article
Various Aloe L. species have been used worldwide to soothe and treat dermal wounds and burns. However, there is a lack of substantiative research on the efficacy of Aloe L. species for wound healing. The aim of this study was to investigate the differences in biological activities of the gel and ethanolic (EtOH) leaf extracts of seven Aloe arboresc...
Article
Objectives Liver illnesses are a major public health issue all over the world. Medicinal plants constituents a viable alternative for the development of phytopharmaceuticals with hepatoprotective activity in order to solve some of these health-related problems. The present study is focused on the phytochemical and biological investigation on Indian...
Article
Eczema is considered a worldwide concern as more people, particularly children, are affected each year. Side effects of eczema include hyperpigmentation and wrinkle formation. Due to the overexpression of interleukin (IL)-1β and IL-6, large quantities of the tyrosinase enzyme are released causing hyperpigmentation, whereas during wrinkle formation...
Chapter
Sexually transmitted diseases (STDs) are a major problem worldwide, which threatens health and negatively affects the livelihood of millions of people. The prevalence of STDs, such as gonorrhea, and the resultant antimicrobial resistance make it imperative to develop novel therapies for the treatment of the diseases. Since medicinal plants have bee...
Chapter
Wound prevalence in South Africa is a major burden on the healthcare system. A large percentage of South Africans still rely on traditional medicine to treat various diseases, which includes the use of medicinal plants for the treatment of various dermatological disorders. Numerous plants are traditionally used in South Africa for the treatment of...
Chapter
Tuberculosis (TB) remains a serious global health threat with over one-quarter of the world’s population infected with TB. A small proportion will develop active, progressive TB whilst the remaining individuals will be victims of bacterial persistence and latent infection. Inefficient healthcare practices and the development of antimicrobial drug r...
Article
In South Africa, plants belonging to the Restionaceae family possess an ecological dominance. As a result, they have been the subject of numerous morphological, anatomical, and evolutionary studies. However, few studies have focused on their phytochemical profile and their potential pharmacological activities. The genus Elegia L. is the second larg...
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This study investigated a unique one-pot microwave-assisted green synthesis method of gold (Au) and silver (Ag) nanoparticles (NPs) using cannabidiol (CBD) as a capping and reducing agent. Furthermore, Au and Ag NPs were also chemically synthesized using poly(vinyl pyrrolidone), which functioned as reference materials when comparing the size, shape...
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The human skin is home to millions of bacteria, fungi, and viruses which form part of a unique microbiome. Commensal microbes, including Cutibacterium acnes can occasionally become opportunistic resulting in the onset of dermatological diseases such as acne. Acne is defined as a chronic inflammatory disorder based on its ability to persist for long...
Article
The aim of this study was to determine the antiproliferative effect of an ethanolic leaf extract of Combretum apiculatum (CA) against human epidermoid carcinoma (A431) and human malignant melanoma (UCT-MEL1) cells, the toxic potential of CA on non-cancerous human keratinocytes (HaCat) and to evaluate the inhibitory activity against the phosphatidyl...
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Without a doubt, potatoes play a vital food and nutrition security role in the world as more than a billion people consume this vegetable. Furthermore, the polyphenolic constituents of pigmented potato cultivars and their associated health benefits have been reported. However, the antioxi-dant, anticancer, and antimycobacterial activity of pigmente...
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Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), still remains one of the leading causes of death from a single infectious agent worldwide. The high prevalence of this disease is mostly ascribed to the rapid development of drug resistance to the current anti-TB drugs, exacerbated by lack of patient adherence due to drug toxicity. The...
Article
As the global desire for natural remedies derived from botanicals increases, the pressure on plant populations and biodiversity intensifies. Therefore, to conserve biodiversity as a valuable genetic and biochemical resource, sustainable utilisation and commercial production should be prioritised. Myrsine africana L. (MA), has recently been found to...
Article
Introduction The study investigated a natural solution for the hypopigmentary disorder, progressive macular hypomelanosis (PMH). The aim was to determine whether gold nanoparticles synthesized from Aspalathus linearis (Burm.f.) R.Dahlgren could be effective for PMH. Methods Gold nanoparticles (ALAuNPs) were synthesized using the ethanolic extract o...
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In the interest of developing more effective and safer anti-tuberculosis drugs, we used a GCxGC-TOF-MS metabolomics research approach to investigate and compare the metabolic profiles of Mtb in the presence and absence of ciprofloxacin. The metabolites that best describe the differences between the compared groups were identified as markers charact...
Article
Eight prenylated xanthones including four new analogues were extracted and purified from the leaves of Garcinia xipshuanbannaensis. Multiple techniques including UV, 1D and 2D NMR, and HRESIMS were used to determine the structures of the isolated xanthones. These xanthones were evaluated for their cytotoxicity toward human cancer cells, and compoun...
Preprint
Full-text available
In the interest of developing more effective and safer anti-Tuberculosis treatment, we aimed for a better understanding of the antimycobacterial action of ciprofloxacin against Mycobacterium tuberculosis (Mtb). We used GCxGC-TOF-MS and well described metabolomics statistical approaches, to investigate and compare the metabolic profiles of Mtb in th...
Article
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Keratinocyte carcinoma (KC) is a form of skin cancer that develops in keratinocytes, which are the predominant cells present in the epidermis layer of the skin. Keratinocyte carcinoma comprises two sub-types, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This review provides a holistic literature assessment of the origin, dia...
Article
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Pigmentation, a process controlled by melanogenesis, plays a vital role in protecting the skin against harmful ultraviolet rays. The level of protection is compromised in case of hypopigmentation. This study aimed to evaluate an Aspalathus linearis extract, fractions and phytoconstituents, for their efficacy on melanogenesis stimulation. Fifteen co...
Article
Exposure to solar ultraviolet (UV) radiation is a major contributing factor to the increasing number of skin cancer cases. Interest has grown to use plant extracts as natural ingredients in cosmetic formulations due to their photoprotective effect, antioxidant and anti-inflammatory activity, as well as other biological activities. The aim of this s...
Chapter
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Plants belonging to Withania genus are well-known medicinal plants and are commonly used as herbal medicine in the Ayurvedic health system. These plants belong to the family Solanaceae and comprise of 23 known species distributed in North Africa, the Middle East, Asia, the Mediterranean, and the Canary Islands. However, only six species, namely, Wi...
Article
Ethnopharmacological relevance Plectranthus madagascariensis (Pers.) Benth. is an indigenous aromatic South African plant species that are traditionally used to treat various dermatological and respiratory ailments. Aim of the study Three varieties of P. madagascariensis exist in South Africa, namely, Plectranthus aliciae (Codd) van Jaarsv. & T.J....
Article
In the present study, an immunological arabinan, LCP70-2A, was isolated from Ligusticum chuanxiong for the first time. The absolute molecular weight of LCP70-2A was determined to be 6.46 × 10⁴ g/mol using the HPSEC-MALLS-RID method. The absolute configuration of arabinose in LCP70-2A was determined to be L-configuration. Physicochemical characteriz...
Article
Ten new ent-kaurane diterpenoids, including two pairs of epimers 1/2 and 4/5 and a 6,7-seco-ent-kauranoid 10, were obtained from the aerial parts of Isodon serra. The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to eval...
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Full-text available
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), known to cause the disease COVID-19, was declared a pandemic in early 2020. The objective of this review was to collate information regarding the potential of plants and natural products to inhibit coronavirus and targets associated with infection in humans and to highlight known dru...
Book
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Kew’s State of the World’s Plants and Fungi project provides assessments of our current knowledge of the diversity of plants and fungi on Earth, the global threats that they face, and the policies to safeguard them. Produced in conjunction with an international scientific symposium, Kew’s State of the World’s Plants and Fungi sets an important inte...
Article
Tuberculosis (TB) is a threat to a large population across the globe. Rapanea melanophloeos (L.) Mez, commonly known as the Cape beech, is a plant that is traditionally used in the treatment of tuberculosis and TB-related symptoms. The aim of this study, was to evaluate the pharmacological effects of a leaf ethanolic extract (1:10, w:v) of R. melan...
Article
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Kigelia africana is used to manage inflammation among indigenous communities. We hypothesized that K. africana extracts contain phytoconstituents with good antioxidant and anti-inflammatory activities. The methanolic extract of K. africana fruits and Spathodea campanulata leaves (SPK04), K. africana aqueous fruit extract (KFM02), and K. africana ac...
Article
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Kigelia africana has been used in the management of human ailments since time immemorial. Ethnobotanists have documented the traditional uses of K. africana, which include treatment of skin disorders, cancer and gynecological complaints, among others. This has interested scientists, who have examined K. africana plant parts for their bioactivity. T...
Article
Ethnopharmacological relevance Approximately 70% of anticancer drugs were developed or derived from natural products or plants. Southern Africa boasts an enormous floral diversity with approximately 22,755 plant species with an estimated 3000 used as traditional medicines. In South Africa more than 27 million individuals rely on traditional medicin...
Article
Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effect...
Article
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Leucosidea sericea is an evergreen shrub belonging to the Rosaceae family with previous studies that indicated that L. sericea extracts exhibited strong anti-bacterial properties against Propionibacterium acnes, showing potential as a cosmeceutical. The plant is traditionally used as a vermifuge, as an astringent and to treat conjunctivitis. Commer...
Article
A phytochemical investigation to obtain bioactive substances as lead compounds or agents for cancer led to the obtainment of six new and two known clerodane diterpenoids from the leaves of Casearia kurzii. Their structures were elucidated using NMR techniques and electronic circular dichroism (ECD) calculations. The subsequent biological cytotoxici...
Article
Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated...
Article
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The Gram-positive bacterium Cutibacterium acnes (previously Propionibacterium acnes), plays an important role in the pathogenesis and progression of the dermatological skin disorder acne vulgaris. The methanolic extract of Helichrysum odoratissimum (L.) Sweet (HO-MeOH) was investigated for its ability to target bacterial growth and pathogenic virul...
Article
Full-text available
Dermal aging is characterized by states of oxidative stress, chronic inflammation, and abnormal proteolytic degradation due to the action of hydrogen peroxide, superoxide, 5-lipoxygenase, and elastase, respectively. Noteworthy elastase inhibition has previously been reported, and so this study aimed to investigate the ability of Myrsine africana an...