Namik Kirlic

Namik Kirlic
Laureate Institute for Brain Research | LIBR

PhD, clinical psychology

About

74
Publications
5,348
Reads
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497
Citations
Additional affiliations
January 2019 - present
Laureate Institute for Brain Research
Position
  • Associate Investigator
August 2016 - December 2018
Laureate Institute for Brain Research
Position
  • PostDoc Position
August 2010 - present
University of Tulsa
Position
  • PhD Student

Publications

Publications (74)
Article
Full-text available
Background: We have previously reported activation in reward, salience and executive control regions during functional MRI (fMRI) using an approach–avoidance conflict (AAC) decision-making task with healthy adults. Further investigations into how anxiety and depressive disorders relate to differences in neural responses during AAC can inform their...
Article
Full-text available
Objective To further delineate risk and resilience factors contributing to trajectories of mental health symptoms experienced by college students through the pandemic. Participants n = 183 college students (67.2% female). Methods Linear mixed models examined time effects on depression and anxiety. Propensity-matched subgroups exhibiting “increase...
Article
American Indians (AI) experience disproportionately high prevalence of suicide and substance use disorders (SUD). However, accounting for risk burden (e.g., historical trauma, discrimination) the likelihood of mental health disorders or SUD is similar or decreased compared to the broader population. Such findings have spurred psychological research...
Article
Full-text available
Computational modelling is a promising approach to parse dysfunctional cognitive processes in substance use disorders (SUDs), but it is unclear how much these processes change during the recovery period. We assessed 1-year follow-up data on a sample of treatment-seeking individuals with one or more SUDs (alcohol, cannabis, sedatives, stimulants, ha...
Article
Full-text available
Background Dysregulation of fear learning has been associated with psychiatric disorders that have altered positive and negative valence domain function. While amygdala-insula-prefrontal circuitry is considered important for fear learning, there have been inconsistencies in neural findings in healthy and clinical human samples. This study aimed to...
Article
Full-text available
Mindfulness training (MT) promotes the development of one’s ability to observe and attend to internal and external experiences with objectivity and nonjudgment with evidence to improve psychological well-being. Real-time functional MRI neurofeedback (rtfMRI-nf) is a noninvasive method of modulating activity of a brain region or circuit. The posteri...
Article
Full-text available
Mindfulness training (MT) reduces self-referential processing and promotes interoception, the perception of sensations from inside the body, by increasing one’s awareness of and regulating responses to them. The posterior cingulate cortex (PCC) and the insular cortex (INS) are considered hubs for self-referential processing and interoception, respe...
Article
Objective Repetitive negative thinking (RNT) is an important symptom in the development and maintenance of eating disorders (EDs). RNT Research on RNT’s effect on cognition in EDs is scarce. This investigation focused on associations between RNT and cognition in individuals with EDs. Methods Ruminative Response Scale (RRS) was used from Tulsa-1000...
Article
Full-text available
Altered interoception, or the processing of bodily signals, has been argued to play a role in the development and maintenance of substance use disorders (SUD). Therefore, interoceptive interventions focusing on bodily awareness, such as mindfulness meditation, may improve treatment outcomes for individuals with SUD. Here we review: (1) subjective,...
Article
Background Repetitive Negative Thinking (RNT) is a symptom dimension of depression that is associated with a poorer prognosis in terms of higher recurrence, treatment resistance, residual symptoms, and disability. This investigation examined whether RNT is associated with aberrant reward processing and fear learning. Methods Very High RNT [n=60] a...
Article
Full-text available
Purpose of Review Substance use disorders (SUD) are chronic and disabling conditions associated with significant public health burden. Current evidence-based treatments, while effective, have limited success and result in high relapse rates. Interventions that directly target the neurobiological mechanisms of addiction may be better poised to impro...
Article
Introduction : Treatment effectiveness for major depressive disorder (MDD) is often affected by client non-adherence, dropout, and non-response. Identification of client characteristics predicting successful treatment completion and/or response (i.e., symptom reduction) may be an important tool to increase intervention effectiveness. It is unclear...
Article
Full-text available
Objective: To identify robust and reproducible factors associated with suicidal thoughts and behaviors (STBs) in college students. Methods: 356 first-year university students completed a large battery of demographic and clinically-relevant self-report measures during the first semester of college and end-of-year (n = 228). Suicide Behaviors Ques...
Article
Full-text available
Maladaptive behavior during approach-avoidance conflict (AAC) is common to multiple psychiatric disorders. Using computational modeling, we previously reported that individuals with depression, anxiety, and substance use disorders (DEP/ANX; SUDs) exhibited differences in decision uncertainty and sensitivity to negative outcomes versus reward (emoti...
Article
Full-text available
Background: The COVID-19 pandemic has brought on far-reaching consequences for adolescents. Adolescents with early life stress (ELS) may be at particular risk. We sought to examine how COVID-19 impacted psychological functioning in a sample of healthy and ELS-exposed adolescents during the pandemic. Methods: A total of 24 adolescents (15 healthy, n...
Article
Full-text available
Background Early life stress (ELS) has been linked to poor mental and physical health outcomes in adolescence and adulthood. Mindfulness reduces symptoms of depression and anxiety and improves cognitive and social outcomes in both youth and adults. However, little is known whether mindfulness can mitigate against the adverse neurobiological and psy...
Article
Full-text available
This study used a machine learning framework in conjunction with a large battery of measures from 9,718 school‐age children (ages 9–11) from the Adolescent Brain Cognitive DevelopmentSM (ABCD) Study to identify factors associated with fluid cognitive functioning (FCF), or the capacity to learn, solve problems, and adapt to novel situations. The ide...
Article
Full-text available
Neural and behavioral mechanisms during approach-avoidance conflict decision-making are relevant across various psychiatric disorders, particularly anxiety disorders. Studies using approach-avoidance conflict paradigms in healthy adults have identified preliminary neural mechanisms, but findings must be replicated and demonstrated as reliable befor...
Article
Background Substance use disorders (SUD) with comorbid depression and anxiety are linked to poor treatment outcome and relapse. Although some depressed individuals exhibit elevated blood-based inflammation (interleukin-6 [IL-6] and C reactive protein [CRP]), few studies have examined whether the presence of SUD exacerbates inflammation. Methods Tr...
Article
Full-text available
Background The Monetary Incentive Delay task (MID) has been used extensively to probe anticipatory reward processes. However, individual differences evident during this task may relate to other constructs such as general arousal or valence processing (i.e., anticipation of negative versus positive outcomes). This investigation used a latent variabl...
Preprint
Full-text available
Background: Early life stress (ELS) has been linked to poor mental and physical health outcomes in adolescence and adulthood. Mindfulness reduces symptoms of depression and anxiety and improves cognitive and social outcomes in both youth and adults. However, little is known whether mindfulness can mitigate against the adverse neurobiological and ps...
Preprint
Full-text available
Maladaptive behavior during approach-avoidance conflict (AAC) is common to multiple psychiatric disorders. Using computational modeling, we previously reported that individuals with depression, anxiety, and substance use disorders (DEP/ANX; SUDs) exhibited differences in decision uncertainty and sensitivity to negative outcomes vs. reward (emotiona...
Article
Background An inflammation-induced imbalance in the kynurenine pathway (KP) has been reported in major depressive disorder but the utility of these metabolites as predictive or therapeutic biomarkers of behavioral activation (BA) therapy is unknown. Methods Serum samples were provided by 56 depressed individuals before BA therapy and 29 of these i...
Article
Full-text available
Background: Imbalances in approach-avoidance conflict (AAC) decision-making (e.g., sacrificing rewards to avoid negative outcomes) are considered central to multiple psychiatric disorders. We used computational modelling to examine 2 factors that are often not distinguished in descriptive analyses of AAC: decision uncertainty and sensitivity to neg...
Preprint
Full-text available
The COVID-19 pandemic has brought on far-reaching consequences for adolescents. Adolescents with early life stress (ELS) may be at particular risk. We sought to examine how COVID-19 impacted psychological functioning in a preliminary sample of healthy and ELS-exposed adolescents. A total of 24 adolescents (15 healthy, 9 ELS) completed self-report m...
Preprint
Full-text available
Background Early life stress (ELS) has been linked to poor mental and physical health outcomes in adolescence and adulthood. Mindfulness reduces symptoms of depression and anxiety and improves cognitive and social outcomes in both youth and adults. However, little is known whether mindfulness can mitigate against the adverse neurobiological and psy...
Preprint
Background: The Monetary Incentive Delay Task (MID) has been used extensively to probe anticipatory reward processes. However, individual differences evident during this task may relate to other constructs such as general arousal or valence processing (i.e., anticipation of negative versus positive outcomes). This investigation used a latent variab...
Article
Full-text available
Functional magnetic resonance imaging studies frequently use emotional face processing tasks to probe neural circuitry related to psychiatric disorders and treatments with an emphasis on regions within the salience network (e.g., amygdala). Findings across previous test-retest reliability studies of emotional face processing have shown high variabi...
Preprint
Background: An estimated 1100 college students die by suicide each year. Our ability to predict who is at risk for suicide, as well as our knowledge of resilience factors protecting against it, remains limited. We used a machine learning (ML) framework in conjunction with a large battery of self-report and demographic measures to select features co...
Preprint
PurposeFluid cognitive functioning (FCF), or the capacity to learn, solve problems, and adapt to novel situations, is instrumental for academic success, psychological well-being, and adoption of healthy behaviors. Our knowledge concerning factors associated with FCF, including those that may be targeted with interventions to improve outcomes, remai...
Preprint
Full-text available
Background: Imbalances in approach-avoidance conflict (AAC) decision-making (e.g. sacrificing rewards to avoid negative outcomes) are considered central to multiple psychiatric disorders. We used computational modeling to examine two factors often not distinguished within model-free analyses of AAC: decision uncertainty (DU) and sensitivity to nega...
Article
Full-text available
Background: One in three college students experience significant depression or anxiety interfering with daily functioning. Resilience programs that can be administered to all students offer an opportunity for addressing this public health problem. The current study objective was to assess the benefit of a brief, universal resilience program for fir...
Article
Full-text available
Exposure to early life adversity (ELA) is a major public health crisis posing as a significant risk of immediate and sustained mental and physical health consequences. While a remarkable body of knowledge has been amassed showing psychological, cognitive, social, developmental, and neurobiological consequences of ELA exposure, little has been done...
Article
Full-text available
Background: Only 40-60% of patients with generalized anxiety disorder experience long-lasting improvement with gold standard psychosocial interventions. Identifying neurobehavioral factors that predict treatment success might provide specific targets for more individualized interventions, fostering more optimal outcomes and bringing us closer to t...
Preprint
Background: Only 40 to 60% of patients with generalized anxiety disorder experience long-lasting improvement with gold-standard psychosocial interventions. Identifying neurobehavioral factors that predict treatment success might provide specific targets for more individualized interventions, fostering more optimal outcomes and bringing us closer to...
Preprint
Background: Only 40 to 60% of patients with generalized anxiety disorder experience long-lasting improvement with gold-standard psychosocial interventions. Identifying neurobehavioral factors that predict treatment success might provide specific targets for more individualized interventions, fostering more optimal outcomes and bringing us closer to...
Article
Negative affect is considered an important factor in the etiology of depression and anxiety, and is highly related to pain. However, negative affect is not a unitary construct. To identify specific targets for treatment development, we aimed to derive latent variables of negative affect and test their unique contributions to affective processing du...
Article
Full-text available
The emotional stress response is relevant to a number of psychiatric disorders, including posttraumatic stress disorder (PTSD) in particular. Research using neuroimaging methods such as functional magnetic resonance imaging (fMRI) to probe stress-related neural processing have provided some insights into psychiatric disorders. Treatment providers a...
Article
Full-text available
Background: Mood and anxiety disorders are characterized by altered prefrontal-amygdala function and increased behavioral inhibition (BI) in response to potential threat. Whether these alterations constitute a vulnerability or a symptom of illness remains unclear. The medial orbitofrontal cortex (mOFC) is thought to play a central role in estimati...
Article
Avoidance behavior in clinical anxiety disorders is often a decision made in response to approach-avoidance conflict, resulting in a sacrifice of potential rewards to avoid potential negative affective consequences. Animal research has a long history of relying on paradigms related to approach-avoidance conflict to model anxiety-relevant behavior....
Poster
Aspects of interoceptive regulation are impaired in major depressive disorder and may be restored by Behavioral Activation therapy.
Article
Full-text available
Background: The parent-child relationship may be an important factor in the development of adolescent depressive and anxious symptoms. In adults, depressive symptoms relate to increased amygdala and attenuated prefrontal activation to maternal criticism. The current pilot study examined how depressive and anxiety symptoms in a high-risk adolescent...
Article
Full-text available
Individuals with high-trait anxiety frequently report decreased perceived control. However, it is unclear how these processes are instantiated at a neural level. Prior research suggests that individuals prone to anxiety may have exaggerated activity in the anterior insula and altered activity in the cingulate cortex during anticipation of aversive...
Article
Full-text available
Although many post-disaster interventions for children and adolescent survivors of disaster and terrorism have been created, little is known about the effectiveness of such interventions. Therefore, this meta-analysis assessed PTSD outcomes among children and adolescent survivors of natural and man-made disasters receiving psychological interventio...
Article
Full-text available
Objective: Until now, the functioning of the hypothalamic-pituitary-adrenal (HPA) axis in children with prenatal methamphetamine exposure (PME) had been unexamined. Previous research indicates that prenatal exposure to stimulant drugs is associated with dose-response alterations in neural growth and connectivity and consequent neurobehavioral defi...
Article
Full-text available
There has been increasing interest in the interaction of the basal ganglia with the cerebellum and the brainstem in motor control and movement disorders. In addition, it has been suggested that these subcortical connections with the basal ganglia may help to coordinate a network of regions involved in mediating posture and stabilization. While stud...
Data
This supporting information section describes the segmentation procedures used to define the search volumes for patient versus control contrast analyses. The first section describes the segmentation of a priori areas of evaluation (AOEs) for FA and MD contrasts, and the second section describes segmentation of the a priori search volume for the tra...
Data
Examples of the segmentation used as the a priori search volume in the tractography contrasts, shown from a sagittal view. MNI talairach coordinates are indicated for each image. LH: left hemisphere. (TIF)
Data
Examples of the segmentation used as the a priori search volume in the tractography contrasts, shown from a coronal view. MNI talairach coordinates are indicated for each image. LH: left hemisphere; RH: right hemisphere. (TIF)