Namdeo Jadhav

Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University) Karad MS

Background Curcumin (CUR) is a natural polyphenol and one of the key phytoconstituents found in the rhizomes of Curcuma Longa . It exhibits various pharmacological properties, encompassing antioxidant, anticancer effects, antiseptic, and anti-inflammatory, among several others. A significant drawback of using CUR is its limited bioavailability, whi...

The present study aims to use a natural protein silk fibroin (SF) to enhance solubility, dissolution, tablettability, and subsequently, delivery of naproxen (NP) using a green technique  ball milling. The development of SF and NP solid dispersion (SF-NP-SD) for enhancing the solubility, dissolution, and compatibility of NP using ball milling. In s...

EUTECTIC MIXTURE AND PROCESS OF PREPARING THEREOF The present invention relates to the eutectic mixture comprising curcumin and a coformer and to the solid oral dosage form comprising the eutectic mixture of curcumin and a coformer. The present invention also provides the process for preparing the eutectic mixture of curcumin and a coformer and the...

Despite the high medicinal value of tiopronin, there are substantial adverse effects such as yellow skin, yellow eyes, muscle aches, etc. Therefore, there is a huge necessity to identify tiopronin using advanced sensors in provided samples. Recently, the preference for graphene quantum dots (GQDs) and inorganic nanomaterial-based fluorescent sensor...

BACKGROUND AND PURPOSE We aimed to develop a dosage form comprising of Capecitabine loaded carbon nanotubes for its targeted delivery to the colon. EXPERIMENTAL APPROACH Single walled carbon nanotubes (SWCNT) were functionalized by -COOH and chitosan along with folic acid. Capecitabine was loaded in these SWCNT’s and the system was analyzed by FTIR...

Background and purpose Metal-organic frameworks (MOFs) have gained incredible consideration in the biomedical field due to their flexible structural configuration, tunable pore size and tailorable surface modification. These inherent characteristics of MOFs portray numerous merits as potential drug carriers, depicting improved drug loading, site-sp...

Since the last few years, metal organic frameworks (MOFs) have been attracting attention from scientific sororities. MOFs are novel porous materials with robust architectures that demonstrate a multitude of applications in theranostics. Interestingly, it shows adaptable porosity, versatile chemical configuration, tunable size and shape, tailorable...

Background Site-specific transport of medicinal products to malignant cells and tissues is an intriguing area since it has an ability to safeguard healthy cells. Selective upregulation of folate receptors on colon cancer cells is usual. Consequently, folate receptors have become one of extensively studied target moieties for targeting the delivery...

Scientific fraternity revealed the potential of stimuli-responsive nanotherapeutics for cancer treatment that aids in tackling the major restrictions of traditionally reported drug delivery systems. Among stimuli-responsive inorganic nanomaterials, metal-organic frameworks (MOFs) have transpired as unique porous materials displaying resilient struc...

The current study aimed at the preparation and evaluation of single-walled carbon nanotube (SWCNTs) loaded Ciprofloxacin ophthalmic ointment. SWCNTs were functionalized and further Chitosan was loaded on the FSWCNT to achieve solubility of the SWCNT and further Ciprofloxacin was loaded on developed system. The developed system was mixed in ophthalm...

Traditional drug formulations are facing issues of toxicity to normal cells, stability, and bioavailability, calling for suitable nanocarriers such as polymeric nanoparticles for targeting prostate cancer. This chapter reviews the basics of polymeric nanoparticles and targeted treatment of prostate cancer. We detail targeting strategies and types o...

Metal nanoparticles (NPs) exhibit distinctive attributes and continue to entice researchers to investigate new dimensions of their worth. Amongst the different noble metal NPs, silver (Ag) and gold (Au) nanoparticles have stolen the limelight. AgNPs and AuNPs are typically synthesized using hazardous chemicals, which affect the environment and huma...

Background In Aayurveda, Blumea eriantha DC has been used in the management of various diseases and is found to exhibit antioxidant and anti-hyperlipidemic, hypoglycemic, anti-diarrhoeal, larvicidal, antimicrobial properties. Objective The present study has focused on isolation of the active fraction from B. eriantha DC extract and to investigate...

The present study aims to develop and optimize anastrozole (ANZ)-nanostructured lipid carriers (ANZ-NLCs) for improved anticancer efficacy. In a nutshell, ANZ-NLCs were prepared by a 3² factorial design approach through the solvent evaporation method. In this study, key formulation factors impacting particle size, % drug encapsulation, and zeta pot...

Objective: Development of dosage form comprising of Capecitabine loaded carbon nanotubes for its targeted delivery to the colon. Method: Single walled carbon nanotubes (SWCNT) were functionalized by -COOH and Chitosan along with Folic acid. Capecitabine was loaded in these SWCNT's, and the system was analyzed by FTIR, SEM and Raman spectroscopy....

Floating gastro-retentive delivery approach provides a significant pathway for controlled release of drug with increase gastric residence. In this study, we report crystallinity modulated electrospun silk fibroin nanofibers (SF-NFs) floating scaffolds for the controlled release of felodipine (FD). The alteration in the crystallinity behavior due to...

Floating gastro-retentive delivery approach provides a significant pathway for controlled release of drug with increase gastric residence. In this study, we report crystallinity modulated electrospun silk fibroin nanofibers (SF-NFs) floating scaffolds for the controlled release of felodipine (FD). The alteration in the crystallinity behavior due to...

Background Numerous challenges are faced during formulation and biopharmaceutics of newly developed drug molecules due to polymorphic conversion, poor bioavailability, stability issues, etc. The condition gets further worsened due to poor solubility or slight solubility of drugs. Thus, the formation of efficient drugs and their incorporation in the...

Gout is the world's most popular inflammatory arthritis and the prevalence of gout is rapidly rising worldwide. Typically, gout develops in a single joint as excessive swelling and intense pain wherein excessive deposition of uric acid (UA) crystals results in inflammation of the joint. Accordingly, UA is considered an effective biomarker to diagno...

Second Position “International Conference on Recent Advances in Nanotechnology and Radiopharmaceuticals in Drug Design and Development” at Surat in Feb. 2019.

Bananas are considered as one of the most important tropical fruits in the world market. Banana fruit peels comprise a significant quantity of wastes products from Saba banana processing. These peels are just left as solid waste at large expense and are not being used for any other purpose. Thus, the operation of food processing wastes in the indus...

Transdermal drug delivery system networks are primarily affected by poor penetration of therapeutically active compounds. The stratum corneum (SC) is the foremost barrier of the skin, which restricts the permeation of the drug molecule. In this context, to date, numerous approaches have been implemented to overcome the SC barrier limitations. Out o...

The need of the current article is to review the advancements in physicochemical and biological properties of Moringa Seed Protein (obtained from Moringa oleifera seeds, family- Moringaceae) along with drug delivery applications. The exact physicochemical composition and coagulation mechanism of moringa protein are surrounded by a cloud of mystery...

The aim of this work was to test repurposing of Simvastatin and Alendronate sodium against three targets HER2, EGFR kinase and AR involved in breast cancer, lung cancer and prostate cancer respectively using molecular docking. In silico screening was carried out by grip-based docking methodology. The molecular coupling analysis was performed with P...

The whole world facing COVID-19 pandemic, so there has been a lot of interest in ways to boosting our immune system, and thus build a first line of defense against the deadly virus. Since ancient times, medicinal plants, herbs and spices were well known for their medicinal properties. Therefore, the medicinal plants and herbs playing a critical rol...

Chyawanprash is an Ayurvedic dietary health supplement used for boosting immunity and help in making a person feel young. Chyawanprash is one of the anti-aging supplements, which is purely herbal in nature. It has Amla as its main ingredient, which is a powerful antioxidant. Master Charaka is the first to mention this herbal medicine. Ayurveda reco...

dried, pulverized into fine powder and extracted exhaustively with ethanol and water by the simple maceration method. After that we concentrate it and made some dilution and used as an indicator. The good results were obtained when it was tested against standard synthetic indicators. Titration shows sharp color change at the equivalence point. The...

Our study aimed at development of Silver, Iron and Gold nanoparticles of Lycopene isolated from tomato by using green synthesis technique and to evaluate its anticancer potential against colorectal and cervical cancer. Lycopene was extracted by benzene extraction method and the silver, iron and gold nanoparticles were developed by green synthesis m...

PurposeThe objective of the present study was to screen oils and suspending agents for the formulation of novel progesterone (PGT) suspension, demonstrating improved solubility, drug release, stability, and non-allergenicity. Presumably, formulated novel PGT suspensions could supersede clinically available peanut oil and lecithin based formulations...

Carbon quantum dots (CQDs, C-dots, or CDs), are generally small carbon nanoparticles having a size less than 10 nm. Carbon dots (CDs) were accidentally discovered during the purification of single-walled carbon nanotubes through preparative electrophoresis in 2004. Carbon is an organic material having poor water solubility that emits less fluoresce...

Background: In the current research, we have developed silver and iron nanoparticles of isolated proanthocynidin (PAC) from grape seed by green synthesis and evaluated for antimicrobial, antioxidant activity and in vitro cytotoxicity against colon cancer cell lines. Results: One percent solution of isolated proanthocynidin in water was vigorousl...

The present investigation aims to develop novel curcumin-ascorbic acid cocrystal for enhancing the solubility, stability, and complementary biological activities for curcumin. Based on in silico approach to screen ascorbic acid as a coformer for curcumin, cocrystals were prepared by the solvent evaporation method, and further evaluated for saturati...

The aim of the present research was to perform green synthesis of gold nanoparticles of isolated citrus bioflavonoid from Citrus sinensis (orange) peel extract and to evaluate its anticancer potential. Methanolic extract of orange peel was obtained by Soxhlet extraction and citrus bioflavonoid was isolated by using column chromatography. Gold nanop...

Amongst assorted regio-selective and targeted oral drug delivery strategies accepted for the gastro-retentive drug delivery system (GRDDS), the floating drug delivery system (FDDS) holds a major share as clinically accepted formulations. The major objective of the present investigation was to explore the silk industry waste protein, silk fibroin (S...

Background The goal of the proposed study was to validate a rapid, simple, an accurate, robust, and sensitive bioanalytical method for quantifying Meloxicam and Lornoxicam (as internal standard) in rabbit plasma. Result Limit of detection and limit of quantification for Meloxicam were found to be 0.0081 and 0.1035 μg mL ⁻¹ , respectively. The bioa...

Study aimed to prepare and evaluate carbon based kajal formulation and carry out its comparative evaluation with the marketed formulations of kajal. Initially, carbon soot was deposited on Aloe vera mucilage spreaded on a copper plate, in specifically designed apparatus. Subsequently, sun dried plate was allowed to expose to the flame of cow ghee f...

Objective: To prepare and evaluate different types of Kajal formulations and evaluation of its antimicrobial activity along with preliminary verification of the content responsible for the said effect. Methods: We have prepared kajal formulations by use of different metal plates, marble tile, ghee and Aloe vera mucilage and tried to verify the anti...

Biodegradable Prosopis africana peel powders (PAPPs) are effective excipients to achieve amorphous drug delivery better than β-cyclodextrin and Gelucire 50/13. In this study, we investigated the fundamental properties of PAPPs as powders through solid micromeritics determination, solid state characteristics of size, shape, thermal property, interac...

The objective of the present study was to screen the effect of increased simvastatin (SVS) solubility, through mixed micelles as a model approach, on in vitro anticancer efficacy in combination with hydrophilic alendronate sodium (ADS) as a strategy to improve therapeutic efficacy and to repositioning the existing drugs. The SVS-loaded mixed micell...

PurposeThe objective of present work was to develop fibroin-sodium alginate floating microspheres of felodipine (FD) showing modified release.Method Binary polymer system of fibroin-sodium alginate was used to prepare microspheres by spray drying technique. Thus, FD loaded microspheres obtained were evaluated for % drug content, % entrapment effica...

The aim of this work was to perform in silico analysis of selected biomolecules from Terminalia arjuna (T. arjuna) by using virtual screening, molecular docking and pharmacophore modeling. Reported 30 biomolecules of T. arjuna were used as ligands. Grip-based docking was carried out to produce the target-specific complex model using vLife MDS 4.4 s...

Development of tailor-made pharmaceutical nanofibers has gained vital prominence due to ease of fabrication and versatility of electrospinning (ES). ES is one of the flexible and, wonderful strategies for the fabrication of nanofibers. ES unit comprises a supplier of high voltage current, a syringe (pump), spinneret and a metal plate collector. The...

Aim of this research was to create nanostructured lipid carriers (NLCs) of a poorly water-soluble drug erlotinib. NLCs filled with erlotinib were formulated with solvent diffusion method. Application of 2³ full factorial design approach was carried out to study an effect of independent variables such as total lipid concentration, drug concentration...

DOI: 10.1002/sscp.201900061 The cover picture shows a chromatogram of bioanalytical method depicting separated internal standard (Meloxicam) and test drug (Lornoxicam), developed by protein protein precipitation HPLC method in a Rabbit Plasma. The retention time of the Meloxicam and Lornoxicam is 6.08 min and 7.74 min respectively. The rabbit plasm...

Objective: The objective of the present study was to the preparation of a coamorphous (COAM) system of paracetamol (PA) (Biopharmaceutics Classification System [BCS] Class-III) and ibuprofen (IB) (BCS Class-II) for enhancement of solubility and dissolution of IB. Methods: The COAM system was prepared by chemical electric magnetic field microwave-as...

The purpose of the present investigation was to analyze devitrification of amorphous drugs such as lornoxicam, meloxicam, and felodipine in the presence of sericin. The binary solid dispersions comprising varying mass ratios of drug and sericin were subject to amorphization by spray drying, solvent evaporation, ball milling, and physical mixing. Fu...

The aim of present study was to develop a simple, rapid, selective, sensitive and robust reverse phase high‐performance liquid chromatography method for quantification of Lornoxicam and internal standard meloxicam in rabbit plasma at the wavelength of 370 nm. Protein was precipitated from rabbit plasma sample by addition of acetonitrile as a vehicl...

Objective: The aim of this work was to develop stable emulsified formulations containing Terminalia arjuna (T. arjuna) extract and to assess antioxidant potential of the final product with in silico molecular screening. Methods: Terminalia arjuna emulsified formulations were prepared by application of ternary phase diagram design and were evaluated...

The number of unit operations to be followed in the preparation of tablets was cumbersome and may introduce material as well as process-related critical parameters which may negatively affect the quality of final formulation. The hypothesis of the present research was to develop directly compressible, high-strength extended-release spherical agglom...

Secured 3rd Position in “AVISHKAR 2018”, Poster presentation competition at Shivaji University, Kolhapur in December 2018.

Objective: The objective of this research work was to prepare a transdermal matrix formulation containing different polymer components for topical delivery. Methods: Terminalia arjuna bark extract loaded transdermal patches were prepared using solvent casting technique with different amount of chitosan and Eudragit RL 100 batches were prepared acco...

The objective of present work was to prepare nanocrystals of Lopinavir (LPN) to enhance its solubility and dissolution rate with aim of dose reduction and minimising the side effects associated with it’s oral administration. Nanocrystals of LPN were prepared by anti-solvent precipitation method using a 32 full factorial design, employing stirring s...

Asava is self-generated herbal formulation belonging to traditional ayurvedic system. Actually, it is an alcoholic medicament prepared by allowing the herbal juices to undergo fermentation with the addition of sugar. Fermentation of mulberry leaves was carried out by addition of sugar/jaggery with dhataki (Woodfordia Fructicosa) flowers, which is m...

Co-amorphous (COAM) systems of ibuprofen (IB) and paracetamol (PA), in clinical dose ratios, were prepared by ball milling to enhance solubility and dissolution of IB. Subsequently, COAM were characterized by solubility, processability, XRPD, DSC, ATR-FTIR, SEM, in-vitro dissolution and accelerated stability studies. Maximum increase in aqueous sol...

Objective: The aim of present study was to develop a simple, rapid, selective, sensitive and robust reverse phase high performance liquid chromatographic method for quantification of felodipine in rabbit plasma at the wavelength of 360nm. Method: Protein was precipitated from rabbit plasma sample by addition of acetonitrile as a vehicle. An isoc...

The traditional and alternative systems of medicine have been resulting more than 85% of the drugs from a plant source. Terminalia arjuna (T. arjuna) stem bark contain glycosides, ample quantities of flavonoids, tannins, and minerals. Flavonoids have been identified to exert antioxidant, anti-inflammatory, and lipid-lowering effects while glycoside...

An objective of the present study was to prepare colon specific microspheres of Curcumin (CUR) containing Ascorbic acid (AA) for improved oral bioavailability. 3² factorial design was used to optimize Chitosan microspheres (CSMS) containing CUR and AA. Subsequently, optimized CSMS were coated with Eudragit S-100, for delivery to colon. In vitro dru...

Background: Terminalia arjuna is used in various indigenous system of medicine such as Ayurveda, Siddha, and Unani. The traditional medical forms provide drug delivery with peaks often above the required dose and face problems such as first-pass metabolism, stability, and low therapeutic efficacy. To enhance topical delivery and to allow for contro...

The aim of present attempt deals with preparation of binary dispersion of sericin, waste of sericulture industry in order to enhance solubility and dissolution of poorly soluble drugs. Solid dispersions (SDs) of BCS-II drugs were prepared by spray drying, solvent evaporation, ball milling and physical mixing in ratio of drug:sericin (1:0.5, 1:1, 1:...

Mulberry (Species Morus alba, Moraceae) is known as the plant of immortality. Actives present in mulberry are triterpenes, bioflavonoid, alkaloids, major constituent is 1-deoxynojirimycin. Mainly the plant has been used for bronchitis, wound healing, diabetes, hyperlipidemia, etc. Looking at prospects of asava preparation, we have prepared novel mu...

Background: The quest to improve the therapeutic effectiveness of herbal drugs has driven rigorously the pharmaceutical research towards development of herbal nanoparticles. Till date, various approaches have been adopted for the design of herbal nanoparticles. Methods: We carried out an organized search of bibliographic databases consisting of...

The aim of present attempt deals with preparation of binary dispersion of sericin, waste of sericulture industry in order to enhance solubility and dissolution of poorly soluble drugs. Solid dispersions (SDs) of BCS-II drugs were prepared by spray drying, solvent evaporation, ball milling and physical mixing in ratio of drug:sericin (1:0.5, 1:1, 1:...

Objective The rhizome of Tectaria cicutaria has been used in Indian traditional medicine for the treatment of various disorders. The objective of present investigation is to screen various extracts of the rhizomes of Tectaria cicutaria for anti-cancer activity and to investigate the mechanism involved. Materials and methods The rhizomes of Tectari...

Objectives: Nateglinide, an Antidiabetic drug (BCS II), shows pH-dependent solubility and variable bioavailability. The purpose of study was to increase dissolution and bioavailability of Nateglinide by development of its microenvironmental pH-regulated ternary solid dispersion (MeSD). Methods: MeSD formulation of Nateglinide, poloxamer-188 and...

Objective: The objective of this research work was to develop mucoadhesive particulates gel of Propranolol HCl for intranasal delivery.Method: Drug loaded mucoadhesive particulates were prepared by spray drying technique using polymers such as HPMC K100 and Carbopol 934P. Batches were prepared according to 32 factorial designs. Result: The mucoadhe...

The aim of present work was to investigate the role of liquisolid technique in improving dissolution of high dose Progesterone. Progesterone-PEG 400 dispersions were prepared and evaluated for technological properties, and further formulated into liquisolid tablets using Neusilin US2 and Syloid 244 FP as a carrier and coat respectively. Due to poly...

In the present work, an attempt has been made to screen Prosopis africana seed gum (PG), anionic polymer for extended release tablet formulation. Different categories of drugs (charge basis) like diclofenac sodium (DS), chlorpheniramine maleate (CPM), and ibuprofen (IB) were compacted with PG and compared with different polymers (charge basis) like...

Purpose The aims of the present work were to pelletize talc by extrusion-spheronization technique using microcrystalline cellulose (MCC) as a pelletization aid and to study its performance as a neutral substrate for coating. A 32 factorial design was used to study the effect of independent variables (X1, amount of talc, and X2, MCC) on pellet prop...

Atorvastatin calcium (ATR) and felodipine (FEL) are beneficial in combination for elderly people in management of hypertension and atherosclerosis. Aim of present study is to develop simple, accurate, and precise method for simultaneous quantitative estimation of ATR and FEL from combined tablet dosage form. Method involves simultaneous equation, u...