Najmah Binti Hassan

Universiti Teknologi MARA | UiTM · School of Chemistry and Environment

A full account of our efforts towards an asymmetric synthesis of crisamicin A are presented. The key steps include a Hauser-Kraus annulation of a cyanophthalide with a chiral enone-lactone, a stereoselective cyclisation-reduction to install the pyran unit and a Suzuki homocoupling to forge the key biaryl bond. This work has culminated in the asymme...

A chemical investigation of the crude extracts of Cinnamomum mollissimum bark resulted in the isolation of five aporphine alkaloids, namely N-methyl-1,2,10-trimethoxyaporphine, N-methylhernagine, N-methylhemovine, hernagine and hernovine. Their structures were elucidated by spectral analysis. The alkaloid crude extract demonstrated significant anti...