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583
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Introduction
Additional affiliations
January 2020 - present
Mexican Institute of Social Security
Position
- Professor (Full)
October 2014 - October 2021
Publications
Publications (34)
Early life stress (ELS) affects hippocampal neurogenesis, increases depressive-like behavior, and causes mild metabolic imbalance in early adulthood (2 months). However, whether these effects worsen in mid life remains unclear. To test whether age-dependent effects of ELS on hippocampal neurogenesis are related to deficient hypothalamic-pituitary-a...
Early life stress (ELS) is a risk factor for many psychopathologies that happen later in life. Although stress can occur in cases of child abuse, studies on non-accidental brain injuries in pediatric populations do not consider the possible increase in vulnerability caused by ELS. Hence, we sought to determine whether ELS increases the effects of p...
Early life stress (ELS) programs hypothalamus‐pituitary‐adrenal (HPA) axis activity and affects synaptic plasticity and cognitive performance in adults; however, the effects of ELS during the temporal window of vulnerability are poorly understood. This study aimed to thoroughly characterize the effects of ELS in the form of periodic maternal separa...
Early life stress (ELS) followed by pediatric mild traumatic brain injury (mTBI) negatively impacts spatial learning and memory and increases microglial activation in adolescent rats, but whether the same paradigm negatively affects higher order executive function is not known. Hence, we utilized the attentional set-shifting test (AST) to evaluate...
Early life stress induced by maternal separation (MS) causes neuroendocrine, behavioral, and metabolic alterations that are related to gut dysbiosis. MS also increases microglial activation and decreases neurogenesis. Whether these long-term alterations are maintained or worsened in the absence of gut microbiota remains unknown. Hence, this study e...
Objetivo: determinar la frecuencia de experiencias infantiles adversas y su relación con la presencia de síntomas depresivos en una unidad de medicina familiar en Michoacán. Métodos: se realizó un estudio transversal y analítico en 139 participantes adscritos a la Unidad de Medicina Familiar No. 80 del Instituto Mexicano del Seguro Social. Se aplic...
Objetivo: determinar la frecuencia de síntomas depresivos y síndrome metabólico en mayores de 45 años, así como sus posibles asociaciones. Métodos: se realizó un estudio transversal analítico. Se incluyó a 120 participantes adscritos a la Unidad de Medicina Familiar No. 80 del Instituto Mexicano del Seguro Social. Los síntomas depresivos fueron eva...
Objetivo: evaluar la frecuencia de experiencias infantiles adversas y fortalezas familiares en la niñez, en adultos jóvenes con hipertensión y su relación con depresión y riesgo cardiometabólico. Método: estudio transversal comparativo. Participaron 133 adultos jóvenes (con hipertensión: n=60 y control: n=73) adscritos a una unidad de medicina fami...
Traumatic brain injury (TBI) causes persistent cognitive impairment and neurodegeneration. Environmental enrichment (EE) refers to a housing condition that promotes sensory and social stimulation and improves cognition and motor performance but the underlying mechanisms responsible for such beneficial effects are not well defined. In this study, an...
Sea turtle egg relocation and hatchery incubation (hereafter termed ex situ incubation) is an effective strategy to protect clutches when in situ egg incubation is not viable. Nevertheless, it negatively affects the ontogenesis of male gonads and brain areas homologous to the mammalian hippocampus, as well as body size and fitness. Thus, it is impe...
Chronic early life stress (ECS) induced by limited bedding and nesting (LBN) material in rodents is a naturalistic stress model that mimics many of the behavioral and neural consequences of child abuse and neglect; however, the effect of ECS on adult impulsivity has never been studied. The aim of our work was to determine the effects of ECS on cogn...
p> Objetivo: determinar la prevalencia de depresión en adultos mayores en una Unidad de Medicina Familiar (umf) de Michoacán, México y su asociación con el género, la escolaridad y la edad. Métodos: estudio transversal analítico. Participaron adultos mayores de 60 a 84 años de edad en la umf No. 5 de Sahuayo, Michoacán, de marzo a junio de 2019, se...
p> Objetivo: determinar la prevalencia de depresión en adultos mayores en una Unidad de Medicina Familiar (umf) de Michoacán, México y su asociación con el género, la escolaridad y la edad. Métodos: estudio transversal analítico. Participaron adultos mayores de 60 a 84 años de edad en la umf No. 5 de Sahuayo, Michoacán, de marzo a junio de 2019, se...
Prenatal immobilization stress (PNS) and postnatal maternal separation (MS180) are two widely used rodent models of early‐life stress (ELS) that affect the hypothalamus–pituitary–adrenal (HPA) axis, cause behavioral alterations, and affect glucose tolerance in adults. We compared anxiety‐like behavior, coping strategies, and HPA axis activity in PN...
In rodents, daily maternal separation for 180 minutes (MS180) during the first weeks of life affects hippocampal granule cell neurogenesis. Development of the cerebellum granule cell layer also occurs during the first weeks of life. However, whether MS180 affects this neurogenic niche remains unknown. To study this, we evaluated the immediate and l...
Environmental enrichment (EE) confers motor and cognitive recovery in preclinical models of traumatic brain injury (TBI), and neurogenesis has been attributed to mediating the benefits. Whether that ascription is correct has not been fully investigated. Hence, the goal of the current study is to further clarify the possible role of learning-induced...
More than 10 million people worldwide incur a traumatic brain injury (TBI) each year, with two million cases occurring in the United States. TBI survivors exhibit long-lasting cognitive and affective sequelae that are associated with reduced quality of life and work productivity, as well as mental and emotional disturbances. While TBI-related disab...
Behavioral assessments in rats are overwhelmingly conducted during the day, albeit that is when they are least active. This incongruity may preclude optimal performance. Hence, the goal of this study was to determine if differences in neurobehavior exist in traumatic brain injured (TBI) rats when assessed during the day vs. night. The hypothesis wa...
Antipsychotic drugs, such as haloperidol (HAL), are prescribed in the clinic to manage traumatic brain injury (TBI)-induced agitation. While preclinical studies have consistently shown that once-daily administration of HAL hinders functional recovery after TBI in male rats, its effects in females are unknown. Hence, the objective of this study was...
INTERACTION OF BRAIN TRAUMA AND CHRONIC
STRESS ON COGNITION, ANXIETY, AND MARKERS OF
NEUROTRANSMISSION AND NEUROINFLAMMATION
Darik O’Neil, Lindsay Kutash, Patricia B. de la Tremblaye, Ian
Marshall, Jeffrey Cheng, Hannah Radabaugh, Naima Lajud, Anthony
Kline, Corina Bondi
University of Pittsburgh, Safar Center for Resuscitation Research/
PMR, Pitt...
The typical environmental enrichment (EE) paradigm, which consists of continuous exposure after experimental traumatic brain injury (TBI), promotes behavioral and histological benefits. However, rehabilitation is often abbreviated in the clinic and administered in multiple daily sessions. While recent studies have demonstrated that a once daily 6-h...
Environmental enrichment (EE) promotes behavioral recovery after experimental traumatic brain injury (TBI). However, the chronic rehabilitation provided in the laboratory is not analogous to the clinic where physiotherapy is typically limited. Moreover, females make up approximately 40% of the clinical TBI population, yet they are seldom studied in...
Environmental enrichment (EE) enhances cognition after traumatic brain injury (TBI). Galantamine (GAL) is an acetylcholinesterase inhibitor that may also promote benefits. Hence, the aims of this study were to assess the efficacy of GAL alone (standard (STD) housing) and in combination with EE in adult male rats after TBI. The hypothesis was that b...
Early-life stress is associated with depression and metabolic abnormalities that increase the risk of cardiovascular disease and diabetes. Such associations could be due to increased glucocorticoid levels. Periodic maternal separation in the neonate and rearing in social isolation are potent stressors that increase hypothalamus-pituitary-adrenal ax...
Adverse early life experience decreases adult hippocampal neurogenesis and results in increased vulnerability to neuropsychiatric disorders. Despite that the effects of postnatal stress on neurogenesis have been widely studied in adult individuals, few efforts have been done to evaluate its immediate effects on the developing hippocampus. Moreover,...
Tight regulation of hormone and neurochemical milieu during developmental periods is critical for adequate physiological functions. For instance, activation of peptide systems during early life stress induces morphological changes in the brain resulting in depression and anxiety disorders. Prolactin (PRL) exerts different actions within the brain;...
Although not directly evaluated, the early rise of glucocorticoid (GC) levels, as occur after exposure to adverse early life experience, are assumed to affect hippocampal ontogeny by altering the hippocampus negative feedback on adult HPA axis. To test whether hippocampal ontogeny is affected by early exposure to stress we estimated the survival of...
The presence of glia and glial glutamate transporters seems to modify glutamate-mediated toxicity in neuronal cultures. In this work we cultured cortical cells in serum-containing medium and in a serum-free medium (Neurobasal medium + B27 supplement) and studied the expression of the glutamate transporters GLAST, GLT, and EAAC by immunocytochemistr...
