Nailya Kubysheva

Learning from data in almost any human activity is a very important task, usually using similarity or dissimilarity between data. Recently, it was shown the importance of considering the involution operation defined on the data domain which reflects a symmetry of data structures. This symmetry should be taken into account in data analysis. Co-symme...

In today’s data-rich era, there is a growing need for developing effective similarity and dissimilarity measures to compare vast datasets. It is desirable that these measures reflect the intrinsic structure of the domain of these measures. Recently, it was shown that the space of finite probability distributions has a symmetric structure generated...

Negation of probability distributions (PD) was initially introduced by Yager as a transformation of probability distributions representing linguistic terms like High Price, into probability distributions representing linguistic terms like Not High Price. Further, different negations of PD and formal definitions of negations of probability distribut...

The paper presents the method of measuring the similarity and difference in the frequency distributions of one categorical variable for different levels of another variable. This method calculates the similarity and correlation between the rows of the contingency table. In this work, we use it for the analysis of associations of cognitive indicator...

Studying the features of changes in markers of oxidative stress (OS) and inflammation indicators in COPD patients depending on the degree of bronchial obstruction is one of the priority directions for improving the prognosis and monitoring of the course of this pathology. We conducted a comparative investigation of changes in markers of OS and apop...

In recent years many papers have been devoted to the analysis and applications of negations of finite probability distributions (PD), first considered by Ronald Yager. This paper gives a brief overview of some formal results on the definition and properties of negations of PD. Negations of PD are generated by negators of probability values transfor...

Suppose that we know the probability distribution corresponding to some property A. How can we then describe the distribution describing the negation of this property? In this paper, we show that, in general, we need additional information to uniquely determine the desired probability distribution. If we do not have this additional information and...

Recently, the notation of a negation of a probability distribution was introduced. The need for such negation arises when a knowledge-based system can use the terms like NOT HIGH, where HIGH is represented by a probability distribution (pd). For example, HIGH PROFIT or HIGH PRICE can be considered. The application of this negation in Dempster–Shafe...

Recently it was introduced a negation of a probability distribution. The need for such negation arises when a knowledge-based system can use the terms like NOT HIGH, where HIGH is represented by a probability distribution (pd). For example, HIGH PROFIT or HIGH PRICE can be considered. The application of this negation in Dempster-Shafer theory was c...

Introduction: The relationship between objective indicators of nasal obstruction and airflow limitation in children with bronchial asthma (BA) and allergic rhinitis (AR) has not yet been studied. Objective: To study the relationship between objective parameters of nasal obstruction and airflow limitation, determined using the methods of anterior ac...

Circular scales appear in many applications related to a comparative analysis of the timing of events, wind directions, animals and vehicle movement directions, etc. The paper introduces a new non-statistical correlation function on circular scales based on a recently proposed approach to constructing correlation functions (association measures) us...

This review describes the unique links of the functioning of the nitric oxide cycle in the respiratory tract in normal and pathological conditions. The concept of a nitric oxide cycle has been expanded to include the NO-synthase and NO-synthase-independent component of its synthesis and the accompanying redox cascades in varying degrees of reversib...

The involvement of periostin in Th2-dependent allergic inflammation has been documented. However, the significance of periostin as a biomarker of local allergic inflammation in the nasal mucosa (NM) of patients with atopic bronchial asthma (BA) and allergic rhinitis (AR) is yet to be determined. The aim of the study was to determine the presence of...

Background: Uncontrolled asthma (BA) can be complicated by cardiac conduction disturbances and arrhythmias. It is typical mainly for adult asthmatics patients. In asthmatics children the effect of bronchoconstriction on cardiac conduction, including the supraventricular component of the ECG, is currently under discussion. The objective of the resea...

Determination of markers of systemic inflammation is one of the important directions in the study of pathogenesis and improvement of diagnosis of chronic obstructive pulmonary disease (COPD), asthma-COPD overlap (ACO), and bronchial asthma (BA). The aim of our work was a comparative study of the features of changes in serum levels of IL-17, IL-18,...

The potential mechanisms of bronchial asthma (BA) negative modification under the influence of obesity are currently being actively studied. However, at present, the effect of nutritional status on bronchial obstruction in children with BA cannot be considered established. In this regard, the purpose of this work was to study the relationship of sp...

Hematological parameters and blood biochemical markers were measured in 131 children and adolescent patients (70 boys) aged 2 to 17 years with acute hypersensitivity reactions induced by food (59 patients) and medicines (72 patients) in order to establish differences in clinical manifestations and hematological parameters in children with food and...

The paper proposes a new class of fuzzy set similarity measures taking into account the proximity of membership values to the border values 0 and 1. These similarity measures take values in [0,1] and generalize the crisp weak equality relation of fuzzy sets considered in the theory of fuzzy sets. We present the method constructing a contrast simila...

Respiratory diseases are accompanied by intensification of free radical processes at different levels of the biological body organization. Simultaneous stress and suppression of various parts of antioxidant protection lead to the development of oxidative stress (OS) and nitrosative stress (NS). The basic mechanisms of initiation and development of...

Bronchial asthma is associated with upper airway (UA) disorders, primarily with allergic rhinitis, which, in turn, occurs in combination with other UA conditions, including hyperplasia of the nasal mucosa. Chronic rhinosinusitis, if confirmed, is a predictor of asthma severity. The pathogenesis of these diseases includes the remodeling (restructuri...

Soluble molecules of the major histocompatibility complex play an important role in the development of various immune-mediated diseases. However, there is not much information on the participation of these proteins in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of our work was to determine the content of soluble molecu...

Background: Atopic bronchial asthma (BA) in children is associated with upper airways pathology (UAP). Among them, a combination of allergic rhinitis (AR) and nasal obstructive disorders (NOD), including hypertrophy of the pharyngeal tonsil (HPT) and anomalies of the intranasal structures (AINS), is abundant. In such patients, anterior active rhin...

We introduce new correlation measures for measuring similarity and association of rating profiles obtained from bipolar rating scales. Instead of the measurement based approach when the user’s rating is considered as a number measured in ordinal, interval or ratio scales we use model based approach when user’s rating is modeled by bipolar score fun...

Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children...

Bronchial asthma (BA) is often associated with chronic inflammatory processes in the nasal mucosa; these processes give rise to allergic rhinitis, chronic rhinosinusitis, adenoiditis, and polypous rhinosinusitis. Due to their multiple symptoms, these diseases of the upper respiratory tract, especially allergic rhinitis, are often difficult to verif...

The definition of new markers of local and systemic inflammation of chronic obstructive pulmonary disease (COPD) is one of the priority directions in the study of pathogenesis and diagnostic methods improvement for this disease. We investigated 91 patients with COPD and 21 healthy nonsmokers. The levels of soluble CD25, CD38, CD8, and HLA-I-CD8 mol...

Influence of bronchial asthma (BA) severity on physical development in children patients was evaluated in comparison with healthy population. Materials and Methods . 1042 children and adolescents (768 boys) with atopic BA were evaluated. All children underwent standard examination in a clinical setting, including anthropometry. The control group in...

The aim of the investigation was to assess the significance of the content of metabolites of the nitric oxide, sICAM-1 and sICAM-3 in blood serum and in exhaled breath condensate, the serum level of endothelin-1 as systemic and topical markers of inflammation in patients with COPD, and their correlations with the parameters of lung ventilation func...

The aim of the investigation was to estimate the possibilities of using relative body mass index (RBMI) for determining age- and gender-specific aspects of nutritional status in children and adolescents with bronchial asthma (BA) of different severity degrees. Materials and Methods. The study involved 887 children and adolescents with BA of differe...

A bipolar rating scale is a linearly ordered set with symmetry between elements considered as negative and positive categories. First, we present a survey of bipolar rating scales used in psychology, sociology, medicine, recommender systems, opinion mining, and sentiment analysis. We discuss different particular cases of bipolar scales and, in part...

This is a review of published data on oxidative stressinduced antibiotic resistance of pathogens caused by antimicrobials. Known mechanisms of oxidative stress in a bacterial cell include occurrence of oxygen reactive species, protein oxidation products, fat acids, intracellular molecular oxy gen and transition metal ions. Investigations of bacteri...

We propose methods of 3D visualization of the main similarity measures for binary data and 2 x 2 tables. We present the shapes of Jaccard, Dice, Sokal & Sneath, Roger & Tanimoto and other similarity measures. Such visualization of the similarity measures gives the direct, visual, method of comparison of these measures and helps to understand the si...

Objective: To research the soluble major histocompatibility complex class II (sHLA-II)level in serum, sputum and exhaled breath condensate (EBC) in the patientswith COPD. Methods:We examined 61 patients 44-69 years old (62 ± 4.8) with COPD I (n = 21), COPD II (n = 22) and stage III (n = 27) and 30 healthy non-smokers. Results: Levels of the soluble...

Background: Proinflammatory cytokines play an important role in chronic airways inflammation in COPD. However, the role of cytokines in the development of Asthma-COPD Overlap Syndrome (ACOS) has not been clarified. The aim was to study the blood levels of IL-17, IL-18, TNF-α and to analyze relation between circulating cytokines and FEV1 in patients...

Objective: To investigate the contentsmetabolites of nitric oxide and concentration of cytokines γ-INF, IL-1β, IL-4, IL-8 in various biological fluids at patients with exacerbation of COPD. Materials and methods: We examined 49 patients 44-69 years old (62 ± 4,8) with COPD II (n = 22) and stage III (n = 27) and 30 healthy non-smokers. Results: Prog...

At the present stage of study of chronic obstructive pulmonary disease (COPD) one of the problem is the definition of new criteria for the topical and systemic chronic inflammation of this disease. The aim of the research was to study the concentration of nitric oxide metabolites, the level of soluble human leukocyte antigens class I (sHLA-I) and o...

Aim of investigation is establishment of regularity of the nitrogen oxide metabolite content change in the exhaling air condensate (EAC) in children with a bronchial asthma control different level, assessed with a use of the ACQ day and week scales (Asthma Control Questionnaire). Materials and Methods. A summarized content of nitrites and nitrates...

Soluble forms of membrane-bound molecules play an important role in modulation of immune reactions and take part in pathogenesis of various diseases. In the present work, the levels of soluble forms of CD8 molecules (sCD8), class I HLA molecules (sHLA-I) and their complexes (sHLA-I/sCD8) in blood sera and in the condensate of exhaled air were deter...

The levels of soluble CD95 (sCD95) antigen and CD95+ mononuclear cells were studied in the peripheral blood, induced sputum (IS), expired air condensate (EAC) of patients with chronic obstructive pulmonary disease (COPD). There was an increase in the relative count of CD95+ mononuclear cells and a reduction in the level of sCD95 antigen in the peri...

The objective of this study was to measure CD25+ and CD38+ in mononuclear cells, soluble CD25 (sCD25 antigen) and CD38 (sCD38 antigen) in the peripheral blood and the exhaled air condensate (EAC) in patients with chronic obstructive pulmonary disease (COPD) of different severity. Serum and topical sCD25 and sCD39 antigen levels were found to be inc...

The levels of calcium, magnesium and iron were examined on an automated biochemical analyzer in saliva and blood serum of 102 patients with chronic obstructive disease of lungs (CODL) and of 20 healthy subjects. Reliably reduced levels of magnesium and iron in saliva as well as low permeability of the hematosalivary barrier (HSB) for magnesium and...

To study content of interleukin-1 beta (IL-1 beta) and free radical oxidation in neutrophils of blood, saliva and bronchoalveolar lavage (BAL) in chronic bronchitis for prediction of obstructive defects. Enzyme immunoassay was used to measure IL-1 beta in the blood, saliva, BAL of 49 males with chronic bronchitis aged 39-72 years. Functional abilit...