Naiara Rodriguez-Florez

Naiara Rodriguez-Florez
Universidad de Navarra | UNAV · Department of Mechanical Engineering

PhD

About

39
Publications
6,370
Reads
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670
Citations
Citations since 2017
26 Research Items
619 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
Additional affiliations
May 2019 - present
Tecnun, Uversidad de Navarra
Position
  • Professor (Associate)
September 2017 - May 2019
Mondragon Unibertsitatea
Position
  • Lecturer
May 2015 - August 2017
University College London
Position
  • Research Associate
Description
  • http://www.ucl.ac.uk/ich/dbc/scrm/craniofacial
Education
October 2011 - April 2015
Imperial College London
Field of study
  • Bone Biomechanics
September 2005 - May 2011
Universidad de Navarra
Field of study
  • Industrial Engineering

Publications

Publications (39)
Article
Full-text available
Trigonocephaly in patients with metopic synostosis is corrected by fronto-orbital remodeling (FOR). The aim of this study was to quantitatively assess aesthetic outcomes of FOR by capturing 3D forehead scans of metopic patients pre- and post-operatively and comparing them with controls. Ten single-suture metopic patients undergoing FOR and 15 age-m...
Article
This study aimed at using eXtended finite element method (XFEM) to characterize crack growth through bone's intra-cortical pores. Two techniques were compared using Abaqus: (1) void material properties were assigned to pores; (2) multiple enrichment regions with independent crack-growth possibilities were employed. Both were applied to 2D models of...
Article
Full-text available
Bone is a strong and tough material composed of apatite mineral, organic matter and water. Changes in composition and organization of these building blocks affect bone's mechanical integrity. Skeletal disorders often affect bone's mineral phase, either by variations in the collagen or directly altering mineralization. The aim of the current study w...
Article
The determination of lacunar-canalicular permeability is essential for understanding local fluid flow in bone, which may indicate how bone senses changes in the mechanical environment to regulate mechano-adaptation. The estimates of lacunar-canalicular permeability found in the literature vary by up to eight orders of magnitude, and age-related per...
Article
Nanoindentation provides the ideal framework to determine mechanical properties of bone at the tissue scale without being affected by the size, shape, and porosity of the bone. However, the values of tissue level mechanical properties vary significantly between studies. Since the differences in the bone sample, hydration state, and test parameters...
Article
Full-text available
Objective To investigate the relationship between perception of craniofacial deformity, geometric head features, and 3D head shape analyzed by statistical shape modeling (SSM). Patients A total of 18 unoperated patients with scaphocephaly (age = 5.2 ± 1.1m)—6 were followed-up after spring-assisted cranioplasty (SAC) (age = 9.6 ± 1.5m)—and 6 contro...
Article
Full-text available
Limited information is available on the effect of sagittal craniosynostosis (CS) on morphological and material properties of the parietal bone. Understanding these properties would not only provide an insight into bone response to surgical procedures but also improve the accuracy of computational models simulating these surgeries. The aim of the pr...
Article
The aim of this study is, firstly, to create a population-based 3D head shape model for the 0 to 2-year-old subjects to describe head shape variability within a normal population and, secondly, to test a combined normal and sagittal craniosynostosis (SAG) population model, able to provide surgical outcome assessment. 3D head shapes of patients affe...
Article
Spring-assisted cranioplasty (SAC) is a minimally invasive technique for treating sagittal synostosis in young infants. Yet, follow-up data on cranial growth in patients who have undergone SAC are lacking. This project aimed to understand how the cranial shape develops during the postoperative period, from spring insertion to removal. 3D head scans...
Article
Spring-assisted surgery for the correction of scaphocephaly has gained popularity over the past 2 decades. Our unit utilizes standardized torsional springs with a central helix for spring-assisted surgery. This design allows a high degree of accuracy and reproducibility of the force vectors and force distance curves. In this manuscript, we expand o...
Article
Full-text available
Sagittal craniosynostosis consists of premature fusion (ossification) of the sagittal suture during infancy, resulting in head deformity and brain growth restriction. Spring-assisted cranioplasty (SAC) entails skull incisions to free the fused suture and insertion of two springs (metallic distractors) to promote cranial reshaping. Although safe and...
Article
Full-text available
While human adipose-derived stem cells (hADSCs) are known to possess osteogenic differentiation potential, the bone tissues formed are generally considered rudimentary and immature compared with those made by bone-derived precursor cells such as human bone marrow-derived mesenchymal stem cells (hBMSCs) and less commonly studied human calvarium oste...
Article
Full-text available
In this work the suitability of the criterion of maximum effective amplitude of the normal stress (Δσn,eff)max and the criterion of minimum shear stress range (Δτ)min for 2D cylindrical plain fretting contact condition has been analysed. The numerical analysis has been performed by means of the extended finite element method, which takes into accou...
Article
Full-text available
Purpose Cranial lacunae (foci of attenuated calvarial bone) are CT equivalents of “copper beating” seen on plain skull radiographs in children with craniosynostosis. The qualitative presence of copper beating has not been found to be useful for the diagnosis of intracranial hypertension (IH) in these patients. 3D morphometric analysis (3DMA) allows...
Article
Objectives Cranial lacunae on CT is equivalent to the plain X-ray ‘copper beating’ seen in craniosynostosis. Copper beating has not been shown to correlate to intracranial hypertension (IH). However it is a purely quantitative assessment – can qualitative measurement of CT cranial lacunae more accurately predict IH in children with craniosynostosis...
Article
Purpose: Late deformity/indentation is well-recognised following fronto-orbital remodelling (FOR) for metopic synostosis. We hypothesise that if damage to temporalis muscle were a contributor, the thickness of soft tissue and bone in the affected area would be reduced. Materials and methods: Soft tissues and bone were separately segmented and recon...
Article
Full-text available
Objective: When analysing intracranial volume gain due to operative intervention in craniosynostosis, it is necessary to understand the underlying growth. We sought to create comprehensive intracranial volume (ICV) and occipitofrontal circumference (OFC) growth charts, as measured on unoperated craniosynostotic children. Furthermore, we aimed to i...
Article
Full-text available
Repositioning of the maxilla in orthognathic surgery is carried out for functional and aesthetic purposes. Pre-surgical planning tools can predict 3D facial appearance by computing the response of the soft tissue to the changes to the underlying skeleton. The clinical use of commercial prediction software remains controversial, likely due to the de...
Article
Full-text available
The Melbourne technique was described in 2008 as a novel method for complete correction of scaphocephaly. Since 2015, it has become our operation of choice for children with sagittal synostosis who are too old at presentation for minimally invasive techniques. Our modifications were 2-position (initially supine then prone) technique and undertaking...
Article
Implantation of spring-like distractors in the treatment of sagittal craniosynostosis is a novel technique that has proven functionally and aesthetically effective in correcting skull deformities; however, final shape outcomes remain moderately unpredictable due to an incomplete understanding of the skull-distractor interaction. The aim of this stu...
Conference Paper
Background Spring use in Craniofacial surgery was popularised by the Swedish Group led by Lauritzen, starting in 1997. We developed and pioneered the use of bespoke springs as an adjunct in our Craniofacial surgery programme in January 2008 and have since undertaken over 300 cases utilising some 800 springs; to our knowledge this constitutes the la...
Article
The ability to calculate intracranial volume (ICV) from 3-dimensional imaging is a useful tool in a craniofacial team's armamentarium. Intracranial volume uses range from decision making to assessment. Various methods to calculate ICV exist including fully manual, semiautomatic, and fully automatic techniques and they are used with varying frequenc...
Article
OBJECTIVE Scaphocephaly secondary to sagittal craniosynostosis has been treated in recent years with spring-assisted cranioplasty, an innovative approach that leverages the use of metallic spring distractors to reshape the patient skull. In this study, a population of patients who had undergone spring cranioplasty for the correction of scaphocephal...
Article
Full-text available
Background: While spring-assisted cranioplasty has become a widespread technique to correct scaphocephaly in children with sagittal synostosis, predicting head shape changes induced by the gradual opening of the springs remains challenging. This study aimed to explore the role of cranial bone structure on surgical outcomes. Methods: Patients wit...
Article
Full-text available
PurposeSpring-assisted cranioplasty is performed to correct the long and narrow head shape of children with sagittal synostosis. Such corrective surgery involves osteotomies and the placement of spring-like distractors, which gradually expand to widen the skull until removal about 4 months later. Due to its dynamic nature, associations between surg...
Article
Full-text available
Background: Spring-assisted cranioplasty has been proposed as an alternative to total calvarial remodelling for sagittal craniosynostosis. Advantages include its minimally invasive nature, reduced morbidity and hospital stay. Potential drawbacks include the need for a second procedure for removal and the lack of published long-term follow-up. We p...
Article
Three-dimensional (3D) surface imaging devices designed to capture and quantify craniofacial surface morphology are becoming more common in clinical environments. Such scanners overcome the limitations of two-dimensional photographs while avoiding the ionizing radiation of computed tomography. The purpose of this study was to compare standard anthr...
Article
Two-dimensional photographs are the standard for assessing craniofacial surgery clinical outcomes despite lacking three-dimensional (3D) depth and shape. Therefore, 3D scanners have been gaining popularity in various fields of plastic and reconstructive surgery, including craniomaxillofacial surgery. Head shapes of eight adult volunteers were acqui...
Article
Three-dimensional (3D) imaging is an important tool for diagnostics, surgical planning, and evaluation of surgical outcomes in craniofacial procedures. Gold standard for acquiring 3D imaging is computed tomography that entails ionizing radiations and, in young children, a general anaesthesia. Three-dimensional photographic imaging is an alternative...
Thesis
Full-text available
This PhD aimed at characterising mechanical, structural and compositional properties of cortical bone at the micro- and nano-scale employing various techniques applied to mouse models of ageing and disease. Nanoindentation was used to probe bone at the micro-scale. Nanoindentation properties of the same control mouse bones were measured using a ran...
Conference Paper
Full-text available
Aging and skeletal diseases lead to an increase in bone fracture risk. In particular, micro-porosity might have a profound influence on crack propagation. In osteogenesis imperfecta murine (oim) bones, which represent the moderate to severe condition of osteogenesis imperfecta in humans, a genetic mutation results in high bone fragility. Oim bones...
Conference Paper
The determination of lacunar-canalicular permeability is essential to understand the mechano-transduction mechanism of bone. Murine models are widely used to investigate skeletal growth and regulation, but the value of lacunar-canalicular permeability is still unclear. To address this question, a poroelastic analysis based on nanoindentation data w...

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