Nagwan Rashwan

South Valley University · Department of Pediatrics

Background: Considering the global SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) outbreak, comorbid conditions in children may enhance the risk of COVID-19-related severe morbidity and mortality with failure of chronic disease management. Objectives: To explore the various clinical, laboratory, and radiological presentations of COVI...

Coronavirus Disease 2019 (COVID-19) is an infectious condition caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Unlike adults, children are less frequently affected by SARSCoV-2, with milder symptoms and a lower mortality rate. Conversely, as individuals age, the severity of COVID-19 tends to increase for both genders. Th...

Background: The specific aetiology of autism spectrum disorder (ASD) is still unclear. We aimed to evaluate the potential association between three vitamin D receptor single nucleotide polymorphisms (VDR-SNPs) [ApaI (rs7975232), TaqI (rs 731236), and BsmI (rs1544410)] with susceptibility and severity of autism. Methods: The current research involv...

Background: Physiological Jaundiceis more common in neonates. While causes such as incompatibility of blood groups or polycythemia can be easily identified, most are still undiagnosed. Phototherapy is an effective way to reduce the accumulation of bilirubin. Vitamin D is a fat-soluble vitamin that plays an important role in bone remodeling. It is a...

Febrile seizures (FSs) are a common occurrence in young children and a serious concern in pediatric practice; nevertheless, the causes and mechanisms of FS are still unknown. We hypothesized a relation of neuropeptides such as neurotrophin-3 (NT-3) and growth-associated protein-43 (GAP-43) as well as zinc and the oxidant/antioxidant system with ped...

Background: Epilepsy is one of the most common neurological disorders, and it places a significant economic strain on the healthcare system around the world. Although the exact mechanism of epilepsy has yet to be illustrated, various pathogenic cascades involving neurotransmitters and trace elements have been reported. We aimed to investigate the s...

Background: The pathogenesis and effects of maternal diabetes on their infants is still not entirely understood, but it's likely to have several teratogenic mechanisms. The fetal heart is anatomically and physiologically altered by diabetes mellitus. About 400 genes are thought to be involved in the etiology of congenital heart disease such as DAW1...

Background:Mild microcytic hypochromic anemias caused by iron deficiency (IDA) and beta-thalassemia trait (βTT) continue to be problematic and a significant threat to society, particularly in relatively poor developing countries.The goal of this study was to use accuracy approach to improve the diagnostic function of eight different prejudiced indi...

Nephrotic syndrome (NS) is a common paediatric kidney disease characterised by leakage of protein from the blood into the urine through damaged glomeruli. It is classically defined by nephrotic-range proteinuria (≥40 mg/ m2/hour or urine protein/creatinine ratio ≥ 200 mg/mL or 3 + protein on urine dipstick), hypoalbuminaemia (<25 g/L) and edema. Du...

Purpose: Majority of the assessments, appraisals and placements have been disturbed, with some being cancelled, postponed, or modified in design. New approaches for assessment should be well-thought-out. This work attempts at capturing the collective wisdom of educators in the Middle East and North Africa region (MENA), providing an understanding...

Background In newborns, jaundice is the most common ailment that necessitates medical treatment and hospital readmission. The aim of this study was to evaluate vitamin D3 status and investigate the role of phototherapy in the treatment of jaundice and the improvement of vitamin D3 status in neonates with physiological jaundice. Materials and Method...

Background: Early diagnosis of sepsis is a clinical challenge as the clinical symptoms are subtle, late, and nonspecific. Minimum of 48 hours is required for the earliest result of blood culture, and it can be negative despite clinical signs of sepsis. Delaying the treatment leads to an increase in mortality. Thus, it is crucial to diagnose neonata...

Background:In critical illness, there also is evidence of rapid falls in circulating 25(OH)D concentrations. So, we aim to assess the prevalence of VDD in a pediatric ICU (PICU) patients and to determine whether there is any relationship between VDD and illness severity and mortality. Patients and methods:this is a case control study that included...

http://ijp.mums.ac.ir/article_16335.html Background: The diagnosis of inborn errors of metabolism is generally challenging. We aimed to explore various types of urea cycle disorders (UCDs) and their clinical presentations among pediatric patients. Materials and methods: This case-control study was conducted on 86 participants categorized into 43 p...

Purpose The current study aimed to assess the serum levels of vitamin D and immunoglobulin E (IgE) among asthmatic Egyptian children and to find out the possible associations of vitamin D receptor (VDR) polymorphisms with bronchial asthma development. Methods The study included 100 Egyptian children, 50 asthmatic children who were comparable with...

Background: Neonatal hyperbilirubinemia is a common problem in neonates with an incidence of about 60% in term babies and 80% in preterm babies. It is the commonest cause of admission to the hospitals in the newborn period. We should assess all babies for jaundice at every opportunity. Methods include visual assessment, transcutaneous bilirubinomet...

Background: Iron deficiency anemia (IDA) and beta thalassemia trait (β-TT) are most common causes of microcytic hypochromic anemia. When the diagnosis of iron deficiency anemia and thalassemia minor, is based only on hematological parameters and erythrocyte morphology, It is necessary to carry out the gold standard tests to differentiate between th...

In the present study, 45 children in Upper Egypt (less than 16 years old) were admitted to the Pediatric Intensive Care Unit for scorpion envenomation (SE).They were compared with 30 apparently healthy children of matching age and sex as controls. Out of the studied victims, 35 children (78 %) showed signs of severe envenomation, while 10 victims (...

Background: Urea Cycle Disorders (UCDs) represent a group of rare inborn errors of metabolism leading to accumulation of ammonia, a toxic product of protein metabolism. Normal function of the urea cycle requires six enzymes: N-Acetylglutamate Synthase (NAGS), Carbamoyl Phosphate Synthetase I (CPS1), Ornithine Transcarbamylase (OTC), Argininosuccina...

Background: Macrosomia defined as birth-weight over 4,000 g irrespective of gestational age or greater than the 90th percentile for gestational age. Macrosomia affect 3-15% of all pregnancies. Macrosomia is associated with numerous perinatal and maternal complications. Objectives: To assess the echocardiographic changes of macrosomic Infants of Dia...

Background: The diagnosis of neonatal sepsis still considered to be a challenge for both the clinicians and the laboratory due to the non-specific clinical presentations. The present study aimed to compare and assess the diagnostic & prognostic values of C-reactive protein (CRP), high sensitivity CRP (hsCRP), presepsin, interleukin-6 (IL6) and proc...

Globally, prematurity is a major cause of death and a significant cause of long-term loss of human potential amongst survivors all around the world. Complications of preterm birth are the single largest direct cause of neonatal deaths, responsible for 35% of the world’s 3.1 million deaths a year in almost all countries with reliable data. Preterm b...