
Naeimeh TayebiWashington University in St. Louis | WUSTL , Wash U · Department of Psychiatry
Naeimeh Tayebi
M.D., PhD
About
36
Publications
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Introduction
Additional affiliations
March 2020 - May 2023
March 2017 - March 2020
January 2007 - May 2011
Welfare and rehabilitation center
Position
- Genetic counselor
Education
May 2013 - April 2017
July 2011 - May 2013
July 1997 - September 2005
Publications
Publications (36)
Objective:
The goal of this study is to demonstrate the utility of a growth assay to quantify the functional impact of single nucleotide variants (SNVs) in SLC2A1, the gene responsible for Glut1DS.
Methods:
The functional impact of 40 SNVs in SLC2A1 was quantitatively determined in HAP1 cells in which SLC2A1 is required for growth. Donor librari...
Background
Congenital vertical talus (CVT), also known as “rocker-bottom foot”, is a rare foot deformity associated with a dislocation of the talonavicular joint. Although genetic causes of CVT have been described in single isolated and syndromic families, whole-exome sequencing (WES) of large cohorts have not yet been reported.
Methods
In this st...
Induced pluripotent stem cells (iPSC) derived from healthy individuals are important controls for disease-modeling studies. Here we apply precision health to create a high-quality resource of control iPSCs. Footprint-free lines were reprogrammed from four volunteers of the Personal Genome Project Canada (PGPC). Multilineage-directed differentiation...
Induced Pluripotent Stem Cells (iPSC) derived from healthy individuals are important controls for disease modeling studies. To create a resource of genetically annotated iPSCs, we reprogrammed footprint-free lines from four volunteers in the Personal Genome Project Canada (PGPC). Multilineage directed differentiation efficiently produced functional...
Purpose:
Inherited retinal diseases (IRDs) are clinically and genetically heterogeneous showing progressive retinal cell death which results in vision loss. IRDs include a wide spectrum of disorders, such as retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), cone-rod dystrophy (CRD), and Stargardt disease (STGD1).
Methods:
In this stud...
Hearing loss (HL) is a common sensory disorder in humans with high genetic heterogeneity. To date, over 145 loci have been identified to cause nonsyndromic deafness. Furthermore, there are countless families unsuitable for the conventional linkage analysis. In the present study, we used a custom capture panel (MiamiOtoGenes) to target sequence 180...
Table S1. PCR primers surrounding the variants of 5 genes used in the experiments.
The CRISPR/Cas technology enables targeted genome editing and the rapid generation of transgenic animal models for the study of human genetic disorders. Here we describe an autosomal recessive human disease in two unrelated families characterized by a split-foot defect, nail abnormalities of the hands, and hearing loss, due to mutations disrupting...
Synpolydactyly (SPD) is a rare congenital limb disorder characterized by syndactyly between the third and fourth fingers and an additional digit in the syndactylous web. In most cases SPD is caused by heterozygous mutations in HOXD13 resulting in the expansion of a N-terminal polyalanine tract. If homozygous, the mutation results in severe shorteni...
Background
A growing number of non-coding regulatory mutations are being identified in congenital disease. Very recently also some exons of protein coding genes have been identified to act as tissue specific enhancer elements and were therefore termed exonic enhancers or “eExons”.
Methods
We screened a cohort of 134 unrelated families with split-h...
Crohn's disease (CD) is an intractable inflammatory bowel disease (IBD) of unknown cause. Recent meta-analysis of the genome-wide association studies (GWAS) and Immunochip data identified 163 susceptibility loci to IBD in Caucasians, however there are limited studies in other populations.
We performed a GWAS and two validation studies in the Korean...
Background
Hyperlipidaemia is a major risk factor for coronary artery disease (CAD) and cholesteryl ester transfer protein (CETP) gene polymorphisms are known to be associated with lipid profiles.
Methods
In this study, we investigated the association of two polymorphisms in the CETP, Taq1B (rs708272) and -629C > A (rs1800775), with CAD and lipid...
Background:
Recent genome-wide association studies and meta-analyses have identified 47 susceptibility loci for ulcerative colitis (UC) in Caucasian populations. A previous genome-wide association study of UC in a Japanese population suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. We performed a genome-wi...
Objective:
A recent genome wide association study in the Chinese population has implicated rs6903956 within the ADTRP gene on chromosome 6p24.1 as a novel susceptibility locus for coronary artery disease (CAD). In this study, we evaluated the association of rs6903956 with CAD in the different ethnic groups of Singaporean population comprising Chin...
Objective
Sexuality is an important and integral part of every woman's life. The aim of this study was to assess the degree of sexual dysfunction among infertile women and its correlation with age, duration of marriage and etiology of infertility in women.
Materials and methods
300 infertile women who were referred to IVF center for management of...
Pericentric inversions are among the most frequent chromosomal rearrangements with a frequency of 1-2%. There is no phenotypic effect in the majority of pericentric inversion heterozygote carriers, when it is a balanced rearrangement. However, miscarriages, infertility and/or chromosomally unbalanced offspring can be observed in carriers of a peric...
Aim of this study is to determine the risk of adverse pregnancy outcome by maternal serum alpha-fetoprotein (MSAFP) level. We followed 295 pregnant women from MSAFP screening in the 14th to 22th week of gestation until the end of pregnancy and information on pregnancy outcome have been recorded in questionnaires. Of 295 pregnant women, 270 had term...
Consanguinity has been a long standing social habit among some Iranians. This study is aimed at determining the role of consanguinity on congenital malformations and the correlation of inbreeding coefficient with anomalies.
In this cross-sectional study, all the newborns who were born during 9 months period from April to December 2008. (n=1195) at...
Background: Waardenburg syndrome (WS) is a rare, autosomal dominant disorder characterized by congenital hearing loss; dystopia canthorum; broad nasal root; depigmantation of hair, skin or both; and heterochromic iris. WS is classified into four types, WS1, WS2, WS3 and WS4. In this paper, we report a new case of Waardenburg syndrome type I in an I...
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ABSTRACT
Objective: Sexuality is an important and integral part of every woman’s life. The aim of this study was to assess the degree of sexual dysfunction among infertile women and its correlation with age, duration of marriage and etiology of infertility in women.
Materials and Methods: 300 infertile women who were referred to IVF center for ma...
We present an unknown case of an 11-year-old boy with mental retardation, microcephaly, prominent ears, unilateral ptosis, long philtrum, prominent and everted lower lip, abnormally shaped teeth and developmental delay. This is an unknown case with special facial features and mental retardation which can probably be the second case of Mehta-Lewis-P...
Aim: The aim of this study was to assess the degree of sexual dysfunction among infertile women and its correlation with age, duration of marriage and etiology of infertility in women. Methods: 300 infertile women who were referred to IVF center for management of their infertility problem involved in this study after inform consent. They are asked...
BACKGROUND:
Bloom's syndrome, an autosomal recessive inherited disorder, belongs to the group of chromosomal breakage syndromes. The clinical diagnosis of BS is confirmed cytogenetically. Its frequency in the general population is unknown but it is common in eastern European Ashkenazi Jews.
CASE REPORT:
A 12-year-old girl was referred to us becaus...
Anti-Mullerian hormone is produced by the granulosa cells of preantral and small antral follicles. The objective of this study was to investigate whether anti-Mullerian hormone and antral follicle count can be useful in predicting the ovarian reserve and pregnancy outcome in assisted reproductive technology cycles.
This prospective study included a...
BACKGROUND:
Cornelia de Lange syndrome (CDLS) is a rare multiple congenital anomaly syndrome characterized by a distinctive facial appearance, developmental delay, growth retardation, low birth weight, skeletal formation anomaly, and hirsutism.
CASE:
Here for the first time a case of CDLS from Iran, a 15-week-old male infant who was refereed as a...
• Aim: To investigate clinical presentation, classification, diagnosis, pathogenesis, complication and treatment of blepharitis. • Methods: In this study, 300 patients referred to general eye clinic have been chosen with diagnosis of blepharitis by Haag-streit slit-lamp examination. A questionnaire was filled in for patient with blepharitis. Then,...
Background: The sternoclavicular joint (SCJ) is the only synovial articulation between the upper extremity and the trunk. This joint is one of the most frequently used joints, so osteoarthritis (OA) should be very common. However, there are few studies about OA in this joint. Methods: In this study, 48 sternoclavicular joints from the left and righ...
Background: Recent reports have suggested that ultrasound-guided embryo transfer (UG-ET) might improve pregnancy rates.Objective: To determine whether transabdominal UG-ET is a useful tool for increasing pregnancy and implantation rates in patients undergoing IVF or ICSI.Materials and Methods: A prospective randomized clinical trial was conducted i...
The aim of this study was to investigate the outcome of frozen-thawed embryo transfer in exogenous estrogen plus progesterone without GnRH agonist and with GnRH agonist cycles for endometrial preparation in women with regular menstrual cycles. This study was designed as a prospective randomized clinical trial. In total, 60 patients were randomly di...
The Kartagener syndrome is an autosomal recessive disorder characterized by bronchiectasis, sinusitis and situs inversus. This research reports a 28 years old woman with dextrocardia ask for genetic counseling to have a healthy child. She suffers from recurrent chronic sinusitis and bronchitis with situs inversus including right-sided heart and pan...
This paper reports two cases of inversion chromosome 9 in one of partners from two sub fertile couples. The first case was the woman with idiopathic recurrent spontaneous abortion in the first trimester of her pregnancy, which referred to genetic counseling clinic. Cytogenetic examination showed that her karyotype was 46 XX, inv (9) (p11q13), and h...
The aim of this study was to find out whether the administration of piroxicam prior to embryo transfer might improve implantation and pregnancy rates in patients under IVF therapy. This study was designed as a prospective randomized clinical trial. In total, 180 fresh IVF-ET cycles were randomly divided into treatment and control groups. The treatm...
Objective: The aim of the present study was to compare the effectiveness of laparoscopic ovarian drilling (LOD) with monopolar diathermy and CO2 laser on the serum levels of hormone and pregnancy outcome in clomiphene citrate (CC) resistant infertile women with polycystic ovarian syndrome (PCOS). Materials and Methods: Thirty women underwent laparo...
Objective: To compare the effects of letrozole 5mg and clomiphene citrate (CC) 100mg on total follicle number, endometrial thickness, hormone levels, pregnancy, miscarriage and OHSS rate in women undergoing superovulation and I.U.I. Material and methods: This study was done as a prospective randomized trial in Research and Clinical Center for Infer...
Objective: To evaluate follicle growth and maturation supported by daily late follicular phase low-dose human chorionic gonadotropins (hCG) administration following pre-stimulation with clomiphene citrate(CC) and human menopausal gonadotropin (hMG) in comparison with a sequential CC and hMG regime only. Materials and methods: A prospective controll...