Nadir Mustafa Qadir Nanakali

Salahaddin University - Erbil | SUH · Department of Biology

Natural products such as curcumin, quercetin, and resveratrol have been shown to have antitumor effectsand several studies have examined their role in treating cancer, either alone or in combination with other chemotherapeutic drugs. These compounds are capable of affecting different cancer-related mechanisms, such as proliferation, inflammation, i...

Morinda elliptica L. (Rubiaceae) is a phytomedicinal herb, used to treat gastrointestinal complications in Peninsular Malaysia. The study evaluates the in vivo hepatoprotective activity of ethanolic extract of M. elliptica stem in thioacetamide (TAA) induced liver fibrosis in male Sprague Drawly rats. Thirty adult rats were divided into five groups...

Garcinia mangostana L. (Clusiaceae) principally contains gamma (γ)-mangostin, a xanthone that exhibits a wide spectrum of bioactivities. The current study was aimed to establish the gastroprotective effect of this compound in ethanol-induced gastric mucosal injuries in rats. Experimental Sprague Dawley (SD) rats (n = 30) were arbitrarily alienated...

Garcinia mangostana L. (Clusiaceae) principally contains gamma (γ)-mangostin, a xanthone that exhibits a wide spectrum of bioactivities. The current study was aimed to establish the gastroprotective effect of this compound in ethanol-induced gastric mucosal injuries in rats. Experimental Sprague Dawley (SD) rats (n = 30) were arbitrarily alienated...

One of the preeminent factors of Coronary heart disease contemplated to be Hyperlipidemia. High cholesterol additives activates hyperlipidemia and Oxidative stress in rats eliciting biochemical and toxicological changes. Traditionally, Terminalia arjuna bark consumed as medicinal agents for various purposes, mainly as cardiac protectives. The prese...

The purpose of this study was to evaluate the prophylactic effects of quercetin (QUE) against oxidative damages and histological changes induced by 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin (TCDD) in rat heart. For this purpose, 20 adult male Wistar rats were divided into four groups as fellow control group, TCDD group (10µg/kg BW/day by gavage daily...

The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method and their physicochemical propert...

Mercury (Hg) is known as a poisonous heavy metal which stimulates a wide range of adverse effects on the human health. Therefore, development of some feasible, practical and highly sensitive platforms would be desirable in determination of Hg²⁺ level as low as nmol L⁻¹ or pmol L⁻¹. Different approaches such as ICP-MS, AAS/AES, and nanomaterial-base...

The present study is designed to investigate the harmful effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on some physiological, histopathological, and biochemical aspects in rats, and the preventive role of quercetin. Thirty albino rats were distributed into five groups (6 in each group). The Control group received corn oil as a vehicle; in t...

AuNPs with enzyme-like features have received strong attention in different areas, although limited data is available in literature on their biological/industrial functions. NPs especially Au counterparts have been shown to functionally mimic the activity of antioxidant enzyme. Indeed, due to low cytotoxicity and SPR characteristics of AuNPs, there...

In this study, the protective effects of antioxidant quercetin(QCT) were studied on indices of oxidative stress, liver enzymes activity and the expression of cytochrome P450 1A1 (CYP1A1) against hepatotoxicity induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in male rat. Thirty adult male Wistar rats randomly divided into five equal groups....

Nicotine is the most common ingredient in cigarette and is associated with the pathogenesis of lung carcinoma and raise the risk of promoting hepatocellular carcinoma and liver cirrhosis. Prohibition of lung cancer caused by nicotine and liver damage can be achieved by reducing the pathogenic effects of nicotine. The naturalistic nutrition system c...

Abdulkareem-Nanakali: Quercetin reduces oxidative stress damage to reproductive profile induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in male albino rats (Rattus norvegicus L.)-13185-APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH 17(6):13185-13197. Abstract. The article aimed to investigate the effect of the antioxidant quercetin (QCT) on male Wistar...

Herein, the interaction of CeO2 NPs with HSA was explored by fluorescence, CD, UV–vis and molecular docking studies. Afterwards, the antioxidant activity of CeO2 NPs against H2O2-induced oxidative stress in BM-MSCs were explored by MTT, ROS and apoptosis assays. Antibacterial assay was also done on two Gram-positive and Gram-negative bacterial stra...

Aim Among therapeutic proposals for amyloid-associated disorders, special attention has been given to the exploitation of nanoparticles (NPs) as promising agents against aggregation. Methods In this paper, the inhibitory effect of cerium oxide (CeO2) NPs against α-synuclein (α-syn) amyloid formation was explored by different methods such as Thiofl...

Enzymes are one of the foundations and regulators for all major biological activities in living bodies. Hence, enormous efforts have been made for enhancing the efficiency of enzymes under different conditions. The use of nanomaterials as novel carriers for enzyme delivery and regulating the activities of enzymes has stimulated significant interest...

This study have been designed to study the effect of extracted pure oleuropein from Oleaeuropaealeaf against alloxan induced type 1 diabetic rats.Diabetic male ratwas induced by injectingsingle subcutaneous injection of 100 mg/kg b.wof alloxan.Respectively, pure oleuropein compound (5, 10, 15 and 20 mg/kg.b.w)was orally administered once per a day...

Background and objective: Malondialdehyde is the end product of lipid peroxidation by oxidative stress (free radicals). Superoxide dismutase is one of the important antioxidant enzymes that catalyze conversion of superoxide to hydrogen peroxide. The aim of present study is to measure the serum Malondialdehyde concentration and Superoxide dismutase...